dr. sc. Andreja Ambriović Ristov

1989. Zagreb, Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, Diplomirani inženjer medicinske biokemije
1993. Zagreb, Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu, Magistar bioloških znanosti
1997. Zagreb, Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu, Doktor bioloških znanosti

(2014-2018) HRZZ istraživački projekt
„Molekularni mehanizmi povećanja osjetljivosti na protutumorske lijekove stanica karcinoma dojke i melanoma čovjeka utišavanjem integrina“
Uloga na projektu: voditeljica

(2016-2017) HAMAG BICRO POC6: „VirusHunter - otkrivanje novih potencijalno patogenih virusa“

Uloga na projektu: suradnica

(2014-2015): bilateralni projekt s Njemačkom
”Povećanje osjetljivosti stanica melanoma i glioma na alkilirajuće lijekove utišavanjem integrina αvβ3, αvβ5, α3β1 i α4β1”
Uloga na projektu: voditeljica

(2013-2016) FP7-REGPOT projekt
”Enhancement of the Innovation Potential in SEE through New Molecular Solutions in Research and Development” leader dr. sc. Oliver Vugrek
Uloga na projektu: suradnica
(2012-2013) bilateralni projekt s Njemačkom
„Spojevi sa platinom: Stanični odgovor i mehanizmi otpornosti“ Institut za toksikologiju, Sveučilište Heinrich Heine University Düsseldorf, Düsseldorf,  Njemačka
Uloga na projektu: suradnica

(2008-2009) bilateralni projekt s Njemačkom
„Molekularni mehanizmi koji određuju staničnu osjetljivost na spojeve sa platinom”, Johannes Gutenberg University, Mainz, Germany
Uloga na projektu: suradnica

(2007-2013) Ministarstvo znanosti obrazovanja i sporta RH
„Povećanje transdukcije adenovirusnih vektora i otpornost stanica na citostatike“, Ministarstvo znanosti obrazovanja i sporta RH
Uloga na projektu: voditeljica

(2007-2013) Ministarstvo znanosti obrazovanja i sporta RH
Stanični odgovor na citotoksične agense i razvoj otpornosti“
Uloga na projektu: suradnica

(2007-2010) Tehnološki projekt, Ministarstvo znanosti obrazovanja i sporta RH
„Regeneracija hrskavice koljenskog zgloba“
Uloga na projektu: voditeljica

(2004-2006) Integrated action: Ministarstvo znanosti obrazovanja i sporta RH i Francuska vlada: COGITO, “Adenovirus retargeting to aminopeptidase N and potential use in gene therapy of cystic fibrosis”
Uloga na projektu: voditeljica

(2002-2004) NATO Science Program, Collaborative linkage grant,
“Human adenovirus type 5 retargeted on aminopeptidase N”
Uloga na projektu: voditeljica

(1990-1995) , Ministarstvo znanosti obrazovanja i sporta RH  
„Istraživanje otpornosti stanica na genotoksične agense“
Uloga na projektu: suradnica

(1998-2000) , Ministarstvo znanosti obrazovanja i sporta RH,  Projekti za mlade istraživače
“Vektorske vakcine protiv pseudorabies virusa”
Uloga na projektu: voditeljica

(1996-2002) , Ministarstvo znanosti obrazovanja i sporta RH
„Stanični odgovor na genotoksične agense“
Uloga na projektu: suradnica

2008. Priručniku "Metode u molekularnoj biologiji", glavna urednica Andreja Ambriović Ristov i urednice Anamaria Brozović, Branka Bruvo Mađarić, Helena Ćetković, Maja Herak Bosnar, Dubravka Hranilović, Silva Katušić Hećimović, Nevenka Meštrović Radan, Snježana Mihaljević, Neda Slade, Dušica Vujaklija, dodijeljena je povelja za najuspješniji izdavački pothvat.

2004. Nagrada ravnatelja Instituta Ruđer Bošković za doprinos Institutu i općem dobru.

2008-, Nositeljica kolegija «Genska terapija», diplomski studij Molekularne biotehnologije pri Prehrambeno-biotehnološkom fakultetu Sveučilišta u Zagrebu.

2008-, Nositeljica kolegija «Metode u molekularnoj biologiji i medicini», doktorski studij iz biofizike, Fakultet prirodoslovno matematičkih znanosti i kineziologije Sveučilišta u Splitu.

