Knjige i poglavlja u knjigama

Poglavlja u knjigama

• Grienke, U., Radić Brkanac, S., Vujčić, V., Urban, E., Ivanković, S., Stojković, R., Rollinger, M., Kralj, J., Brozović, A. & Radić Stojković, M. (2019) Biological Activity of Flavonoids and Rare Sesquiterpene Lactones Isolated From Centaurea ragusina L.. U: Hohmann, J., Karolina Kiss, A., Rollinger, J. & Atanasov, A. (ur.) Ethnopharmacology in Central and Eastern Europe in the Context of Global Research Developments. Lausanne, Frontiers Media, str. 20-58 doi:10.3389/fphar.2018.00972.

  doiwww.frontiersin.org

Radovi u časopisima

Znanstveni i pregledni radovi

• Kralj, J., Pernar Kovač, M., Dabelić, S., Stupin Polančec, D., Wachtmeister, T., Köhrer, K. & Brozovic, A. (2023) Transcriptome analysis of newly established carboplatin-resistant ovarian cancer cell model reveals genes shared by drug resistance and drug-induced EMT. British journal of cancer, 128, 1344-1359 doi:10.1038/s41416-023-02140-1.

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• Fabijanić, I., Kurutos, A., Tomašić Paić, A., Tadić, V., Kamounah, F., Horvat, L., Brozovic, A., Crnolatac, I. & Radić Stojković, M. (2023) Selenium-Substituted Monomethine Cyanine Dyes as Selective G-Quadruplex Spectroscopic Probes with Theranostic Potential. Biomolecules, 13 (128), 13-00128, 20 doi:10.3390/biom13010128.

  doiwww.mdpi.com

• Pantalon Juraj, N., Tandarić, T., Tadić, V., Perić, B., Moreth, D., Schatzschneider, U., Brozovic, A., Vianello, R. & Kirin, S. (2022) Tuning the coordination properties of chiral pseudopeptide bis(2-picolyl)amine and iminodiacetamide ligands in Zn(II) and Cu(II) complexes. Dalton transactions, 51 (44), 17008-17021 doi:10.1039/d2dt02895f.

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• Zonjić, I., Kurutos, A., Mihovilović, P., Crnolatac, I., Tumir, L., Tomašić Paić, A., Kralj, J., Horvat, L., Brozovic, A., Stojković, R. & Radić Stojković, M. (2022) Formation of triplex rA/dA-containing nucleic acid helices induced by new thiazole orange analogues and their biological evaluation. H-aggregate formation conditioned by rA sequence. Dyes and pigments, 207, 110715, 14 doi:10.1016/j.dyepig.2022.110715.

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• Zonjić, I., Radić Stojković, M., Crnolatac, I., Tomašić Paić, A., Pšeničnik, S., Vasilev, A., Kandinska, M., Mondeshki, M., Baluschev, S., Landfester, K., Glavaš-Obrovac, L., Jukić, M., Kralj, J., Brozovic, A., Horvat, L. & Tumir, L. (2022) Styryl dyes with N-Methylpiperazine and N-Phenylpiperazine Functionality: AT-DNA and G-quadruplex binding ligands and theranostic agents. Bioorganic chemistry, 127, 105999, 15 doi:10.1016/j.bioorg.2022.105999.

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• Wei, C., Jin, X., Wu, C., Brozović, A. & Zhang, W. (2022) Carbon spheres with high photothermal conversion efficiency for photothermal therapy of tumor. Diamond and Related Materials, 126, 109048, 9 doi:10.1016/j.diamond.2022.109048.

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• Jakopec, S., Pantalon Juraj, N., Brozović, A., Jadreško, D., Perić, B., Kirin, S. & Raić-Malić, S. (2022) Ferrocene conjugates linked by 1,2,3-triazole and their Zn(II) and Cu(II) complexes: Synthesis, characterization and biological activity. Applied organometallic chemistry, 36 (4), e6575, 22 doi:10.1002/aoc.6575.

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• Miletić, M., Murati, T., Šimić, B., Bilandžić, N., Brozović, A. & Kmetič, I. (2021) Ortho-substituted PCB 153: effects in CHO-K1 cells. Arhiv za higijenu rada i toksikologiju, 72 (4), 326-332 doi:10.2478/aiht-2021-72-3588.

