1997-1999 Postdoctoral fellow at Australian National University (ANU), RSBS, Canberra, Australia

1996 Postdoctoral fellow at Max-Planck-Institute for Cellbiology, Heidelberg (Ladenburg), Germany

1995 PhD in biology (magna cum laude) at Ruprechts Karl University, Heidelberg, Germany

1992-1995 PhD thesis at Max-Planck-Institute for Cellbiology, Heidelberg (Ladenburg), Germany

1992 University degree in biology (Diploma) at Albert Einstein University, Ulm, Germany

1985 Abitur at grammar school 'Friedrich-Schiller-Gymnasium', Marbach, Germany

2025-2028: EASIGEN-DS Design study for a European infrastructure on advanced genomics 

technologies (Proposal ID 101187908). HORIZON-INFRA-2024-DEV-01.  Budget 3M EUR

(IRB 70.000,00 EUR). Project start 02/2025.

2024-2028: GOE - Genome of Europe. DIGITAL-2023-CLOUD-AI-04-GENOME (ID: 101168231). 

01.10.2024 - 01.04.2028). Budget 40M EUR (IRB 610.000,00 EUR).

2024-2025: NPOO 'Dokazivanje inovativnog koncepta - Drugi Poziv', C3.2.R3-I1.05 projekt "Dokazivanje inovativnog koncepta za karakterizaciju genskih varijanti nepoznatog značaja (VUS)". Budget 66.000,00 EUR.

2022-2026: GDI - Genomic Data Infrastructure, funded from the European Union’s Digital Europe Programme under grant agreement number 101081813; 40 million EUR, Principal investigator

2019-2023: HRZZ IP IP-2018-01-5632: Molecular aspects of pathogenic processes in AHCY deficiency (Croatian Science Foundation);  985.340,48 HRK; Principal investigator

2019-2022: Centre of competence  in molecular diagnostics (CEKOM);  2.204.739,05 HRK (PI: Oliver Vugrek).

2013-2016: Coordinator: FP7-REGPOT-2012-2013-1 Project - Enhancement of the Innovation Potential in SEE through new Molecular Solutions in Research and Development (1. June 2013;  EUR 4,739,000).

2012-2013 DAAD bilateral grant. Research Project AHCY deficiency: Epigenetic characterization of a novel human methylation disorder' (PI’s: Dr. Oliver Vugrek and Dr. Ulrich Zechner, Institute for Human Genetics, Mainz, Germany

2010-2012 - Project leader for grant of IPA Regional Development Component in Croatia (EUR 491,485):'Creation of research related infrastructure for Translational Medicine and Applied Genomics.

2010 – 2011: DAAD bilateral grant. Research Project ‘AHCY deficiency: Proteomics of a new methylation disorder in human' (PI’s: Dr. Oliver Vugrek and Dr. Gerhard Mittler (Max-Planck-Institute for Immunobiology, Freiburg, Germany).

2009 – 2011: CROATIA-ISRAEL JOINT RESEARCH PROGRAM: Research project ‘Molecular dynamics of S-Adenosylhomocysteine hydrolase (AHCY) and its role in regulation of gene expression (PI’s: Dr. Oliver Vugrek and Dr. Yaron Shav-Tal (Bar-Ilan University, Ramat Gan, Israel).

2007– : Croatian Ministry of Science and Technology project 098-0000000-2463; Research Project: ‘S-Adenosylhomocysteine hydrolase (AHCY) deficiency: Molecular Mechanims of a new human disease’ (PI Dr. Oliver Vugrek).

