University:

1984 - 1987, PhD  Ludwig  Maximilian’s University, Munich, Germany

1981-1984, Master of Sciences, Postgraduate Studies of Natural  Sciences (Molecular Biology), University of Zagreb, Croatia

1976-1981 Graduate Studies of Natural  Sciences University of Zagreb, Croatia

PROJECTS

1. 2021 – 2025 Croatian Science Foundation, IP-2020-02- 2431 Thymus renewal for precision medicine in cancer and leukaemia treatment, principal investigator
2. 01/07/2020 – 18/10/2022 Healthcareonline-HERO, Central European Initiative (CEI) COVID-19 Extraordinary Call for Proposals 2020, principal investigator https://health-online-hero.com/en/
3. 2017 - 2022 Scientific Center of Excellence for Reproductive and Regenerative Medicine (Grant Agreement KK01.1.1.01.0008 which is funded by  the European Union through the European Regional Development Fund), Biomedical research on reproduction and development, coordinated by Professor Davor Ježek, PhD, MD and Regenerative medicine, coordinated by Professor Slobodan Vukicevic, PhD, MD, M. Antica partner from RBI
4. 2017-2021 COST Action (The European Cooperation in Science and Technology) CA16223: LEukaemia GENe Discovery by data sharing, mining and collaboration (LEGEND) M.Antica is representative and Management Committee member for Croatia, Funded by the Horizon 2020 Framework Programme of the European Union.
5. 2013 – 2017 FP7-HEALTH-2013-INNOVATION-1 Development of Stem Cell Based Therapy for Thymic Regeneration, Thymistem, http://www.thymistem.org/Partner, M. Antica leader of the Croatian research team,  funding recieved from the European Union’s Seventh Programme for research, technological development and demonstration under grant agreement No.602587
6. 2016 - 2018 Terry Fox Foundation  Leukaemia research, M. Antica principal investigator
7. 2014 – 2018 Croatian Science Foundation, IP-2013-11- 7140 Notch in hematopoietic stem cell differentiation and leukaemia development,  M. Antica principal investigator
8. 2014 – 2016 Bilateral research project between Croatia and the People’s Republic of China, Tsinghua University Beijing, The function of transcription factors in the development of lymphocytes and dendritic cells, PI 
9. 2014 - 2018 Project for career development of young scientist Croatian Science Foundation,
10. 2012 Project of the French Croatian collaboration for science and technology 
11. 2006 – 2013 Ministry of Science, Education and Sport of the Republic of Croatia Molecular interactions in lymphocyte differentiation, No. 098-0982913-2332, PI

1995 - 2013 Held 4 International and 5 National projects

AWARDS

Federal Award for Young Scientists for Outstanding Scientific Achievements, 1987

Award of the Croatian Academy of Sciences and Arts, 1999

Federal Award of the Croatian Ministry of Science and Technology, 2000

Award of the Croatian Immunological society for the best paper of the year, 2009

Ruđer Bošković Institute Annual Award,  2012                                                  

FELLOWSHIPS

Fellowship of the German Government, 1984-1987

EMBO 1990 and 2019

UICC  1992

Teaching activities:

Molecular interactions in lymphocyte development, Faculty of Medicine, Zagreb, Croatia

Mechanisms of cell differentiation, Faculty of Science, Zagreb, Croatia

Industrial Immunology, Faculty of Science, Zagreb and Faculty of Science Orleans, France

Books:

1. Book Editor:  Acute Leukemia - The Scientist's Perspective and Challenge, M. Antica (Ed.), ISBN: 978953-307-553-2, InTech,2011. 
2. Book translation: Your amazing immune system,  (Ed. Masayuki Miyasaka) 2011 Tvoj čudesni imunosni sustav, ISBN: 978-953-7941-09-3,  M. Antica (Ed.)  .

