Primjeri istraživanja unutar grupe
RSC Advances, 6, 2016, 83044
Good overlap of the standard DPP III substrate Arg-Arg-2NA (magenta) and the most efficient novel inhibitor (guanidiniocarbonyl-pyrrole - pyrene conjugate, blue-red) in DPP III binding site.
Anal. Chim. Acta(2016) accepted.
- Novel dyes emit fluorescence only for poly rA even at high excess of all other ss-RNA
- fluorescence response for AT-DNA is 8 times stronger than for GC-DNA
- florescence induced by ds-RNA is 20 % stronger that emission induced by ds-DNA
- intrinsically non-chiral, dyes show strong and characteristic ICD response for poly Ru
Org. Biomol. Chem., 14, (2016), 4865
The α-hydrazino group in peptide systematically decreased its fluorimetric response to DNA/RNA binding in line: mono-hydrazino<alternating-hydrazino< sequential-hydrazino. Two sequential α-hydrazino3specific for poly rG.
Curr. Protein & Peptide Sci. 17 (2016) 127
“Advances in peptide-based DNA/RNA-intercalators”
Org. Biomol. Chem., 13, (2015), 1629.
DNA-targeting dye exhibited pH-dependent selectivity toward AT-(pH 7) or GC- (pH 5), accompanied by fluorimetric (pH 5) and ICD (pH 7) recognition.
Beilstein J. Org. Chem. 10, (2014), 2175
Chirooptical (ICD) recognition of AT-DNA sequences among other ds-DNA/RNA (ICD inactive) as well as ss-DNA-dT (lacking ICD band 350 nm) was reported only by DBTAA-propyl-adenine conjugates, but not DBTAA analogues with longer linkers or referent DBTAA lacking adenine.