Nela Pivac

DVM, PhD

senior scientist
+385 1 457 1207

1321
1749

+3851 4561010

_

Biologija 2/21

Laboratory for Molecular Neuropsychiatry, Division for Molecular Medicine, Ruđer Bošković Institute
BIjenička 54, HR-10000 Zagreb, Croatia

HRZZ eng NP.doc 325.00 kB

Education

School of Veterinary Medicine University of Zagreb, 1981 DVM

School of Veterinary Medicine University of Zagreb 1981-1982 Internship and field work

School of Medicine University of Zagreb 1987 MSc (neuroendocrinology, neuropharmacology)

School of Veterinary Medicine University of Zagreb 1994 PhD (neuroendocrinology, neuropharmacology)

McGill University, Montreal Neurological Institute, Montreal, Canada 1996-1997 postdoc (neurosciences, neuropharmacology)

Projects

2007 – present; leader of „Molecular basis and treatment of psychiatric and stress related disorders“ supported by the Croatian Ministry of Science, Education and Sport, grant No 098-0982522-2455

Awards and Achievements

2010. Annual award of the Director General of the Ruđer Bošković Institute for the exceptional success in science in the year 2010 given for the scientific research in the field in molecular medicine.

2009. State annual award of the Republic of Croatia for the year 2008, for the significant scientific achievements in the field of molecular basis and treatment of psychiatric disorders.

1986. State annual award for young scientists for scientific research.

1979. Award of the Dean of School of Veterinary Medicine University of Zagreb for exceptional success in learning and study.

Classes

Present- 2010: lecture at the course :“Genomic approaches in biomedical and translational researches“ for postgraduate students of the Doctoral studies in Biomedicine and health at University of Zagreb Medical School and Postgraduate Study Programme of the Zagreb University

Present – 2008: leader of the course „Molecular biology of mental disorders“, in colaboration with Dorotea Muck-Seler, for postgraduate students of the Doctoral studies in Molecular Biosciences at University of

Osijek, organized by University JJ Strossmayer Osijek, Rudjer Boskovic Institute  and University of Dubrovnik

Present- 2006: lectures at elective course „The change in organization and stress at work“  for students at specialistic studies in Project Management, joint study of the Rudjer Boskovic Institute and the College for Business and Management ''Baltazar Adam Krcelic'', Zapresic, Zagreb

Present - 2005:  leader of the course “Selected animal models of psychiatric disorders”, for postgraduate students of the Doctoral studies in Biomedicine and Health at the University of Zagreb Medical School and Postgraduate Study Programme of the Zagreb University

2009-1999: lectures at the couse „Psychoneuroimmunology“ for postgraduate students of the Doctoral studies in Biomedicine and health at University of Zagreb Medical School and Postgraduate Study Programme of the Zagreb University

2008-1992: lectures at the course „Neuroimmunology“ for postgraduate students of the Doctoral studies at Faculty of Science, University of Zagreb

Featured Publications

Scientific articles with IF more than 3 and chapters in the scientific books

Pivac N, Diksic M (2011) The lumped constant of α-methyl-L-tryptophan is not influenced by drugs acting through serotonergic system. Neurochemistry Int. 58: 826-832. IF=3.60

Pivac N,  Pregelj P, Nikolac M, Zupanc T, Nedić G, Muck-Šeler D, Videtič Paska A (2011) The association between catechol-O-methyl-transferase Val108/158Met polymorphism and suicide. Genes, Brain and Behavior, 10: 565-569, IF=4.06

Pregelj P, Nedic G, Videtič Paska A, Zupanc T, Nikolac M, Balažic J,  Tomori M, Komel R, Muck Seler D, Pivac N. (2011) The association between brain-derived neurotrophic factor polymorphism (BDNF Val66Met) and suicide. J Affect Disord, 128: 287-290. IF=3.74