2007-, Sunositeljica obaveznog kolegija «Osnove metoda u molekularnoj biologiji i medicini», Sveučilišni interdisciplinarni doktorski studij «Molekularne bioznanosti», Sveučilište u Osijeku, Sveučilište u Dubrovniku i Institut Ruđer Bošković.

2007-, Sunositeljica izbornog kolegija «Metode u biologiji i medicini-praktikum», Sveučilišni interdisciplinarni doktorski studij «Molekularne bioznanosti», Sveučilište u Osijeku, Sveučilište u Dubrovniku i Institut Ruđer Bošković.

2002-, Nositeljica kolegija «Molekularne osnove genske terapije» doktorski studija biologije pri Prirodoslovno-matematičkom fakultetu Sveučilišta u Zagrebu.

Stojanović, N. *, Dekanić, A. *, Paradžik, M., Majhen, D., Ferenčak, K., Ruščic, J., Bardak, I., Supina, C., Tomičić, M., Christmann, M., Osmak, M., Ambriović-Ristov, A. (2018) Differential effects of integrin αv knockdown and cilengitide on sensitisation of triple- negative breast cancer and melanoma cells to microtubule poisons. Molecular pharmacology, 118, 113027, 46 doi:10.1124/mol.118.113027. *jednaki doprinos

Ruščić J. *, Ambriović-Ristov A.*, Majhen D., Kolundžija S., Barut M., Benihoud K., Krajačić M. Manipulating adenoviral vector ion-exchange chromatography: Hexon versus fiber.Journal of Separation Science. 39(22): 4299-4304, 2016. *jednaki doprinos

Christmann M., Diesler K., Majhen D., Steigerwald C., Berte N., Freund H., Stojanović N., Kaina B., Osmak M., Ambriović-Ristov A.*, Tomicic M.T.* Integrin αVβ3 silencing sensitizes malignant glioma cells to temozolomide by suppression of homologous recombination repair,Oncotarget, 8(17): 27754-27771, 2017. *dopisni autori

Stojanovic N., Brozovic A., Majhen D., Herak Bosnar M., Fritz G., Osmak M., Ambriovic-Ristov A. Integrin αvβ3 expression in tongue squamous carcinoma cells Cal27 confers anticancer drug resistance through loss of pSrc(Y418), Biochimica et Biophysica Acta 1863: 1969–1978, 2016.

Majhen D., Stojanović N., Vukić D., Pichon C., Leduc C., Osmak M., Ambriović-Ristov A. Increased Adenovirus Type 5 Mediated Transgene Expression Due to RhoB Down-regulation, PLoS One, 9(1): e86698, 2014.

Brozovic A., Vuković L., Polančac D.S., Arany I., Köberle B., Fritz G., Fiket Z., Majhen D., Ambriović-Ristov A., Osmak M. Endoplasmic reticulum stress is involved in the response of human laryngeal carcinoma cells to carboplatin but is absent in carboplatin-resistant cells. PLoS One, 8(9): e76397, 2013.

Majhen D., Richardson J., Vukelić B., Dodig I., Cindrić M., Benihoud K., Ambriović-Ristov A. The disulfide bond of an RGD4C motif inserted within the HI loop of the adenovirus type 5 fiber protein is critical for retargeting to αv-integrins. Journal of Gene Medicine, 14(12): 788-797, 2012.

Majhen D., Stojanović N., Špeljko T., Brozović A., De Zan T., Osmak M., Ambriović-Ristov A. Increased expression of the coxsackie and adenovirus receptor downregulates alpha v beta 3 and alpha v beta 5 integrin expression, reduces cell adehesion and migration. Life Sciences, 89(7-8): 241-249, 2011.

Brozovic A., Ambriović-Ristov A., Osmak M. The relationship between cisplatin-induced reactive oxygen species, glutathione and BCL-2, and resistance to cisplatin. Critical reviews in toxicology, 40(4): 347-359, 2010.

Majhen D., Nemet J., Richardson J., Gabrilovac J., Hajsig M., Osmak M., Eloit M., Ambriović-Ristov A. Differential role of αvβ3 and αvβ5 integrins in internalization and transduction efficacies of wild type and RGD4C fiber-modified adenoviruses. Virus Research. 139(1): 64-73, 2009.