Original articles:

1. V. Shichkin and M. Antica (2020) Thymus regeneration and future challenges. Stem Cell Reviews and Reports (29.1.2020. Epub ahead of print)
2. M. Antica, & J. Skelin, (2019) Current trends in targeted therapy of leukaemia and lymphoma Advances in General Practice of Medicine,2(1), 16-18.                     
3. R. Ribić, R. Stojković, L. Milković, M. Antica, M. Cigler and S. Tomić (2019)  Design, synthesis and biological evaluation of immunostimulating mannosylated desmuramyl peptides  Beilstein Journal of Organic Chemistry 15, 1805–1814.
4. L. Horvat, M. Grubar, J. Madunic, M. Antica, M. Matulić (2019) Inhibition of PARP activity does not affect the differentiation processes caused by retinoid acid in SH-SY5Y cells. Molecular and experimental biology in medicine 2 (1), 38-43. 
5. L. Horvat, J. Skelin, B. Jelić Puškarić, I. Feliciello, D. Heckel, J. Madunić, I. Kardum-Skelin, M. Matulić,  D. Radić-Krišto and M. Antica (2018) Notch pathway connections in primary leukaemia samples of limited size Translational Medicine Communications  3:8 5.
6. L. Horvat , M. Antica and M. Matulić (2018) Effect of Notch and PARP Pathways’ Inhibition in Leukemic Cells. Cells, 7(6), 58; 
7. J. Madunić, L. Horvat, I. Majstorović, I. Jodłowska, M.  Antica, M.  Matulić (2017) Sodium Salicylate Inhibits Urokinase Activity in MDA MB-231 Breast Cancer Cells. Clinical breast cancer. 17, (8):  629-637
8. J. Madunić, M. Antica, P. Cvjetko, L. Požgaj, M. Matulić (2016) Modulation of urokinase plasminogen activator system by poly(ADP-ribose)polymerase-1 inhibition Cytotechnology; 68(4):783-94 
9.  M. Matulić, J. Skelin, D. Radic-Krišto, I. Kardum-Skelin, D. Grčević, M. Antica (2015) Notch affects the prodifferentiating effect of retinoic acid and PMA on leukemic cells. Cytometry A. 87 129-136.  and
10. M. Antica (2015) Notched player in myeloid leukaemia - new insights exposed, In this issue. Cytometry, 87 129-136.
11.  A. J. Martić, S. Ivanković, M. Antica, N. Hiršl, T. Jukić, M. Jurin (2015) Transplanted tumour growth and the incidence of T-lymphocyte populations in the spleen of Newcastle virus-treated mice. Cancer Biother Radiopharm. 30(4):182-186.
12. M. Antica, M Paradžik, S Novak, S Džebro, M Dominis (2010) Gene expression in formalin-fixed paraffin-embedded lymph nodes. J. Immunol Met.359 42-46.
13. M. Paradžik,  S. Novak, G. Mokrović, T. Bordukalo Nikšić, D. Heckel, J. Stipić, D.  Pavičić Baldani, L. Čičin-Šain, M. Antica (2012) Ikaros family transcription factors expression in rat thymus: detection of impaired development.  Int J Immunopathol Pharmacol.25 893-900 
14. Matulic, Paradzik, M., Cicin-Sain, L., Kapitanovic, S., Dubravcic, K., Batinic, D., Antica, M. (2009) Ikaros family transcription factors in chronic and acute leukaemia. Am J Hematol. 84 375 -377. 
     
15. M. Antica, L. Cicin-Sain, S. Kapitanovic, M. Matulić, S. Dzebro and M. Dominis (2008) Aberrant Ikaros, Aiolos and Helios expression in Hodgkin and non-Hodgkin lymphoma.  Blood 111 3296 - 3297.
16. M. Antica, Dubravcic, K., Rajic, LJ., Labar, B., Batinic, D. (2007) A search for a mutation of the Aiolos phosphorylation domain in lymphocytes from leukaemia patients. Haematologica Haematologica. 92 260-261
17. M. Antica, R. Scollay (1999) Development of T lymphocytes at extrathymic sites.  J. Immunol., 163 206-211.
18. J. Ismaili, M. Antica and L. Wu (1996) CD4 and CD8 expression and T cell antigen receptor gene rearrangement in early intrathymic precursor cells. Eur. J. Immunol. 26 731-737.
19. M. Antica L. Wu, K. Shortman and R. Scollay (1994) Thymic stem cells in the mouse bone marrow. Blood 84, 111-117
20. M. Antica L. Wu, K. Shortman and R. Scollay (1993) Intrathymic lymphoid precursor cells during fetal thymus development. J. Immunol.151, 1-9
21. L. Wu, M. Antica G. R. Johnson, R. Scollay and K. Shortman (1991) Developmental potential of the earliest precursor cells from the adult mouse thymus. J. Exp. Med174, 1617 – 1627

Books and book chapters

Authored books

• Menac, A., Fink-Arsovski, Ž., Mironova Blažina, I. & Venturin, R. (2011) Croatian-Russian phraseological Dictionary : index of Croatian and Russian idioms. Zagreb, Knjigra.

