Andreja Jakas

Andreja Jakas


+385 1 468 0103

Research Associate

Krilo 2/238

Rudjer Boskovic Institute
Bijenička c. 54



B. Sc.  December 20, 1991, University of Zagreb, Faculty of Science, Department of Chemistry

M. Sc. January 31, 1995, University of Zagreb, Faculty of Science, Department of Chemistry, M. Sc. Thesis: Synthesis of new Amadori compounds, derivatives of  d-fructose and [Leu5]enkephalin

Ph. D. October 19, 2001, University of Zagreb, Faculty of Science, Department of Chemistry, Ph. D. Thesis: Synthesis and reactivity of Amadori compounds related to biologically active peptides


2008-2012     Principal investigator on the project (NATO SfP 983154): Artificial Receptors for Bacillus Anthracis Sepecific Anthrose Detection


1. Biomarkers (University of Rijeka; Study of Medicinal Chemistry)

Featured Publications

1.         Lj. Glavaš-Obrovac, A. Jakas, S. Marczi and Š. Horvat:

The influence of cell growth media on the stability and antitumor activity of methionine enkephalin

J. Peptide Sci. 11 (2005) 506-511.


2.       Š. Horvat, K. Mlinarić-Majerski, Lj. Glavaš-Obrovac, A. Jakas, J. Veljković,  S. Marczi, G. Kragol, M. Roščić, M. Matković, A. Milostić-Srb:
Tumor-Cell Targeted Methionine-enkephalin Analogues Containing Unnatural Amino Acids: Design, Synthesis and In Vitro Antitumor Activity.

J. Med. Chem. 49 (2006)  3136-3142.

3.       A. Jakas, M. Vinković, V. Smrečki, M. Šporec, Š. Horvat:
Fructose induced N-terminal glycation of enkephalins and related peptides 

J. Peptide  Sci. 14 (2008) 936-945.

4.       A. Jakas, A. Katić, N. Bionda,  Š. Horvat:
Glycation of a lysine-containing tetrapeptide by D-glucose and D-fructose - Influence of different reaction conditions on the formation of Amadori/Heyns products

Carbohydr.  Res. 343 (2008) 2475-2480.

5.       A. Jakas, Š. Horvat:
Reactivity and oxidative potential of fructose and glucose in enkephalin-sugar model systems

Amino Acids. 34 (2008) 329-332.

6.       Š. Horvat, M. Kralj, M. Perc, I. Jerić, L. Varga-Defterdarović, A. Jakas, M. Roščić, L. Šuman, M. Gredičak:
Novel side-chain glucosylated and adamantylated [Asp2/Glu2]enkephalin analogues: synthesis and in vitro growth inhibition of human tumor cells.

Chem. Biol. Drug Design. 73 (2009) , 2; 253-257.


Membership in professional associations / societies

Croatian Chemical Society

European Peptide Society