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• Schürmann, L., Schumacher, L., Roquette, K., Brozovic, A. & Fritz, G. (2021) Inhibition of the DSB repair protein RAD51 potentiates the cytotoxic efficacy of doxorubicin via promoting apoptosis-related death pathways. Cancer letters, 520, 361-373 doi:10.1016/j.canlet.2021.08.006.

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• De Las Rivas, J., Brozović, A., Izraely, S., Casas-Pais, A. & Witz IP, Figueroa, Angelica. (2021) Cancer drug resistance induced by EMT: novel therapeutic strategies. Archives of toxicology, 95, 2279-2297 doi:10.1007/s00204-021-03063-7.

  doilink.springer.comdoi.orgfulir.irb.hr

• Erin, N., Grahovac, J., Brozovic, A. & Efferth, T. (2020) Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance. Drug resistance updates, 53, 100715, 22 doi:10.1016/j.drup.2020.100715..

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• Torić, J., Brozović, A., Baus Lončar, M., Jakobušić Brala, C., Karković Marković, A., Benčić, Đ. & Barbarić, M. (2020) Biological Activity of Phenolic Compounds in Extra Virgin Olive Oils through Their Phenolic Profile and Their Combination with Anticancer Drugs Observed in Human Cervical Carcinoma and Colon Adenocarcinoma Cells. Antioxidants, 9 (5), 453, 15 doi:10.3390/antiox9050453.

  doiwww.mdpi.comfulir.irb.hr

• Kralj, J., Bolje, A., Stupin Polančec, D., Gržan, T., Tupek, A., Steiner, I., Stojanović, N., Hohloch, S., Urankar, D., Osmak, M., Sarkar, B., Brozovic, A. & Košmrlj, J. (2019) Half-Sandwich Ir(III) and Os(II) Complexes of Pyridyl-Mesoionic Carbenes as Potential Anticancer Agents. Organometallics, 38 (21), 4082-4092 doi:10.1021/acs.organomet.9b00327.

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• Assaraf, Y., Brozović, A., Gonçalves, A., Jurkovicova , D., Linē, A., Machuqueiro, M., Saponara, S., Sarmento-Ribeiro, A., Xavier, C. & Vasconcelos, M. (2019) The multi-factorial nature of clinical multidrug resistance in cancer. Drug resistance updates, 46, 100645, 78 doi:10.1016/j.drup.2019.100645.

  doiwww.sciencedirect.comdoi.org

• Tomičić, M., Steigerwald, C., Rasenberger, B., Brozović, A. & Christmann, M. (2019) Functional mismatch repair and inactive p53 drive sensitization of colorectal cancer cells to irinotecan via the IAP antagonist BV6. Archives of toxicology, 93 (8), 2265-2277 doi:10.1007/s00204-019-02513-7.

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• Matić, J., Šupljika, F., Tandarić, T., Dukši, M., Piotrowski, P., Vianello, R., Brozović, A., Piantanida, I., Schmuck, C. & Radić Stojković, M. (2019) DNA/RNA recognition controlled by the glycine linker and the guanidine moiety of phenanthridine peptides. International journal of biological macromolecules, 134, 422-434 doi:10.1016/j.ijbiomac.2019.05.063.

  doifulir.irb.hr

• Pernar, M., Kokan, Z., Kralj, J., Glasovac, Z., Tumir, L., Piantanida, I., Eljuga, D., Turel, I., Brozovic, A. & Kirin, S. (2019) Organometallic ruthenium(II)-arene complexes with triphenylphosphine amino acid bioconjugates: Synthesis, characterization and biological properties. Bioorganic chemistry, 87, 432-446 doi:10.1016/j.bioorg.2019.03.048.

