Oliver Vugrek

Oliver Vugrek


Research associate
+385 1 457 1381




Biologija 1/13

Bijenička 54
10000 Zagreb

CV_ENG_OV2013_v2.pdf 167.25 kB


1997-1999 Postdoctoral fellow at Australian National University (ANU), RSBS, Canberra, Australia

1996 Postdoctoral fellow at Max-Planck-Institute for Cellbiology, Heidelberg (Ladenburg), Germany

1995 PhD in biology (magna cum laude) at Ruprechts Karl University, Heidelberg, Germany

1992-1995 PhD thesis at Max-Planck-Institute for Cellbiology, Heidelberg (Ladenburg), Germany

1992 University degree in biology (Diploma) at Albert Einstein University, Ulm, Germany

1985 Abitur at grammar school 'Friedrich-Schiller-Gymnasium', Marbach, Germany


2013-2016: Coordinator: FP7-REGPOT-2012-2013-1 Project - Enhancement of the Innovation Potential in SEE through new Molecular Solutions in Research and Development (1. June 2013;  EUR 4,739,000).

2012-2013 DAAD bilateral grant. Research Project AHCY deficiency: Epigenetic characterization of a novel human methylation disorder' (PI’s: Dr. Oliver Vugrek and Dr. Ulrich Zechner, Institute for Human Genetics, Mainz, Germany

2010-2012 - Project leader for grant of IPA Regional Development Component in Croatia (EUR 491,485):'Creation of research related infrastructure for Translational Medicine and Applied Genomics.

2010 – 2011: DAAD bilateral grant. Research Project ‘AHCY deficiency: Proteomics of a new methylation disorder in human' (PI’s: Dr. Oliver Vugrek and Dr. Gerhard Mittler (Max-Planck-Institute for Immunobiology, Freiburg, Germany).

2009 – 2011: CROATIA-ISRAEL JOINT RESEARCH PROGRAM: Research project ‘Molecular dynamics of S-Adenosylhomocysteine hydrolase (AHCY) and its role in regulation of gene expression (PI’s: Dr. Oliver Vugrek and Dr. Yaron Shav-Tal (Bar-Ilan University, Ramat Gan, Israel).

2007– : Croatian Ministry of Science and Technology project 098-0000000-2463; Research Project: ‘S-Adenosylhomocysteine hydrolase (AHCY) deficiency: Molecular Mechanims of a new human disease’ (PI Dr. Oliver Vugrek).

Awards and Achievements

Director's award for exceptional contribution to research at Rudjer Boskovic Institute in 2010


Postgraduate lecturer at the Medical Faculty Zagreb since 2003: Leader of courses ‘From disease to gene – from gene to function: Role of recombinant proteins in functional genomics, and Translational Medicine – From disease to gene

Postgraduate lecturer at the Natural Sciences and Mathematics Faculty Zagreb, since 2008: Leader of course 'omics' methods: Application in research of new disorders

Featured Publications

  1. Whittington A T, Vugrek O, Wei K, Hasenbein N G, Sugimoto K, Rashbrooke M C, Wasteneys G O:  MOR1 is essential for organizing cortical microtubules in plants. Nature 2001, 411: 610-613.
  2. Barić I, Fumić K, Glenn B, Ćuk M, Schulze A, Finkelstein J D, Jill James S, Mejaški-Bošnjak V, Pažanin L, Pogribny I P, Radoš M, Sarnavka V, Šćukanec-Špoljar M, Allen R H, Stabler S, Uzelac L, Vugrek O, Wagner C, Zeisel S, Mudd H: S-adenosylhomocysteine hydrolase deficiency in a human: A genetic disorder of methionine metabolism. PNAS USA 2004, 101(12): 4234-4239.
  3. Belužić R, Ćuk M, Pavkov T, Fumić K, Barić I, Mudd SH, Jurak I, Vugrek O: A single mutation at tyrosine 143 of human S-adenosylhomocysteine hydrolase renders the enzyme thermosensitive and effects the oxidation state of bound co-factor NAD. Biochemical Journal 2006: 400: 245-253.
  4. Fumić K, Belužić R, Čuk M, Pavkov T, Kloor D, Barić I, Mijić I, Vugrek O: Functional analysis of human S-adenosylhomocysteine hydrolase isoforms SAHH-2 and SAHH-3. European Journal of Human Genetics 2007: 15, 347-351.
  5. Beluzic R, Cuk M, Pavkov T, Baric I, and Vugrek O: S-Adenosylhomocysteine hydrolase (AdoHcyase) deficiency: Enzymatic capabilities of human AdoHcyase are highly effected by changes to codon 89 and its surrounding residues. Biochemical and Biophysical Research Communications 2008, 368: 30-36.
  6. Vugrek O, Belužić R, Nakić N, Mudd SH: S-Adenosylhomocysteine hydrolase (AHCY) deficiency: Two novel mutations with lethal outcome. Human Mutation, 2009: 30 (4): E555-E565.
  7. Taki, H; Gomi, T; Knuckley, B; Thompson, RP; Vugrek, O; Hirata, K; Miyahara, T; Shinoda, K; Hounoki, H; Sugiyama, E; Usui, I; Urakaze, M; Tobe, K; Ishimoto, T; Inoue, R: Tanaka, A; Mano, H; Ogawa, H; Mori, H. Purification of enzymatically inactive peptidylarginine deiminase type 6 from mouse ovary that reveals hexameric structure different from other dimeric isoforms. Advances in Bioscience and Biotechnology.2(2011) ; 304-310.

Membership in professional associations / societies

2005 Croatian Society of Biochemistry and Molecular Biology

2008 Croatian Society of Human Genetics


2010- RBI commission member for intellectual property rights


Agilent technologies: Certificate of Achievement in 'Cytogenomics Software familiarization, introduction to algorithms and application to clinical cases interpretation' 2012

IAEA-WIPO (World Intellectual Property Organization) -

Certificate for advanced Innovation, Technology Transfer and Successful Technology Licensing in Research & Development Institutions, 2011

Certificate for Innovation Promotion, Technology Transfer and Successful Technology Licensing, 2010