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Laboratory for physical-organic chemistry

We are engaged in fundamental studies related to the omnipresent and everlasting problem of reactivity of organic and organometallic compounds. In conducting these studies, an integrated approach is employed involving synthesis, product analysis, determination of reaction mechanisms and structural interrogation via spectroscopic and computational methods. In synthetic work, extensive use of high pressure techniques and microwave assisted synthetic methods is made. 

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We are engaged in fundamental studies related to the omnipresent and everlasting problem of reactivity of organic and organometallic compounds. In conducting these studies, an integrated approach is employed involving synthesis, product analysis, determination of reaction mechanisms and structural interrogation via spectroscopic and computational methods. In synthetic work, extensive use of high pressure techniques and microwave assisted synthetic methods is made.

Research emphasis area include:

  • study of acid/base properties of selected classes of molecules in the ground and electronically excited states
  • reactivity studies of highly strained compounds with particular emphasis on cyclopropene derivatives substituted with 14a elements
  • mechanistic studies of carbanionic reactions
  • high pressure chemistry with principal objective of elucidating reactivity of 14-group metalloids
  • synthesis and theoretical studies of fused norbornenes and their heteroatom analogues with nonplanar double bonds
  • synthesis and investigation of chemical and physical properties of novel norbornenes and heteronorbornenes and their functional derivatives, Diels-Alder and 1,3-dipolar cycloadditions

The second major activity within laboratory, concernes applications of basic principles of physical-organic chemistry in tayloring specific bioactive molecules, to mention only potential antioxidative (vitamine C derivatives) and potential guanidine based drugs.

At the beginning of 2010, dr.sc. Eckert-Maksić became destinguished scientist of Ruđer Bošković Institute while dr. sc. Davor Margetić became a head of the Laboratory.

Danijela Vojta

+385 1 457 1382
1919

Davor Margetić
Ph. D.

Senior scientist
+385 1 468 0197
1488

Ivana Antol
Dr.

research associate
+385 1 456 1008
1208

Mario Vazdar
Dr.

research associate
+385 1 457 1382
1919

Mateja Đud

+385 1 456 1008
1208

Mirjana Maksić

+385 1 468 0197
1488 1208

Sanja Škulj

+385 1 457 1382
1919

Zoran Glasovac
PhD

higher research associate
+385 1 456 1008
1208 1657

Non-covalent interactions in design of novel photosensitive molecules

Glavni istraživač / voditelj: Davor Margetić

Project addresses two key research objectives in the European Union: energy and environment conservation. The scientific approach is based on a combination of theoretical and experimental knowledge and experience of collaborators, and includes quantum-chemical calculations and molecular modelling in the molecular design, chemical synthesis and study of physico-chemical properties of systems obtained through self-association by non-covalent interactions. It is multidisciplinary, covering topics in physical-organic, supramolecular and computational chemistry, photophysics and materials science.

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Optimizing bidirectional “highway” for photoactive response through guanidine-chromophore junction

Glavni istraživač / voditelj: Ivana Antol

Suradnja s dr. Mariom Barbattiem s Max-Planck instituta u Muelheimu, Njemačka

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Synthesis and efficacy of chlorophyllin derivatives as photosensitizers for photodynamic therapy

Synthesis and efficacy of chlorophyllin derivatives as photosensitizers for photodynamic therapy

Glavni istraživač / voditelj: Davor Margetić

Croatian-Chinese scientifiy and technological cooperation with Prof. Dr. Zhi-Long Chen from College of Chemistry and Biology, Donghua University, Shanghai

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High-preassure reactors

High-preassure reactors

There are two high-pressure reactors installed in the Laboratory

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Microwave reactor

Microwave reactor

Very efficient heating of reaction mixtures.

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Mills

High-speed vibrational mills

Mechanochemical reactions in solid phase without solvents are possible in high-speed vibrational mills.

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