dr. sc. Diana Trnski
1512
10000 Zagreb
Hrvatska
Obrazovanje
2015. - dr.sc. iz znanstvenog područja biomedicine i zdravstva, znanstvenog polja temeljnih medicinskih znanosti, Sveučilišni poslijediplomski interdisciplinarni doktorski studij Molekularne bioznanosti, Sveučilište J.J. Strossmayera u Osijeku, Sveučilište u Dubrovniku, Institut Ruđer Bošković
2008. - dipl.inž. biologije, molekularna biologija, Prirodoslovno-matematički fakultet, Sveučilište u Zagrebu
Nagrade i priznanja
2011 - EACR Travel Fellowship Award
2018 - EACR Travel Fellowship Award
Nastava
suradnica u nastavi preddiplomskih i postdiplomskih kolegija (voditeljica dr.sc. Sonja Levanat)
- "Metode rekombinantne DNA“, Specijalistički studij sanitarnog inženjerstva, Viša zdravstvena škola, Zagreb
- "Metode istraživanja u molekularnoj onkologiji", doktorski studij Biomedicina i zdravstvo Medicinskog fakulteta Sveučilišta u Zagrebu
Istaknute publikacije
- Levanat, Sonja; Sabol, Maja; Musani, Vesna; Ozretić, Petar; Trnski, Diana. Hedgehog Signaling Pathway as Genetic and Epigenetic Target in Ovarian Tumors. // Current pharmaceutical design. 23 (2017), 1; 73-94.
- *Ozretić, Petar; *Trnski, Diana; Musani, Vesna; Maurac, Ivana; Kalafatić, Držislav; Orešković, Slavko; Levanat, Sonja; Sabol, Maja. Non-canonical Hedgehog signaling activation in ovarian borderline tumors and ovarian carcinomas. // International journal of oncology. 51 (2017), 6; 1869-1877. *autori dijele prvo autorstvo
- Trnski, Diana; Sabol, Maja; Gojević, Ante; Martinić, Marina; Ozretić, Petar; Musani, Vesna; Ramić, Snježana; Levanat, Sonja. GSK3β and Gli3 play a role in activation of Hedgehog-Gli pathway in human colon cancer — Targeting GSK3β downregulates the signaling pathway and reduces cell proliferation. // Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1852 (2015), 12; 2574-2584.
- *Sabol, Maja; *Trnski, Diana; Užarević, Zvonimir; Ozretić, Petar; Musani, Vesna; Rafaj, Maja; Cindrić, Mario; Levanat, Sonja. Combination of cyclopamine and tamoxifen promotes survival and migration of MCF-7 breast cancer cells – interaction of Hedgehog-Gli and Estrogen receptor signaling pathways. // PLOS ONE. 9 (2014), 12; e114510-1-e114510-23. *autori dijele prvo autorstvo
- Leović, Dinko; Sabol, Maja; Ozretić, Petar; Musani, Vesna; Car, Diana; Marjanović, Ksenija; Zubčić, Vedran; Sabol, Ivan; Sikora, Miroslav; Grce, Magdalena; Glavaš-Obrovac, Ljubica; Levanat, Sonja. Hh-Gli signaling pathway activity in oral and oropharyngeal squamous cell carcinoma. // Head and neck. 34 (2012), 1; 104-112.
Publikacije
Radovi u časopisima
Znanstveni i pregledni radovi
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Zubčić, V., Rinčić, N., Kurtović, M., Trnski, D., Musani, V., Ozretić, P., Levanat, S., Leović, D. & Sabol, M. (2020) GANT61 and Lithium Chloride Inhibit the Growth of Head and Neck Cancer Cell Lines Through the Regulation of GLI3 Processing by GSK3beta. International journal of molecular sciences, 21, 6410, 13 doi:10.3390/ijms21176410.
doiwww.mdpi.comfulir.irb.hr -
Ozretić, P., Hanžić, N., Proust, B., Sabol, M., Trnski, D., Radić, M., Musani, V., Ciribilli, Y., Milas, I., Puljiz, Z., Bosnar Herak, M., Levanat, S. & Slade, N. (2019) Expression profiles of p53/p73, NME and GLI families in metastatic melanoma tissue and cell lines. Scientific Reports, 9 (1), 12470, 13 doi:10.1038/s41598-019-48882-y.
doiwww.nature.comfulir.irb.hr -
Sušac, I., Ozretić, P., Gregorić, M., Levačić Cvok, M., Sabol, M., Levanat, S., Trnski, D., Eljuga, D., Seiwerth, S., Aralica, G., Stanec, M. & Musani, V. (2019) Polymorphisms in survivin (BIRC5 gene) are associated with age of onset in breast cancer patients. Journal of Oncology, 2019, 3483192, 10 doi:10.1155/2019/3483192.
doifulir.irb.hrwww.hindawi.comdoi.org -
Trnski, D., Gregorić, M., Levanat, S., Ozretić, P., Rinčić, N., Majić Vidaković, T., kalafatić, D., Maurac, I., Orešković, S., Sabol, M. & Musani, V. (2019) Regulation of Survivin Isoform Expression by GLI Proteins in Ovarian Cancer. Cells, 8 (2), 128, 13 doi:10.3390/cells8020128.
doiwww.mdpi.comdoi.orgfulir.irb.hr -
Sabol, M., Trnski, D., Musani, V., Ozretić, P. & Levanat, S. (2018) Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets. International journal of molecular sciences, 19 (9), 2562, 37 doi:10.3390/ijms19092562.
doiwww.mdpi.comfulir.irb.hrwww.mdpi.com -
Ozretić, P., Trnski, D., Musani, V., Maurac, I., Kalafatić, D., Orešković, S., Levanat, S. & Sabol, M. (2017) Non-canonical Hedgehog signaling activation in ovarian borderline tumors and ovarian carcinomas. International journal of oncology, 51 (6), 1869-1877 doi:10.3892/ijo.2017.4156.