Brozović A., Majhen D, Roje V., Mikac N., Jakopec S., Fritz G., Osmak M., Ambriović-Ristov A. αvβ3 integrin mediated drug resistance in human laryngeal carcinoma cells is caused by glutathione dependent elimination of drug induced reactive oxidative species. Molecular Pharmacology. 74: 298-306, 2008.

Žaja R., Munić V., Sauerborn Klobučar R., Ambriović-Ristov A., Smital T. Cloning and molecular characterization of apical efflux transporters (ABCB1, ABCB11 and ABCC2) in rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquatic Toxicology, 90(4): 322-332, 2008.

Majhen D., Ambriović-Ristov, A. Adenoviral vectors-how to use them in cancer gene therapy, Virus Research, 119: 121-133, 2006.

Majhen D., Gabrilovac J., Eloit M., Richardson J., Ambriović-Ristov A. Disulfide bond formation in NGR fiber-modified adenovirus is essential for retargeting to aminopeptidase N. Biochemical and Biophysical Research Communications. 348: 278-287, 2006.

Ambriović-Ristov A., Gabrilovac J., Čimbora-Zovko T., Osmak M. Increased adenoviral transduction efficacy in human laryngeal carcinoam cells resistant to cisplatin isassociated with increased expression of integrin αvβ3 and coxsackie adenovirus receptor, International Journal of Cancer, 110: 660-667, 2004.

Ambriović-Ristov A., Mercier S., Eloit M. Shortening adenovirus type 5 fiber shaft decreases the efficiency of post binding steps in CAR-expressing and non-expressing cells, Virology, 312: 425-433, 2003.

Monteil M., Le Pottier M. F., Ambriović Ristov A., Cariolet R., L'Hospitalier R., Klonjkowski B., Eloit M. Single inoculation of replication-defective adenovirus-vectored vaccines at birth in piglets with maternal antibodies induces high level of antibodies and protection against pseudorabies, Vaccine, 18: 1738-1742, 2000.

Chetboul V., Adam M., Deprez I., Ambriović A., Rosenberg D., Crespeau F., Saana M., Pham I., Eloit M., Adnot S., Pouchelon JL. Expression of biologically active atrial natriuretic factor following intrahepatic injection of a replication-defective adenoviral vector in dogs, Human Gene Therapy, 10(2):281-290, 1999.

Ambriović A., Adam M., Monteil M., Paulin D., Eloit M. Efficacy of replication-defective adenovirus vectored vaccines: Protection following intramuscular injection is linked to promoter efficiency in muscle representative cells, Virology 238: 327-335, 1997.

Radovi u časopisima

Znanstveni i pregledni radovi

• Stojanović, N., Dekanić, A., Paradžik, M., Majhen, D., Ferenčak, K., Ruščic, J., Bardak, I., Supina, C., Tomičić, M., Christmann, M., Osmak, M. & Ambriović-Ristov, A. (2018) Differential effects of integrin αv knockdown and cilengitide on sensitisation of triple-negative breast cancer and melanoma cells to microtubule poisons. Molecular pharmacology, 94 (6), 1334-1351 doi:10.1124/mol.118.113027.

  doifulir.irb.hr

• Pinterić, M., Podgorski, I., Sobočanec, S., Popović Hadžija, M., Paradžik, M., Dekanić, A., Marinović, M., Halasz, M., Belužić, R., Davidović, G., Ambriović Ristov, A. & Balog, T. (2018) De novo expression of transfected sirtuin 3 enhances susceptibility of human MCF-7 breast cancer cells to hyperoxia treatment. Free radical research, 52 (6), 672, 684 doi:10.1080/10715762.2018.1462495.

  doiwww.tandfonline.com

• Christmann, M., Diesler, K., Majhen, D., Steigerwald, C., Berte, N., Freund, H., Stojanović, N., Kaina, B., Osmak, M., Ambriović-Ristov, A. & Tomicic, M. (2017) Integrin αVβ3 silencing sensitizes malignant glioma cells to temozolomide by suppression of homologous recombination repair. Oncotarget, 8, 27754-27771 doi:10.18632/oncotarget.10897.

