Neda Slade

Neda Slade

Ph.D.

senior scientist
+385 1 456 0926

1511

+385 1 456 1010

Krilo 5/309

Bijenička cesta 54, 10000 Zagreb, Croatia

Education

1972-1980 Elementary school, Zagreb

1980-1984 High school (V gymnasium, Zagreb)

1984-1989 graduate school in molecular biology, Faculty of Science, University of Zagreb, B.Sc. in molecular biology

1989-1993 postgraduate study in molecular and cellular biology, Faculty of Science, University of Zagreb, M.Sc. in molecular and cellular biology

1993-1999 doctoral study, Faculty of Science, University of Zagreb, Ph.D. in molecular biology

Projects

2014 - 2018 "New Protein Networks for Novel Therapeutic Avenues in Human Melanoma - ProNetMel", research project by Croatian Science Foundation, principal investigator 

2007 –2013 "The role of p53/p73 protein network in soft tissue sarcoma“, Ministry of Science, Education and Sports, Republic of Croatia, principal investigator

2007-2008 “The role of p73 in cell cycle control”, French-Croatian bilateral project “Cogito”, principal investigator

2006.-2007."p53/p73 Network in chemoresistance. The relevance of dominant - negative p73 isoforms for chemosenstivity“; Austrian-Croatian bilateral project, principal investigator 

Awards and Achievements

2007 "J.J. Strossmayer" Award by Croatian Academy of Sciences and Zagreb Fair for the best publishing venture:

University textbook “Methods in Molecular Biology”. Editors: Andreja Ambriović Ristov, Anamaria Brozović, Branka Bruvo Mađarić, Helena Ćetković, Maja Herak Bosnar, Dubravka Hranilović, Silva Katušić Hećimović, Nevenka Meštrović Radan, Snježana Mihaljević, Neda Slade,  Dušica Vujaklija; Zagreb, Ruđer Bošković Institute

2010 and 2012 Annual Director's Prize for scientific paper in the field of molecular medicine 

Classes

2003-2013: teaching Methodological courses in biology and medicine, RBI

2006-present: Doctoral study of Molecular Biosciences, RBI in collaboration with Universities in Osijek and Dubrovnik, teaching courses:
"Basic methods in molecular biology and medicine"   
"Methods in molecular biology and medicine –practical course"
"Tumor suppressor gene p53 and its relatives"
"Cell cycle control, genomic integrity maintenance and carcinogenesis"

2010-present: Doctoral study of Biology, Faculty of Science, University of Zagreb, teaching course "Genetics of cancer and biology of tumor cells"/from 2015 Biology of tumor cells

Featured Publications

Zaika A.I., Slade N., Erster S., Sansome C., Joseph T.W., Pearl M., Chalas E., Moll U.M. DeltaNp73, a dominant negative inhibitor of wild type p53 and TA p73, is upregulated in human tumors. J Exp Med (2002) 196: 765-780.

Slade N., Zaika A.I., Erster S., Moll U.M. DeltaNp73 stabilizes TAp73 proteins but compromises their function due to inhibitory hetero-oligomer formation. Cell Death Differ (2004) 11: 357-360.

Concin N., Becker K., Slade N., Erster S.,  Mueller-Holzner E., Ulmer H., Daxenbichler G., Zeimet A., Zeillinger R., Marth C., Moll U.M. Transdominant deltaTAp73 isoforms are frequently up-regulated in ovarian cancer. Evidence for their role as epigenetic p53 inhibitors in vivo. Cancer Res (2004) 64: 2449–2460.

Moll U.M., Slade N. p63 and p73: Roles in Development and Tumor Formation. Mol Cancer Res (2004) 2: 371-386.

Grollman A.P., Shibutani S., Moriya M., Miller F., Wu L., Moll M., Suzuki N., Fernandes A., Rosenquist T., Medverec Z., Jakovina K., Brdar B., Slade N., Turesky R.J., Goodenough A.K., Rieger R., Vukelić M., Jelaković B. Aristolochic acid and the etiology of endemic (Balkan) nephropathy. Proc Natl Acad Sci USA (2007) 104: 12129-12134.

Slade N., Moll U.M., Brdar B., Zorić A., Jelaković B. p53 mutations as fingerprints for aristolochic acid – an environmental carcinogen in endemic (Balkan) nephropathy. MutatRes/Fund Mol M (2009) 663: 1-6.

Hofstetter G., Berger A., Fiegl H., Slade N., Zorić A., Holzer B., Schuster E., Mobus V.J., Reimer D., Daxenbichler G., Marth C., Zeimet A.G., Concin N.,Zeillinger R. Alternative splicing of p53 and p73: the novel p53 splice variant p53delta is an independent prognostic marker in ovarian cancer. Oncogene (2010) 29:1997-2004. 

Slade N., Horvat A. Targeting p73 - A Potential Approach in Cancer Treatment. Curr Pharm Des (2011) 17: 591-602.

Moriya M., Slade N., Brdar B., Medverec Z., Tomić K., Jelaković B., Wu L., Truong S., Fernandes A., Grollman AP. TP53 Mutational signature for aristolochic acid: An environmental carcinogen. Int J Cancer (2011) 129:1532-1536. 