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• Grienke, U., Radić Brkanac, S., Vujčić, V., Urban, E., Ivanković, S., Stojković, R., Rollinger, J., Kralj, J., Brozović, A. & Radić Stojković, M. (2018) Biological Activity of Flavonoids and Rare Sesquiterpene Lactones Isolated From Centaurea ragusina L.. Frontiers in Pharmacology, 9, 972, 15 doi:10.3389/fphar.2018.00972.

  doifulir.irb.hrwww.frontiersin.orgdoi.org

• Kokan, Z., Perić, B., Kovačević, G., Brozovic, A., Metzler-Nolte, N. & Kirin, S. (2017) Cis- vs. trans- square-planar palladium(II) and platinum(II) complexes with triphenylphosphine amino acid bioconjugates. European journal of inorganic chemistry, 2017 (33), 3928-3937 doi:10.1002/ejic.201700679.

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• Brozović, A. (2017) The relationship between platinum drug resistance and epithelial–mesenchymal transition. Archives of toxicology, 91 (2), 605-619 doi:10.1007/s00204-016-1912-7.

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• Vajs, J., Proud, C., Brozović, A., Gazvoda, M., Lloyd, A., Roper, D., Osmak, M., Košmrlj, J. & Dowson, C. (2017) Diaryltriazenes as Antibacterial Agents Against Methicillin Resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis. European journal of medicinal chemistry, 127, 223-234 doi:10.1016/j.ejmech.2016.12.060.

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• Steiner, I., Stojanović, N., Bolje, A., Brozović, A., Polančec, D., Ambriović-Ristov, A., Radić Stojković, M., Piantanida, I., Eljuga, D., Košmrlj, J. & Osmak, M. (2016) Discovery of ‘click’ 1, 2, 3-triazolium salts as potential anticancer drugs. Radiology and oncology, 50 (3), 280-288 doi:10.1515/raon-2016-0027.

  doiwww.ncbi.nlm.nih.gov

• Stojanović, N., Brozovic, A., Majhen, D., Herak Bosnar, M., Fritz, G., Osmak, M. & Ambriović-Ristov, A. (2016) Integrin αvβ3 Expression in Tongue Squamous Carcinoma Cells Cal27 Confers Anticancer Drug Resistance Through Loss of pSrc(Y418). Biochimica et biophysica acta-molecular cell research, 1863 (8), 1969-1978 doi:10.1016/j.bbamcr.2016.04.019.

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• Vajs, J., Steiner, I., Brozović, A., Pevec, A., Ambriović-Ristov, A., Matković, M., Piantanida, I., Urankar, D., Osmak, M. & Janez Košmrlj (2015) The 1, 3-diaryltriazenido(p-cymene)ruthenium(II) complexes with a high in vitro anticancer activity. Journal of inorganic biochemistry, 153, 42-48 doi:10.1016/j.jinorgbio.2015.09.005.

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• Brozovic, A., Duran, G., Wang, Y., Francisco, B. & Sikic, B. (2015) The miR-200 family differentially regulates sensitivity to paclitaxel and carboplatin in human ovarian carcinoma OVCAR-3 and MES-OV cells. Molecular Oncology, 9 (8), 1678-1693 doi:10.1016/j.molonc.2015.04.015.

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• Murati, T., Šimić, B., Brozović, A., Kniewald, J., Miletić Gospić, A., Bilandžić, N. & Kmetič, I. (2015) PCB 77 action in ovary cells – cytotoxicity, apoptosis induction and cell cycle analysis. Toxicology mechanisms and methods, 25 (4), 302-311 doi:10.3109/15376516.2015.1028605.

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• Moisan, F., Francisco, E., Brozović, A., Duran, G., Wang, Y., Chaturvedi, S., Seetharamb, S., Snyder, L., Doshi, P. & Sikić, B. (2014) Enhancement of Paclitaxel and Carboplatin Therapies by CCL2 Blockade in Ovarian Cancers. Molecular Oncology, 8 (7), 1231-1239 doi:10.1016/j.molonc.2014.03.016.

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• Brozović, A., Stojanović, N., Ambriović-Ristov, A., Brozović Krijan, A., Polanc, S. & Osmak, M. (2014) 3-Acetyl-bis(2-chloro-4-nitrophenyl) triazene is a potent antitumor agent that induces oxidative stress and independently activates the stress-activated protein kinase/c-Jun NH2-terminal kinase pathway. Anti-cancer drugs, 25 (3), 289-295 doi:10.1097/CAD.000000000000006.