doi -
Levanat, S., Sabol, M., Musani, V., Ozretić, P. & Trnski, D. (2017) Hedgehog Signaling Pathway as Genetic and Epigenetic Target in Ovarian Tumors. Current pharmaceutical design, 23 (1), 73-94 doi:10.2174/1381612822666161006154705.
doi -
Trnski, D., Sabol, M., Gojević, A., Martinić, M., Ozretić, P., Musani, V., Ramić, S. & Levanat, S. (2015) GSK3β and Gli3 play a role in activation of Hedgehog-Gli pathway in human colon cancer — Targeting GSK3β downregulates the signaling pathway and reduces cell proliferation. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1852 (12), 2574-2584 doi:10.1016/j.bbadis.2015.09.005.
doi -
Ozretić, P., Bisio, A., Musani, V., Trnski, D., Sabol, M., Levanat, S. & Inga, A. (2015) Regulation of human PTCH1b expression by different 5' untranslated region cis-regulatory elements. RNA Biology, 12 (3), 290-304 doi:10.1080/15476286.2015.1008929.
doi -
Sabol, M., Trnski, D., Užarević, Z., Ozretić, P., Musani, V., Rafaj, M., Cindrić, M. & Levanat, S. (2014) Combination of cyclopamine and tamoxifen promotes survival and migration of MCF-7 breast cancer cells – interaction of Hedgehog-Gli and Estrogen receptor signaling pathways. PLOS ONE, 9 (12), e114510-1 doi:10.1371/journal.pone.0114510.
doifulir.irb.hr -
Musani, V., Sabol, M., Car, D., Ozretić, P., Kalafatić, D., Maurac, I., Orešković, S. & Levanat, S. (2013) PTCH1 gene polymorphisms in ovarian tumors: Potential protective role of c.3944T allele. Gene, 517 (1), 55-59 doi:10.1016/j.gene.2012.12.089.
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Sabol, M., Car, D., Musani, V., Ozretić, P., Orešković, S., Weber, I. & Levanat, S. (2012) The Hedgehog signaling pathway in ovarian teratoma is stimulated by Sonic Hedgehog which induces internalization of Patched. International journal of oncology, 41 (4), 1411-1418 doi:10.3892/ijo.2012.1554.
doifulir.irb.hr Tkalec, M., Car, D., Gospočić, J., Križaić, I., Duž, K. & Vidaković-Cifrek, Ž. (2012) Response of Kalanchoe daigremontiana to wounding and infection with Agrobacterium tumefaciens. PERIODICUM BIOLOGORUM, 114 (1), 83-90.
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Levanat, S., Musani, V., Levačić Cvok, M., Sušac, I., Sabol, M., Ozretić, P., Car, D., Eljuga, D., Eljuga, L. & Eljuga, D. (2012) Three novel BRCA1/BRCA2 mutations in breast/ovarian cancer families in Croatia. Gene, 498 (2), 169-176 doi:10.1016/j.gene.2012.02.010.
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Maurac, I., Sabol, M., Musani, V., Car, D., Ozretić, P., Kalafatić, D., Orešković, S., Babić, D. & Levanat, S. (2012) A low grade ovarian carcinoma case with coincident LOH of PTCH1 and BRCA1, and a mutation in BRCA1. International journal of gynecological pathology, 31 (3), 264-271 doi:10.1097/PGP.0b013e31823b6f0f.
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Musani, V., Sabol, M., Car, D., Ozretić, P., Orešković, S., Leović, D. & Levanat, S. (2012) LOH of PTCH1 region in BCC and ovarian carcinoma: microsatellite vs. HRM analysis. Frontiers in bioscience (Elite ed.), E4 (3), 1049-1057.
fulir.irb.hr -
Leović, D., Sabol, M., Ozretić, P., Musani, V., Car, D., Marjanović, K., Zubčić, V., Sabol, I., Sikora, M., Grce, M., Glavaš-Obrovac, L. & Levanat, S. (2012) Hh-Gli signaling pathway activity in oral and oropharyngeal squamous cell carcinoma. Head and neck, 34 (1), 104-112 doi:10.1002/hed.21696.
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Ozretić, P., Levačić Cvok, M., Musani, V., Sabol, M., Car, D. & Levanat, S. (2010) In silico analysis of potential structural and functional significance of human breast cancer gene BRCA2 sequence variants found in 5' untranslated region. Periodicum biologorum, 112 (4), 469-474.
hrcak.srce.hrhrcak.srce.hrfulir.irb.hr -
Car, D., Sabol, M., Musani, V., Ozretić, P. & Levanat, S. (2010) Epigenetic regulation of the Hedgehog-Gli signaling pathway in cancer. Periodicum biologorum, 112 (4), 419-423.
hrcak.srce.hr
Ocjenski radovi
Doktorske disertacije
Trnski, D. (2015) 'Uloga protein kinase GSK3b u aktivaciji signalnog puta Hedgehog-Gli u stanicama karcinoma debelog crijeva čovjeka', doktorska disertacija, Sveučilište Josipa Jurja Strossmayera u Osijeku, Osijek.
Trnski, D. (2015) 'Uloga protein-kinase GSK3b u aktivaciji signalnog puta Hedgehog-Gli u stanicama karcinoma debelog crijeva čovjeka', doktorska disertacija, Sveučilište J J Strossmayera, Osijek.
Članstva u profesionalnim udrugama / društvima
HDIR – Hrvatsko društvo za istraživanje raka
EACR – European Association for Cancer Research
HDBMB – Hrvatsko društvo za biokemiju i molekularnu biologiju