2019.− Poslijediplomski doktorski sveučilišni studij Kemija, Prirodoslovno-matematički fakultet, Sveučilište u Zagrebu

Mentor: dr. sc. Robert Vianello

2013.−2018. Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, smjer Farmacija

Diplomski rad: Kvantno-kemijska studija enantiomerizacije oksazepama

Mentor: prof. dr. sc. Valerije Vrček, Neposredni voditelj: doc. dr. sc. Davor Šakić

31. 12. 2020. Godišnja nagrada Instituta Ruđer Bošković za znanstveni rad: Experimental and Computational Study of the Antioxidative Potential of Novel Nitro and Amino Substituted Benzimidazole/Benzothiazole-2-Carboxamides with Antiproliferative Activity

17. 12. 2019. Godišnja nagrada Instituta Ruđer Bošković za znanstveni rad: Chlorination of 5−fluorouracil: Reaction mechanism and ecotoxicity assessment of chlorinated products

06. 07. 2017. Rektorova nagrada za individualni znanstveni rad (Sveučilište u Zagrebu): Mehanizam reakcije kloriranja 5-fluorouracila i ekotoksikološka analiza kloriranih produkata

[1] A. Beč, L. Hok, L. Persoons, E. Vanstreels, D. Daelemans, R. Vianello, M. Hranjec. Synthesis, Computational Analysis, and Antiproliferative Activity of Novel Benzimidazole Acrylonitriles as Tubulin Polymerization Inhibitors: Part 2. Pharmaceuticals, 2021, 14, 1052‒1078.

[2] N. Sakač, D. Madunić-Čačić, D. Marković, L. Hok, R. Vianello, B. Šarkanj, B. Đurin, K. Hajdek, B. Smoljan, S. Milardović, B. Matasović, M. Jozanović. Potentiometric Surfactant Sensor Based on 1,3- Dihexadecyl-1H-benzo[d]imidazol-3-ium for Anionic Surfactants in Detergents and Household Care Products. Molecules, 2021, 26, 3627.

[3] L. Hok, E. Lluch Sanchez, R. Vianello, B.-M. Kukovec, Z. Popović. Self‐assembly of cobalt(II) coordination polymers with differently halosubstituted nicotinate ligands and 4,4’‐bipyridine – the effect of the halosubstituent positions on polymer types. Eur J Inorg Chem, 2021, 15, 1470–1480.

[4] L. Ptiček, L. Hok, P. Grbčić, F. Topić, M. Cetina, K. Rissanen, S. Kraljević Pavelić, R. Vianello, L. Racané. Amidino substituted 2-aminophenols: biologically important building blocks for the amidino- functionalization of 2-substituted benzoxazoles. Org Biomol Chem, 2021, 19, 2784–2793.

[5] L. Hok, R. Vianello. Direct Metal-Free Transformation of Alkynes to Nitriles: Computational Evidence for the Precise Reaction Mechanism. Int J Mol Sci, 2021, 22, 3193.

[6] N. Perin, L. Hok, A. Beč, L. Persoons, E. Vanstreels, D. Daelemans, R. Vianello, M. Hranjec. N-substituted benzimidazole acrylonitriles as in vitro tubulin polymerization inhibitors: Synthesis, biological activity and computational analysis. Eur J Med Chem, 2021, 211, 113003.

[7] L. Hok, J. Mavri, R. Vianello. The Effect of Deuteration on the H₂ Receptor Histamine Binding Profile: A Computational Insight into Modified Hydrogen Bonding Interactions. Molecules, 2020, 25, 6017.

[8] S. Roca, L. Hok, R. Vianello, M. Borovina, M. Đaković, Lj. Karanović, D. Vikić-Topić, Z. Popović. The role of non-covalent intermolecular interactions on the diversity of crystal packing in supramolecular dihalopyridine–silver(I) nitrate complexes. CrystEngComm, 2020, 22, 7962–7974.

[9] T. Tandarić, L. Hok, R. Vianello. From Hydrogen Peroxide-Responsive Boronated Nucleosides Towards Antisense Therapeutics – A Computational Mechanistic Study. Croat Chem Acta, 2019, 92, 287–295.

