Division of Organic Chemistry and Biochemistry
The mission of the Division of Organic Chemistry and Biochemistry (DOCB) is to sustain excellence in fundamental scientific research covering selected experimental and theoretical topics of organic chemistry and biochemistry, to promote and intensify international collaboration in these fields and actively participate at the undergraduate and postgraduate levels of education in organic chemistry and biochemistry at Croatian universities by providing specific expertise and facilities.
Research in the DOCB covers broad topics in modern experimental and theoretical organic chemistry and biochemistry: the development of new synthetic methods and their application in the preparation of new organic molecules and materials, experimental and theoretical studies of molecular properties and reaction mechanisms, as well as research in the field of medicinal chemistry.
In the last few years, we have considerably increased our contribution to higher education in Croatia. DOCB scientists are teaching over 30 undergraduate and graduate courses at the Universities of Zagreb, Rijeka, Osijek, Split and Dubrovnik.
DOCB scientists are members of many scientific EU-committees, such as ESF, the COSTESOR-Standing Committee, as well as members of national committees, boards and councils. Some were members of the organizational committees of international symposiums (ESOC, ESOR), as well as COST and FP6-workshops.
In 2005, on the basis of EU patent “Potential anticancer drugs” from the Laboratory for Supramolecular and Nucleoside Chemistry, a spin-off company, BioZyne, was established. Also in 2006, from the Laboratory for Stereoselective Catalysis and Biocatalysis, another spin-off company, CHIRALLICA, was established. For work on chiral stationary phases, chiral separation and production of chiral HPLC-columns, ISO 9001 certification was obtained.
The group is involved in design and synthesis of novel small molecules that non-covalently bind to DNA/RNA, determination of their affinity and mode of binding as well as DNA/RNA induced spectroscopic changes.
- Recognition of specific secondary structures of various DNA/RNA
- Recognition of specific nucleobase or sequence of nucleobases (basepairs) within DNA/RNA
Recognition is manifested by difference in affinity and / or differences in spectroscopic response caused by binding of small molecule to targeted DNA/RNA.
Small molecules designed and synthesized are characterized by heterocyclic aromatic systems (usually DNA/RNA intercalators, such as pyrene, phenanthridine, etc.) equipped by various substituents that control selectivity.more »
We are engaged in fundamental studies related to the omnipresent and everlasting problem of reactivity of organic and organometallic compounds. In conducting these studies, an integrated approach is employed involving synthesis, product analysis, determination of reaction mechanisms and structural interrogation via spectroscopic and computational methods. In synthetic work, extensive use of high pressure techniques and microwave assisted synthetic methods is made.more »
Research activities of the LSC are focused on Supramolecular chemistry and Self-Organization of Low Molecular Weight organo- and hydro-Gelators.more »
Laboratory for Synthetic Organic Chemistry is continuing the tradition of the former Laboratory of Synthetic and Physical Organic Chemistry dealing with the chemistry of cage molecules. Research interests have recently been shifted to three main themes:
- photochemical reaction mechanisms and supramolecular control of photochemical reactivity
- synthesis of host and guest molecules for different supramolecular systems and applications
- synthesis of biologically active molecules
Covering various synthetic, analytical and spectroscopic techniques on substrates including polycyclic molecules, heterocycles, and peptides, the research activities in the laboratory are ideal for training young researchers in graduate and post-graduate education (BSc, MSc, and PhD thesis).more »
B) HAMAG-BICRO Proof of concept programme: PoC6_11_47 "New diagnostic method for Alzheimer type dementia"
With this project we aim to check the validity of the new diagnostic method for Alzheimer type dementia. The members of the project team are experts in molecular neuropsychiatry, biomolecular interactions and protein chemistry. The partners on the project are the leading Croatian specialists for Alzheimer type dementia.more »
C) ESF - HR.3.2.01-0254 "Enhacement of the capacity in medicinal chemistry and bioactive systems research".
