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  4. Andreja Ambriović Ristov

Dr. Andreja Ambriović Ristov

Head of laboratory
E-mail
Andreja.Ambriovic.Ristov@irb.hr
Telephone
+385 1 457 1240
Internal phone number
1543
1545
Department
Division of Molecular Biology
Laboratory
Laboratory for Cell Biology and Signalling
Address
Laboratory for Cell Biology and Signalling
Division of Molecular Biology
Ruđer Bošković Institute
Bijenička 54
10000 Zagreb
Croatia
Curriculum vitae
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Education

1989, Zagreb, Croatia, Faculty of Pharmacy and Biochemistry, University of  Zagreb, B. Sc.(clinical chemistry)
1993, Zagreb, Croatia, Faculty of Science, University of  Zagreb, Mr.Sc. (biology)
1997, Zagreb, Croatia, Faculty of Science, University of  Zagreb, Ph. D. (biology)

Research Areas

Projects

(2020-2024) HRZZ Research Project „Integrin αVβ5-associated Focal and Reticular Adhesions in Melanoma” Role on the project: Leader

(2014-2018) HRZZ Research Project
„Molecular mechanisms of chemosensitisation of human breast carcinoma and melanoma cell lines by silencing of integrins“
Role on the project: Leader

(2016-2017) HAMAG BICRO Proof of concept: „VirusHunter-identifying new potentially pathogen viruses“Role on the project:  Co-worker

(2014-2015): bilateral project with Germany
”Sensitization of melanoma and glioma cells to alkylating drugs by integrin αvβ3, αvβ5, α3β1 and α4β1 silencing”
Role on the project:  Leader

(2013-2016) FP7-REGPOT project
”Enhancement of the Innovation Potential in SEE through New Molecular Solutions in Research and Development” leader dr. sc. Oliver Vugrek
Role on the project:  Co-worker

(2012-2013) bilateral project with Germany
„Platinum compounds: Drug-induced stress responses and mechanisms of drug- resistance“ Institute for toxicology, Heinrich Heine University Düsseldorf, Düsseldorf,  Germany
Role on the project:  Co-worker

(2008-2009) bilateral project with Germany
„Molecular mechanisms that deterimines cell sensitivity to platinum compounds” Institut for toxicology, Johannes Gutenberg University, Mainz, Germany
Role on the project:  Co-worker

(2007-2013) Ministry of Science, Education and Sports, “Increase of adenovirus transduction efficacy and resistance to cytostatics”
Role on the project:  Leader

(2007-2013) Ministry of Science, Education and Sports, “Cell respones to cytotoxic agents and resistance development “
Role on the project:  Co-worker

(2007-2010) Technological project awarded by Ministry of Science, Education and Sports, “Regeneration of knee articular cartilage”
Role on the project: Leader

(2004-2006) Integrated action: Ministry of Science, Education and Sports and French Government: COGITO, “Adenovirus retargeting to aminopeptidase N and potential use in gene therapy of cystic fibrosis”
Role on the project: Leader

(2002-2004) NATO Science Program, Collaborative linkage grant, “Human adenovirus type 5 retargeted on aminopeptidase N”
Role on the project: Leader

(1990-1995) Ministry of Science, Education and Sports Science and Technology  
“The investigation of cell resistance to genotoxic agents”
Role on the project: Co-worker

(1998-2000) Ministry of Science, Education and Sports,  Young researcher grant
“Vector vaccines against pseudorabies virus”
Role on the project:  Leader

(1996-2002) Ministry of Science, Education and Sports, Cell response to physical, chemical and biological noxa
Role on the project: Co-worker

Awards and Achievements

2008. Award J. J. Strossmayer (Croatian Academy of Sciences and Arts/ Zagreb fair), for the best publishing venture in science, for the book «Methods in molecular biology» by Andreja Ambriović Ristov (Editor-in-chief) and Anamaria Brozović, Branka Bruvo Mađarić, Helena Ćetković, Maja Herak Bosnar, Dubravka Hranilović, Silva Katušić, Hećimović, Nevenka Meštrović Radan, Snježana Mihaljević, Neda Slade, Dušica Vujaklija (Eds.).

2004. The award of director of Ruđer Bošković Institute for contribution in Institute development and common prosperity.

Classes

2008-, Course leader «Gene therapy», graduate Studies programme in Molecular Biotechnology, Faculty of Food Technology and Biotechnology, University of Zagreb.

2008-, Course leader «Methods in molecular biology and medicine», The Ph.D. study in biophysics, Faculty of Science, University of Split.

2007-, Course co-leader «Methods in molecular biology and medicine», PhD Studies in Molecular Biosciences, University of Osijek, University of Dubrovnik and Ruđer Bošković Institute,

2007-, Course co-leader «Methods in molecular biology and medicine-practicum», PhD Studies in Molecular Biosciences, University of Osijek, University of Dubrovnik and Ruđer Bošković Institute.

2002-, Course Leader «Molecular basis of Gene Therapy» PhD Studies in biology, Faculty of Science, University of Zagreb.

