dr. sc. Diana Trnski

2015. - dr.sc. iz znanstvenog područja biomedicine i zdravstva, znanstvenog polja temeljnih medicinskih znanosti, Sveučilišni poslijediplomski interdisciplinarni doktorski studij Molekularne bioznanosti, Sveučilište J.J. Strossmayera u Osijeku, Sveučilište u Dubrovniku, Institut Ruđer Bošković

2008. - dipl.inž. biologije, molekularna biologija, Prirodoslovno-matematički fakultet, Sveučilište u Zagrebu

2011 - EACR Travel Fellowship Award

2018 - EACR Travel Fellowship Award

suradnica u nastavi preddiplomskih i postdiplomskih kolegija (voditeljica dr.sc. Sonja Levanat)

• "Metode rekombinantne DNA“, Specijalistički studij sanitarnog inženjerstva, Viša zdravstvena škola, Zagreb
• "Metode istraživanja u molekularnoj onkologiji", doktorski studij Biomedicina i zdravstvo Medicinskog fakulteta Sveučilišta u Zagrebu

1. Levanat, Sonja; Sabol, Maja; Musani, Vesna; Ozretić, Petar; Trnski, Diana. Hedgehog Signaling Pathway as Genetic and Epigenetic Target in Ovarian Tumors. // Current pharmaceutical design. 23 (2017), 1; 73-94.
2. *Ozretić, Petar; *Trnski, Diana; Musani, Vesna; Maurac, Ivana; Kalafatić, Držislav; Orešković, Slavko; Levanat, Sonja; Sabol, Maja. Non-canonical Hedgehog signaling activation in ovarian borderline tumors and ovarian carcinomas. // International journal of oncology. 51 (2017), 6; 1869-1877. *autori dijele prvo autorstvo
3. Trnski, Diana; Sabol, Maja; Gojević, Ante; Martinić, Marina; Ozretić, Petar; Musani, Vesna; Ramić, Snježana; Levanat, Sonja. GSK3β and Gli3 play a role in activation of Hedgehog-Gli pathway in human colon cancer — Targeting GSK3β downregulates the signaling pathway and reduces cell proliferation. // Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1852 (2015), 12; 2574-2584.
4. *Sabol, Maja; *Trnski, Diana; Užarević, Zvonimir; Ozretić, Petar; Musani, Vesna; Rafaj, Maja; Cindrić, Mario; Levanat, Sonja. Combination of cyclopamine and tamoxifen promotes survival and migration of MCF-7 breast cancer cells – interaction of Hedgehog-Gli and Estrogen receptor signaling pathways. // PLOS ONE. 9 (2014), 12; e114510-1-e114510-23. *autori dijele prvo autorstvo
5. Leović, Dinko; Sabol, Maja; Ozretić, Petar; Musani, Vesna; Car, Diana; Marjanović, Ksenija; Zubčić, Vedran; Sabol, Ivan; Sikora, Miroslav; Grce, Magdalena; Glavaš-Obrovac, Ljubica; Levanat, Sonja. Hh-Gli signaling pathway activity in oral and oropharyngeal squamous cell carcinoma. // Head and neck. 34 (2012), 1; 104-112.

Radovi u časopisima

Znanstveni i pregledni radovi

• Ozretić, P., Hanžić, N., Proust, B., Sabol, M., Trnski, D., Radić, M., Musani, V., Ciribilli, Y., Milas, I., Puljiz, Z., Bosnar Herak, M., Levanat, S. & Slade, N. (2019) Expression profiles of p53/p73, NME and GLI families in metastatic melanoma tissue and cell lines. Scientific Reports, 9 (1), 12470, 13 doi:10.1038/s41598-019-48882-y.

  doifulir.irb.hrwww.nature.com

• Sušac, I., Ozretić, P., Gregorić, M., Levačić Cvok, M., Sabol, M., Levanat, S., Trnski, D., Eljuga, D., Seiwerth, S., Aralica, G., Stanec, M. & Musani, V. (2019) Polymorphisms in survivin (BIRC5 gene) are associated with age of onset in breast cancer patients. Journal of Oncology, 2019, 3483192, 10 doi:10.1155/2019/3483192.

  doidoi.orgwww.hindawi.comfulir.irb.hr

• Trnski, D., Gregorić, M., Levanat, S., Ozretić, P., Rinčić, N., Majić Vidaković, T., kalafatić, D., Maurac, I., Orešković, S., Sabol, M. & Musani, V. (2019) Regulation of Survivin Isoform Expression by GLI Proteins in Ovarian Cancer. Cells, 8 (2), 128, 13 doi:10.3390/cells8020128.

  doifulir.irb.hrdoi.orgwww.mdpi.com

• Sabol, M., Trnski, D., Musani, V., Ozretić, P. & Levanat, S. (2018) Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets. International journal of molecular sciences, 19 (9), 2562, 37 doi:10.3390/ijms19092562.

  doiwww.mdpi.comfulir.irb.hrwww.mdpi.com

• Ozretić, P., Trnski, D., Musani, V., Maurac, I., Kalafatić, D., Orešković, S., Levanat, S. & Sabol, M. (2017) Non-canonical Hedgehog signaling activation in ovarian borderline tumors and ovarian carcinomas. International journal of oncology, 51 (6), 1869-1877 doi:10.3892/ijo.2017.4156.

