dr. sc. Tana Tandarić
Institut Ruđer Bošković
Bijenička 54
HR-10000 Zagreb
Obrazovanje
Prirodoslovno-matematički fakultet, Sveučilište u Zagrebu 2016.- 2021.
- Doktorski studij kemije (smjer organska kemija)
- Doktorska disertacija "Računalno istraživanje mehanizma ireverzibilne inhibicije enzima monoamin-oksidaze B" izrađen u Zavodu za organsku kemiju i biokemiju, Institut Ruđer Bošković, mentor dr. sc. Robert Vianello
Farmaceutsko-biokemijski fakultet, Sveučilište u Zagrebu 2011.- 2016.
- Integrirani studij medicinske biokemije
- Diplomski rad "Mehanizam reakcije kloriranja 5-fluorouracila." izrađen u Zavodu za organsku kemiju, mentor prof. dr. sc. Valerije Vrček
- Stručno osposobljavanje obavljeno u medicinsko biokemijskom laboratoriju Klinike za tumore, KBC Sestre milosrdnice
XV. gimnazija Zagreb 2007.-2011.
OŠ Murterski škoji Murter 1999.-2007.
Nagrade i priznanja
- 2021: Stipendija Austrijske akademije znanosti i umjetnosti (JESH – Croatia) za boravak u trajanju od šest mjeseci u Max Perutz labs (Beč, Austrija)
- 12/2020: Godišnja nagrada Instituta Ruđer Bošković za znanstveni rad „Computational Insight into the Mechanism of the Irreversible Inhibition of Monoamine Oxidase Enzymes by the Antiparkinsonian Propargylamine Inhibitors Rasagiline and Selegiline“
- 12/2019: Godišnja nagrada Instituta Ruđer Bošković za znanstveni rad „Chlorination of 5-fluorouracil: Reaction mechanism and ecotoxicity assessment of chlorinated products“
- 2019: Stipendija Francuske Vlade 2019. za boravak u trajanju od mjesec dana na Sveučilištu Sorbonne 09/2019: Thiene poster award, 16th European Symposium of Organic Reactivity, Dubrovnik
- 09/2015 Godišnja Dekanova nagrada za studentski znanstveni rad „Kemijska sudbina antiepileptika u neutrofilima. In silico istraživanje reakcije s hipoklorastom kiselinom.“ za akademsku godinu 2014./2015.
- 09/2014 Godišnja Dekanova nagrada za znanstveni rad „Chlorination of N-Metylacetamide and Amide- Containing Pharmaceuticals. QuantumChemical Study of the Reaction Mechanism.“ za objavljen u znanstvenom časopisu Journal of Physical Chemistry A za akademsku godinu 2013./2014.
Nastava
Opća kemija sa stehiometrijom, seminari, Farmaceutsko biokemijski fakultet, Sveučilište u Zagrebu, ak.god. 2019/2020.
Publikacije
Radovi u časopisima
Znanstveni i pregledni radovi
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Matić, J., Tandarić, T., Radić Stojković, M., Šupljika, F., Karačić, Z., Tomašić Paić, A., Horvat, L., Vianello, R. & Tumir, L. (2023) Phenanthridine–pyrene conjugates as fluorescent probes for DNA/RNA and an inactive mutant of dipeptidyl peptidase enzyme. Beilstein journal of organic chemistry, 19, 550-565 doi:10.3762/bjoc.19.40.
doiwww.beilstein-journals.orgfulir.irb.hr -
Pantalon Juraj, N., Tandarić, T., Tadić, V., Perić, B., Moreth, D., Schatzschneider, U., Brozovic, A., Vianello, R. & Kirin, S. (2022) Tuning the coordination properties of chiral pseudopeptide bis(2-picolyl)amine and iminodiacetamide ligands in Zn(II) and Cu(II) complexes. Dalton transactions, 51 (44), 17008-17021 doi:10.1039/d2dt02895f.
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Poje, G., Pessanha de Carvalho, L., Held, J., Moita, D., Prudêncio, M., Perković, I., Tandarić, T., Vianello, R. & Rajić, Z. (2022) Design and synthesis of harmiquins, harmine and chloroquine hybrids as potent antiplasmodial agents. European journal of medicinal chemistry, 238, 114408, 15 doi:10.1016/j.ejmech.2022.114408.
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Marinović, M., Poje, G., Perković, I., Fontinha, D., Prudêncio, M., Held, J., Pessanha de Carvalho, L., Tandarić, T., Vianello, R. & Rajić, Z. (2021) Further investigation of harmicines as novel antiplasmodial agents: synthesis, structure-activity relationship and insight into the mechanism of action. European journal of medicinal chemistry, 224, 113687, 20 doi:10.1016/j.ejmech.2021.113687.
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Matić, J., Jukić, M., Ismaili, H., Saftić, D., Ban, Ž., Tandarić, T., Vianello, R., Opačak-Bernardi, T., Glavaš-Obrovac, L. & Žinić, B. (2021) 6-Morpholino- and 6-amino-9-sulfonylpurine derivatives. Synthesis, computational analysis, and biological activity. Nucleosides, nucleotides & nucleic acids, 40 (4), 470-503 doi:10.1080/15257770.2021.1896001.