[10] M. Cindrić, I. Sović, M. Mioč, L. Hok, I. Boček, P. Roškarić, K. Butković, I. Martin-Kleiner, K. Starčević, R. Vianello, M. Kralj, M. Hranjec. Experimental and Computational Study of the Antioxidative Potential of Novel Nitro and Amino Substituted Benzimidazole/Benzothiazole-2-Carboxamides with Antiproliferative Activity. Antioxidants, 2019, 8, 477.

[11] L. Hok, L. Božičević, H. Sremec, D. Šakić, V. Vrček. Racemization of oxazepam and chiral 1,4-benzodiazepines. DFT study of the reaction mechanism in aqueous solution. Org Biomol Chem, 2019, 17, 1471–1479.

[12] L. Hok, L. Ulm, T. Tandarić, A. Krivohlavek, D. Šakić, V. Vrček. Chlorination of 5-fluorouracil: Reaction mechanism and ecotoxicity assessment of chlorinated products. Chemosphere, 2018, 207, 612–619.

[13] L. Hok, A. Akrap, F. J. Marelja, S. Morić, M. Parlov, M. Bojić. The Role of Cytochrome P450 in Aerotoxic Syndrome. Farmaceutski glasnik, 2018, 1, 15–29.

Radovi u časopisima

Znanstveni i pregledni radovi

• Radović, M., Hok, L., Panić, M., Cvjetko Bubalo, M., Vianello, R., Vinković, M. & Radojčić Redovniković, I. (2022) Deep eutectic solvents as a stabilising medium for NAD coenzyme: unravelling the mechanism behind coenzyme stabilisation effect. Green chemistry, 24 (19), 7661-7674 doi:10.1039/d2gc02656b.

  doi

• Hok, L., Vianello, R., Matković- Čalogović, D., Karanović, L., Roca, S., Jaźwiński, J., Tašner, M., Vušak, D., Đaković, M. & Popović, Z. (2022) A series of nickel(II) thiocyanate complexes comprising various molar contents of isonicotinamide and water as ligands or co-crystallized moieties – an experimental and computational study. CrystEngComm, 24 (37), 6564-6578 doi:10.1039/d2ce00847e.

  doi

• Mehić, E., Hok, L., Wang, Q., Dokli, I., Svetec Miklenić, M., Findrik Blažević, Z., Tang, L., Vianello, R. & Majerić Elenkov, M. (2022) Expanding the scope of enantioselective halohydrin dehalogenases – group B. Advanced synthesis & catalysis, 364 (15), 2576-2588 doi:10.1002/adsc.202200342.

  doi

• Boček, I., Hok, L., Persoons, L., Daelemans, D., Vianello, R. & Hranjec, M. (2022) Imidazo[4,5-b]pyridine derived tubulin polymerization inhibitors: Design, synthesis, biological activity in vitro and computational analysis. Bioorganic chemistry, 127, 106032, 13 doi:10.1016/j.bioorg.2022.106032.

  doi

• Hok, L., Rimac, H., Mavri, J. & Vianello, R. (2022) COVID-19 infection and neurodegeneration: Computational evidence for interactions between the SARS-CoV-2 spike protein and monoamine oxidase enzymes. Computational and Structural Biotechnology Journal, 20, 1254-1263 doi:10.1016/j.csbj.2022.02.020.

  doiwww.sciencedirect.comfulir.irb.hr

• Beč, A., Hok, L., Persoons, L., Vanstreels, E., Daelemans, D., Vianello, R. & Hranjec, M. (2021) Synthesis, computational analysis, and antiproliferative activity of novel benzimidazole acrylonitriles as tubulin polymerization inhibitors: Part 2. Pharmaceuticals, 14 (10), 1052, 26 doi:10.3390/ph14101052.

  doiwww.mdpi.comdx.doi.orgfulir.irb.hr

• Sakač, N., Madunić-Čačić, D., Marković, D., Hok, L., Vianello, R., Šarkanj, B., Đurin, B., Hajdek, K., Smoljan, B., Milardović, S., Matasović, B. & Jozanović, M. (2021) Potentiometric surfactant sensor based on 1,3-dihexadecyl-1H-benzo[d]imidazol-3-ium for anionic surfactants in detergents and household care products. Molecules, 26 (12), 3627, 14 doi:10.3390/molecules26123627.