Nedic G, Nikolac M, Nenadic Sviglin K, Muck Seler D, Borovecki F, Pivac N (2011): Association study of a functional catechol-o-methyltransferase (COMT) val108/158Met and suicide attempts in patients with alcohol dependence. Int J Neuropsychopharmacol 14: 377-388. IF=4.70

Pivac N, Knežević A, Gornik O, Pučić M, Igl W, Peeters H, Crepel A, Steyaert J, Novokmet M,  Redžić I, Nikolac M, Novković Hercigonja V, Dodig Ćurković K, Ćurković M, Nedić G, Muck-Seler D, Borovecki F, Rudan I, Lauc G. (2011) Human plasma glycome in attention-deficit hyperactivity disorder and autism spectrum disorders. Mol Cell Proteomics, 10.1: 1-7. IF=8.35

Muck-Šeler D, Šagud M, Mihaljević-Peleš A, Jakovljević, Pivac N (2011) Baseline lipid levels and acute treatment response to paroxetine and tianeptine in depressed women. Letters to the Editors. J Clin Psychopharmacology, 31: 387-390. IF=4.86

Pivac N, Diksic M. (2011) The lumped constant of α-methyl-L-tryptophan is not influenced by drugs acting through serotonergic system. Neurochemistry Int. 58: 826-832. IF=3.60

Pivac N, Nedić G, Nikolac M, Mück-Šeler D: Genetics of suicidal behaviour (2010). In: Coping with posttraumatic stress disorder in returning troops. Wounds of war II. NATO Science through peace and security series E: human and societal dynamics. Vol 68. Editor: Wiederhold, Brenda K. IOS Press Amsterdam, pp 31-55.

Pivac N, Kozarić-Kovačić D, Nedić G, Nikolac M, Mustapić M, Babić A, Grubišić-Ilić M, Kovačić Z, Muck-Šeler D (2010). Genetic markers in suicidal and non-suicidal veterans with combat-related posttraumatic stress disorder, Chapter 4. In: Posttraumatic stress disorder (PTSD): causes, symptoms and treatment / Egan, Sylvia J (Editor), New York : NOVA SCI Publisher, pp 109-139. 

Pivac N, Nedić G, Nikolac M, Nenadić-Šviglin K, Kozarić-Kovačić D, Mustapić M, Kovačić Z, Grubišić Ilić M, Borovečki F, Hajnšek S, Muck-Šeler D (2010): Sleep disturbances and serotonergic markers in psychiatric disorders. In: Advances in Psychology Research. Vol 71.  Editor: Columbus, Alexandra M. Nova Science publisher Inc.  New York, pp 1-85.

Muck-Šeler, Mustapic M, Nedic G, Babic A, Mimica N, Kozaric Kovacic D, Nenadic Sviglin K, Stipcevic T, Presecki P, Nikolac M, Borovecki F, Folnegovic Smalc V, Kovacic Z, Pivac N. (2010). Genetic and biochemical markers of serotonergic and catecholaminergic systems in neuropsychiatric disorders. Nova Sci Publ. In: Advances in Genetic Research, chapter I, Editor: Urbano Kevin V, pp 1-68, New York.

Poljak-Blazi M, Morana Jaganjac M, Mustapic M, Pivac N, Muck-Seler D (2009) Acute immunomodulatory effects of iron polyisomaltosate in rats: Immunobiology, 214: 121-128. IF=4.11

Sagud M, Pivac N, Nedić G, Mihaljević Peleš A, Kramarić M, Jakovljević M, Muck Šeler D (2008) The effect of lamotrigine on platelet serotonin concentration in patients with bipolar depression. Letter to the editors. Psychopharmacology, 4: 683-685. IF=3.82

Pivac N. Hypothalamic-pituitary-adrenal axis activity and stress, pp 17-51, chapter 3. In: Psychoneuroimmunology: association between immune system with nervous and endocrine systems (2008). Milivoj Boranić et al., (Balog T, Ćurić G, Gabrilovac J,  Gregurek R, Koršić M, Lauc G, Marotti T, Martin Kleiner I, Pivac N, Mück-Šeler D,  Stojević Z, Trkulja V), ( in Croatian) Editor: Krznarić Vohalski, Gordana, Školska knjiga dd. Zagreb. 