RBI Project team of five young researchers and postdocs works on scientific research in medicinal chemistry, relevant for the Croatian pharmaceutical industry and Health sector. The enhacement of the leadership, entrapreneurship and research capabilities of young researchers and postdocs will be fullfiled by education on specific workshops. With the aim of establishing connection with the scientists in the European research area, the dissemination of the project results will be accomplished.more »
Cage compounds are characterized by three-dimensional structures which have defined rigid geometry and as such, they are very useful synthons in organic synthesis, as well as the indispensable substrates for the mechanistic studies. Moreover, the various atomic positions in a cage can serve as branching points where the additional ligating group can be introduced. These substituted derivatives can be used as building blocks in supramolecular chemistry. The first step towards employing cage compounds in the synthesis of more complex molecular systems is the understanding of their reactions.more »
D) Multifunctional molecular sensing of DNA/RNA secondary structure by chemical sensors - DNA/RNA-MolSense
Molecular recognition of nucleic acids is of fundamental importance e.g. for gene transcription and regulation, protein synthesis or cell-division. Small molecules selectively targeting specific DNAs or RNAs are therefore highly interesting not only to understand such processes in more detail on a molecular level but also for potential medicinal applications, as sensors or probes for fluorescence based bioimaging as well as for analytical purposes in isolated biosamples.more »
Ligands which bind receptors giving stable supramolecular systems are of utmost importance in biotechnology and technological applications. Cucurbituril systems (CB[n], n = 5, 6, 7, 8, 10) have recently been studied as efficient supramolecular receptors for molecular recognition in water. The water environment is a challenge when designing suitable ligands, seeing as they are usually small, hydrophobic organic molecules. The best binding interactions with CB[n] can be accomplished by ligands that combine cationic and hydrophobic subunits in their structure, like for example diamondoid compounds.more »
The largest infrastructure project with the highest budget in natural sciences ever to be conducted in Croatia will foster a research pipeline at the RBI and facilitate innovation and technology for the investigation of relevant diseases such as cancer.more »
The aim of this project is to elucidate the physiological roles, and disease relevance of DPP III by determining its interactors through the combined use of different molecular biology approachesmore »
Dynamics of the supramolecular systems facilitates control of the photochemical reactivity and opens opportunities for reactions which cannot be conducted by conventional synthetic methods, in the thermal reactions in isotropic solution. The main strategy of the proposed project is to apply different supramolecular systems to control photochemical reactivity.more »
Project addresses two key research objectives in the European Union: energy and environment conservation. The scientific approach is based on a combination of theoretical and experimental knowledge and experience of collaborators, and includes quantum-chemical calculations and molecular modelling in the molecular design, chemical synthesis and study of physico-chemical properties of systems obtained through self-association by non-covalent interactions. It is multidisciplinary, covering topics in physical-organic, supramolecular and computational chemistry, photophysics and materials science.more »
Photochemistry of polycyclic molecules: From mechanistic studies to new drugs and medicinal applications
Photons are phenomenal reagents which open new opportunities in chemical synthesis that cannot be attained in the chemistry of ground state. The goal of the project was to find new photochemical transformations applicable in organic synthesis, as well as investigation of the photochemical reaction mechanisms. In addition, the aim of the project was to go beyond the state of the art, and ultimately find application of photochemistry in new medical treatments and synthesis of new compounds, potential drug molecules for treating malignant diseases.more »
Dynamics of supramolecular systems facilitates control of the photochemical reactivity and opens opportunities for reactions which cannot be conducted by conventional synthetic methods, in the thermal reactions in isotropic solution. The main strategy of the proposed project is to apply different supramolecular systems to control photochemical reactivity.more »
Photocages (photochemically cleavable protective groups) have wide spectrum of applications in chemistry, biology and medicine, and therefore, they have been intensively investigated recently. The main goal of this project is the design and synthesis of new photocleveable protective groups. Within the project implementation new aniline photocages with improved properties will be prepared and the photochemical reaction mechanisms of deprotection investigated. A series of carboxylic acid and alcohol derivatives protected with new aniline photocages will be prepared. These compounds are anticipated to react in the photochemical reaction of heterolysis, leading to deprotection.more »
Spectrometer Jasco J-815 measures spectra of circular dichroism CD and optical rotational dichroism ORD, together with simultaneous measurement of several variants of UV/vis spectra.
During the measurement instrument is under flow of nitrogen.
Dizajn, modeliranje, priprava složenih organskih spojeva, izdvajanje i karakterizacija, sinteza supramolekulskih vrsta, samoorganizacija i kompleks...
Dizajn, modeliranje, priprava složenih organskih spojeva, izdvajanje i karakterizacija, sinteza supramolekulskih vrsta, samoorganizacija i kompleksnih kemijskih sustavamore »
Fluorescence spectrophotometer Agilent Eclipsemore »
Fourier Transform Infrared (FTIR) spektrometar ABB Bomem MB102 can be used to record IR spectra of solid and liquid samples in transmission and reflexion mode as well as at different temperatures in the spectral range 4000 – 200 cm-1.more »