Krunoslav Brčić-Kostić

Krunoslav Brčić-Kostić

+385 1 457 1285

1417
1608

Krilo 5/115

Department of Molecular Biology, Ruđer Bošković Institute, Bijenička 54, 10002 Zagreb, Croatia

Education

  Formal education

1969-1977                                                                                                                  Primary School, Subotica

1977-1981                                                                                                                  Secondary School, Subotica

1982-1986                                                                                                                  Faculty of Science, University of Zagreb,

Croatia

Achievement:

B.Sc. – Biology

1987-1990                                                                                                                  Faculty of Science, University of Zagreb,

Croatia

Achievement:

Ph.D. – Genetics

                                                                          Faculty of Science, Univesity of Zagreb

                                                                          Croatia

Ph.D. title: «Interaction of RecBCD enzyme and damaged DNA in bacteria Escherichia coli»

Summer Schools and Workshops

1990   Supramolecular Structure and Function – Summer School in Biophysics

           Kupari, Dubrovnik, Croatia

1990   Summer School in Transcription

           Marina di Aurisima, Trieste, Italy

2002   Microsatellites, Mitochondrial DNA and Conservation Genetics: Principles and

           Applications – A Training Course

           University of Zagreb, Zagreb, Croatia

2004   Summer Institute in Statistical Genetics (Population Genetic Data Analysis, Principles

           of Quantitative Genetics, QTL-mapping I)

     North Carolina State University, Raleigh, NC, USA

               

Formal education

1969-1977                                                                                                                  Primary School, Subotica

1977-1981                                                                                                                  Secondary School, Subotica

1982-1986                                                                                                                  Faculty of Science, University of Zagreb,

Croatia

Achievement:

B.Sc. – Biology

1987-1990                                                                                                                  Faculty of Science, University of Zagreb,

Croatia

Achievement:

Ph.D. – Genetics

                                                                          Faculty of Science, Univesity of Zagreb

                                                                          Croatia

Ph.D. title: «Interaction of RecBCD enzyme and damaged DNA in bacteria Escherichia coli»

Summer Schools and Workshops

1990   Supramolecular Structure and Function – Summer School in Biophysics

           Kupari, Dubrovnik, Croatia

1990   Summer School in Transcription

           Marina di Aurisima, Trieste, Italy

2002   Microsatellites, Mitochondrial DNA and Conservation Genetics: Principles and

           Applications – A Training Course

           University of Zagreb, Zagreb, Croatia

2004   Summer Institute in Statistical Genetics (Population Genetic Data Analysis, Principles

           of Quantitative Genetics, QTL-mapping I)

     North Carolina State University, Raleigh, NC, USA

Projects

Research Grants

2006-2011       The role of recombination in DNA repair and genome evolution, the Project funded by the Croatian Ministry of Science, Education and Sport

2009-2011       Destruction of bacterial spores by solar UV radiation, NATO for Peace and    Security Program - with Ralf Moeller (Germany) and Jose-Luis Sagripanti (USA)

Classes

Teaching Activity

 Since 1999, I have been teaching Population Genetics at the Faculty of Science, University of Zagreb. The course of Population Genetics consists of lectures about basic principles of population, quantitative and evolutionary genetics. Since 2006, I am Assistant Professor at the Faculty of Science, University of Zagreb, Croatia. Since 2011 I participate in teaching of population genetics at the University Centre for Forensic Sciences of the University of Split.

Featured Publications

List of publications

Vlašić I., Šimatović A., Brčić-Kostić K. (2011) Genetic requirements for high constitutive SOS expression in recA730 mutants of Escherichia coli. J. Bacteriol. 193: 4643-4651.

Jokić M., Brčić-Kostić K., Štefulj J., Ivković T. C., Božo L., Gamulin M., Kapitanović S. (2011) Association of MTHFR, MTR, MTRR, RFC1 and DHFR gene polymorphisms with susceptibility  to sporadic  colon cancer. DNA and Cell Biol. ,  in press.

Vlašić I., Šimatović A., Brčić-Kostić K. (2011) The recA730 dependent suppression of recombination deficiency in RecA loading mutants of Escherichia coli. Res. Microbiol. 162: 262-269.

Brčić-Kostić K. (2010) Quantitative genetics and evolution. Period. Biol. 112: 395-402.

Vlašić I., Ivančić-Baće I., Imešek M., Mihaljević B., Brčić-Kostić K. (2008) RecJ nuclease is required for SOS induction after introduction of a double-strand break in a RecA loading deficient recB mutant of Escherichia coli. Biochimie 90: 1347-1355.

Mastelić J., Jerković I., Blažević I., Poljak-Blaži M., Borović S., Ivančić-Baće I., Smrecki V., Žarković N., Brčić-Kostić K., Vikić-Topić D., Muller N. (2008) Comparative study on the antioxidant and biological activities of carvacrol, thymol, and eugenol derivatives. J. Agric. Food Chem. 56: 3989-3996.