  doiwww.mdpi.comdx.doi.orgfulir.irb.hr

• Hok, L., Lluch Sanchez, E., Vianello, R., Kukovec, B. & Popović, Z. (2021) Self‐assembly of cobalt(II) coordination polymers with differently halosubstituted nicotinate ligands and 4,4’‐bipyridine – the effect of the halosubstituent positions on polymer types. European journal of inorganic chemistry, 2021 (15), 1470-1480 doi:10.1002/ejic.202100055.

  doi

• Ptiček, L., Hok, L., Grbčić, P., Topić, F., Cetina, M., Rissanen, K., Kraljević Pavelić, S., Vianello, R. & Racané, L. (2021) Amidino substituted 2-aminophenols: biologically important building blocks for the amidino-functionalization of 2-substituted benzoxazoles. Organic & biomolecular chemistry, 19, 2784-2793 doi:10.1039/d1ob00235j.

  doi

• Hok, L. & Vianello, R. (2021) Direct Metal-Free Transformation of Alkynes to Nitriles: Computational Evidence for the Precise Reaction Mechanism. International journal of molecular sciences, 22 (6), 3193, 16 doi:10.3390/ijms22063193.

  doiwww.mdpi.comwww.mdpi.comdoi.orgfulir.irb.hr

• Perin, N., Hok, L., Beč, A., Persoons, L., Vanstreels, E., Daelemans, D., Vianello, R. & Hranjec, M. (2021) N-substituted benzimidazole acrylonitriles as in vitro tubulin polymerization inhibitors: Synthesis, biological activity and computational analysis. European journal of medicinal chemistry, 211, 113003, 14 doi:10.1016/j.ejmech.2020.113003.

  doi

• Hok, L., Mavri, J. & Vianello, R. (2020) The Effect of Deuteration on the H2 Receptor Histamine Binding Profile: A Computational Insight into Modified Hydrogen Bonding Interactions. Molecules, 25 (24), 6017, 17 doi:10.3390/molecules25246017.

  doiwww.mdpi.comdoi.orgfulir.irb.hr

• Roca, S., Hok, L., Vianello, R., Borovina, M., Đaković, M., Karanović, L., Vikić-Topić, D. & Popović, Z. (2020) The role of non-covalent intermolecularinteractions on the diversity of crystal packing insupramolecular dihalopyridine–silver(I) nitratecomplexes. Crystengcomm, 22, 7962-7974 doi:10.1039/d0ce01257b.

  doi

• Tandarić, T., Hok, L. & Vianello, R. (2019) From Hydrogen Peroxide-Responsive Boronated Nucleosides Towards Antisense Therapeutics – A Computational Mechanistic Study. Croatica chemica acta, 92 (2), 287-295 doi:10.5562/cca3592.

  doihrcak.srce.hrdoi.orgfulir.irb.hr

• Cindrić, M., Sović, I., Mioč, M., Hok, L., Boček, I., Roškarić, P., Butković, K., Martin-Kleiner, I., Starčević, K., Vianello, R., Kralj, M. & Hranjec, M. (2019) Experimental and computational study of the antioxidative potential of novel nitro and amino substituted benzimidazole/benzothiazole-2-carboxamides with antiproliferative activity. Antioxidants, 8 (10), 477, 22 doi:10.3390/antiox8100477.

  doidx.doi.orgwww.mdpi.comfulir.irb.hr

• Hok, L., Božičević, L., Sremec, H., Šakić, D. & Vrček, V. (2019) Racemization of oxazepam and chiral 1, 4-benzodiazepines. DFT study of the reaction mechanism in aqueous solution. Organic & biomolecular chemistry, 17, 1471-1479 doi:10.1039/C8OB02991A.

  doipubs.rsc.org

• Hok, L., Ulm, L., Tandarić, T., Krivohlavek, A., Šakić, D. & Vrček, V. (2018) Chlorination of 5-fluorouracil: Reaction mechanism and ecotoxicity assessment of chlorinated products. Chemosphere, 207 (18), 612-619 doi:10.1016/j.chemosphere.2018.05.140.

  doiwww.sciencedirect.com

Hrvatska ljekarnička komora (od 2021.)

Hrvatsko kemijsko društvo (od 2019.)