Jelaković B., Karanović S., Vuković-Lela I., Miller  F., Edwards K., Nikolić J., Tomić K.,Slade N., Brdar B., Turesky R., Stipanćić Ž, Dittrich D., Grollman A.P., Dickman K.G. Aristolactam-DNA Adducts in the Renal Cortex: Biomarkers of Environmental Exposure to Aristolochic Acid. Kidney Int (2012) 81:559-567.

Zorić A, Horvat A,Slade N. Differential effects of diverse p53 isoforms on TAp73 transcriptional activity and apoptosis. Carcinogenesis (2013) 34:522-529.

Laganović M, Bendix L, Rubelj I, Kirhmajer Vrkić M,Slade N, Vuković Lela I, Premužić V, Nilsson PM, Jelaković B. Reduced telomere length is not associated with early signs of vascular aging in young men born after intrauterine growth restriction: a paradox? J Hypertens (2014) 32:1613-1619.

Membership in professional associations / societies

Croatian Association for Cancer Research (branch of the European Association for Cancer Research), member of the Presidency

Croatian Society of Biochemistry and Molecular Biology

Croatian Biological Society

Committee of genomics and proteomics in oncology by Croatian Academy of Sciences and Arts 

Croatian Society of Human Genetic

Miscellaneous

Supervisor of doctoral thesis:

Arijana Zorić, "The effect of p53 mutants and isoforms on p73 activity in tumor cells", Faculty of Science, University of Zagreb, 2009 

Neven Tučkar, "The role of p73 isoforms in DNA methylation in cancer cells", Faculty of Science, University of Zagreb, 2012

Anđela Horvat, "The effect of ΔNp73α on the cell cycle control after DNA damage in human cells", Ruđer Bošković Institute in collaboration with Universities J.J. Strossmayer in Osijek and Dubrovnik, 2015

Supervisor of diploma thesis:

Anđela Runje, "Characterization of p53 tumor-suppressor protein isoforms-differences in stability", Faculty of Science, University of Zagreb, 2007 

Dina Rambrot, "The effect of overexpressed p73 gene on cell survival after DNA damage", Faculty of Science, University of Zagreb, 2008 

Marina Kovačević, "Transcriptional activity of p53 isoforms", Faculty of Science, University of Zagreb, 2011 

Anamarija Pfeiffer, "Complex formation between protein p63 and mutant p53 in human tumor cell line“, Faculty of Science, University of Zagreb, 2014 

Lidija Petrović, "Expression of p53 and p73 protein isoforms in human melanoma cells after exposure to ɣ-irradiation", Faculty of Pharmacy and Biochemistry, University of Zagreb, 2016 

Training:

1999 Short-term fellowship of the French Republic, CNRS Laboratoire de Biologie et Thérapeutique des Pathologies Immunitaires, CERVI, Hôpital de la Pitié, Paris, France

2001-2003 postoctoral training, Department of Pathology, SUNY at Stony Brook, NY, USA

Editor and author of several chapters in the textbook:

University textbook “Methods in Molecular Biology”. Editors: Andreja Ambriović Ristov, Anamaria Brozović, Branka Bruvo Mađarić, Helena Ćetković, Maja Herak Bosnar, Dubravka Hranilović, Silva Katušić Hećimović, Nevenka Meštrović Radan, Snježana Mihaljević, Neda Slade,  Dušica Vujaklija; Zagreb, Ruđer Bošković Institute

Author of chapters in the textbooks and handbooks:

Slade N., Moll U.M. (2003) Mutational analysis of p53 in human tumors: immunocytochemistry. IN: Methods in Molecular Biology: p53 Protocols, Eds. Deb S, Palit Deb S. Totowa, New Jersey, USA : Humana Press, 234: 231-243.

Erster S., Slade N., Moll U.M. (2003) Mutational analysis of p53 in human tumors: direct DNA sequencing and SSCP. In: Methods in Molecular Biology: p53 Protocols, eds. Deb S, Palit Deb S. Totowa, New Jersey, USA : Humana Press,234:219-230.

Slade N., Pavelić J., Pavlić K. (2004) Osnovna načela sistemskog liječenja zloćudnih tumora - Gensko liječenje i kemoprevencija. In: Internistička onkologija, eds. Mršić-Krmpotić Z., Roth A et al. Medicinska naklada, Zagreb, 80-113.

Moll U.M., Slade N. (2005) The role of p53 and p73 genes in tumor formation. In: Handbook of Immunohistochemistry andin situhibridization of human carcinomas. Vol 3: Molecular Genetics: Liver Carcinoma and Pancreatic Carcinoma, ed; Hayat M.A. Academic Press, USA, 103-117.

Participation in organization of several international conferences:

1st International Conference on Signal Transduction, 08.-12. 10.1998, Cavtat-Dubrovnik

2nd International Conference on Signal Transduction, 26.-31. 10. 2000, Cavtat-Dubrovnik

"50 years of molecular biology in Croatia", 20.-21. 11. 2008, Zagreb

HDIR-1 - 1st Meeting with International Participation “From Bench to Clinic”, Zagreb, 11. 11. 2010

HDIR-2 – 2nd Meeting with International Participation “From Bench to Clinic”, Zagreb, 8.-9. 11.2012, scientific committee

HDIR-3 – 3rd Meeting with International Participation “From Bench to Clinic”, Zagreb, 6.-7. 11. 2014, scientific committee

HDIR-4 – 4th Meeting with International Participation “From Bench to Clinic”, Zagreb, 3.-4.11. 2016, scientific committee 

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