Ivančić-Baće I., Vlašić I., Čogelja-Čajo G., Brčić-Kostić K., Salaj-Šmic E. (2006) Roles of PriA protein and double-strand DNA repair functions in UV-induced restriction alleviation in Escherichia coli. Genetics 174: 2137-2149.

Ivančić-Baće I., Vlašić I., Salaj-Šmic E., Brčić-Kostić K. (2006) Genetic evidence for the requirement of RecA loading activity in SOS induction after UV irradiation in Escherichia coli. J. Bacteriol. 188: 5024-5032.

Brčić-Kostić K. (2005)  Neutral mutation as the source of genetic variation in life history traits. Genet. Res. 86: 53-63.

Ivančić-Baće I., Salaj-Šmic E., Brčić-Kostić K. (2005)  Effects of recJ, recQ, and recFOR mutations on recombination in nuclease-deficient recB recD double mutants of Escherichia coli. J. Bacteriol. 187: 1350-1356.

Ivančić-Baće I., Peharec P., Moslavac S., Škrobot N., Salaj-Šmic E., Brčić-Kostić K. (2003)  RecFOR function is required for DNA repair and recombination in a RecA loading-deficient recB mutant of Escherichia coli. Genetics 163: 485-494.

Ivančić-Baće I., Škrobot N., Zahradka D., Salaj-Šmic E., Brčić-Kostić K. (2002)  Genetic requirements for conjugational recombination in the presence of l Gam protein in Escherichia coli. Food Technol. Biotech. 40: 261-265.

Zahradka D., Zahradka K., Petranović M., Đermić D., Brčić-Kostić K. (2002)  The RuvABC resolvase is indispensable for recombinational repair in sbcB15 mutants of Escherichia coli. J. Bacteriol. 184: 4141-4147.

Paškvan I., Salaj-Šmic E., Ivančić-Baće I., Zahradka K., Trgovčević Ž., Brčić-Kostić K. (2001)  The genetic dependence of RecBCD-Gam mediated double strand end repair in Escherichia coli. FEMS Microbiol. Lett. 205: 299-303.

Čogelja-Čajo G., Brčić-Kostić K., Ivančić I., Trgovčević Ž., Salaj-Šmic E. (2001)  Inactivation of the EcoKI restriction in UV-irradiated Escherichia coli: The role of RecBCD enzyme. Period. Biol. 103: 157-161.

Salaj-Šmic E., Đermić D., Brčić-Kostić K., Čogelja-Čajo G., Trgovčević Ž. (2000)  In vivo studies of Escherichia coli RecB polypeptide lacking its nuclease center. Res. Microbiol. 151: 769-776.

Lerš N., Salaj-Šmic E., Kovačević G., Brčić-Kostić K., Trgovčević Ž. (1997)  Homologous recombination in Escherichia coli: A model for the formation of invasive DNA strands. Period. Biol. 99: 303-305.

Brčić-Kostić K., Stojiljković I., Salaj-Šmic E., Trgovčević Ž. (1992)  Overproduction of the RecD polypeptide sensitizes Escherichia coli cells to gamma radiation. Mutat. Res. 281: 123-127.

Trgovčević Ž., Petranović M., Brčić-Kostić K., Petranović D., Lerš N., Salaj-Šmic E. (1991)  A possible interaction of single-strand binding protein and RecA protein during post-ultraviolet DNA synthesis. Biochimie 73: 515-517.

Brčić-Kostić K., Salaj-Šmic E., Maršić N., Kajić S., Stojiljković I., Trgovčević Ž. (1991)  Interaction of RecBCD enzyme with DNA damaged by gamma radiation. Mol. Gen. Genet. 228: 136-142.

Brčić-Kostić K., Stojiljković I., Salaj-Šmic E., Trgovčević Ž. (1989)  The recB gene product is essential for exonuclease V-dependent DNA degradation in vivo. Mutat. Res. 227: 247-250.

Trgovčević Ž., Lerš N., Brčić-Kostić K., Salaj-Šmic E. (1989)  Post-ultraviolet DNA synthesis in the absence of repair: role of the single-strand DNA-binding protein. Int. J. Radiat. Biol. 55: 739-745.

Membership in professional associations / societies

Functions and Memberships in Professional Organizations and Societies

From 2004 to 2009 I was a Steering Committee member of the European Science Foundation (ESF) Programme Integrating population genetics and conservation biology: Merging theoretical, experimental and applied approaches (ConGen). I am a member of Croatian Genetics Society, Croatian Society for Biochemistry and Molecular Biology, Croatian Society for Theoretical and Mathematical Biology, and Croatian Biological Society.

Miscellaneous

Reviews

I reviewed manuscripts for BMC Molecular Biology, BMC Microbiology, Frontiers in Bioscience, Food Technology and Biotechnology, and Periodicum Biologorum

Ph.D. and Diploma Students

I was supervisor for one Ph.D. thesis in the field of genetics of recombination and DNA repair. I was supervisor for 9 Diploma thesis (8 in genetics of recombination and DNA repair, and one in population genetics).