  doifulir.irb.hr

• Ruščić, J., Ambriović-Ristov, A., Majhen, D., Kolundžija, S., Barut, M., Benihoud, K. & Krajačić, M. (2016) Manipulating adenoviral vector ion-exchange chromatography: Hexon versus fiber. Journal of separation science, 39 (22), 4299-4304 doi:10.1002/jssc.201600829.

  doi

• Stojanović, N., Brozovic, A., Majhen, D., Herak Bosnar, M., Fritz, G., Osmak, M. & Ambriović-Ristov, A. (2016) Integrin αvβ3 Expression in Tongue Squamous Carcinoma Cells Cal27 Confers Anticancer Drug Resistance Through Loss of pSrc(Y418). Biochimica et biophysica acta-molecular cell research, 1863 (8), 1969-1978 doi:10.1016/j.bbamcr.2016.04.019.

  doi

• Steiner, I., Stojanović, N., Bolje, A., Brozović, A., Polančec, D., Ambriović-Ristov, A., Radić Stojković, M., Piantanida, I., Eljuga, D., Košmrlj, J. & Osmak, M. (2015) Discovery of ‘click’ 1, 2, 3-triazolium salts as potential anticancer drugs. Radiology and oncology, 50 (3), 280-288 doi:10.1515/raon-2016-0027.

  doi

• Vajs, J., Steiner, I., Brozović, A., Pevec, A., Ambriović-Ristov, A., Matković, M., Piantanida, I., Urankar, D., Osmak, M. & Janez Košmrlj (2015) The 1, 3-diaryltriazenido(p-cymene)ruthenium(II) complexes with a high in vitro anticancer activity. Journal of inorganic biochemistry, 153, 42-48 doi:10.1016/j.jinorgbio.2015.09.005.

  doi

• Brozović, A., Stojanović, N., Ambriović-Ristov, A., Brozović Krijan, A., Polanc, S. & Osmak, M. (2014) 3-Acetyl-bis(2-chloro-4-nitrophenyl) triazene is a potent antitumor agent that induces oxidative stress and independently activates the stress-activated protein kinase/c-Jun NH2-terminal kinase pathway. Anti-cancer drugs, 25 (3), 289-295 doi:10.1097/CAD.000000000000006.

  doi

• Majhen, D., Stojanović, N., Vukić, D., Pichon, C., Leduc, C., Osmak, M. & Ambriović-Ristov, A. (2014) Increased Adenovirus Type 5 Mediated Transgene Expression Due to RhoB Down-regulation. PLoS One, 9 (1) doi:10.1371/journal.pone.0086698.

  doi

• Brozović, A., Vuković, L., Stupin Polančec, D., Arany, I., Köberle, B., Fritz, G., Fiket, Ž., Majhen, D., Ambriović-Ristov, A. & Osmak, M. (2013) Endoplasmic reticulum stress is involved in response of human laryngeal carcinoma cells to carboplatin but is absent in carboplatin resistant cells. PLoS One, 8 (9), e763973-1 doi:10.1371/journal.pone.0076397.

  doifulir.irb.hr

• Arbanasić, H., Galov, A., Ambriović-Ristov, A., Grizelj, J., Arsenos, G., Marković, B., Dovenski, T., Vince, S. & Čurik, I. (2013) Extensive polymorphism of the major histocompatibility complex DRA gene in Balkan donkeys: perspectives on selection and genealogy. Animal genetics, 44 (6), 711-716 doi:10.1111/age.12054.

  doi

• Stojanović, N., Urankar, D., Brozović, A., Ambriović-Ristov, A., Osmak, M. & Košmrlj, J. (2013) Design and evaluation of biological activity of diazenecarboxamide-extended cisplatin and carboplatin analogues. Acta chimica Slovenica, 60 (2), 368-374.

  fulir.irb.hr

• Majhen, D., Richardson, J., Vukelić, B., Dodig, I., Cindrić, M., Benihoud, K. & Ambriović-Ristov, A. (2012) The disulfide bond of an RGD4C motif inserted within the HI loop of the adenovirus type 5 fiber protein is critical for retargeting to α(v) -integrins. Journal of gene medicine, 14 (12), 788-797 doi:10.1002/jgm.2686.

