Division of Organic Chemistry and Biochemistry

Division of Organic Chemistry and Biochemistry

The mission of the Division of Organic Chemistry and Biochemistry (DOCB) is to sustain excellence in fundamental scientific research covering selected experimental and theoretical topics of organic chemistry and biochemistry, to promote and intensify international collaboration in these fields and actively participate at the undergraduate and postgraduate levels of education in organic chemistry and biochemistry at Croatian universities by providing specific expertise and facilities.

Davor Margetić

Head of Division

Ph. D. Davor Margetić

+385 1 468 0197

Administration

Barica Baborsky
tel. +385 1 4680 195
fax. +385 1 4680 195
e-mail: baborsky@irb.hr

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Research in the DOCB covers broad topics in modern experimental and theoretical organic chemistry and biochemistry: the development of new synthetic methods and their application in the preparation of new organic molecules and materials, experimental and theoretical studies of molecular properties and reaction mechanisms, as well as research in the field of medicinal chemistry.

In the last few years, we have considerably increased our contribution to higher education in Croatia. DOCB scientists are teaching over 30 undergraduate and graduate courses at the Universities of Zagreb, Rijeka, Osijek, Split and Dubrovnik.

DOCB scientists are members of many scientific EU-committees, such as ESF, the COSTESOR-Standing Committee, as well as members of national committees, boards and councils. Some were members of the organizational committees of international symposiums (ESOC, ESOR), as well as COST and FP6-workshops.

In 2005, on the basis of EU patent “Potential anticancer drugs” from the Laboratory for Supramolecular and Nucleoside Chemistry, a spin-off company, BioZyne, was established. Also in 2006, from the Laboratory for Stereoselective Catalysis and Biocatalysis, another spin-off company, CHIRALLICA, was established. For work on chiral stationary phases, chiral separation and production of chiral HPLC-columns, ISO 9001 certification was obtained.

The group is involved in design and synthesis of novel small molecules that non-covalently bind to DNA/RNA, determination of their affinity and mode of binding as well as DNA/RNA induced spectroscopic changes.

  • Recognition of specific secondary structures of various DNA/RNA
  • Recognition of specific nucleobase or sequence of nucleobases (basepairs) within DNA/RNA

Recognition is manifested by difference in affinity and / or differences in spectroscopic response caused by binding of small molecule to targeted DNA/RNA.

Small molecules designed and synthesized are characterized by heterocyclic aromatic systems (usually DNA/RNA intercalators, such as pyrene, phenanthridine, etc.) equipped by various substituents that control selectivity.

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We are engaged in fundamental studies related to the omnipresent and everlasting problem of reactivity of organic and organometallic compounds. In conducting these studies, an integrated approach is employed involving synthesis, product analysis, determination of reaction mechanisms and structural interrogation via spectroscopic and computational methods. In synthetic work, extensive use of high pressure techniques and microwave assisted synthetic methods is made.

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Research activities of the LSC are focused on Supramolecular chemistry and Self-Organization of Low Molecular Weight organo- and hydro-Gelators.

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Laboratory for Synthetic Organic Chemistry is continuing the tradition of the former Laboratory of Synthetic and Physical Organic Chemistry dealing with the chemistry of cage molecules. Research interests have recently been shifted to three main themes:

  • photochemical reaction mechanisms and supramolecular control of photochemical reactivity
  • synthesis of host and guest molecules for different supramolecular systems and applications
  • synthesis of biologically active molecules

Covering various synthetic, analytical and spectroscopic techniques on substrates including polycyclic molecules, heterocycles, and peptides, the research activities in the laboratory are ideal for training young researchers in graduate and post-graduate education (BSc, MSc, and PhD thesis).

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Andreja Jakas
PhD

Research Associate
+385 1 468 0103
1284 1276

Ante Pupačić

+385 1 456 1008
1208

Antonela Šimunić

+385 1 456 1002
1202

Bara Baborsky

+385 1 468 0195
1433

Biserka Žinić
Dr. Sc.

Senior research associate, Associate Professor
+385 1 456 1066
1466
385 99 3093322

Danijela Vojta

+385 1 457 1382
1919

Darko Kontrec
Ph.D.

research associate
+385 1 456 1029
1628 1626

Davor Margetić
Ph. D.

Senior scientist
+385 1 468 0197
1488

Davorka Pevec Rak

+385 1 456 1066
1466

Dijana Saftić
PhD

Senior research assistant
+385 1 456 1066
1466

Iva Jušinski

+385 1 456 1008
1208

Ivana Antol
Dr.

research associate
+385 1 456 1008
1208

Ivanka Jerić
Dr.