• Genome of Europe- GoE

  12.06.2026 - 11.06.2031 | 0.00 EUR

  CroRISIRB

• The molecular mechanisms of dsRNA sensor activation and ADAR1-mediated suppression in HSV-1 infection - HSVdsRNA-IJ

  15.12.2025 - 14.12.2028 | 196,535.00 EUR

  CroRIS

• Design Study for a European Infrastructure on Advanced Genomics Technologies - EASIGEN-DS

  01.02.2025 - 31.01.2028 | 2,999,266.00 EUR

  CroRISIRB

• Dokazivanje inovativnog koncepta za karakterizaciju genskih varijanti nepoznatog značaja - VUS

  21.01.2025 - 20.01.2026 | 66,000.00 EUR

  CroRISIRB

• Genome of Europe - GoE

  01.10.2024 - 31.03.2028 | 45,000,000.00 EUR

  CroRISIRB

• Genomic Data Infrastructure -GDI - GDI

  01.11.2022 - 31.12.2026 | 40,000,000.00 EUR

  CroRISIRB

• Molecular aspects of disease pathogenesis in AHCY deficiency - MAPinAD

  10.03.2021 - 15.05.2026 | 0.00 EUR

  CroRISIRB

• - - MAPinAD

  05.06.2019 - 05.12.2023 | 0.00 EUR

  CroRISIRB

• - - MAPinAD

  30.04.2019 - 29.10.2023 | 130,777.16 EUR

  CroRISIRB

• Integrated test for identification of genetic changes that cause infertility - Genom-IGT

  31.05.2018 - 30.06.2021 | 1,244,880.88 HRK

  CroRISIRB

• Center of Competence in Molecular Diagnostics - CEKOM

  01.04.2018 - 08.11.2022 | 53,179,363.28 HRK

  CroRISIRB

• Enhancement of the Innovation Potential in SEE through new Molecular Solutions in Research and Development - INNOMOL

  01.06.2013 - 30.11.2016 | 5,313,649.00 EUR

  CroRISIRB

• Becoming entrepreneurial: Knowledge transfer from the University of Rijeka Faculty of Medicine to the biotechnology business sector

  20.04.2013 - 19.04.2015 | 517,649.99 EUR

  CroRIS

• Molekularna dinamika S-Adenozilhomocistein hidrolaze (SAHH) i uloga u regulaciji genske expresije

  01.01.2009 - 31.12.2010 | 50,000.00 USD

  CroRISIRB

• Adenosylhomocysteine hydrolase deficiency: Molecular mechanisms of a new disease

  01.01.2007 - 01.01.2009 | 0.00 EUR

  CroRISIRB

Director's award for exceptional contribution to research at Rudjer Boskovic Institute in 2010

Postgraduate lecturer at the Medical Faculty Zagreb since 2003: Leader of courses ‘From disease to gene – from gene to function: Role of recombinant proteins in functional genomics, and Translational Medicine – From disease to gene

Postgraduate lecturer at the Natural Sciences and Mathematics Faculty Zagreb, since 2008: Leader of course 'omics' methods: Application in research of new disorders

1. Whittington A T, Vugrek O, Wei K, Hasenbein N G, Sugimoto K, Rashbrooke M C, Wasteneys G O:  MOR1 is essential for organizing cortical microtubules in plants. Nature 2001, 411: 610-613.
2. Barić I, Fumić K, Glenn B, Ćuk M, Schulze A, Finkelstein J D, Jill James S, Mejaški-Bošnjak V, Pažanin L, Pogribny I P, Radoš M, Sarnavka V, Šćukanec-Špoljar M, Allen R H, Stabler S, Uzelac L, Vugrek O, Wagner C, Zeisel S, Mudd H: S-adenosylhomocysteine hydrolase deficiency in a human: A genetic disorder of methionine metabolism. PNAS USA 2004, 101(12): 4234-4239.
3. Vugrek O, Belužić R, Nakić N, Mudd SH: S-Adenosylhomocysteine hydrolase (AHCY) deficiency: Two novel mutations with lethal outcome. Human Mutation, 2009: 30 (4): E555-E565.
4. Grbeša I, Kalo A, Belužić R, Kovačević L, Lepur A, Rokić F, Hochberg H, Kanter I, Simunović V, Muńoz-Torres PM, Shav-Tal Y, Vugrek O (2017). Mutations in S-adenosylhomocysteine hydrolase (AHCY) effect its nucleocytoplasmic distribution and capabilities for interaction with S-adenosylhomocysteine hydrolase-like 1 protein. European Journal of Cell Biology, 96(6):579-590. doi: 10.1016/j.ejcb.2017.05.002.
5. Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020. Eurosurveillance Euro Surveill. 2020;25(32); https://doi.org/10.2807/1560-7917.ES.2020.25.32.2001410.
6. Pavičić, I., Rokić, F., Vugrek, O.*. (2023). Effects of S-Adenosylhomocysteine Hydrolase Downregulation on WNT Signaling Pathway in SW480 Cells, International Journal of Molecular Sciences. 24, no.22:16102, 2023. https://doi.org/10.3390/ijms242216102. 