  doi

• Majhen, D., Stojanović, N., Špeljko, T., Brozović, A., De Zan, T., Osmak, M. & Ambriović-Ristov, A. (2011) Increased expression of the coxsackie and adenovirus receptor downregulates alpha v beta 3 and alpha v beta 5 integrin expression, reduces cell adehesion and migration. Life sciences, 89 (7-8), 241-249 doi:10.1016/j.lfs.2011.06.009.

  doi

• Brozović, A., Ambriović-Ristov, A. & Osmak, M. (2010) The relationship between cisplatin-induced reactive oxygen species, glutathione, and BCL-2 and resistance to cisplatin. Critical reviews in toxicology, 40 (4), 347-359 doi:10.3109/10408441003601836.

  doi

• Majhen, D., Brozović, A., Buger, T., Gabrilovac, J., Osmak, M. & Ambriović-Ristov, A. (2010) Vincristine-resistant human laryngeal carcinoma cells demonstrate increased Rous sarcoma virus promoter activity. Life sciences, 87 (15/16), 468-474 doi:10.1016/j.lfs.2010.08.012.

  doi

• Čubrić Čurik, V., Feligini, M., Ferenčaković, M., Džidić, A., Salajpal, K., Ambriović-Ristov, A., Ćetković, H., Majhen, D. & Čurik, I. (2009) Sequence polymorphism of PrP exon 3 gene in Istrian and crossbred sheep. Italian journal of animal science, 8 (S3), 86-88. (https://www.bib.irb.hr/416266).

• Majhen, D., Nemet, J., Richardson, J., Gabrilovac, J., Hajsig, M., Osmak, M., Eloit, M. & Ambriović-Ristov, A. (2009) Differential role of alpha(v)beta(3) and alpha(v)beta(5) integrins in internalization and transduction efficacies of wild type and RGD4C fiber-modified adenoviruse. Virus research, 139 (1), 64-73 doi:10.1016/j.virusres.2008.10.004.

  doi

• Brozović, A., Majhen, D., Roje, V., Mikac, N., Jakopec, S., Fritz, G., Osmak, M. & Ambriović-Ristov, A. (2008) Alpha v beta 3 integrin mediated drug resistance in human laryngeal carcinoma cells is caused by glutathione dependent elimination of drug induced reactive oxidative species. Molecular pharmacology, 74 (1), 298-306 doi:10.1124/mol.107.043836.

  doi

• Žaja, R., Munić, V., Sauerborn Klobučar, R., Ambriović-Ristov, A. & Smital, T. (2008) Cloning and molecular characterization of apical efflux transporters (ABCB1, ABCB11 and ABCC2) in rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquatic Toxicology, 90 (4), 322-332.

• Čimbora-Zovko, T., Ambriović-Ristov, A., Lončarek, J. & Osmak, M. (2007) Altered cell-cell adhesion in cisplatin-resistant human carcinoma cells: A link between β -catenin/plakoglobin ratio and cisplatin resistance. European Journal of Pharmacology, 558 (1-3), 27-36.

• Majhen, D., Gabrilovac, J., Eloit, M., Richardson, J. & Ambriović-Ristov, A. (2006) Disulfide bond formation in NGR fiber-modified adenovirus is essential for retargeting to aminopeptidase N. Biochemical and Biophysical Research Communications, 348, 278-287.

• Majhen, D. & Ambriović-Ristov, A. (2006) Adenoviral vectors-How to use them in cancer gene therapy?. Virus Research, 119, 121-133.

• Ambriović-Ristov, A. & Osmak, M. (2006) Integrin-mediated drug resistance. Current Signal Transduction Therapy, 1 (2), 227-237.

• Breljak, D., Ambriović-Ristov, A., Kapitanović, S., Čačev, T. & Gabrilovac, J. (2005) Comparison of three RT-PCR-based methods for relative quantification of mRNA.. Food technology and biotechnology, 43 (4), 379-388.

• Gabrilovac, J., Breljak, D., Čupić, B. & Ambriović-Ristov, A. (2005) Regulation of aminopeptidase N (EC 3.4.11.2 ; APN ; CD13) by interferon-gamma on the HL-60 cell line. Life sciences, 76 (23), 2681-2697.

