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Division of Molecular Biology

At the Division of Molecular Biology, we investigate the molecular basis and functional roles of fundamental biological structures and processes.

Administration

Marija Kober
tel/fax: +385 1 4561177
email: mkober@irb.hr

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Research in the Division of Molecular Biology is based on the methods of modern molecular biology, biochemistry, cell biology, genetics, biophotonics and bioinformatics. The model organisms used in these studies include bacteria, yeasts, cellular slime molds, several invertebrates, plants, lab animals and mammalian cells in culture.

The projects in the Division broadly involve the following fields of study: the maintenance of genome integrity and regulation of genome variation (DNA replication, recombination and repair); genome organization and repetitive DNA sequences; expression of genomic information (transcription and translation); signal transduction in the molecular regulation of cell division, growth, differentiation and senescence; cellular responses to toxic agents and resistance to cytostatics and antibiotics; the genetic background and regulatory mechanisms of neurotransmission; the regulatory mechanisms of photosynthesis; the physiology, biochemistry and structural biology of plant hormones; dynamical processes in the cytoskeleton; and the evolution of genes and genomes.

The primary purpose of these research projects is the general broadening of our knowledge of biological processes at the molecular level and the underlying principles of life, as well as the training of young scientists for professional work in the molecular biosciences, including biomedicine and biotechnology.

 We are a young and dynamic laboratory, one of the biggest laboratories in the Division of Molecular Biology, consisting of two research groups working on different subjects with some degree of overlap. We collaborate with several researchers groups within the Institute and even more research groups abroad (Germany, France, USA, Slovenia). We use state-of-the-art cell biology, molecular biology and biochemistry techniques.

The directions of our research are:

  1. Integrin signaling in cancer cell chemoresistance
  2. Cell response to genotoxic agents and mechanisms involved in drug resistance
  3. The involvement of miRNA in cancer in sensitivity to anticancer drugs
  4. Adenoviruses as vectors for gene transfer
  5. New synthesized compounds as potential anticancer drugs
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Laboratory for Chemical Biology (LCB) is oriented to interdisciplinary research in the field of plant growth and development and its molecular regulation, as well as secondary metabolism.

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The main goal of our research is to get new insights into molecular mechanisms of DNA recombination and repair in prokaryotes

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At the center of our research are processes of photosynthesis, the most important autotrophic biochemical process on the plant Earth.

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Research in the Laboratory is focused to the function and regulation of central and peripheral serotonin systems, with areas of research interest ranging from the gene regulation, through cellular and extracellular signalling to animal behaviour. Another research focus is pathophysiology of the cerebrospinal fluid at the experimental and clinical level.

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Our research is focused on satellite DNAs and other repetitive DNA sequences with the goal to understand their structure, evolutionary mechanisms, functionality and impact on genome dynamics and plasticity. Current research is done on different invertebrate model organisms, namely, root-knot nematodes, bivalve mollusks and insects (tenebrionid beetles).

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In the Laboratory of cell biophysics we primarily investigate the structure, dynamics and function of the cytoskeleton.

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LEG embraces three independent research groups that approach questions in evolutionary genetics from different angles. (Grupa dr. Ugarković, Grupa dr. Brčić-Kostić i Grupa dr. Domazet-Lošo)

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Andreja Ambriović Ristov
Ph.D.

Senior Scientist
+385 1 457 1240
1543 1545

Mariastefania Antica
Prof.dr.sc.

znanstveni savjetnik
+385 1 456 1065
1540 1609

Vlatka Antolović
PhD

senior research assistant
+385 1 457 1350
1755

Robert Bakarić
dipl.ing.

znanstveni novak
1417

Helena Bilandžija
BSc

assistant
+385 1 457 1239
1458

Krunoslav Brčić-Kostić

+385 1 457 1285
1417 1608

Anamaria Brozović
PhD

Senior Associate Scientist
+385 1 456 1145
1545 1877

Branka Bruvo-Mađarić
dr. sc.

research assistant
+385 1 457 1273
1603 1445

Helena Ćetković
dr. sc.

senior research associate
+385 1 456 1115
1515

Svjetlana Cvjetan
PhD in Biology

PhD student
+385 1 456 0971
1546

Lipa Čičin-Šain
Dr. sc.

Senior scientist
+385 1 456 1045
1307 1844

Tihana De Zan
B. Sc.

Research Fellow, Assistant
+385 1 456 1145
1545 1305

Ana Dekanić

+385 1 456 1145
1545 1876

Tomislav Domazet-Lošo
Dr. rer. nat.

research scientist, assistant professor
1417 1302

Blaženka Dumić

1654

Senka Džidić
dr

assistant
1419

Damir Đermić
Ph.D.

