Our broad interest is in natural product mimetics, particularly peptides and carbohydrates, as pluripotent molecular structures susceptible to various modifications and transformations that facilitate their structural and functional diversification. A focus of our current work is development of biomolecular functional materials built upon finely tailored peptidomimetic structures.
Recently, we applied simple, robust and scalable multicomponent methodology to access different classes of nature-like molecules. With a rich portfolio of structurally diverse scaffolds and elaborated methodology in hands, our next goal is to access more complex systems and probe their functionality. Our approach relies on utilization of small-molecule structural mimetics, peptidomimetics comprising non-natural C-glycosyl amino acids and hydrogen-bond-guided synthons.