Books and book chapters

Book chapters

• Antica, M. (2011) Lymphocyte commitment and Ikaros transcription factors. U: Antica, M. (ur.) Acute Leukemia - the Scientist's Perspective and Challenge. Rijeka, Intech, str. 69-74 doi:10.5772/19794.

  doi

• Antica, M. (1997) Razvoj limfocita u kulturama fetalnih tumisa. U: Stavljenić-Rukavina, A., Batinić, D. & Bilić-Zulle, L. (ur.) Protočna citometrija u kliničkolaboratorijskoj praksi., Medicinski fakultet Sveučilišta u Zagrebu : KBC, str. 83-89.

• Scollay, R. & Antica, M. (1995) Stem cells for lymphocytes: comments on the time and place of commitment of precursors for the T lineage. U: Ikehara, F., Takaku, R. & Good, A. (ur.) Bone Marrow Transplantation, Basic and Clinical Studies., Springer Verlag, str. 20-28.

• Antica, M. & Spaventi, R. (1989) Oncogene c-myc in normal and malignant cell. U: Ikić, D., Pavelić, K. & Spaventi, R. (ur.) Onkogeni i faktori rasta. Zagreb, Jugoslavenska akademija znanosti i umjetnosti : Globus, str. -.

Journal articles

Scientific and review papers

• Filipović, M., Flegar, D., Šućur, A., Šisl, D., Kavazović, I., Antica, M., Kelava, T., Kovačić, N. & Grčević, D. (2022) Inhibition of Notch Signaling Stimulates Osteoclastogenesis From the Common Trilineage Progenitor Under Inflammatory Conditions. Frontiers in Immunology, 13, 902947, 19 doi:10.3389/fimmu.2022.902947.

  doiwww.frontiersin.orgdoi.orgfulir.irb.hr

• Shichkin, V. & Antica, M. (2022) Key Factors for Thymic Function and Development. Frontiers in Immunology, 13, 926516, 18 doi:10.3389/fimmu.2022.926516.

  doiwww.frontiersin.org

• Korać, P., Antica, M. & Matulić, M. (2021) MiR-7 in Cancer Development. Biomedicines, 9 (3), 325, 20 doi:10.3390/biomedicines9030325.

  doiwww.mdpi.comfulir.irb.hr

• Petrović Peroković, V., Car, Ž., Draženović, J., Stojković, R., Milković, L., Antica, M., Škalamera, Đ., Tomić, S. & Ribić, R. (2021) Design, Synthesis, and Biological Evaluation of Desmuramyl Dipeptides Modified by Adamantyl-1,2,3-triazole. Molecules, 26 (21), 6352, 13 doi:10.3390/molecules26216352.

  doiwww.mdpi.comdoi.orgfulir.irb.hr

• Jukić, T., Jurin Martić, A., Ivanković, S., Antica, M., Pavan Jukić, D., Rotim, C. & Jurin, M. (2020) The role of regulatory T Lymphocytes in immune control of MC-2 Fibrosarcoma. Acta clinica Croatica, 59 (2), 351-358 doi:10.20471/acc.2020.59.02.20.

  doiactaclinica.euhrcak.srce.hrfulir.irb.hr

• Kolić, D., Horvat, L., Šetinc, M., Antica, M. & Matulić, M. (2020) miR-7 AND miR-34a sequence cloning and expression in a1235 glioblastoma cell line. Molecular and experimental biology in medicine, 3 (2), 31-38 doi:10.33602/mebm.3.2.4.

  doimebm.eumebm.eudoi.orgfulir.irb.hr

• Shichkin, V. & Antica, M. (2020) Thymus Regeneration and Future Challenges. Stem cell reviews and reports, 16, 239-250 doi:10.1007/s12015-020-09955-y.