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• Brozović, A., Vuković, L., Stupin Polančec, D., Arany, I., Köberle, B., Fritz, G., Fiket, Ž., Majhen, D., Ambriović-Ristov, A. & Osmak, M. (2013) Endoplasmic reticulum stress is involved in response of human laryngeal carcinoma cells to carboplatin but is absent in carboplatin resistant cells. PLoS One, 8 (9), e763973-1 doi:10.1371/journal.pone.0076397.

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• Stojanović, N., Urankar, D., Brozović, A., Ambriović-Ristov, A., Osmak, M. & Košmrlj, J. (2013) Design and evaluation of biological activity of diazenecarboxamide-extended cisplatin and carboplatin analogues. Acta chimica Slovenica, 60 (2), 368-374.

  fulir.irb.hr

• Sauerborn Klobučar, R., Brozović, A. & Štambuk, A. (2013) Ecotoxicological assessment of nitrofurantoin in fish cell lines, unicellular algae Desmodesmus subspicatus, and bacterial strains of Salmonella typhimurium. Fresenius environmental bulletin, 22 (9a), 2669-2675.

• Gabrilovac, J., Čupić, B., Zapletal, E. & Brozović, A. (2012) IFN-γ up-regulates kappa opioid receptors (KOR) on murine macrophage cell line J774. Journal of neuroimmunology, 245 (1-2), 56-65 doi:10.1016/j.jneuroim.2012.02.006.

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• Majhen, D., Stojanović, N., Špeljko, T., Brozović, A., De Zan, T., Osmak, M. & Ambriović-Ristov, A. (2011) Increased expression of the coxsackie and adenovirus receptor downregulates alpha v beta 3 and alpha v beta 5 integrin expression, reduces cell adehesion and migration. Life sciences, 89 (7-8), 241-249 doi:10.1016/j.lfs.2011.06.009.

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• Čimbora-Zovko, T., Brozović, A., Piantanida, I., Fritz, G., Virag, A., Alič, B., Majce, V., Kočevar, M., Polanc, S. & Osmak, M. (2011) Synthesis and biological evaluation of 4-nitro-substituted 1, 3-diaryltriazenes as a novel class of potent antitumor agents. European journal of medicinal chemistry, 46 (7), 2971-2983 doi:10.1016/j.ejmech.2011.04.024.

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• Helbig, L., Damrot, J., Johannes Hülsenbeck, Köberle, B., Brozović, A., Osmak, M., Fiket, Ž., Kaina, B. & Fritz, G. (2011) Late activation of stress-activated protein kinases/C-JUN-N- terminal kinases triggered by cisplatin-induced DNA damage repair defective cells. The Journal of biological chemistry, 286 (15), 12991-13001 doi:10.1074/jbc.M110.190645.

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• Brozović, A., Ambriović-Ristov, A. & Osmak, M. (2010) The relationship between cisplatin-induced reactive oxygen species, glutathione, and BCL-2 and resistance to cisplatin. Critical reviews in toxicology, 40 (4), 347-359 doi:10.3109/10408441003601836.

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• Majhen, D., Brozović, A., Buger, T., Gabrilovac, J., Osmak, M. & Ambriović-Ristov, A. (2010) Vincristine-resistant human laryngeal carcinoma cells demonstrate increased Rous sarcoma virus promoter activity. Life sciences, 87 (15/16), 468-474 doi:10.1016/j.lfs.2010.08.012.

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• Sauerborn Klobučar, R., Žaja, R., Franjević, D., Brozović, A. & Smital, T. (2010) Presence of Ecotoxicologically Relevant Pgp- and MRP- Transcripts and Proteins in Cyprinid Fish. Arhiv za higijenu rada i toksikologiju, 61 (2), 175-181. (https://www.bib.irb.hr/446731).

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• Brozović, A., Damrot, J., Tsaryk, R., Helbig, L., Nikolova, T., Hartig, C., Osmak, M., Roos, W., Kaina, B. & Fritz, G. (2009) Cisplatin sensitivity is related to late DNA damage processing and checkpoint control rather than to the early DNA damage response. Mutation research, 670 (1-2), 32-41 doi:10.1016/j.mrfmmm.2009.07.002.