Pivac N, Kozarić-Kovačić D, Nedić G, Mustapić M, Stipčević T, Nenadić-Šviglin K, Grubišić-Ilić M, Mück-Šeler D (2008) Neurobiology of Suicidal Behaviour. In: Wounds of War: Lowering Suicide Risk in Returning Troops. NATO Science through peace and security – Editor: Wiederhold, Brenda K. IOS Press Amsterdam, pp 3-22.

Pivac N, Kozarić-Kovačić D, Mustapić M, Deželjin M, Nenadić-Šviglin K, Muck-Šeler D (2008) Peripheral biological markers in alcoholism. Editor: Pivac N. New York, Nova Publishers, pp 1-93.

Šagud M, Mihaljević-Peleš A, Pivac N, Jakovljević M, Mück-Šeler D (2007) Platelet serotonin and serum lipids in psychotic mania. J. Affect. Disord., 97: 247-251. IF=3.74

Kozaric-Kovacic D, Pivac N (2007) Quetiapine treatment in an open trial in combat related posttraumatic stress disorder with psychotic features, Int. J. Neuropsychopharmacology, 10, 253-261. IF=4.70

Pivac N, Knežević J, Kozarić-Kovačić  D, Deželjin M, Mustapić M, Rak D, Matijević T, Pavelić J, Muck-Šeler D (2007) Monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity in combat related posttraumatic stress disorder, J Affect Disord., 103, 131-138. IF=3.74

Mustapić M, Pivac N, Kozarić-Kovačić D, Deželjin M, Cubells JF, Mück-Šeler D (2007) Dopamine beta-hydroxylase (DBH) activity and -1021C/T polymorphism of DBH gene in combat-related posttraumatic stress disorder. Am J Med Genetics Part B Neuropsychiatry Genetics, 144B: 1087-1089. IF=4.16

Mark Agius, Mimica N , Ivezic S, Oruc L, Martic-Biocina S, Murphy CL, Hrabak-Zerjavic V, Silobrcic Radic M, Pivac N, Kozaric-Kovacic D (2007). The importance of Combat related Trauma and Psychosis. Br J Psychiatry 2007; Electronic letter Electronic letters published (29 May 2007); http://bjp.rcpsych.org/cgi/eletters/190/4/339 IF=5.95

Pivac N, Kozarić-Kovačić D, Mustapić M, Deželjin M, Nenadić-Šviglin K, Muck-Šeler D (2007) New research on alcohol abuse and alcoholism (Peripheral biological markers in alcoholism) poglavlje I. In: Drug and Alcohol abuse Research Focus. Editor: Walcott, Terry A. New York, Nova Publishers, pp 1-62.

Pivac N, Kozarić-Kovačić D, Deželjin M, Mustapić M, Jovanović T, Mück-Šeler D (2007) Neurobiology of Posttraumatic Stress Disorder. In: The Integration and Menagement of Traumatized people after Terrorist Attack. NATO Security through Science series E: Human and Societal Dynamics – Editor: Begec, Suat., vol 15. IOS Press Amsterdam pp 41-62.

Kozaric-Kovacic D, Pivac N (2007) Novel approaches to the diagnosis and treatment of posttraumatic stress disorder. In: The Integration and Menagement of Traumatized people after Terrorist Attack. NATO Security through Science series E: Human and Societal Dynamics – Editor: Begec, Suat, vol 15. IOS Press Amsterdam, pp 13-40.