Senior Research Associate
+385 1 456 0980
1740 1276

Ivo Crnolatac
dr.sc.

Senior assistant
+385 1 457 1326
1537

Ivo Piantanida
dr. sc.

senior scientist
+385 1 457 1326
1537

Josipa Suć
PhD

+385 1 456 0998
1276

Kata Majerski
prof. dr.

senior scientist
+385 1 468 0196
1465 1474

Katarina Vazdar
dr.sc.

senior research assitant
+385 1 456 1157
1357

Leo Frkanec
Prof. Dr.

Senior Scientist (Full Professor)
Head of laboratory
+385 1 468 0217
1360
+385 1 4571 328

Lidija Brkljačić

+385 1 457 1321
1865 1276

Lidija Perić

+385 1 468 0195
1433

Lidija Varga-Defterdarović
Ph.D.

senior research associate
+385 1 457 1290
1284 1746

Lidija-Marija Tumir
dr. sc.

Research associate
+385 1 457 1220
1775

Maja Majerić Elenkov
dr. sc.

research associate
+385 1 456 0965
1629 1627

Marijana Radić Stojković
dr.sc.

Research associate
+385 1 457 1220
1775

Marin Roje

+385 1 456 1029
1628 1626
+385 99 2492 731

Marina Šekutor
Ph.D.

Research associate
+385 1 456 1165
1465

Mario Vazdar
Dr.

research associate
+385 1 457 1382
1919

Mateja Đud

+385 1 456 1008
1208

Matija Gredičak
PhD

research associate
+385 1 456 0998
1276

Milica Perc

+385 1 468 0103
1284

Mirjana Maksić

+385 1 468 0197
1488 1208

Mladen Žinić

+385 1 468 0217
1360

Nikola Basarić

+385 1 456 1141
1341 1465

Petra Radošević

+385 1 456 1061
1261

Renata Kobetić
dr.sc.

research assistant
+385 1 457 1220
1775 1523

Robert Vianello
Dr.

Senior Scientist
Group Leader
+385 1 456 1117
1707
+385 91 2547100

Sanja Škulj

+385 1 457 1382
1919

Sanja Tomić
dr. sc.

senior scientist
+385 1 457 1251
1265 1335

Tamara Vraneša

+385 1 456 1002
1202

Tihomir Pospišil

+385 1 457 1210
1306

Tomislav Portada
doc- dr. sc.

znanstveni suradnik
+385 1 457 1210
1306

Trpimir Ivšić
dr. sc.

senior research assistant
+385 1 456 1029
1629 1627

Zdenko Hameršak
dr.sc.

senior scientist
+385 1 457 1300
1625 1626

Zoran Džolić

+385 1 457 1210
1306

Zoran Glasovac
PhD

higher research associate
+385 1 456 1008
1208 1657

B) HAMAG-BICRO Proof of concept programme: PoC6_11_47 "New diagnostic method for Alzheimer type dementia"

Glavni istraživač / voditelj: Ivo Crnolatac

With this project we aim to check the validity of the new diagnostic method for Alzheimer type dementia. The members of the project team are experts in molecular neuropsychiatry, biomolecular interactions and protein chemistry. The partners on the project are the leading Croatian specialists for Alzheimer type dementia. 

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C) ESF - HR.3.2.01-0254 "Enhacement of the capacity in medicinal chemistry and bioactive systems research".

Glavni istraživač / voditelj: Ivo Piantanida

RBI Project team of five young researchers and postdocs works on scientific research in medicinal chemistry, relevant for the Croatian pharmaceutical industry and Health sector. The enhacement of the leadership, entrapreneurship and research capabilities of young researchers and postdocs will be fullfiled by education on specific workshops. With the aim of establishing connection with the scientists in the European research area, the dissemination of the project results will be accomplished.

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Cage Compounds: Building Blocks for Molecular Architecture

Glavni istraživač / voditelj: Kata Majerski

Cage compounds are characterized by three-dimensional structures which have defined rigid geometry and as such, they are very useful synthons in organic synthesis, as well as the indispensable substrates for the mechanistic studies. Moreover, the various atomic positions in a cage can serve as branching points where the additional ligating group can be introduced. These substituted derivatives can be used as building blocks in supramolecular chemistry. The first step towards employing cage compounds in the synthesis of more complex molecular systems is the understanding of their reactions.