  doi

• Levanat, S., Sabol, M., Musani, V., Ozretić, P. & Trnski, D. (2017) Hedgehog Signaling Pathway as Genetic and Epigenetic Target in Ovarian Tumors. Current pharmaceutical design, 23 (1), 73-94 doi:10.2174/1381612822666161006154705.

  doi

• Trnski, D., Sabol, M., Gojević, A., Martinić, M., Ozretić, P., Musani, V., Ramić, S. & Levanat, S. (2015) GSK3β and Gli3 play a role in activation of Hedgehog-Gli pathway in human colon cancer — Targeting GSK3β downregulates the signaling pathway and reduces cell proliferation. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1852 (12), 2574-2584 doi:10.1016/j.bbadis.2015.09.005.

  doi

• Ozretić, P., Bisio, A., Musani, V., Trnski, D., Sabol, M., Levanat, S. & Inga, A. (2015) Regulation of human PTCH1b expression by different 5' untranslated region cis-regulatory elements. RNA Biology, 12 (3), 290-304 doi:10.1080/15476286.2015.1008929.

  doi

• Sabol, M., Trnski, D., Užarević, Z., Ozretić, P., Musani, V., Rafaj, M., Cindrić, M. & Levanat, S. (2014) Combination of cyclopamine and tamoxifen promotes survival and migration of MCF-7 breast cancer cells – interaction of Hedgehog-Gli and Estrogen receptor signaling pathways. PLOS ONE, 9 (12), e114510-1 doi:10.1371/journal.pone.0114510.

  doifulir.irb.hr

• Musani, V., Sabol, M., Car, D., Ozretić, P., Kalafatić, D., Maurac, I., Orešković, S. & Levanat, S. (2013) PTCH1 gene polymorphisms in ovarian tumors: Potential protective role of c.3944T allele. Gene, 517 (1), 55-59 doi:10.1016/j.gene.2012.12.089.

  doi

• Sabol, M., Car, D., Musani, V., Ozretić, P., Orešković, S., Weber, I. & Levanat, S. (2012) The Hedgehog signaling pathway in ovarian teratoma is stimulated by Sonic Hedgehog which induces internalization of Patched. International journal of oncology, 41 (4), 1411-1418 doi:10.3892/ijo.2012.1554.

  doifulir.irb.hr

• Tkalec, M., Car, D., Gospočić, J., Križaić, I., Duž, K. & Vidaković-Cifrek, Ž. (2012) Response of Kalanchoe daigremontiana to wounding and infection with Agrobacterium tumefaciens. PERIODICUM BIOLOGORUM, 114 (1), 83-90.

• Levanat, S., Musani, V., Levačić Cvok, M., Sušac, I., Sabol, M., Ozretić, P., Car, D., Eljuga, D., Eljuga, L. & Eljuga, D. (2012) Three novel BRCA1/BRCA2 mutations in breast/ovarian cancer families in Croatia. Gene, 498 (2), 169-176 doi:10.1016/j.gene.2012.02.010.

  doi

• Maurac, I., Sabol, M., Musani, V., Car, D., Ozretić, P., Kalafatić, D., Orešković, S., Babić, D. & Levanat, S. (2012) A low grade ovarian carcinoma case with coincident LOH of PTCH1 and BRCA1, and a mutation in BRCA1. International journal of gynecological pathology, 31 (3), 264-271 doi:10.1097/PGP.0b013e31823b6f0f.

  doi

• Musani, V., Sabol, M., Car, D., Ozretić, P., Orešković, S., Leović, D. & Levanat, S. (2012) LOH of PTCH1 region in BCC and ovarian carcinoma: microsatellite vs. HRM analysis. Frontiers in bioscience (Elite ed.), E4 (3), 1049-1057.

  fulir.irb.hr

• Leović, D., Sabol, M., Ozretić, P., Musani, V., Car, D., Marjanović, K., Zubčić, V., Sabol, I., Sikora, M., Grce, M., Glavaš-Obrovac, L. & Levanat, S. (2012) Hh-Gli signaling pathway activity in oral and oropharyngeal squamous cell carcinoma. Head and neck, 34 (1), 104-112 doi:10.1002/hed.21696.

  doi

• Ozretić, P., Levačić Cvok, M., Musani, V., Sabol, M., Car, D. & Levanat, S. (2010) In silico analysis of potential structural and functional significance of human breast cancer gene BRCA2 sequence variants found in 5' untranslated region. Periodicum biologorum, 112 (4), 469-474.

  fulir.irb.hrhrcak.srce.hrhrcak.srce.hr

• Car, D., Sabol, M., Musani, V., Ozretić, P. & Levanat, S. (2010) Epigenetic regulation of the Hedgehog-Gli signaling pathway in cancer. Periodicum biologorum, 112 (4), 419-423.

  hrcak.srce.hr

Ocjenski radovi

Doktorske disertacije

• Trnski, D. (2015) 'Uloga protein kinase GSK3b u aktivaciji signalnog puta Hedgehog-Gli u stanicama karcinoma debelog crijeva čovjeka', doktorska disertacija, Sveučilište Josipa Jurja Strossmayera u Osijeku, Osijek.

• Trnski, D. (2015) 'Uloga protein-kinase GSK3b u aktivaciji signalnog puta Hedgehog-Gli u stanicama karcinoma debelog crijeva čovjeka', doktorska disertacija, Sveučilište J J Strossmayera, Osijek.

HDIR – Hrvatsko društvo za istraživanje raka

EACR – European Association for Cancer Research

HDBMB – Hrvatsko društvo za biokemiju i molekularnu biologiju