Book of abstracts

• Game of Epigenomics Conference - Book of Abstracts / Vugrek, Oliver; Jerić, Ivanka; Ambriović Ristov, Andreja et al. (ur.). Zagreb: Ruđer Bošković Institute, 2016

  goe.irb.hr

Conference abstract

• Marić, Tihana; Barišić, Antun; Murphy, Mark W.; Logara Klarić, Monika; Žunić, Lucija; Merkler, Ana; Ježek, Davor; Vugrek, Oliver; Belužić, Robert; Bertoša, Branimir et al. | A novel heterozygous variant in the DNA binding DM domain of the DMRT1 associated with Sertoli cell-only syndrome // European journal of human genetics, 31, S1, 2023. str. 94-94. doi: 10.1038/s41431-023-01339-3

  doiwww.nature.com

• Logara Klarić, Monika ; Trgovec-Greif, Lovro ; Žunić, Lucija ; Rokić, Filip ; Vičić, Ana ; Marić, Tihana ; Merkler, Ana ; Katušić Bojanac, Ana ; Belužić, Robert ; Stipoljev, Feodora et al. | Genetic analysis of azoospermic men by an integrated NGS panel // European journal of human genetics, 30, 2022. str. 90-90

  www.nature.com

• Šutić, Maja; Fitzner, Antje; Bubanović, Gordana; Linke, Matthias; Lepur, Adriana; Kovačević, Lucija; Brčić, Luka; Seiwerth, Sven; Samaržija, Miroslav; Vugrek, Oliver et al. | Reduced promoter methyilation of MyD88 and ASC/TMS1 genes in tumor tissue of patients with lung carcinoma // Libri oncologici : Croatian journal of oncology, 44, 1, 2016. str. 51-51

  hrcak.srce.hr

• Kovačević, Lucija ; Lepur, Adriana ; Grbeša, Ivana ; Belužić, Robert ; Vugrek, Oliver | „Omics“-approach to investigate cancer associated phenotypic changes in Hep G2 cells after targeted silencing of AHCY hydrolase // Libri oncologici : Croatian journal of oncology, 44, 2016. str. 40-40

• Grbeša, Ivana ; Kovačević, Lucija ; Belužić, Robert ; Lepur, Adriana ; Knežević, Jelena ; Trmčić Cvitaš, Jelena ; Munoz Torres, Pau Marc ; Vugrek, Oliver | IRBIT, a Inositol 1,4,5-trisphosphate receptor (IP3R) binding protein specifically binds to and inactivates S-adenosyl-L-homocysteine hydrolase // The FEBS journal, 281, S1, 2014. str. 577-577

  febs.onlinelibrary.wiley.com

• Barić, Ivo ; Ćuk, Mario ; Petković-Ramadža, Danijela ; Bilić, Karmen ; Zibar, Karin ; Sarnavka, Vladimir ; Vugrek, Oliver ; Burlina, A. ; Mudd, S.H. ; Fumić, Ksenija | S-adenosylhomocysteine hydrolase deficiency- a review of nine patients // Molecular genetics and metabolism, 2012. str. 303-303