Pivac N, Kozaric-Kovacic D, Mustapic M, Deželjin D, Borovecki A, Grubišic-Ilić M, Muck-Seler D (2006) Platelet serotonin in combat related posttraumatic stress disorder with psychotic symptoms. J. Affect. Disord., 93, 223-227. IF=3.74

Šagud M, Mihaljević-Peleš A, Mück-Šeler D, Jakovljević M,  Pivac N (2006) Quetiapine augmentation in treatment-resistant depression: a naturalistic study. Psychopharmacology, 187, 511-514. IF=3.82

Kozarić-Kovačić D, Pivac N (2006) Psychotic features of combat related chronic posttraumatic stress disorder and antipsychotic treatment. In: Novel approaches to the diagnosis and treatment of posttraumatic stress disorder. NATO Security through Science series E: Human and Societal Dynamics – Vol 6. Editor: Roy, Michael J.  IOS Press Amsterdam  Berlin Oxford Tokyo Washington DC., chapter 1: Epidemiology and pathophysiology of PTSD, pp 42-55.

Pivac N, Kozarić-Kovačić D, Mück-Šeler D (2006) Biological markers in Croatian war veterans with combat related posttraumatic stress disorder. In: Novel approaches to the diagnosis and treatment of posttraumatic stress disorder. NATO Security through Science series E: Human and Societal Dynamics – Vol 6. Editor: Roy, Michael J. IOS Press Amsterdam  Berlin Oxford Tokyo Washington DC.,  Epidemiology and pathophysiology of PTSD, pp 3-12.

Pivac N, Muck-Seler D, Mustapic M, Sagud M, Marcinko D, Deželjin M, Jakovljevic M (2006) Peripheral biological markers and treatment response in schizophrenia, Chapter 15, In: Schizophrenic Psychology: New Research. Editor: Douglas P. French. Hauppauge, NY: Nova Science  Publishers, Inc. pp 319-370.

Kozarić-Kovačić D, Pivac N, Mück-Šeler D, Rothbaum BO (2005) Risperidone in psychotic combat related posttraumatic stress disorder: an open trial. J. Clin. Psychiatry, 66,  922-927.  IF=5.02

Pivac N, Muck-Seler D, Kozarić-Kovačić D, Mustapić M, Nenadić-Šviglin K, Deželjin M  (2005) Platelet monoamine oxidase in alcoholism. Psychopharmacology, Letter to the Editors., 182,  194-196. IF=3.82

Muck Šeler D, Pivac N, Šagud M, Mustapić M, Jakovljević M (2005) The effects of serotonin uptake inhibitors on platelet serotonin: From basic to clinical research. Trends in Serotonin uptake inhibitors research. Ur: Shirley AC, NY: Nova Science Publishers, Inc., Chapter II, pp 29-53., cited in CC,

Pivac N, Kozarić-Kovačić D, Mück-Šeler D (2004) Olanzapine versus fluphenazine in an open trial in patients with psychoptic combat related posttraumatic stress disorder. Psychopharmacology, 175, 451-456. IF=3.82

Mück-Šeler D, Pivac N, Jakovljević M, Šagud M, Mihaljević-Peleš A (2003) Platelet 5-HT concentration and comorbid depression in war veterans with or without posttraumatic stress disorder. J. Affect. Disord., 75, 171-179 IF=3.74

Pivac N, Mück-Šeler D, Diksic M (2003) Effects of desipramine on regional serotonin synthesis in the rat brain: acute and chronic autoradiographic studies. Neurochem. Int., 43, 611-619. IF=3.60

Muck-Šeler D, Pivac N: Distinguished Croatian scientists in the world, part two, Editor: Janko Herak, Publisher: Croatian-American Society (2003) Mirko Diksic, radiochemist and neuroscientist. pp 29-37/133-142.

