In daily life viruses and bacteria pose a serious threat to public health. Their structure allows them to bind on different surfaces and they can be spread by touching the contaminated surfaces and transferred further on. Due to remarkable characteristics, properties and flexibility for the tailoring of the charge, architecture and dimensionality, metal nanoparticles (NPs) are recognized as promising agents for battling viruses and bacteria. The aim of the proposed project is a comprehensive study of antibacterial and antiviral properties of zinc oxide and copper oxide NPs coated surfaces such as textile, plastic and metal. The innovative aspect of the proposed project is based on two possible mechanisms that will be investigated in detail: i) inactivation of the microbes when in contact with coated metallic particles due to the release of metal ions; ii) lowering or disabling the adsorption of microbes on the tested surfaces. The proposed project aims to develop an easy “day-to-day” nanocoating procedure that could be used for surface treatment of plastic and metal surfaces in stores, hospitals and other facilities with a high daily circulation of people. Within the project, we will propose a procedure that could reduce the required frequent surface cleaning and disinfection with standard disinfectants. Due to the temperature sensitivity of certain textile materials, required for microbial destruction, a new procedure for textile treatment should be implemented. The proposed project aims to give insight into the extent of COVID-19 proteins binding to different surfaces treated with NPs in a novel way. During this project, we intend to provide an improved hybrid nanoparticle material with an optimal antimicrobial effect.