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Chirality from Achiral Liquid Crystals

Chirality from Achiral Liquid Crystals

Glavni istraživač / voditelj: Andreja Lesac
D) Multifunctional molecular sensing of DNA/RNA secondary structure by chemical sensors - DNA/RNA-MolSense

D) Multifunctional molecular sensing of DNA/RNA secondary structure by chemical sensors - DNA/RNA-MolSense

Glavni istraživač / voditelj: Ivo Piantanida

Molecular recognition of nucleic acids is of fundamental importance e.g. for gene transcription and regulation, protein synthesis or cell-division. Small molecules selectively targeting specific DNAs or RNAs are therefore highly interesting not only to understand such processes in more detail on a molecular level but also for potential medicinal applications, as sensors or probes for fluorescence based bioimaging as well as for analytical purposes in isolated biosamples.

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Diamondoid Amines – New Ligands in Supramolecular Systems

Glavni istraživač / voditelj: Marina Šekutor

Ligands which bind receptors giving stable supramolecular systems are of utmost importance in biotechnology and technological applications. Cucurbituril systems (CB[n], n = 5, 6, 7, 8, 10) have recently been studied as efficient supramolecular receptors for molecular recognition in water. The water environment is a challenge when designing suitable ligands, seeing as they are usually small, hydrophobic organic molecules. The best binding interactions with CB[n] can be accomplished by ligands that combine cationic and hydrophobic subunits in their structure, like for example diamondoid compounds.

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E) Innomol: New Molecular Solutions in Research and Development for Innovative Drugs

E) Innomol: New Molecular Solutions in Research and Development for Innovative Drugs

The largest infrastructure project with the highest budget in natural sciences ever to be conducted in Croatia will foster a research pipeline at the RBI and facilitate innovation and technology for the investigation of relevant diseases such as cancer.

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Elucidation of the physiological roles of human dipeptidyl peptidase III

The aim of this project is to elucidate the physiological roles, and disease relevance of DPP III by determining its interactors through the combined use of different molecular biology approaches

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F) Design, synthesis and research of interactions of small molecules with DNA, RNA and proteins

Glavni istraživač / voditelj: Ivo Piantanida

The project funded by Ministry of Science, education and sports, "Design, synthesis and research of interactions of small molecules with DNA, RNA and proteins" No. 098-0982914-2918 (PI: Ivo Piantanida)

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human DPP III

Flexibility, activity and structure correlations in the dipeptidyl peptidase III family, (FlAcS, ID:7235)

Glavni istraživač / voditelj: Sanja Tomić

Within the project frame we intend to investigate diversity in evolutionary conserved metallopeptidase family M49 (DPP III family) through characterization of catalytic, structural and dynamical properties of its members.

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Fluorescent Anion Sensors: Synthesis and Spectroscopic Characterization

Glavni istraživač / voditelj: Nikola Basarić

Dynamics of the supramolecular systems facilitates control of the photochemical reactivity and opens opportunities for reactions which cannot be conducted by conventional synthetic methods, in the thermal reactions in isotropic solution. The main strategy of the proposed project is to apply different supramolecular systems to control photochemical reactivity.

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H) Croatian-Slovenian bilateral project

Glavni istraživač / voditelj: Ivo Piantanida

2012 – 2013:Croatian-Slovenian bilateral project with Prof. Jurij Lah, Univerza v Ljubljani, Fakulteta za kemijo in kemijsko tehnologijo, Slovenija

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J) Croatian-German bilateral project

Glavni istraživač / voditelj: Ivo Piantanida

2012 – 2013: Croatian-German bilateral project with Prof. Frank Würthner, Julius-Maximilians-Universität Würzburg, Germany

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KELANA - Hrvatsko kemijsko i laboratorijsko nazvilje

KELANA - Croatian Chemical and Laboratory Terminology

Glavni istraživač / voditelj: Lidija Varga-Defterdarović

The aim of KELANA project is to deal with terms used for description of laboratory, pilot plant and industrial equipment and procedures. They will be collected, elaborated by applying terminology expert methodology and introduced in a database of Croatian Special Field Terminology, STRUNA.

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Non-covalent interactions in design of novel photosensitive molecules

Glavni istraživač / voditelj: Davor Margetić

Project addresses two key research objectives in the European Union: energy and environment conservation. The scientific approach is based on a combination of theoretical and experimental knowledge and experience of collaborators, and includes quantum-chemical calculations and molecular modelling in the molecular design, chemical synthesis and study of physico-chemical properties of systems obtained through self-association by non-covalent interactions. It is multidisciplinary, covering topics in physical-organic, supramolecular and computational chemistry, photophysics and materials science.