• Vuković, L., Ambriović-Ristov, A., Čimbora Zovko, T., Ćetković, H., Brozović, A., Majhen, D. & Osmak, M. (2004) Expression of apoptotic genes in low, clinically relevant levels of drug resistance. Periodicum Biologorum, 106 (2), 173-177.

• Ambriović-Ristov, A., Gabrilovac, J., Čimbora Zovko, T. & Osmak, M. (2004) Increased adenoviral transduction efficacy in human laryngeal carcinoma cells resistant to cisplatin is associated with increased expression of integrin avb3 and coxsackie adenovirus receptor. International journal of cancer, 110 (5), 660-667 doi:10.1002/ijc.20176.

  doi

• Ambriović-Ristov, A., Mercier, S. & Eloit, M. (2003) Shortening adenovirus type 5 fiber shaft decreases the efficiency of post binding steps in CAR-expressing and non-expressing cells. Virology, 312, 425-433.

• Šprem, M., Babić, D., Abramić, M., Vrhovec, I., Škrk, J., Miličić, D., Ambriović Ristov, A., Kalafatić, D. & Osmak, M. (2001) Glutathione and glutathione S-transferases as early markers for ovarian carcinomas: case series. Croatian Medical Journal, 42 (6), 393-398.

• Osmak, M., Bordukalo, T., Ambriović-Ristov, A., Jernej, B., Košmrlj, J. & Polanc, S. (2000) Diazenes as modificators of drug-resistance in tumor cells. Neoplasma, 47 (6), 390-395.

• Monteil, M., Le Pottier, M., Ambriović-Ristov, A., Cariolet, R., L'Hospitalier, R., Klonjkowski, B. & Eloit, M. (2000) Single inoculation of replication-defective adenovirus-vectored vaccine at birth in piglets with maternal antibodies induces high level of antibodies and protection against pseudorabies. Vaccine, 18 (17), 1738-1742 doi:10.1016/S0264-410X(99)00545-9.

  doi

• Osmak, M., Nikšić, D., Brozović, A., Ambriović-Ristov, A., Vrhovec, I. & Škrk, J. (1999) Drug resistant tumour cells have increased levels of tumor markers for invasion and metastasis. Anticancer research, 19 (4B), 3193-3197.

• Chetboul, V., Adam, M., Deprez, I., Ambriović-Ristov, A., Rosenberg, D., Crespeau, F., Saana, M., Pham, I., Eloit, M., Adnot, S. & Pouchelon, J. (1999) Expression of biologically active atrial natriuretic factor following intrahepatic injection of a replication-defective adenoviral vector in dogs. Human gene therapy, 10 (2), 281-290.

• Osmak, M., Brozović, A., Ambriović-Ristov, A., Hadžija, M., Pivčević, B. & Smital, T. (1998) Inhibition of apoptosis is the cause of resistance to doxorubicin in human breast adenocarcinoma cells. Neoplasma, 45 (4), 223-230.

• Ambriović, A., Adam, M., Monteil, M., Paulin, D. & Eloit, M. (1997) Efficacy of replication-defective adenovirus-vectored vaccines: protection following intramuscular injection is linked to promoter efficiency in muscle representative cells. Virology, 238 (2), 327-335.

• Osmak, M., Babić, D., Abramić, M., Ambriović, A., Miličić, D., Eljuga, D. & Vuković, L. (1997) Glutathione S-transferase activity as an early marker for malignant tumors of corpus uteri. Neoplasma, 44 (5), 324-328.

• Ambriović, A. & Novak Despot, Đ. (1995) Identification of glycoproteins gE and gC of the pseudorabies virus strain B-Kal 68 by SDS-PAGE and monoclonal antibodies. Periodicum Biologorum, 97 (4), 317-322.

• Osmak, M., Miljanić, S., Ambriović, A. & Kapitanović, S. (1995) Characterization of human primary lung fibroblasts exposed to repeated low doses of gamma-rays. Periodicum biologorum, 97 (3), 229-234.

Hrvatsko društvo za biokemiju i molekularnu biologiju (preko društva i član FEBS)
Hrvatsko mikrobiološko društvo (preko društva i član FEMS)
Hrvatska udruge genetičkih inženjera
Hrvatsko društvo za istraživanje raka
Hrvatsko genetičko društvo