Ruđer Bošković Institute
2019− Doctoral study in Chemistry; Faculty of Science, University of Zagreb
Supervisor: Dr. Robert Vianello
2013−2018 Master’s degree in Pharmacy; University of Zagreb Faculty of Pharmacy and Biochemistry
Thesis: Quantum-Chemical Study of Enantiomerization of Oxazepam
Supervisor: Prof. Valerije Vrček, Co‐supervisor: Dr. Davor Šakić
Awards and Achievements
31/12/2020 Annual Award of Ruđer Bošković Institute for the scientific paper: Experimental and Computational Study of the Antioxidative Potential of Novel Nitro and Amino Substituted Benzimidazole/Benzothiazole-2-Carboxamides with Antiproliferative Activity
17/12/2019 Annual Award of Ruđer Bošković Institute for the scientific paper: Chlorination of 5−fluorouracil: Reaction mechanism and ecotoxicity assessment of chlorinated products
06/07/2017 Rector’s Award for the individual scientific research: Mechanism of Chlorination of 5-Fluorouracil and Ecotoxicological Analysis of Chlorinated Products (University of Zagreb)
N. Sakač, D. Madunić-Čačić, D. Marković, L. Hok, R. Vianello, B. Šarkanj, B. Đurin, K. Hajdek, B. Smoljan, S. Milardović, B. Matasović, M. Jozanović. Potentiometric Surfactant Sensor Based on 1,3- Dihexadecyl-1H-benzo[d]imidazol-3-ium for Anionic Surfactants in Detergents and Household Care Products. Molecules, 2021, 26, 3627.
L. Hok, E. Lluch Sanchez, R. Vianello, B.-M. Kukovec, Z. Popović. Self‐assembly of cobalt(II) coordination polymers with differently halosubstituted nicotinate ligands and 4,4’‐bipyridine – the effect of the halosubstituent positions on polymer types. Eur J Inorg Chem, 2021, 15, 1470–1480.
L. Ptiček, L. Hok, P. Grbčić, F. Topić, M. Cetina, K. Rissanen, S. Kraljević Pavelić, R. Vianello, L. Racané. Amidino substituted 2-aminophenols: biologically important building blocks for the amidino- functionalization of 2-substituted benzoxazoles. Org Biomol Chem, 2021, 19, 2784–2793.
L. Hok, R. Vianello. Direct Metal-Free Transformation of Alkynes to Nitriles: Computational Evidence for the Precise Reaction Mechanism. Int J Mol Sci, 2021, 22, 3193.
N. Perin, L. Hok, A. Beč, L. Persoons, E. Vanstreels, D. Daelemans, R. Vianello, M. Hranjec. N-substituted benzimidazole acrylonitriles as in vitro tubulin polymerization inhibitors: Synthesis, biological activity and computational analysis. Eur J Med Chem, 2021, 211, 113003.
L. Hok, J. Mavri, R. Vianello. The Effect of Deuteration on the H2 Receptor Histamine Binding Profile: A Computational Insight into Modified Hydrogen Bonding Interactions. Molecules, 2020, 25, 6017.
S. Roca, L. Hok, R. Vianello, M. Borovina, M. Đaković, Lj. Karanović, D. Vikić-Topić, Z. Popović. The role of non-covalent intermolecular interactions on the diversity of crystal packing in supramolecular dihalopyridine–silver(I) nitrate complexes. CrystEngComm, 2020, 22, 7962–7974.
T. Tandarić, L. Hok, R. Vianello. From Hydrogen Peroxide-Responsive Boronated Nucleosides Towards Antisense Therapeutics – A Computational Mechanistic Study. Croat Chem Acta, 2019, 92, 287–295.
M. Cindrić, I. Sović, M. Mioč, L. Hok, I. Boček, P. Roškarić, K. Butković, I. Martin-Kleiner, K. Starčević, R. Vianello, M. Kralj, M. Hranjec. Experimental and Computational Study of the Antioxidative Potential of Novel Nitro and Amino Substituted Benzimidazole/Benzothiazole-2-Carboxamides with Antiproliferative Activity. Antioxidants, 2019, 8, 477.
L. Hok, L. Božičević, H. Sremec, D. Šakić, V. Vrček. Racemization of oxazepam and chiral 1,4-benzodiazepines. DFT study of the reaction mechanism in aqueous solution. Org Biomol Chem, 2019, 17, 1471–1479.
L. Hok, L. Ulm, T. Tandarić, A. Krivohlavek, D. Šakić, V. Vrček. Chlorination of 5-fluorouracil: Reaction mechanism and ecotoxicity assessment of chlorinated products. Chemosphere, 2018, 207, 612–619.
L. Hok, A. Akrap, F. J. Marelja, S. Morić, M. Parlov, M. Bojić. The Role of Cytochrome P450 in Aerotoxic Syndrome. Farmaceutski glasnik, 2018, 1, 15–29.
Membership in professional associations / societies
Croatian Chamber of Pharmacists (from 2021)
Croatian Chemical Society (from 2019)