All Projects

Lysosomal dysfunction as a common mechanism of neurodegenerative diseases

Lysosomal dysfunction as a common mechanism of neurodegenerative diseases

Principal Investigator: Silva Katušić Hećimović

Using a lysosomal disorder NPC as a model, the goal of this project is to investigate a role of lysosomal impairment on accumulation of amyloid-beta peptide (Abeta) and alpha-synuclein (a-syn), the two characteristic features in the pathogenesis of AD and PD.

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Monitoring the fish farm RibarstvoF, Cres island

Monitoring the fish farm RibarstvoF, Cres island

Principal Investigator: Neven Cukrov

Monitoring the sediment quality below fish farm.

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Image source: http://www.smartnano.org/

Sensitive MeAsuRmenT, detection and identification of engineered NANO particles in complex matrices

Principal Investigator: Daniel Lyons

Nanotechnology is having a large impact in many industrial sectors and the use of nanoparticles is continuously increasing in many fields, from paints, automotive components, consumer products such as cosmetic sunscreens and anti-odorant up to biology and medicine.

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COST

Supramolecular Chemistry in Water

Principal Investigator: Marina Ilakovac Kveder

COST Action 1005

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The molecular links between cholesterol homeostasis, membrane trafficking and Alzheimer's disease

The molecular links between cholesterol homeostasis, membrane trafficking and Alzheimer's disease

Principal Investigator: Silva Katušić Hećimović

Aberrant proteolytic cleavage of the amyloid precursor protein (APP) leading to increased formation/accumulation of β-amyloid peptide (Aβ) is considered a central event in the pahogenesis of Alzheimer's disease (AD). Although much has been known about the Aβ generation and its clearance, we still do not understand in great detail how Aβ metabolism is altered in the most common late-onset form of AD (LOAD) and what are the molecular trigger(s) that initiate these events. In this project we will test the hypothesis that cholesterol metabolism and membrane trafficking are tightly linked and that their dysregulation leads to Alzheimer's disease. 

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