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Optimizing bidirectional “highway” for photoactive response through guanidine-chromophore junction

Glavni istraživač / voditelj: Ivana Antol

Suradnja s dr. Mariom Barbattiem s Max-Planck instituta u Muelheimu, Njemačka

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Photochemistry of polycyclic molecules: From mechanistic studies to new drugs and medicinal applications

Glavni istraživač / voditelj: Nikola Basarić

 

HRZZ

Photons are phenomenal reagents which open new opportunities in chemical synthesis that cannot be attained in the chemistry of ground state. The goal of the project was to find new photochemical transformations applicable in organic synthesis, as well as investigation of the photochemical reaction mechanisms. In addition, the aim of the project was to go beyond the state of the art, and ultimately find application of photochemistry in new medical treatments and synthesis of new compounds, potential drug molecules for treating malignant diseases.

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Supramolecular control of photoeliminations

Supramolecular control of photoeliminations

Glavni istraživač / voditelj: Nikola Basarić

Dynamics of supramolecular systems facilitates control of the photochemical reactivity and opens opportunities for reactions which cannot be conducted by conventional synthetic methods, in the thermal reactions in isotropic solution. The main strategy of the proposed project is to apply different supramolecular systems to control photochemical reactivity.

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Synthesis and efficacy of chlorophyllin derivatives as photosensitizers for photodynamic therapy

Synthesis and efficacy of chlorophyllin derivatives as photosensitizers for photodynamic therapy

Glavni istraživač / voditelj: Davor Margetić

Croatian-Chinese scientifiy and technological cooperation with Prof. Dr. Zhi-Long Chen from College of Chemistry and Biology, Donghua University, Shanghai

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Synthesis and photochemistry of aniline derivatives for development of new photocages

Glavni istraživač / voditelj: Đani Škalamera

Photocages (photochemically cleavable protective groups) have wide spectrum of applications in chemistry, biology and medicine, and therefore, they have been intensively investigated recently. The main goal of this project is the design and synthesis of new photocleveable protective groups. Within the project implementation new aniline photocages with improved properties will be prepared and the photochemical reaction mechanisms of deprotection investigated. A series of carboxylic acid and alcohol derivatives protected with new aniline photocages will be prepared. These compounds are anticipated to react in the photochemical reaction of heterolysis, leading to deprotection.

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CD-ORD spectrometer Jasco J-815

Circular Dichroism and Optical Rotational Dispersion Spectrometer (CD-ORD)

Spectrometer Jasco J-815 measures spectra of circular dichroism CD and optical rotational dichroism ORD, together with simultaneous measurement of several variants of UV/vis spectra.
During the measurement instrument is under flow of nitrogen.

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Dizajn, modeliranje, priprava složenih organskih spojeva, izdvajanje i karakterizacija, sinteza supramolekulskih vrsta, samoorganizacija i kompleks...

Dizajn, modeliranje, priprava složenih organskih spojeva, izdvajanje i karakterizacija, sinteza supramolekulskih vrsta, samoorganizacija i kompleks...

Dizajn, modeliranje, priprava složenih organskih spojeva, izdvajanje i karakterizacija, sinteza supramolekulskih vrsta, samoorganizacija i kompleksnih kemijskih sustava

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Agilent Eclipse with the temperature control

Fluorescence spectrophotometer Agilent Eclipse

Fluorescence spectrophotometer Agilent Eclipse

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HPLC Agilen 1200 Series and MS Agilent 6410

High performance liquid chromatography coupled with mass spectrometry

The system consists of HPLC Agilent 1200 Series and triple quadrupole mass spectrometer Agilent 6410.

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IR Spectrometer

IR Spectrometer

Fourier Transform Infrared (FTIR) spektrometar ABB Bomem MB102 can be used to record IR spectra of solid and liquid samples in transmission and reflexion mode as well as at different temperatures in the spectral range 4000 – 200 cm-1.

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Microcalorimetry

Microcalorimetry

MicroCal VP-ITC;

TA Instruments DSC

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Microviscometry

Microviscometry

Lovis 2000 M is a rolling-ball viscometer which measures the rolling time of a ball through transparent and opaque liquids according to Hoeppler's falling ball principle

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UV/vis spektrometar Varian Cari 100 Bio

Ultraviolet / visual spectrometer

UV / vis spectrometer Varian Cary 100 Bio records spectra in double beam and single beam mode.
Spectral range: 190 - 900 nm

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