Mück-Šeler D,  Pivac N, Jakovljević M, Brzović Z (1999) Platelet 5-HT, plasma cortisol and dexamethasone suppression test in schizophrenic patients. Biol. Psychiatry,  45, 1433-1439. IF=8.67

Jakovljević M, Mück-Šeler D, Pivac N, Ljubičić Đ, Bujas M, Dodig G (1997) Seasonal influence on platelet 5-HT levels in patients with recurrent major depression and schizophrenia. Biol. Psychiatry, 41, 1028-1034. IF=8.67

Mück-Šeler D, Jakovljević M, Pivac N (1996) Platelet 5-HT concentrations and suicidal behaviour in reccurent major depression. J. Affect. Disord., 39, 73-80. IF=3.74

Boranić M, Peričić D, Šmeikal-Jagar L, Pivac N (1991) Effect of repeated stress and the treatment with ergot alkaloid dihydroergosine on the immune response of rats. chapter 6, In: Psychoneuroimmunology. Interactions between brain, nervous system, behaviour, endocrine and immune system. Editors: H.J. Schmoll, U. Tewes, N.P.  Plotnikoff, Hogreffe and Huber Publishers, Lewiston, N.Y., Toronto, Bern, Gottingen. pp 60-75. 

Lakić N, Peričić D, Manev H (1986) Mechanisms by which picrotoxin and a high dose of diazepam elevate plasma corticosterone levels. Neuroendocrinology, 43, 331-335. IF=3.27

Peričić D, Manev H, Lakić N (1985) Sex differences in the response of rats to drugs affecting GABAergic trensmission. Life Sci., 36, 541-547. IF=2.45                                                                                                                                 

Peričić D, Lakić N, Manev H (1984) Effect of diazepam on plasma corticosterone levels. Psychopharmacology 83, 79-81. IF=3.82

Membership in professional associations / societies

Present-2008: Member of the Regional Executive C.I.N.P (Collegium Internationale Neuro-Psychopharmacologicum) Committee for South-Eastern Europe

Present-1998: Evaluator for serotonin in Investigational Drugs database, Thomson Reuters, London, UK

2006: advisory and expert  duty for programme EUROSTRES for European Science Foundation

Secretary:

Present-2001: Croatian Pharmacological Society

Member:

Collegium Internationale Neuro-Psychopharmacologicum (CINP)

European Pharmacological Society (EPHAR)

International Union of Pharmacological Society (IUPHAR)

World Federation of Societies of Biological Psychiatry

International Brain Research Organization,

Federation of European Neuroscience Societies

Croatian Pharmacological Society

Croatian Society for Biological Psychiatry and Clinical Psychopharmacology

Croatian Society for Neurosciences

Croatian Association for Alzheimer's Disease

Miscellaneous

Supervisor of the Graduation theses:

Martina Rubil: Platelet monoamine oxidase B activity in psychiatric patients with aggressive behavior, Faculty of Natural Sciences University of Zagreb, (Graduation thesis defended on April 4th, 2010).

Irena Pacijent: Polymorphism of the brain derived neurotrophic factor in  patients with Alzheimer's disease, Faculty of Pharmacy and Biochemistry University of Zagreb, (Graduation thesis defended on June 2nd, 2010).

Oliver Šimčić:  Platelet serotonin and suicidality in alcoholic patients, Faculty of Natural Sciences University of Zagreb, (Graduation thesis defended on June 16th, 2010).

Ines Petek: Platelet serotonin in children with ADHD, Faculty of Natural Sciences University of Zagreb, (Graduation thesis defended on June 18th, 2009).

Kristina Duvnjak: Platelet serotonin in psychiatric patients with aggressive behavior, Faculty of Natural Sciences University of Zagreb, (Graduation thesis defended on March 20th, 2009).

Ines Jerić: Polymorphism of the catechol-o-methyl-transferase in patients with Alzheimer's disease, Faculty of Natural Sciences University of Zagreb, (Graduation thesis defended on July 14th 2008).

Lana Gorenec: Polymorphism of the monoamine oxidase type B in healthy men and women, Faculty of Natural Sciences University of Zagreb, (Graduation thesis defended on December  20th, 2006).

