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Preparation, characterization and biocompatibility studies of novel drug/cyclodextrin and drug/dextrin-based nanosponge supramolecular complexes with enhanced functionality

Project type
Znanstveno-istraživački projekti
Programme
Research Projects
Financier
Croatian Science Foundation
Start date
Dec 18th 2023
End date
Dec 18th 2027
Status
Active
Total cost
194651 EUR
More information

The main goal of this project is to improve the therapeutic potential of some poorly soluble drugs which are administered orally, like praziquantel, loratadine, cinnarizine, meloxicam, nabumetone, mebendazole and triclabendazole. The inclusion of drugs in cyclodextrins (CD) is frequently used to increase the dissolution of poorly water-soluble drugs. We aim to improve the solubility of above-mentioned drugs, while maintaining their activity, by encapsulation into beta-cyclodextrin, 2-hydroxypropyl-betacyclodextrin, sulfobutylated and methylated beta-cyclodextrin, known as biocompatible drug-carriers in drug-delivery systems. In addition to CD, the dextrin-based nanosponges (NS) will be used as well. Non-commercially available NS based on maltodextrin (MD) and CD will be prepared. The new polymer formulations that will be developed to optimize the drug-NS affinity will push forward the technology of dextrin-NSs, paving the way towards future innovative applications. Drug-CD, drug-MD and drug-NS complexes will be analyzed in detail in solid state and in solution. Within the project, new analytical methods will be developed, and special attention will be given to sophisticated techniques such as liquid chromatography-high resolution mass spectrometry (LC-HR MS). Chemical stability testing and forced degradation studies will be performed, and identification and structural characterization of degradation products by NMR and HR MS/MS will be done. The solubility of prepared complexes will be investigated in biorelevant media, and biocompatibility of complexes with enhanced properties will be determined. Finally, in vitro permeability of selected supramolecular complexes will be characterized as well.

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