Anamaria Brozović

Anamaria Brozović


Senior Associate Scientist
+385 1 456 1145


+385 1 4561177

Krilo 5/007

Rudjer Boskovic Institute
Bijenicka 54
10000 Zagreb

Resume Brozovic 2016.pdf 628.43 kB

Specific research interests


Featured Publications

Brozovic A*. The relationship between platinum drug resistance and epithelial-mesenchymal transition. Arch Toxicol, 91:605–619, 2017. *invited review

Vajs J*, Steiner I*, Brozovic A*, Pevec A, Ambriović-Ristov A, Matković M, Piantanida I, Urankar D, Osmak M, Košmrlj J. The 1,3-diaryltriazenido(p-cymene)ruthenium(II) complexes with a high in vitro anticancer activity. J Inorg Biochem. 2015 Dec;153:42-8. *equal contribution

Brozovic A, Duran GE, Wang YC, Francisco EB, Sikic BI. The miR-200 family differentially regulates sensitivity to paclitaxel and carboplatin in human ovarian carcinoma OVCAR-3 and MES-OV cells. Mol Oncol. 2015 Oct;9(8):1678-93.

Moisan F, Francisco EB, Brozovic A, Duran GE, Wang YC, Chaturvedi S, Seetharam S, Snyder LA, Doshi P, Sikic BI. Enhancement of paclitaxel and carboplatin therapies by CCL2 blockade in ovarian cancers. Mol Oncol. 2014 Oct;8(7):1231-9.

Brozovic A, Stojanović N, Ambriović-Ristov A, Brozović Krijan A, Polanc S, Osmak M. 3-Acetyl-bis(2-chloro-4-nitrophenyl)triazene is a potent antitumor agent that induces oxidative stress and independently activates the stress-activated protein kinase/c-Jun NH2-terminal kinase pathway. Anticancer Drugs. 2014 Mar;25(3):289-95.

Brozovic A, Vuković L, Polančac DS, Arany I, Köberle B, Fritz G, Fiket Z, Majhen D, Ambriović-Ristov A, Osmak M. Endoplasmic reticulum stress is involved in the response of human laryngeal carcinoma cells to Carboplatin but is absent in Carboplatin-resistant cells. PLoS One. 2013 Sep 23;8(9):e76397.

Cimbora-Zovko T, Brozovic A, Piantanida I, Fritz G, Virag A, Alič B, Majce V, Kočevar M, Polanc S, Osmak M. Synthesis and biological evaluation of 4-nitro-substituted 1,3-diaryltriazenes as a novel class of potent antitumor agents. Eur J Med Chem. 2011 Jul;46(7):2971-83.

Helbig L, Damrot J, Hülsenbeck J, Köberle B, Brozovic A, Osmak M, Fiket Z, Kaina B, Fritz G. Late activation of stress-activated protein kinases/c-Jun N-terminal kinases triggered by cisplatin-induced DNA damage in repair-defective cells. J Biol Chem. 2011 Apr 15;286(15):12991-3001.

Majhen D*, Brozovic A*, Buger T, Gabrilovac J, Osmak M, Ambriović-Ristov A. Vincristine-resistant human laryngeal carcinoma cells demonstrate increased Rous sarcoma virus promoter activity. Life Sci. 2010 Oct 9;87(15-16):468-74. *equal contribution

Brozovic A, Ambriović-Ristov A, Osmak M. The relationship between cisplatin-induced reactive oxygen species, glutathione, and BCL-2 and resistance to cisplatin. Crit Rev Toxicol. 2010 Apr;40(4):347-59.

Brozovic A, Damrot J, Tsaryk R, Helbig L, Nikolova T, Hartig C, Osmak M, Roos WP, Kaina B, Fritz G. Cisplatin sensitivity is related to late DNA damage processing and checkpoint control rather than to the early DNA damage response. Mutat Res. 2009 Nov 2;670(1-2):32-41.

Brozovic A, Majhen D, Roje V, Mikac N, Jakopec S, Fritz G, Osmak M, Ambriovic-Ristov A. alpha(v)beta(3) Integrin-mediated drug resistance in human laryngeal carcinoma cells is caused by glutathione-dependent elimination of drug-induced reactive oxidative species. Mol Pharmacol. 2008 Jul;74(1):298-306.

Brozovic A, Osmak M. Activation of mitogen-activated protein kinases by cisplatin and their role in cisplatin-resistance. Cancer Lett. 2007 Jun 18;251(1):1-16.

Brozovic A, Fritz G, Christmann M, Zisowsky J, Jaehde U, Osmak M, Kaina B.Long-term activation of SAPK/JNK, p38 kinase and fas-L expression by cisplatin is attenuated in human carcinoma cells that acquired drug resistance. Int J Cancer. 2004 Dec 20;112(6):974-85.