Dr. Dijana Pavlović Saftić

Research associate

E-mail

Dijana.Saftic@irb.hr

Internal phone number

1466

Department

Division of Organic Chemistry and Biochemistry

Laboratory

Laboratory for Biomolecular Interactions and Spectroscopy

Address

Ruđer Bošković Institute
Bijenička cesta 54
10000 Zagreb
Croatia

Bibliography

Open bibliography #2

Curriculum vitae

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Education

CURRENT STATUS

07/2019 till today - Research Associate, Laboratory for Biomolecular Interactions and Spectroscopy, Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Zagreb, Croatia

PREVIOUS WORK EXPERIENCE

02/2019 - 05/2019 Senior Research Assistant–Postdoc, Scientific Specialization in Croatia, Laboratory for Green Synthesis, Division of Physical Chemistry, Ruđer Bošković Institute, Zagreb, Croatia
05/2018 - 09/2018 Senior Research Assistant–Postdoc, Scientific Specialization in Croatia, Laboratory for Biomolecular Interactions and Spectroscopy, Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Zagreb, Croatia
11/2016 – 05/2018 Senior Research Assistant–Postdoc, Scientific Specialization abroad, Laboratory of Molecular Virology and Biological Chemistry, Institute of Medical Biology PAS, Lodz, Poland
12/2013 – 11/2016 Senior Research Assistant–Postdoc, Scientific Specialization in Croatia, Laboratory for Biomolecular Interactions and Spectroscopy (previously Laboratory for Supramolecular and Nucleoside Chemistry), Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Zagreb, Croatia
04/2008 – 11/2013 Research Assistant–PhD candidate, Laboratory for Supramolecular and Nucleoside Chemistry, Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Zagreb, Croatia

EDUCATION

11/2016 – 05/2018 Postdoctoral study abroad, Institute of Medical Biology, Polish Academy of Science, Lodz, Poland
11/2013 – 11/2016 Postdoctoral scientific training, Ruđer Bošković Institute, Zagreb, Croatia
11/2013 PhD in Natural Sciences, University of Zagreb, Croatia
05/2008 – 11/2013 Postgraduate Study of Organic Chemistry, Faculty of Science, University of Zagreb, Croatia
11/2007 M.Sc. in Biotechnology, Faculty of Food Technology and Biotechnology, University of Zagreb, Croatia
09/2002 – 11/2007 Biotechnology study, Faculty of Food Technology and Biotechnology, University of Zagreb, Croatia
1998 – 2002 Zagreb Health School, Zagreb, Croatia
1990 – 1998 Primary School, Zagreb, Croatia

Research Areas

Biotehnologija Kemija Organska kemija

Projects

TEAM MEMBER OF RESEARCH PROJECTS

2018 – 2022 „Višekromoforne probe za prepoznavanje pojedinih struktura DNA, RNA i proteina“, Principal Investigator: Dr. Ivo Piantanida, Senior Scientist, Ruđer Bošković Institute, Zagreb, Croatia
2016 – 2019 ˝Mehanokemijska reaktivnost pod kontroliranim uvjetima temperature i atmosfere za čistu sintezu funkcionalnih materijala (MECHANOCONTROL)˝, Principal Investigator: Dr. Krunoslav Užarević, Senior Research Associate, Ruđer Bošković Institute, Zagreb, Croatia
2017 – 2019 ˝Picolyl based cyanostilbene metallogel systems as anion sensors˝, Croatian-Chinese bilateral project, Principal Investigator in Croatia: Dr. Zoran Džolić, research associate, Ruđer Bošković Institute, Zagreb, Croatia; Principal Investigator in China: Prof. dr. Shimei Jinag, State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun City, Jilin Province, PR China
2016 – 2018 ˝Oligo-Derivative Composites of Nucleic Acids and Boron Clusters – a New Material for Bionanotechnology˝, Principal Investigator: Prof. dr. hab. Zbigniew J. Leśnikowski, Institute of Medical Biology PAS, Lodz, Poland
2014 – 2018 ˝Multifunctional molecular sensing of DNA/RNA secondary structure by chemical sensors˝, Principal Investigator: Dr. Ivo Piantanida, Senior Scientist, Ruđer Bošković Institute, Zagreb, Croatia
2014 – 2018 ˝Purine salvage pathway enzymes fromHelicobacter pyloriandEscherichia coli˝, Principal Investigator: Dr. Marija Luić, Senior Scientist, Ruđer Bošković Institute, Zagreb, Croatia
2007 – 2014 ˝Synthesis of novel biologically active nucleobase and nucleotide derivatives˝, Principal Investigator: Dr. Biserka Žinić, Senior Scientist, Full Prof., Ruđer Bošković Institute, Zagreb, Croatia

Awards and Achievements

Annual RBI award for scientific work in 2018
11/2014 Fellowship to attend Zn-Net Conference & Workshop ˝Measuring Zinc˝, London, United Kingdom
02/2014 Fellowship to attend European-Winter School on Physical Organic Chemistry (E-WiSPOC 2014), Bressanone, Italy
09/2002 – 11/2007 Sisak-Moslavina County Fellowship for Top Students
09/1998 – 05/2002 PBZ foundation - Scholarship for Top Students

