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RSC Advances, 6, 2016, 83044

Good overlap of the standard DPP III substrate Arg-Arg-2NA (magenta) and the most efficient novel inhibitor (guanidiniocarbonyl-pyrrole - pyrene conjugate, blue-red) in DPP III binding site.

 

 Anal. Chim. Acta(2016) accepted.

  • Novel dyes emit fluorescence only for poly rA even at high excess of all other ss-RNA
  • fluorescence response for AT-DNA is 8 times stronger than for GC-DNA
  • florescence induced by ds-RNA is 20 % stronger that emission induced by ds-DNA
  • intrinsically non-chiral, dyes show strong and characteristic ICD response for poly Ru

 

Org. Biomol. Chem., 14, (2016), 4865

The α-hydrazino group in peptide systematically decreased its fluorimetric response to DNA/RNA binding in line: mono-hydrazino<alternating-hydrazino< sequential-hydrazino. Two sequential α-hydrazino3specific for poly rG.

  Curr. Protein & Peptide Sci. 17 (2016) 127

“Advances in peptide-based DNA/RNA-intercalators”

 

Org. Biomol. Chem., 13, (2015), 1629.

DNA-targeting dye exhibited pH-dependent selectivity toward AT-(pH 7) or GC- (pH 5), accompanied by fluorimetric (pH 5) and ICD (pH 7) recognition.

Beilstein J. Org. Chem. 10, (2014), 2175

Chirooptical (ICD) recognition of AT-DNA sequences among other ds-DNA/RNA (ICD inactive) as well as ss-DNA-dT (lacking ICD band 350 nm) was reported only by DBTAA-propyl-adenine conjugates, but not DBTAA analogues with longer linkers or referent DBTAA lacking adenine. 

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