Laboratory of Synthetic Organic Chemistry

Laboratory of Synthetic Organic Chemistry

Laboratory for Synthetic Organic Chemistry is continuing the tradition of the former Laboratory of Synthetic and Physical Organic Chemistry dealing with the chemistry of cage molecules. Research interests have recently been shifted to three main themes:

  • photochemical reaction mechanisms and supramolecular control of photochemical reactivity
  • synthesis of host and guest molecules for different supramolecular systems and applications
  • synthesis of biologically active molecules

Covering various synthetic, analytical and spectroscopic techniques on substrates including polycyclic molecules, heterocycles, and peptides, the research activities in the laboratory are ideal for training young researchers in graduate and post-graduate education (BSc, MSc, and PhD thesis).

LSOC - Research

IV. K, room 7c, tel: +385 1 4561 165 (int:1465)

IV. K, room 5a, tel: +385 1 4560-962 (int:1341)

left right

LSOC 2013. 

LSOC 2013

LSOC 2011.

LSOC 2011

LSOC 2010.

LSOC 2010

LSOC 2006.

LSOC 2006

LSOC 2002.

LSOC 2002

Members

Former LSOC employees

Dr.sc. Jelena Veljković, (retired)

Mag. chem. Matija Sambol (Fidelta)

Mag. appl. chem. Martina Tireli (IRB)

Dipl. ing. Jakov Ivković

Dr.sc. Marija Matković (IRB)

Dr.sc. Ines Vujasinović (Fidelta)

Renato Margeta

Dipl. ing. Oliver Franković

Dr.sc. Danko Škare, research associate (retired)

Dr.sc. Maja Vinković, (NMR center, IRB, Zagreb)

Mr.sc. Lada Klaić

Dr.sc. Goran Kragol, research associate (Fidelta, Zagreb)

Mr.sc. Dunja Šafar Cvitaš (retired)

Dr.sc. Dražen Pavlović

Dr.sc. Mira Kaselj

Dr.sc. Vlado Vinković

Collaborations:

Dr.sc. Ivana Antol, Ruđer Bošković Institute, Zagreb

Dr.sc. László Biczók, Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences Hungarian Academy of Sciences, Budapest, Hungary

Prof. Cornelia Bohne, Department of Chemistry, University of Victoria, Canada

Dr.sc. Nađa Došlić, Ruđer Bošković Institute, Zagreb

Prof. Fausto Elisei, Dipartimento di chimica, Universita degli Studi di Perugia

Dr.sc. Ruža Frkanec, Centre for Research and Knowledge Transfer in Biotechnology, University of Zagreb,

Prof. Robert Glaser, Ben-Gurion University of the Negev, Israel

Prof. Axel G. Griesbeck, Department of Chemistry, University of Cologne, Germany

Prof. L. Isaacs, University of Maryland, U.S.A.

Dr.sc. Marijeta Kralj, Ruđer Bošković Institute, Zagreb

Dr.sc. Branka Mihaljević, Ruđer Bošković Institute, Zagreb

Prof. David Lee Phillips, Department of Chemistry, The University of Hong Kong

Prof. Hrvoj Vančik, Faculty of Science, University of Zagreb

Prof. Peter Wan, Department of Chemistry, University of Victoria, Canada

Kata Majerski
prof. dr.

senior scientist
+385 1 468 0196
1465 1474

Marina Šekutor
Ph.D.

Research associate
+385 1 456 1165
1465

Nikola Basarić

+385 1 456 1141
1341 1465

Cage Compounds: Building Blocks for Molecular Architecture

Glavni istraživač / voditelj: Kata Majerski

Cage compounds are characterized by three-dimensional structures which have defined rigid geometry and as such, they are very useful synthons in organic synthesis, as well as the indispensable substrates for the mechanistic studies. Moreover, the various atomic positions in a cage can serve as branching points where the additional ligating group can be introduced. These substituted derivatives can be used as building blocks in supramolecular chemistry. The first step towards employing cage compounds in the synthesis of more complex molecular systems is the understanding of their reactions.

more »

Diamondoid Amines – New Ligands in Supramolecular Systems

Glavni istraživač / voditelj: Marina Šekutor

Ligands which bind receptors giving stable supramolecular systems are of utmost importance in biotechnology and technological applications. Cucurbituril systems (CB[n], n = 5, 6, 7, 8, 10) have recently been studied as efficient supramolecular receptors for molecular recognition in water. The water environment is a challenge when designing suitable ligands, seeing as they are usually small, hydrophobic organic molecules. The best binding interactions with CB[n] can be accomplished by ligands that combine cationic and hydrophobic subunits in their structure, like for example diamondoid compounds.

more »

Fluorescent Anion Sensors: Synthesis and Spectroscopic Characterization

Glavni istraživač / voditelj: Nikola Basarić

Dynamics of the supramolecular systems facilitates control of the photochemical reactivity and opens opportunities for reactions which cannot be conducted by conventional synthetic methods, in the thermal reactions in isotropic solution. The main strategy of the proposed project is to apply different supramolecular systems to control photochemical reactivity.

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Photochemistry of polycyclic molecules: From mechanistic studies to new drugs and medicinal applications

Glavni istraživač / voditelj: Nikola Basarić

 

HRZZ

Photons are phenomenal reagents which open new opportunities in chemical synthesis that cannot be attained in the chemistry of ground state. The goal of the project was to find new photochemical transformations applicable in organic synthesis, as well as investigation of the photochemical reaction mechanisms. In addition, the aim of the project was to go beyond the state of the art, and ultimately find application of photochemistry in new medical treatments and synthesis of new compounds, potential drug molecules for treating malignant diseases.

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Supramolecular control of photoeliminations

Supramolecular control of photoeliminations

Glavni istraživač / voditelj: Nikola Basarić

Dynamics of supramolecular systems facilitates control of the photochemical reactivity and opens opportunities for reactions which cannot be conducted by conventional synthetic methods, in the thermal reactions in isotropic solution. The main strategy of the proposed project is to apply different supramolecular systems to control photochemical reactivity.

more »

Synthesis and photochemistry of aniline derivatives for development of new photocages

Glavni istraživač / voditelj: Đani Škalamera

Photocages (photochemically cleavable protective groups) have wide spectrum of applications in chemistry, biology and medicine, and therefore, they have been intensively investigated recently. The main goal of this project is the design and synthesis of new photocleveable protective groups. Within the project implementation new aniline photocages with improved properties will be prepared and the photochemical reaction mechanisms of deprotection investigated. A series of carboxylic acid and alcohol derivatives protected with new aniline photocages will be prepared. These compounds are anticipated to react in the photochemical reaction of heterolysis, leading to deprotection.

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