  doilink.springer.comfulir.irb.hr

• Horvat, L., Antica, M. & Matulić, M. (2020) The Effect of Casein Kinase 2 Inhibition on three Leukemic Cell Lines. Current drug therapy, 15 (3), 209-215 doi:10.2174/1574885514666190724111509.

  doi

• Ribić, R., Stojković, R., Milković, L., Antica, M., Cigler, M. & Tomić, S. (2019) Design, synthesis and biological evaluation of immunostimulating mannosylated desmuramyl peptides. Beilstein journal of organic chemistry, 15, 1805-1814 doi:10.3762/bjoc.15.174.

  doifulir.irb.hrwww.beilstein-journals.orgdoi.org

• Horvat, L., Madunić, J., Grubar, M., Antica, M. & Matulić, M. (2019) Induction of Urokinase Activity by Retinoic Acid in Two Cell Lines of Neuronal Origin. Biomedicines, 7 (3), 70, 15 doi:10.3390/biomedicines7030070.

  doidoi.orgwww.mdpi.comwww.mdpi.comfulir.irb.hr

• Skelin, J. & Antica, M. (2019) Current trends in targeted therapy of leukaemia and lymphoma. Advances in General Practice of Medicine, 2 (1), 16-18 doi:10.25082/AGPM.2019.01.005.

  doiwww.syncsci.comdoi.orgfulir.irb.hr

• Horvat, L., Grubar, M., Madunić, J., Antica, M. & Matulić, M. (2019) Inhibition of PARP activity does not affect the differentiation processes caused by retinoic acid in SH-SY5Y cells. Molecular and Experimental Biology in Medicine, 2 (1), 38-43. (https://www.bib.irb.hr/993892).

  mebm.eu

• Horvat, L., Antica, M. & Matulić, M. (2018) Effect of Notch and PARP Pathways’ Inhibition in Leukemic Cells. Cells, 7 (6), 58-70 doi:10.3390/cells7060058.

  doifulir.irb.hrwww.ncbi.nlm.nih.govwww.mdpi.comdoi.org

• Horvat, L., Skelin, J., Puškarić, B., Feliciello, I., Heckel, D., Madunić, J., Kardum-Skelin, I., Matulić, M., Radić-Krišto, D. & Antica, M. (2018) Notch pathway connections in primary leukaemia samples of limited size. Translational Medicine Communications, 3, 8, 9 doi:10.1186/s41231-018-0026-z.

  doitransmedcomms.biomedcentral.comfulir.irb.hrdoi.org

• Madunić, J., Horvat, L., Majstorović, I., Jodłowska, I., Antica, M. & Matulić, M. (2017) Sodium Salicylate Inhibits Urokinase Activity in MDA MB-231 Breast Cancer Cells. Clinical breast cancer, 17 (8), 629-637 doi:10.1016/j.clbc.2017.03.015.

  doi

• Madunić, J., Antica, M., Cvjetko, P., Požgaj, L. & Matulić, M. (2016) Modulation of urokinase plasminogen activator system by poly(ADP-ribose)polymerase-1 inhibition. Cytotechnology, 68, 783-794 doi:10.1007/s10616-014-9829-6.

  doi

• Jurin Martić, A., Ivanković, S., Antica, M., Hiršl, N., Jukić, T. & Jurin, M. (2015) Transplanted Tumor Growth and the Incidence of T-Lymphocyte Populations in the Spleen of Newcastle Virus-Treated Mice. Cancer biotherapy & radiopharmaceuticals, 30 (4), 182-186 doi:10.1089/cbr.2014.1787.

  doi

• Matulić, M., Skelin, J., Radić-Kristo, D., Kardum-Skelin, I., Grčević, D. & Antica, M. (2015) Notch affects the prodifferentiating effect of retinoic acid and PMA on leukemic cells. Cytometry part a, 87 (2), 129-136 doi:10.1002/cyto.a.22582.

  doi

• Paradžik, M., Novak, S., Mokrović, G., Bordukalo Nikšić, T., Heckel, D., Stipić, J., Pavičić Baldani, D., Čičin-Šain, L. & Antica, M. (2012) Ikaros family transcription factors expression in rat thymus : detection of impaired development. International journal of immunopathology and pharmacology, 25 (4), 893-900 doi:10.1177/039463201202500407.