Classes

09/2015 Lecturer - within the Course ˝Preparation, Analysis and Application of Oligonucleotides˝, International PhD Study in Medicinal Chemistry, University of Rijeka, Rijeka, Croatia
01/2012, 10/2013 Invited Lecturer with the Course ˝Instrumental Measurement Techniques and Physical Methods in Biomedical Analytics˝, Department of Medicinal Chemistry, Biochemistry and Clinical Chemistry, Faculty of Medicine, University Undergraduate Study in Biomedical Laboratory Technologies, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
07/2013 Mentor of the student’s Praxis, Faculty of Chemical Engineering and Technology, University of Zagreb, Zagreb, Croatia
10/2004 – 01/2005 Teaching Assistant, General Microbiology in the Laboratory for General Microbiology and Food Microbiology, Department of Biochemical Engineering, Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia

Featured Publications

K. Bednarska-Szczepaniak, A. Mieczkowski, A. Kierozalska, D. Pavlović Saftić, K. Głąbała, T. Przygodzki, L. Stańczyk, K. Karolczak, C. Watała, H. Rao, Z.-G. Gao, K. A. Jacobson, Z. J. Leśnikowski, Eur. J. Med. Chem. 2021, 223, 113607–113631.
D. Kodr, C. Pinar Yenice, A. Simonova, D. Pavlović Saftić, R. Pohl, V. Sýkorová, M. Ortiz, L. Havran, M. Fojta, Z. J. Leśnikowski, C. K. O’Sullivan, M. Hocek, J. Am. Chem. Soc. 2021, 143, 7124–7134.
J. Matić, M. Jukić, H. Ismaili, D. Saftić, Ž. Ban, T. Tandarić, R. Vianello, T. Opačak-Bernardi, Lj. Glavaš-Obrovac, B. Žinić, Nucleos. Nucleot. Nucl. 2021, 40(4), 1–34.
D. Saftić, M. Studzińska, E. Paradowska, I. Piantanida, G. Baranović, M. Białek-Pietras, Z. J. Leśnikowski, Bioorg. Chem. 2020, 94, 103466.
H. Ismaili, Ž. Ban, J. Matić, D. Saftić, M. Jukić, Lj. Glavaš-Obrovac, B. Žinić, Croat. Chem. Acta 2019, 92(2), 269–277.
D. Saftić, Ž. Ban, J. Matić, L.-M. Tumir, I. Piantanida, Curr. Med. Chem. 2019, 26(30), 5609–5624.
Lj. Glavaš-Obrovac, M. Jukić, K. Mišković, I. Marković, D. Saftić, Ž. Ban, J. Matić, B. Žinić, J. Trace. Elem. Med. Bio. 2019, 55, 216–222.
A. Kurutos, I. Orehovec, D. Saftić, L. Horvat, I. Crnolatac, I. Piantanida, T. Deligeorgiev, Dyes Pigments 2018, 158, 517–525.
R. Kobetić, V. Ključarić, D. Saftić, J. Matić, Ž. Ban, S. Kazazić, B. Žinić, J. Mass. Spectrom. 2018, 53, 655–664.
D. Saftić, B. Žinić, Lj. Glavaš-Obrovac, M. Studzińska, E. Paradowska, Z. J. Leśnikowski, Nucleos. Nucleot. Nucl. 2018, 37, 397–414.
L. Krstulović, D. Saftić, H. Ismaili, M. Bajić, Lj. Glavaš-Obrovac, B. Žinić, Croat. Chem. Acta 2017, 90(4), 625–636.
D. Saftić, M. Radić Stojković, B. Žinić, Lj. Glavaš-Obrovac, M. Jukić, I. Piantanida, L.-M. Tumir, New J. Chem. 2017, 41, 13240–13252.
V. Ključarić, R. Kobetić, J. Rinkovec, S. Kazazić, D. Gembarovski, D. Saftić, J. Matić, Ž. Ban, B. Žinić, J. Mass. Spectrom. 2016, 51, 998–1005.
D. Saftić, R. Vianello, B. Žinić, Eur. J. Org. Chem. 2015, 35, 7695–7704.
N. Župančić, Ž. Ban, J. Matić, D. Saftić, Lj. Glavaš-Obrovac, B. Žinić, Croat. Chem. Acta 2015, 88(1), 43–52.
D. Saftić, B. Žinić, A. Višnjevac, Tetrahedron 2012, 68, 1062–1070.
M. Cetina, A. Nagl, D. Gašo-Sokač, S. Kovač, V. Bušić, D. Saftić, J. Chem. Crystallogr. 2012, 42(7), 752–758.