Publications - editorial books

Priručnik

Zbornik radova s konferencije

Zbornik sažetaka s konferencije

Publications - book chapters

Stručni rad

Ostalo

Publications - journal articles

Izvorni znanstveni rad

Ostalo

Pregledni rad (znanstveni)

Kratko priopćenje

Publications - Conference journals

Sažetak izlaganja sa skupa

Publications - Conference unpublished

Neobjavljeni prilog sa skupa

Publications - Graded papers

Doktorski rad

Magistarski rad (znanstveni)

Diplomski rad (sveučilišni)

Other Publications

Ostalo

Membership in professional associations / societies

Croatian Society for Biochemistry and Molecular Biology (thus member of FEBS)
Croatian Microbiological Society (thus member of FEMS)
Croatian society of genetic engineers
Croatian Association for Cancer Research
Croatian Genetic Society

2003-2013 The founder and director of educational project “Methodological Courses in Biology and Medicine”

Editor in chief of a book “Methods in molecular biology” with contributions from 119 authors from Ruđer Bošković Institute and University which has been accepted as a regular textbook by the University in Zagreb. Institut Ruđer Bošković (Editor), 2007, Zagreb. http://www.mmb.irb.hr/

MENTORSHIP

Doctoral Thesis

1. Ana Dekanić, „The effect of silencing of integrin subunits α in human melanoma cells on sensitivity to antitumour drugs and motility“, Josip Juraj Strossmayer University of Osijek, University of Dubrovnik, Ruđer Bošković Institute, University postgraduate interdisciplinary Doctoral Study of Molecular biosciences, 2019.

2. Nikolina Stojanović, „Integrin αvβ3 mediated drug resistance in human tongue squamous carcinoma cells“, Josip Juraj Strossmayer University of Osijek, University of Dubrovnik, Ruđer Bošković Institute, University postgraduate interdisciplinary Doctoral Study of Molecular biosciences, 2014.

3. Dragomira Majhen, „Augmentation of adenovirus transduction: Changing expression of natural receptors and retargeting to new ones“, Faculty of Science University of Zagreb, 2008.

Master of Science Thesis:

1. Dragomira Majhen: «Adenovirus type 5 retargeting on amniopeptidase N», Faculty of Science University of Zagreb, 2005.

Diploma Thesis

1. Zrinka Vitković, „Karakterizacija adhesoma u stanicama trostruko negativnog karcinoma dojke MDA-MB-231 nakon stabilnog utišavanja gena za integrin αv“, Faculty of Science, University of Zagreb, 2018.

2. Kristina Čuljak, Karakterizacija adhesoma u stanicama karcinoma pločastog epitela jezika Cal27 nakon de novo ekspresije integrina αvβ3, Faculty of Science, University of Zagreb, 2018.

3. Christine Supina, Kombinirani utjecaj cilengitida i paklitaksela na stanične linije trostruko negativnog tumora dojke i melanoma, Faculty of Science, University of Zagreb, 2018.

4. Nebojša Vujnović, „Kombinirani učinak inhibitora tirozin kinaza i protutumorskih lijekova u stanicama melanoma čovjeka“, Faculty of Science, University of Zagreb, 2017.

5. Delphine Sedda, „Knockdown of the integrin subunit αV in MDA-MB-435 cells decreases sensitivity to cisplatin, Masters „Science of Life“, Masther thesis of biochemistry, molecular biology and biotechnology, University of Orleans, France, 2016.

6. Alen Kovačević, „Proteomic analysis of human breast cancer cells MDA-MB-435S after silencing integrin alpha v“, Faculty of Science, University of Zagreb, 2015. Co-menthors Andreja Ambriović-Ristov and Mario Cindrić

7. Ivan Faraho, „Differential proteome analysis of Cal27 and Cal27-2B1 human tongue squamous cell carcinoma cell lines“, Faculty of Science, University of Zagreb, 2015. Co-menthors Andreja Ambriović-Ristov and Mario Cindrić

8. Kristijan Pažur, „Disulfide bonds in retargeting motifs RGD or NGR inserted into the adenovirus type 5“, Faculty of Science, University of Zagreb, 2013.

9. Krešimir Ferenčak, „Effect of integrin αv or α4 silencing on sensitivity of human breast cancer cells to vincristine and paclitaxel“, Faculty of Science, University of Zagreb, 2013.

10. Buger Tvrtko, „Vincristine cell resistance is accompanied by changes in integrin expression and adenovirus transduction efficiency“, Faculty of Science, University of Zagreb, 2012.

11. Dekanić Ana, „Influence of integrin αvβ3 and αvβ5 silencing on sensitivity of tumor cells to cisplatin“, Faculty of Science, University of Zagreb, 2012.

12. Irena Bardak, „Influence of αvβ3 and αvβ5 integrin silencing on attachment, internalization and transduction with adenoviral vectors“, Faculty of Science, University of Zagreb, 2011.

13. Dunja Vukić, „Increased Ad5-mediated transgene expression in cisplatin-resistant human laryngeal carcinoma cells“, Faculty of Pharmacy and Biochemistry, University of Zagreb, 2010.

14. Tea Špeljko, „The influence of the coxsackie adenovirus receptor expression on integrin expression in human rhabdomyosarcoma cell line“, Faculty of Science, University of Zagreb, 2010.

15. Nikolina Stojanović, „αvβ3 integrin mediated drug resistance in human tongue squamous cell carcinoma“, Faculty of Science, University of Zagreb, 2009.

16. Tihana Jelušić, „Retargeting adenovirus type 5 to integrin α4β1“, Faculty of Science, University of Zagreb, 2009.

VISITS TO FOREIGN RESEARCH INSTITUTIONS

Visiting professor (duration 1 month) year 2018/2019: Molecular Biotechnology Center, University of Torino, Torino, Italy

Visiting professor (duration 1 month) year 2016/2017: Molecular Biotechnology Center, University of Torino, Torino, Italy

Visiting professor (duration 1 month) year 2013/2014: University of Orleans, France.

Visiting professor (duration 1 month) year 2010/2011: University of Orleans, France.

INRA postdoc fellowship; March-August, 2001; Ecole Nationale Veterinaire D’Alfort, 7 avenue du General de Gaulle, 94704 Maisons Alfort, France.

French Government Fellowship: November, 1994 - August, 1995, Ecole Nationale Veterinaire D’Alfort, 7 avenue du General de Gaulle, 94704 Maisons Alfort, France.