  doiwww.biolifesas.org

• Antica, M., Paradžik, M., Novak, S., Džebro, S. & Dominis, M. (2010) Gene expression in formalin-fixed paraffin-embedded lymph nodes. Journal of immunological methods, 359 (1/2), 42-46 doi:10.1016/j.jim.2010.05.010.

  doi

• Matulić, M., Paradžik, M., Jelić Puškarić, B., Stipić, J. & Antica, M. (2010) Analysis of Ikaros Family Splicing Variants in Human Hematopoietic Lineages. Collegium antropologicum, 34 (1), 59-62.

  hrcak.srce.hr

• Gavella, M., Garaj-Vrhovac, V., Lipovac, V., Antica, M., Gajski, G. & Nikica, C. (2010) Ganglioside GT1b protects human spermatozoa from hydrogen peroxide-induced DNA and membrane damage. International journal of andrology, 33 (3), 536-544 doi:10.1111/j.1365-2605.2009.00962.x.

  doi

• Matulić, M., Paradžik, M., Čičin-Šain, L., Kapitanović, S., Dubravčić, K., Batinić, D. & Antica, M. (2009) Ikaros family transcription factors in chronic and acute leukemia. American journal of hematology, 84 (6), 375-377 doi:10.1002/ajh.21401.

  doidoi.org

• Antica, M., Čičin-Šain, L., Kapitanović, S., Matulić, M., Džebro, S. & Dominis, M. (2008) Aberrant Ikaros, Aiolos, and Helios expression in Hodgkin and non-Hodgkin lymphoma. Blood, 111 (6), 3296-3297.

• Antica, M., Dubravčić, K., Weber, I., Rajić, L., Labar, B. & Batinić, D. (2007) A search for a mutation of the Aiolos phosphorylation domain in lymphocytes from patients with leukemia. Haematologica, 92 (2), 260-261.

• Kapitanović, S., Čačev, T., Antica, M., Kralj, M., Cavrić, G., Pavelić, K. & Spaventi, R. (2006) Effect of indomethacin on E-cadherin and β-catenin expression in HT-29 colon cancer cells. Experimental and molecular pathology, 80 (1), 91-96 doi:10.1016/j.yexmp.2005.04.008.

  doi

• Kušić, B., Dominis, M., Džebro, S. & Antica, M. (2003) Molecular insight into the diagnosis of lymphoma. International journal of molecular medicine, 12 (4), 667-671 doi:10.3892/ijmm.12.4.667.

  doi

• Vitale, B., Martinis, M., Antica, M., Kušić, B., Rabatić, S., Gagro, A., Kušec, R. & Jakšić, B. (2003) Prolegomenon for chronic lymphocytic leukaemia. Scandinavian journal of immunology, 58 (6), 588-600 doi:10.1111/j.1365-3083.2003.01331.x.

  doi

• Kušić, B., Gašparov, S., Katičić, M., Dominis, M. & Antica, M. (2003) Monolconality in Helicobacter pylori-positive gastric biopsies : an early detection of mucosa-associated lymphoid tissue lymphoma. Experimental and molecular pathology, 74 (1), 61-67 doi:10.1016/S0014-4800(03)80009-6.

  doi

• Korbler, T., Gršković, M., Dominis, M. & Antica, M. (2003) A Simple method for RNA isolation from formalin fixed and paraffin embedded lymphatic tissues. Experimental and molecular pathology, 74 (3), 336-340 doi:10.1016/S0014-4800(03)00024-8.

  doi

• Antica, M., Kušić, B., Hranilović, D., Dietz, A. & Vuk-Pavlović, S. (2002) Cloning the cDNA for murine U2 snRNP-A' gene and its differential expression in lymphocyte development. Immunology Letters, 82 (3), 217-223.

• Antica, M. & Scollay, R. (1999) Development of T lymphocytes at extrathymic sites. Journal of immunology, 163 (1), 206-211.

  www.jimmunol.org

• Dominis, M., Džebro, S., Kušić, B. & Antica, M. (1998) Inflammatory pseudotumor of the spleen. Acta cytologica, 42 (4), 1053-1056.