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Marinović, M., Perković, I., Fontinha, D., Prudêncio, M., Held, J., Pessanha de Carvalho, L., Tandarić, T., Vianello, R., Zorc, B. & Rajić, Z. (2020) Novel Harmicines with Improved Potency against Plasmodium. Molecules, 25 (19), 4376, 19 doi:10.3390/molecules25194376.
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Tandarić, T., Prah, A., Stare, J., Mavri, J. & Vianello, R. (2020) Hydride Abstraction as the Rate-Limiting Step of the Irreversible Inhibition of Monoamine Oxidase B by Rasagiline and Selegiline: A Computational Empirical Valence Bond Study. International journal of molecular sciences, 21 (17), 6151, 13 doi:10.3390/ijms21176151.
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Rimac, H., Tandarić, T., Vianello, R. & Bojić, M. (2020) Indomethacin increases quercetin affinity for human serum albumin: a combined experimental and computational study and its broader implications. International journal of molecular sciences, 21 (16), 5740, 14 doi:10.3390/ijms21165740.
doiwww.mdpi.comdoi.orgfulir.irb.hr -
Perković, I., Raić-Malić, S., Fontinha, D., Prudêncio, M., Pessanha de Carvalho, L., Held, J., Tandarić, T., Vianello, R., Zorc, B. & Rajić, Z. (2020) Harmicines − harmine and cinnamic acid hybrids as novel antiplasmodial hits. European journal of medicinal chemistry, 187, 111927, 16 doi:10.1016/j.ejmech.2019.111927.
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Tandarić, T., Hok, L. & Vianello, R. (2019) From Hydrogen Peroxide-Responsive Boronated Nucleosides Towards Antisense Therapeutics – A Computational Mechanistic Study. Croatica chemica acta, 92 (2), 287-295 doi:10.5562/cca3592.
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Toma, M., Božičević, L., Lapić, J., Djaković, S., Šakić, D., Tandarić, T., Vianello, R. & Vrček, V. (2019) Transacylation in Ferrocenoyl-Purines. NMR and Computational Study of the Isomerization Mechanism. Journal of organic chemistry, 84 (19), 12471-12480 doi:10.1021/acs.joc.9b01944.
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Tandarić, T. & Vianello, R. (2019) Computational Insight into the Mechanism of the Irreversible Inhibition of Monoamine Oxidase Enzymes by the Antiparkinsonian Propargylamine Inhibitors Rasagiline and Selegiline. ACS Chemical Neuroscience, 10 (8), 3532-3542 doi:10.1021/acschemneuro.9b00147.
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Matić, J., Šupljika, F., Tandarić, T., Dukši, M., Piotrowski, P., Vianello, R., Brozović, A., Piantanida, I., Schmuck, C. & Radić Stojković, M. (2019) DNA/RNA recognition controlled by the glycine linker and the guanidine moiety of phenanthridine peptides. International journal of biological macromolecules, 134, 422-434 doi:10.1016/j.ijbiomac.2019.05.063.
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Hok, L., Ulm, L., Tandarić, T., Krivohlavek, A., Šakić, D. & Vrček, V. (2018) Chlorination of 5-fluorouracil: Reaction mechanism and ecotoxicity assessment of chlorinated products. Chemosphere, 207 (18), 612-619 doi:10.1016/j.chemosphere.2018.05.140.
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Tandarić, T. & Vianello, R. (2018) Design of Exceptionally Strong Organic Superbases Based on Aromatic Pnictogen Oxides: Computational DFT Analysis of the Oxygen Basicity in the Gas Phase and Acetonitrile Solution. The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment, & general theory, 122 (5), 1464-1471 doi:10.1021/acs.jpca.7b11945.
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Dabić, D., Brkljačić, L., Tandarić, T., Žinić, M., Vianello, R., Frkanec, L. & Kobetić, R. (2018) The Metal effect on self-assembling of oxalamide gelators explored by mass spectrometry and DFT calculations. Journal of the American Society for Mass Spectrometry, 28 (1), 103-113 doi:10.1007/s13361-017-1834-5.
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Tandarić, T., Vrček, V. & Šakić, D. (2016) Quantum Chemical Study of HOCl-Induced Transformations of Carbamazepine. Organic & biomolecular chemistry, 14, 10866-10874 doi:10.1039/C6OB02166B.
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Šakić, D., Šonjić, P., Tandarić, T. & Vrček, V. (2014) Chlorination of N-Methylacetamide and Amide-Containing Pharmaceuticals : Quantum-Chemical Study of the Reaction Mechanism. The journal of physical chemistry. A, 118 (12), 2367-2376 doi:10.1021/jp5012846.
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Ocjenski radovi
Doktorske disertacije
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Tandarić, T. (2021) 'Računalno istraživanje mehanizma ireverzibilne inhibicije enzima monoamin-oksidaze B', doktorska disertacija, Prirodoslovno-matematički fakultet, Zagreb.
repozitorij.pmf.unizg.hr
Članstva u profesionalnim udrugama / društvima
Hrvatsko kemijsko društvo (HKD) 2016. - danas