Presenilin 2 - a protector against Alzheimer's disease - BRAINPROTECT
Principal investigator
Category
FP
Area
MC-IEF
Department
ZMM
Start date
Oct 1st 2014
End date
Sep 30th 2016
Status
Done
Finance value
192338 EUR
Accumulation of neurotoxic amyloid beta peptides (Ab) in the brain is considered to be the central event in the pathogenesis of Alzheimer’s disease (AD). Ab is released from the beta-amyloid precursor protein (APP) during specialised processing events. This proposal aims to examine presenilin 2 (PS2) protein-mediated molecular and cellular events that are protective against Ab accumulation and AD and, as such, is aligned with the objective of the FP7’s Health Research Programme that focuses on “Research on the brain and related diseases”.