Lidija Varga-Defterdarović

Lidija Varga-Defterdarović


senior research associate
+385 1 457 1290


Krilo 2/120

Ruđer Bošković Institute
Division of Organic Chemistry and Biochemistry
Laboratory for Carbohydrate, Peptide and Glycopeptide Research
Bijenička cesta 54
HR-10000 Zagreb



1982   Faculty of Chemical Technology, University of Zagreb, Croatia, B.Sc.

1987   Faculty of Natural Sciences and Mathematics, University of Zagreb, Croatia, M.Sc.

1990   Faculty of Natural Sciences and Mathematics, University of Zagreb, Croatia, Ph.D.


"Chemical transformations of natural compounds" (098-0982933-2936, Ministry of Science, Education and Sport of the Republic of Croatia)


  1. Department of Biotechnology, University of Rijeka, Croatia; Master Studies: Pharmaceutical Research and Development, Medicinal Biotechnology and Medicinal Chemistry, course: "Protein Modification in Aging and Diseases"  (course type: optional)
  2. Department of Biotechnology, University of Rijeka, Croatia; Graduate Studies of Medicinal chemistry, course: "The Other Side of Metabolism" (course type: optional)

Featured Publications

  1. Š. Horvat, M. Kralj, M. Perc, I. Jerić, L. Varga-Defterdarović, A. Jakas, M. Roščić, L. Šuman and M. Gredičak: Novel side-chain glucosylated and adamantylated [Asp2/Glu2]enkephalin analogues: synthesis and in vitro growth inhibition of human tumor cells. Chemical Biology & Drug Design. 73(2) (2009) 253-257.
  2. I. Nemet, L. Varga-Defterdarović: The role of methylglyoxal in the non-enzymatic conversion of tryptophan, its methyl ester and tryptamine to 1-acetyl-β-carbolines. Bioorg. Med. Chem. 16 (2008) 4551–4562.
  3. I. Nemet, L. Varga-Defterdarović: Methylglyoxal-derived β-carbolines formed from tryptophan and its derivates in the Maillard reaction. Amino Acids 32 (2007) 291-293.
  4. I. Nemet, L. Varga-Defterdarović, Z. Turk: Methylglyoxal in food and living organisms (Review). Mol. Nutr. Food Res. 50 (2006) 1105-1117.
  5. Z. Turk, I. Nemet, L. Varga-Defterdarović, N. Car: Elevated Level of Methylglyoxal during Diabetic Ketoacidosis and its Recovery Phase. Diabetes & Metabolism 32 (2) (2006) 176-180.
  6. I. Nemet, Z. Turk, L. Duvnjak, N. Car, L. Varga-Defterdarović: Humoral Methylglyoxal Level Reflects Glycemic Fluctuation. Clin. Biochem., 38 (2005) 379-383.
  7. I. Nemet, D. Vikić-Topić, L. Varga-Defterdarović: Spectroscopic studies of methylglyoxal in water and dimethylsulfoxide, Bioorg. Chem., 32 (2004) 560-570.
  8. I. Nemet, L. Varga-Defterdarović, Z. Turk: Preparation and quantification of methylglyoxal in human plasma using reverse-phase high-performance liquid chromatography. Clin. Biochem., 37 (2004) 875-881.
  9. L. Varga-Defterdarović and G. Hrlec: Synthesis and intramolecular reactions of Tyr-Gly and Tyr-Gly-Gly related 6-O-glucopyranose esters. Carbohydr. Res., 339 (2004) 67-75.
  10. Š. Horvat, I. Jerić, L. Varga-Defterdarović, M. Roščić and J. Horvat: Ester-linked Glycopeptides as Tools for the Study of Biological Phenomena, Croatica Chem. Acta 74(4) (2001) 787-799.
  11. Š. Horvat, L.Otvos Jr., L. Urge, J. Horvat, M. Čudić and L. Varga-Defterdarović: Cirkular dichroism study of the carbohydrate-modified opioid peptides. Spectrochimica Acta, Part A   55(11) (1999) 2347-2352.
  12. L. Varga-Defterdarović, D. Vikić-Topić and Š. Horvat: Synthesis and characterisation of mannose-related imidazolidinones formed by the intramolecular rearrangement of the manopyranose ester of leucine-enkephalin. J. Chem. Soc., Perkin Trans 1 19 (1999) 2829-2834.

Membership in professional associations / societies

  1. Croatian Chemical Society, president of the Section for Organic Chemistry Nomenclature
  2. Croatian Society of Chemical Engineers, president of the Section for Organic Chemistry Nomenclature
  3. Croatian Society of Biochemistry and Molecular Biology
  4. European Peptide Society