Biserka Žinić

Biserka Žinić

Dr. Sc.

+385 1 456 1066

1466

385 1 46 80 195

385 91 580 3895
Senior research associate, Associate Professor

Krilo 4/5C

Ruđer Bošković Institute, Division of Organic Chemistry and Biochemistry,
Laboratory of Supramolecular and Nucleoside Chemistry
Bijenicka 54, HR-10000 Zagreb, CROATIA

bibliography

BZinic-C V 2013.doc 170.00 kB

Education

  • 1988.   Ph.D. Degree, Chemistry, Ruđer Bošković Institute, University of Zagreb
  • 1981.   M.Sc. Degree, Chemistry, Faculty of Natural Science and Mathematics, University of Zagreb
  • 1976.   B.Sc. Degree, Chemistry and Biochemistry, Faculty of Natural Sciences and Mathematics, University of Zagreb

Research Areas

Chemistry, Organic Chemistry, Natural Sciences

Specific research interests

medicinal chemistry, chemistry of nucleosides and nucleotides

Projects

  • 2010. Leader and principal investigator of chemistry in the BioZyne Ltd -company for research and development in the life sciences.
  • 2007. Leader of the research project: Synthesis of novel biologically active nucleobase and nucleotide derivatives, which is part of the Program: New small molecules targeting macromolecules of tumor and inflammatory processes, Croatian Ministry of Science, Education and Sports.

Classes

  • 2011. - present-Teaching at the International PhD Study in Medicinal Chemistry, Rijeka, Croatia
    • Course (mandatory): Methods in peptide, carbohydrate and nucleoside synthesis
    • Course (elective): Chemistry of nucleosides and nucleotides
  • 1992. - present- Teaching at the PhD study in organic chemistry, Faculty of Natural Science and Mathematics, University of Zagreb, Croatia
    • Course (elective): "Nucleosides and Nucleotides”.

Featured Publications

  1. Saftić, Dijana, Žinić, Biserka, Višnjevac, Aleksandar, DBU induced formation of 8-bromoguanosine dimer with three hydrogen bonds between the GG– base pairs, Tetrahedron 68 (2012) 1062-1070.
  2. Kašnar-Šamprec, Jelena; Ratkaj, Ivana; Mišković, Katarina; Pavlak, Marina; Baus-Lončar, Mirela; Kraljević Pavelić, Sandra; Glavaš-Obrovac, Ljubica; Žinić, Biserka. In vivo toxicity study of N-1-sulfonylcytosine derivatives and their mechanisms of action in cervical carcinoma cell line. Invest. New Drugs 30 (2012) 981-990.
  3. Kobetić, Renata; Gembarovski, Dubravka; Višnjevac, Aleksandar; Žinić, Biserka; Gabelica-Marković, Vesna. ESI MS Studies of Palladium (II) Complexes with 1-(p-Toulenesulfonyl)cytosine/cytosinato Ligands. J. Mass. Spectrom. 45(2010)51–64..
  4. Višnjevac, Aleksandar; Biliškov, Nikola; Žinić, Biserka. Transition Metal Complexes of N-1-tosylcytosine and N-1-mesylcytosine, Polyhedron 28 (2009) 3101–3109.
  5. Višnjevac, Aleksandar, Luić, Marija; Kobetić, Renata; Gembarovski, Dubravka; Žinić, Biserka. Stabilization of the N-1-substituted cytosinate iminooxo form in dinuclear palladium complexes. Polyhedron 28 (2009) 1057–1064.
  6. Supek, Fran; Kralj, Marijeta; Marjanović, Marko; Šuman, Lidija; Šmuc, Tomislav; Krizmanić, Irena; Žinić, Biserka. Atypical Cytostatic Mechanism of N-1-Sulfonylcytosine Derivatives Determined byIn vitroScreening and Computational Analysis. Invest. New Drugs 26 (2008) 97–110.
  7. Višnjevac, Aleksandar; Žinić, Mladen; Luić, Marija; Žiher, Dinko; Kajfež Novak, Tanja; Žinić; Biserka. Conformational Chirality and Chiral Crystallization of N-Sulfonylpyrimidine derivatives. Tetrahedron 63 (2007) 86-92. 
  8. Pavlak, Marina; Stojković, Ranko; Radačić -Aumiler, Matea; Kašnar-Šamprec, Jelena; Jerčić, Jure; Vlahović, Ksenija; Žinić, Biserka; Radačić,Marko. Antitumor Activity of NovelN-Sulfonylpyrimidine Derivatives on the growth of Anaplastic Mammary Carcinoma In vivo. J. Cancer. Res. Clin. Oncol. 131 (2005) 829-836.
  9. Krizmanić, Irena; Višnjevac, Aleksandar; Luić, Marija; Glavaš-Obrovac, Ljubica, Žinić, Mladen; Žinić, Biserka. Synthesis, Srtucture, and Biological Evaluation of C-2 Sulfonamido Pyrimidine Nucleosides. Tetrahedron 59 (2003) 4047-4057.
  10. Žinić, Biserka; Žinić, Mladen; Krizmanić, Irena. Synthesis of the Sulfonylpyrimidine Derivatives with Anticancer Activity. EP 0 877 022 B1 (Bulletin 1003/16; 16.04.2003.)

Membership in professional associations / societies

  • 2005.-member of the editorial board of Arkivoc
  • 1992.-2005.member of the editorial board of Croatica Chemica Acta
  • 1992.-2000.assistant editor of Croatica Chemica Acta
  • 1992.-membership in the International Society for Nucleosides, Nucleotides and Nucleic Acids
  • 1976.-membership in the Croatian Chemical Society