  www.sciencedirect.com

• Barić, Ivo ; Ćuk, Mario ; Petković-Ramadža, Danijela ; Bilić, Karlo ; Martinac, I. ; Sarnavka, Vladimir ; Vugrek, Oliver ; Mudd, S.H. ; Fumić, Ksenija | S-adenosylhomocysteine hydrolase deficiency : a natural model for study of various neurological problems in children with possible dysmethylation pathogenesis // European journal of paediatric neurology, 2011. str. S27-S27

  www.ejpn-journal.com

• Belužić, Robert ; Ćuk, Mario ; Pavkov, Tea ; Barić, Ivo ; Vugrek, Oliver | Functional analysis of recombinant mutant A89V S-adenosylhomocysteine hydrolase (AdoHcyase) detected ina AdoHcyase deficient patient. // Clinical chemistry and laboratory medicine, 2007. str. A20-A20

• Ćuk, Mario ; Lovrić, Mila ; Fumić, Ksenija ; Mudd, S. Harvey ; Vugrek, Oliver ; Sarnavka, Vladimir ; Barić, Ivo | The fourth S-adenosylhomocysteine hydrolase deficient patient : Further evidence of congenital miopathy // Clinical chemistry and laboratory medicine, 2007. str. 43-43

• Barić, Ivo ; Fumić, Ksenija ; Vugrek, Oliver ; Ćuk, Mario ; Maradin, Miljenka, Glenn, Byron ; Wagner, Conrad ; Stabler, Sally ; Schulze, Andreas ; Radoš, Marko ; Sarnavka, Vladimir et al. | S-Adenosylhomocysteine (AdoHcy) hydrolase deficiency: myopathy seems to be congenital // Journal of inherited metabolic disease, 2005. str. 76-76-x

• Barić, Ivo ; Glenn, B. ; Fumić, Ksenija ; Ćuk, Mario ; James, S.J. ; Pažanin, Leo ; Radoš, Marko ; Sarnavka, Vladimir ; Schulze, A. ; Šćukanec-Špoljar, Mira et al. | S-Adenosylhomocysteine (AdoHcy) hydrolase deficiency: First proven case in a human // Journal of inherited metabolic disease, 2003. str. 62-62-x

Master's thesis (university)

• Mirjana Polović | Obogaćivanje posredovano MBD1 metilirane DNA iz staničnih linija s nedostatnom aktivnosti S-adenozilhomocistein hidrolaze (AHCY) / Oliver Vugrek, Vlatka Zoldoš (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2013

• Selmani, Atiđa | Prolazna ekspresija varijanti s-adenozilhomocistein-hidrolaze / Vugrek, Oliver (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2007

• Regović, Maja | STVARANJE STABILNO TRANSFECIRANIH EUKARIOTSKIH STANICA HELA ZA PREKOMJERNU EKSPRESIJU ENZIMA S-Adenozilhomocistein hidrolaze / Vugrek, Oliver (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2007

• Mijić, Ivana | Preparation and functional analysis of human S- adenosylhomocysteine hydrolase (SAHH) isofroms SAHH-2 and SAHH-3 / Weygand-Đurešević , Ivana (mentor); Vugrek, Oliver (neposredni voditelj) . | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2006

Doctoral thesis

• Lucija Kovačević | Nedostatak S-Adenozilhomocistein hidrolaze: Molekularni mehanizmi novog oboljenja / Oliver Vugrek (mentor); Igor Jurak (neposredni voditelj) . | Rijeka, Sveučilište u Rijeci, Fakultet biotehnologije i razvoja lijekova, 2017

• Belužić, Robert | Nedostatak Aktivnost S-Adenozilhomocistein- Hidrolaze: Molekularna podloga novog nasljednog oboljenja / Oliver Vugrek (mentor); Oliver Vugrek (neposredni voditelj) . | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2010

• Tlak Gajger, Ivana | Uspostavljanje sustava transpozon mutageneze za bakteriju Paenibacillus larvae / Vugrek, Oliver ; Petrinec, Zdravko (mentor). | Zagreb, Veterinarski fakultet, Zagreb, 2010

2005 Croatian Society of Biochemistry and Molecular Biology

2008 Croatian Society of Human Genetics