Research Associate
+385 1 456 1037
1437

Želimira Filić

research assistant
+385 1 456 1111
1459 1617

Mirjana Filipović

1472

Hrvoje Fulgosi
Prof. dr.

senior scientist
+385 1 456 1019
1428 1519

Mirna Halasz

+385 1 457 1239
1458

Matija Harcet
dr. sc.

research associate
1617 1458

Ana Hlevnjak

+385 1 457 1316
1866

Snježana Jurić
PhD

senior assistant
+385 1 456 1019
1519 1263

Katarina Karlo

+385 1 456 1147
1547

Marija Kober

+385 1 456 1177
1677

Mirela Kosinjski

1472

Jasna Lalić

+385 1 457 1324
1518

Marina Leko

1654

Sonja Lesjak

+385 1 457 1369
1201 1797

Dragomira Majhen
dr.sc.

research associate
+385 1 456 1145
1545 1876

Maja Marinović
PhD

senior research assistant
+385 1 457 1324
1518

Nevenka Meštrović Radan
dr. sc.

Associated Researcher
+385 1 457 1273
1603 1445

Snježana Mihaljević
Ph.D.

Senior Research Associate
+385 1 456 1143
1643

Andreja Mikoč
Dr. sc.

Research Associate
+385 1 456 1115
1458 1515

Gordana Mokrović
PhD

Assistent
+385 1 457 1289
1547 1307

Brankica Mravinac
PhD

Research Associate
+385 1 457 1273
1445 1603

Josipa Nemet
dr.sc.

+385 1 456 0981
1728

Maja Novak

1201

Darko Orešković
dr. sc.

Senior research associate
+385 1 468 0218
1547 1845

Mladen Paradžik
B.Sc.

PhD student
+385 1 456 1145
1545 1876

Tina Paradžik
PhD

assistant
+385 1 457 1258
1459

Martina Pavlek

Doctoral student, assistant
1828

Iva Pavlović
MS

PhD student / Research assistant
1642

Željka Pezer
dr. sc.

Research assistant
+385 1 457 1264
1445

Jasenka Piljac Žegarac
Ph.D.

Senior Research Associate
+385 1 456 0987
1642

Bruna Pleše
dr. sc.

Senior assistant
+385 1 457 1239
1458

Miroslav Plohl
Professor dr. sc.

Senior Researcher
+385 1 456 1083
1613

Bruno Polak

+385 1 457 1241
1797 1201

Sanjica Rak
PhD

Assistant
+385 1 457 1293
1545 1305

Jelena Repar

+385 1 457 1316
1546 1866

Ivica Rubelj

+385 1 457 1275
1678 1623

Branka Salopek Sondi
Dr.sc.

senior scientist
+385 1 456 1143
1643

Ana Smolko
mag. mol. bio.

expert assistant
+385 1 456 0987
1642 1202

Marija-Mary Sopta
Dr.sc.

Senior research associate
+385 1 456 0948
1644 1728
098 9696 288

Nikolina Stojanović
PhD

senior research assistant
+385 1 456 1145
1545 1876

Dunja Šamec
PhD

senior research assistant
+385 1 456 0987
1642

Ivana Šarić

+385 1 457 1369
1201 1797

Ivana Šarić

+385 1 457 1369
1201 1797

Eva Šatović
dr.sc.

Postdoctoral Research Assistant
+385 1 457 1322
1828

Ana Šimatović
PhD

Senior Research Assistant
+385 1 456 1099
1299

Jasminka Štefulj
dr.sc.

senior research associate
+385 1 457 1350
1615 1755
++385 (0)95 866 4106

Iva Tolić
Prof. dr. sc.

Senior Research Group Leader, Full Professor
+385 1 457 1370
1730 1201

Petar Tomev Mitrikeski
dr. sc.

+385 1 4561 099
1299

Ana Tupek

+385 1 456 1145
1545 1876

Đurđica Ugarković

+385 1 456 1197
1619 1445

Martina Vacka

1654

Lea Vojta
PhD

Research Associate
+385 1 468 0238
1561 1519

Dušica Vujaklija
Ph.D.

Senior Research Associate
+385 1 457 1258
1459

Kruno Vukušić

+385 1 457 1241
1797 1201

Igor Weber
PhD

senior scientist
+385 1 457 1219
1517

Davor Zahradka
Ph. D.

Senior Research Associate
+385 1 456 0971
1546

Ksenija Zahradka
Ph.D.

Senior Research Associate
+385 1 456 0971
1546

Comparative phosphoproteome analysis of S. rimosus oxytetracycline producers strains

Principal Investigator: Dušica Vujaklija

The aim of this project is to determine the role of protein phosphorylation in antibiotic production from industrially important bacterium.

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Functional characterization of the fungal specific protein Taf14 in S.cerevisiae and C. albicans

Invasive fungal infections have become an important cause of mortality in immunocompromised and severely ill patients, in both the developing world and western countries.

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Invertebrate centromere genomics (CENGEN)

Principal Investigator: Miroslav Plohl

The main goal of this project is to identify CenH3 and CenH3-associated DNA sequences as well as their non-functional counterparts in order to explore genomics of differently organized centromeres: satellite DNA-rich, satellite DNA-poor and dispersed on holocentric chromosomes.

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