• Antica, M., Wu, L. & Scollay, R. (1997) Stem cell antigen 2 expression in adult and developing mice. Immunology letters, 55 (1), 47-51 doi:10.1016/S0165-2478(96)02682-X.

  doi

• Ismaili, J., Antica, M. & Wu, L. (1996) CD4 and CD8 expression and T cell antigen receptor gene rearrangement in early intrathymic precursor cells. European journal of immunology, 26 (4), 731-737 doi:10.1002/eji.1830260402.

  doi

• Li, C., Wu, L., Antica, M., Shortman, K. & Johnson, G. (1995) Purified murine long-term in-vivo hematopoietic repopulating cells are not prothymocytes. Experimental hematology, 23 (1), 21-25.

• Antica, M., Wu, L., Shortman, K. & Scollay, R. (1994) Thymic stem-cells in mouse bone-marrow. Blood, 84 (1), 111-117 doi:10.1182/blood.V84.1.111.111.

  doiwww.bloodjournal.org

• Antica, M., Kušić, B., Spaventi, R., Jakšić, B. & Vitale, B. (1993) Functional differences of T cells in B-chronic lymphocytic leukemia. Leukemia & lymphoma, 9 (4-5), 133-140 doi:10.3109/10428199309148516.

  doi

• Antica, M., Wu, L., Shortman, K. & Scollay, R. (1993) Intrathymic lymphoid precursor cells during fetal thymus development. Journal of immunology, 151 (11), 5887-5895.

• Gabrilovac, J., Antica, M. & Osmak, M. (1992) In vivo biderectional regulation of mouse natural killer (NK) cell cytotoxic activities by Leu-Enkephalin: Reversibility by naloxone. Life sciences, 50 (1), 29-37 doi:10.1016/0024-3205(92)90194-T.

  doi

• Wu, L., Antica, M., Johnson, G., Scollay, R. & Shortman, K. (1991) Developmental potential of the earliest precursor cells from the adult-mouse thymus. The Journal of experimental medicine, 174, 1617-1627 doi:10.1084/jem.174.6.1617.

  doijem.rupress.orgwww.ncbi.nlm.nih.gov

• Spaventi, R., Antica, M. & Pavelić, K. (1990) Insulin and insulin-like growth factor I (IGF I) in early mouse embryogenesis. Development (Cambridge), 108, 491-495.

• Antica, M., Hoffmann-Fezer, G. & Thierfelder, S. (1989) ANTILYMPHOCYTIC ANTIBODIES AND MARROW TRANSPLANTATION.9. T-CELL DEPLETION IN MARROW DONORS WITH C1Q HIGH AND LOW AFFINITY ANTIBODIES FOR SUPPRESSION OF GVHD IN FULLY MISMATCHED MICE. Experimental hematology, 17 (9), 942-947.

• Hoffmann-Fezer, G., Antica, M., Schuh, R. & Thierfelder, S. (1989) Distribution of injected anti-Thy-1 monoclonal antibodies in mouse lymphatic organs: Evidence for penetration of the cortical blood-thymus barrier, and for intravascular antibody-binding onto lymphocytes. Hybridoma, 8 (5), 517-527 doi:10.1089/hyb.1989.8.517.

  doi

• Antica, M., Heiss, M., Kummer, U., Munker, R., Thiel, E. & Thierfelder, S. (1986) Simultaneous Demonstration of two Antigens on Single T cells using Antibodies with Contrasting Labels. Journal of immunological methods, 87 (2), 129-136 doi:10.1016/0022-1759(86)90521-1.

  doi

• Mariastefania, A., Jakšić, B. & Vitale, B. (1986) T-Lymphocyte Colonies from Patients with Chronic Lymphocytic Leukemia (CLL). Periodicum biologorum. Supplement, 88 (suppl.), 503-504.

Conference proceedings papers

Scientific conference proceedings papers

• Antica, M. (1997) T lymphocyte development and commitment. U: Dorić, M. (ur.)Pathogenesis of Infectious Diseases.

Memberships

President-elected of the Croatian Immunological Society  2022

Life Member of the UICC (Union Internationale Contre le Cancer) Association since 1992.

Ambassador of the European Association for Cancer Research (EACR)

Vice-president of the Croatian Immunological Society 1996-2001

Member of the Ethical Board of the Croatian Immunological Society 2016-2022