Tomislav Domazet-Lošo

Tomislav Domazet-Lošo

Dr. rer. nat.

research scientist, assistant professor


Krilo 5/110

Laboratory of Evolutionary Genetics
Ruđer Bošković Institute
Bijenička cesta 54
HR-10000 Zagreb

Google Scholar


Visiting scientist - Zoological Institute, University of Kiel, Germany (2010-2011, Prof. Thomas C. G. Bosch)
Postdoc - Max Planck Institute for Evolutionary Biology, Plön, Germany (2008 – 2010, Diethard Tautz)
Doctorate in Genetics - University of Cologne, Institute for Genetics, Germany (2000 – 2003, Diethard Tautz)
Diploma in Biology - University of Zagreb, Faculty of Science, Croatia (1997)

Awards and Achievements

2014    City of Zagreb Award for outstanding contribution to biological sciences
2012    Order of the Croatian Morning Star for outstanding contributions to science (awarded by the President of Croatia Dr. Ivo Josipović)
2012    State Award for Science (awarded by the President of the Croatian Parliament Josip Leko)
2010 – 2012    Ruđer Bošković Institute Award (awarded three times)
2009    Unity Through Knowledge grant
2008    Fellowship of the Max-Planck Society
2008    Young Investigator Award, "Ruđer Bošković" Institute and Shimadzu
2008    Excellence in science award, Ministry of Science, Croatia
2008    Young Investigator Award, The society of university teachers – Zagreb
2008    Adris Foundation grant
2008    “Željko Trgovčević Award”, Croatian Genetic Society
2007    Excellence in science award, Ministry of Science, Croatia
2007    Young Investigator Award, International Society for Applied Biological Sciences (ISABS)