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• Brozović, A., Majhen, D., Roje, V., Mikac, N., Jakopec, S., Fritz, G., Osmak, M. & Ambriović-Ristov, A. (2008) Alpha v beta 3 integrin mediated drug resistance in human laryngeal carcinoma cells is caused by glutathione dependent elimination of drug induced reactive oxidative species. Molecular pharmacology, 74 (1), 298-306 doi:10.1124/mol.107.043836.

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• Jakopec, S., Karlović, D., Dubravčić, K., Batinić, D., Sorić, J., Brozović, A., Buljan, D. & Osmak, M. (2008) Lithium effect on glutamate induced damage in glioblastoma cells. Collegium antropologicum, 32 (S1), 87-91.

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• Brozović, A. & Osmak, M. (2007) Activation of mitogen-activated protein kinases by cisplatin and their role in cisplatin-resistance. Cancer letters, 251 (1), 1-16 doi:10.1016/j.canlet.2006.10.007.

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• Jakopec, S., Dubravčić, K., Brozović, A., Polanc, S. & Osmak, M. (2006) Structurally similar diazenes exhibit significantly different biological activity. Cell biology and toxicology, 22 (1), 61-71 doi:10.1007/s10565-006-0023-2.

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• Brozović, A., Fritz, G., Christmann, M., Zisowsky, J., Jaehde, U., Osmak, M. & Kaina, B. (2004) Long-term activation of SAPK/JNK, p38 kinase and fas-L expression by cisplatin is attenuated in human carcinoma cells that aquired drug resistance. International journal of cancer, 112 (6), 974-985 doi:10.1002/lijc.20522.

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• Vuković, L., Ambriović-Ristov, A., Čimbora Zovko, T., Ćetković, H., Brozović, A., Majhen, D. & Osmak, M. (2004) Expression of apoptotic genes in low, clinically relevant levels of drug resistance. Periodicum Biologorum, 106 (2), 173-177.

• Brozović, A., Šimaga, Š. & Osmak, M. (2001) Induction of heat shock protein 70 in drug-resistant cells by anticancer drugs and hyperthermia. Neoplasma, 48 (2), 99-103.

• Osmak, M., Nikšić, D., Brozović, A., Ambriović-Ristov, A., Vrhovec, I. & Škrk, J. (1999) Drug resistant tumour cells have increased levels of tumor markers for invasion and metastasis. Anticancer research, 19 (4B), 3193-3197.

• Osmak, M., Brozović, A., Ambriović-Ristov, A., Hadžija, M., Pivčević, B. & Smital, T. (1998) Inhibition of apoptosis is the cause of resistance to doxorubicin in human breast adenocarcinoma cells. Neoplasma, 45 (4), 223-230.

• Osmak, M., Abramić, M., Brozović, A. & Hadžija, M. (1997) Cell response to low repeated doses of ionising radiation: inhibition of apoptosis in cisplatin treated human cells. Periodicum biologorum, 99 (3), 329-333.

Radovi u zbornicima skupova

Znanstveni radovi u zbornicima skupova

• Osmak, M. & Brozović, A. (2003) Niske doze gama zračenja smanjuju osjetljivost tumorskih stanica grlića maternice na cisplatinu. U: Krajcar-Bronić, I., Miljanić, S. & Obelić, M. (ur.)Zbornik radova V. Simpozija Hrvatskog društva za zaštitu od zračenja.

Patenti

• Osmak, M., Slovenko, Polanc, Čimbora-Zovko, Tamara, Brozović, A., Kočevar, M., Majce, V. & Alić, B. (2012) Analogues of 1, 3-bis(4-nitrophenyl)triazenes, their pharmaceutically acceptable salts and N-acyl derivatives for tumour treatment, US 8, 217, 022 B2.

Ocjenski radovi

Doktorske disertacije

• Brozović, A. (2002) 'Molekularni mehanizmi apoptoze i popravka oštećenja u osjetljivosti stanica na cisplatinu', doktorska disertacija, Prirodoslovno-matematički fakultet, Zagreb.

Magistarski radovi

• Brozović, A. (1999) 'Indukcija "heat shock" proteina u stanicama nakon djelovanja citostatika ili hipertermije', magistarski rad, Prirodoslovno-matematički, Zagreb.