Gordana Nedić: Polymorphism of the monoamine oxidase type B in patients with posttraumatic stress disorder, Faculty of Natural Sciences University of Zagreb, (Graduation thesis defended  on October 27th, 2006).

Petra Brbora: Platelet serotonin in psychiatric  patients with alcohol dependance, Faculty of Natural Sciences University of Zagreb, (Graduation thesis defended on September 19th, 2006).

Anita Majsec: Serotonin and monoamine oxidase in platelets of alcoholic patients, Faculty of Natural Sciences University of Zagreb, (Graduation thesis defended  on February 2nd, 2006).

 

Supervisor of the doctoral theses:

Zrnka Kovačić: Serotonin transporter gene promoter polymorphism in patients with posttraumatic stress disorder, School of Medicine University of Zagreb (Doctoral theses defended on December 21st, 2010).

Ivan Barišić: Evaluation of the survival of hemodialyzed renal patients based on the quality of dialysis, platelet serotonin concentration and depression. School of Medicine University of Zagreb (Doctoral thesis proposal accepted and defended)

Marijana Škledar: Distribution of the brain derived neurotrophic factor (BDNF) genotypes and serum level of N-glycans as predictors of overweight in children. School of Medicine University of Zagreb (Doctoral theses proposal accepted  and defended)

Gordana Nedić:  doctoral thesis in progress in Molecular Biosciences at University of Osijek,  University JJ Strossmayer Osijek, Rudjer Boskovic Institute  and University of Dubrovnik

Matea Nikolac: doctoral thesis in progress in Molecular Biosciences at University of Osijek,  University JJ Strossmayer Osijek, Rudjer Boskovic Institute  and University of Dubrovnik

Josip Podobnik: doctoral thesis in progress at the  School of Medicine University of Zagreb.

Montreal Neurological Institute, McGill University, Montreal, Canada postdoc 1996-1997

Present-2001: Secretary of the Croatian Pharmacological Society

Present-2004: Member of the Commission for scientific awards  in the field of biomedicine for the Ministry of Sciences, education and Sport

Present-2008. Member of the Regional Executive C.I.N.P (Collegium Internationale Neuro-Psychopharmacologicum) Committee for South-Eastern Europe

2011-2004: Main editor of the Ruđer Bošković Institute Annual report

2009-2005: Vice-president of the Scientific Counsel of Biomedicine at the Ruđer Bošković Institute

2007-2005 godine: Member of the Commission for scientific and professional work for the  «Ivan Filipović Award» for the Ministry of Sciences, Education and Sport

2007 -2006: Member of the Evaluation Commission for the Scientific Projects in the field of biomedicine and health- neurosciences for the Ministry of Sciences, Education and Sport

2007-2006: Reviewer of the projects in the field of biomedicine and health- neurosciences for the Ministry of Sciences, Education and Sport

Present-2008: Reviewer of the projects for the Slovak Academy of Sciences and Slovak Research and Development Agency.

Present - 2005  reviewer for :

-domestic journals: Periodicum Biologorum, Croatian Medical Journal, Psychiatria Danubina, Biochemia Medica; -international journals: Psychoneuroendocrinology, Biological Psychology, Genes, Brain and Behavior, Journal of Affective Disorders, Journal of Psychiatric Research, Psychiatry Research, Human Psychopharmacology, Acta Psychiatrica Scandinavica, Neuropsychobiology, Progress in Neuro-Psychopharmacology and Biological Psychiatry, World Journal of Biological Psychiatry, Psychoneuroendocrinology, British Medical Journal;

-scientific online journals: Medical Science Monitor, World Journal of Pediatrics, Turkish Journal of Medical Sciences, Archives of Medical Sciences; Translational Neurosciences, African Journal of Biotechnology, Journal of the American Aging Association.

Present-2005: Invited speaker on  conferences organized by NATO programme security through science advanced research workshops.

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