Croatian Catholic University - Courses in Evolutionary Biology

Featured Publications

  • Mirjana Domazet-Lošo, Tomislav Domazet-Lošo (2016) gmos: Rapid detection of genome mosaicism over short evolutionary distances. bioRxiv 053694, doi: (pre-print)
  • Hajk-Georg Drost, Alexander Gabel,Tomislav Domazet-Lošo, Marcel Quint, Ivo Grosse (2016) Capturing Evolutionary Signals in Developmental Transcriptomes with myTAI. bioRxiv 051565 doi: (pre-print)
  • Šestak MS, Domazet-Lošo T (2015) Phylostratigraphic profiles in zebrafish uncover chordate origins of the vertebrate brain. Molecular Biology and Evolution 32, 299–312
  • Bosch TCG, Adamska M, Augustin R, Domazet-Loso T, Foret S, Fraune S, Funayama N, Grasis J, Hamada M, Hatta M, Hobmayer B, Kawai K, Klimovich A, Manuel M, Shinzato C, Technau U, Yum S, Miller DJ. (2014) How do environmental factors influence life cycles and development? An experimental framework for early-diverging metazoans. Bioessays. 36, 1185–1194, doi: 10.1002/bies.201400065.
  • Domazet-Lošo T, Klimovich A, Anokhin B, Anton-Erxleben F, Hamm MJ, Lange C, Bosch TCG (2014) Naturally occurring tumors in the basal metazoan Hydra. Nature Communications 5, 4222, doi: 10.1038/ncomms5222
  • Fuchs B, Wang W, Graspeuntner S, Li Y, Insua S, Herbst E-M, Dirksen P, Böhm A-M, Hemmrich G, Sommer F, Domazet-Lošo T, Klostermeier UC, Anton-Erxleben F, Rosenstiel P, Bosch TCG, Khalturin K (2014) Regulation of Polyp-to-Jellyfish Transition in Aurelia aurita. Current Biology 24, 263–273. Evaluated  by Faculty of 1000
  • Mendoza A de, Sebé-Pedrós A, Šestak MS, Matejčić M, Torruella G, Domazet-Lošo T, Ruiz-Trillo I (2013) Transcription factor evolution in eukaryotes and the assembly of the regulatory toolkit in multicellular lineages. PNAS 110, E4858–E4866. Evaluated  by Faculty of 1000
  • Šestak MS, Božičević V, Bakarić R, Dunjko V, Domazet-Lošo T (2013) Phylostratigraphic profiles reveal a deep evolutionary history of the vertebrate head sensory systems. Frontiers in Zoology 10:18
  • Tautz D, Neme R, Domazet-Lošo T (2013) Evolutionary origin of orphan genes. In: eLS. John Wiley & Sons Ltd, Chichester.  [DOI: 10.1002/9780470015902.a0024601]
  • McFall-Ngai M, Hadfield MG, Bosch, TCG, Carey HV, Domazet-Lošo T, Douglas AE, Dubilier N, Eberl G, Fukami T, Gilbert SF, et al.(2013) Animals in a bacterial world: a new imperative for the life sciences. PNAS 110, 3229–36
  • Franzenburg S, Fraune S, Künzel S, Baines JF, Domazet-Lošo T, Bosch TCG (2012) MyD88-deficient Hydra reveal an ancient function of TLR signaling in sensingbacterial colonizers. PNAS 109:19374-9 Evaluated  by Faculty of 1000
  • Zhang G, Fang X, Guo X, Li L, Luo R, Xu F, Yang P, Zhang L, Wang X, Qi H,Xiong Z, Que H, Xie Y, Holland PW, Paps J, Zhu Y, Wu F, Chen Y, Wang J, Peng C,Meng J, Yang L, Liu J, Wen B, Zhang N, Huang Z, Zhu Q, Feng Y, Mount A, HedgecockD, Xu Z, Liu Y, Domazet-Lošo T, et al.(2012) The oyster genome reveals stress adaptation and complexity of shell formation. Nature. 2012 490:49-54
  • Hemmrich G, Khalturin K, Boehm AM, Puchert M, Anton-Erxleben F, Wittlieb J, Klostermeier UC, Rosenstiel P, Oberg HH, Domazet-Lošo T, Sugimoto T, Niwa H, Bosch TC (2012) Molecular signatures of the three stem cell lineages in hydra and the emergence of stem cell function at the base of multicellularity. Molecular Biology and Evolution 29(11):3267-80
  • Tautz D, Domazet-Lošo T (2011) The evolutionary origin of orphan genes. Nature Reviews Genetics 12(10):692-702. 
  • Domazet-Lošo T ,Tautz D (2010) A phylogenetically based transcriptome age index mirrors ontogenetic divergence patter. Nature 468(7325):815–818 Nature cover story, Nature News and Views
  • Domazet-Lošo T, Tautz D (2010) Phylostratigraphic tracking of cancer genes suggests a link to the emergence of multicellularity in metazoans. BMC Biology 8:66 Evaluated  by Faculty of 1000: Hide W: 2010.; Commentary by Ciccarelli FD (2010). The (r)evolution of cancer genetics. BMC Biol. 2010 8:74. 
  • Domazet-Lošo T, Tautz D (2008) An ancient evolutionary origin of genes associated with human genetic diseases. Molecular Biology and Evolution 25(12):2699-2707 Evaluated by Faculty of 1000: Swalla W: 2009., Covered by The Economist and New Scientist
  • Domazet-Lošo T, Brajković J, Tautz D (2007) A phylostratigraphy approach to uncover the genomic history of major adaptations in metazoan lineages. Trends in Genetics 23(11):533-539 Evaluated by Faculty of 1000: Telford M: 2007.
  • Pozhitkov A, Noble N, Domazet-Lošo T, Nolte A, Staehler P, Beier M, Tautz D (2006) Tests of rRNA hybridization to microarrays suggest that hybridization characteristics of oligonucleotide probes for species discrimination cannot be predicted. Nucleic Acid Research 34(9):e66
  • Marais G, Domazet-Lošo T, Tautz D, Charlesworth B  (2004) Correlated evolution of the synonymous and nonsynonymous sites in Drosophila. Journal of Molecular Evolution 59:771-9
  • Domazet-Lošo T, Tautz D (2003) An evolutionary analysis of orphan genes in Drosophila. Genome Research 13:2213-9