Publications

Journal articles

Scientific and review papers

Bednarska-Szczepaniak, K., Mieczkowski, A., Kierozalska, A., Pavlović Saftić, D., Głąbała, K., Przygodzki, T., Stańczyk, L., Karolczak, K., Watała, C., Rao, H., Gao, Z., Jacobson, K. & Leśnikowski, Z. (2021) Synthesis and evaluation of adenosine derivatives as A1, A2A, A2B and A3 adenosine receptor ligands containing boron clusters as phenylisosteres and selective A3 agonists. European journal of medicinal chemistry, 223, 113607-113631 doi:10.1016/j.ejmech.2021.113607.
doi
Kodr, D., Pinar Yenice, C., Simonova, A., Pavlović Saftić, D., Pohl, R., Sýkorová, V., Ortiz, M., Havran, L., Fojta, M., Lesnikowski, Z., K. O'Sullivan, C. & Hocek, M. (2021) Carborane- or Metallacarborane-Linked Nucleotides for Redox Labeling. Orthogonal Multipotential Coding of all Four DNA Basesfor Electrochemical Analysis and Sequencing. Journal of the American Chemical Society, 143, 7124-7134 doi:10.1021/jacs.1c02222.
doipubs.acs.orgdoi.org
Matić, J., Jukić, M., Ismaili, H., Saftić, D., Ban, Ž., Tandarić, T., Vianello, R., Opačak-Bernardi, T., Glavaš-Obrovac, L. & Žinić, B. (2021) 6-Morpholino- and 6-amino-9-sulfonylpurine derivatives. Synthesis, computational analysis, and biological activity. Nucleosides, nucleotides & nucleic acids, 40 (4), 470-503 doi:10.1080/15257770.2021.1896001.
doi
Saftić, D., Studzińska, M., Paradowska, E., Piantanida, I., Baranović, G., Białek-Pietras, M. & Leśnikowski, Z. (2020) Comparative study of the effects of ortho-, meta- and para-carboranes (C2B10H12) on the physicochemical properties, cytotoxicity and antiviral activity of uridine and 2’-deoxyuridine boron cluster conjugates. Bioorganic chemistry, 94, 103466, 11 doi:10.1016/j.bioorg.2019.103466.
doi
Ismaili, H., Ban, Ž., Matić, J., Saftić, D., Jukić, M., Glavaš-Obrovac, L. & Žinić, B. (2019) An Efficient Synthesis and In vitro Cytostatic Activity of 5-Aminosulfonyl Uracil Derivatives. Croatica chemica acta, 92 (2), 269-277 doi:10.5562/cca3567.
doidoi.orghrcak.srce.hrfulir.irb.hr
Saftić, D., Ban, Ž., Matić, J., Tumir, L. & Piantanida, I. (2019) Conjugates of classical DNA/RNA binder with nucleobase: chemical, biochemical and biomedical applications. Current medicinal chemistry, 26 (30), 5609-5624 doi:10.2174/0929867325666180508090640.
doi
Glavaš-Obrovac, L., Jukić, M., Mišković, K., Marković, I., Saftić, D., Ban, Ž., Matić, J. & Žinić, B. (2019) Antiproliferative and proapoptotic activity of molecular copper(II) complex of N-1-tosylcytosine. Journal of trace elements in medicine and biology, 55, 216-222 doi:10.1016/j.jtemb.2017.10.009.
doi
Kobetić, R., Ključarić, V., Saftić, D., Matić, J., Ban, Ž., Kazazić, S. & Žinić, B. (2018) The transformation from 2°‐amine to 3°‐amine of cyclam ring alters the fragmentation patterns of 1‐tosylcytosine‐cyclam conjugates. Journal of mass spectrometry, 53, 655-664 doi:10.1002/jms.4197.
doi
Saftić, D., Žinić, B., Glavaš- Obrovac, L., Studzińska, M., Paradowska, E. & Leśnikowski, Z. (2018) Synthesis and in vitro evaluation of antiviral and cytostatic properties of novel 8-triazolyl acyclovir derivatives. Nucleosides, nucleotides & nucleic acids, 37 (7), 397-414 doi:10.1080/15257770.2018.1485932.
doi
Kurutos, A., Orehovec, I., Saftić, D., Horvat, L., Crnolatac, I., Piantanida, I. & Deligeorgiev, T. (2018) Cell penetrating, mitochondria targeting multiply charged DABCO-cyanine dyes. Dyes and pigments, 158, 517-525 doi:10.1016/j.dyepig.2018.05.035.
doi
Krstulović, L., Saftić, D., Ismaili, H., Bajić, M., Glavaš-Obrovac, L. & Žinić, B. (2017) Synthesis and In vitro Activity of N- sulfonylamidine-derived Pyrimidine Analogues. Croatica chemica acta, 90 (4), 625-636 doi:10.5562/cca3273.
doi
Saftić, D., Radić Stojković, M., Žinić, B., Glavaš-Obrovac, L., Jukić, M., Piantanida, I. & Tumir, L. (2017) Impact of linker between triazolyl-uracil and phenanthridine on recognition of DNA and RNA. Recognition of uracil – containing RNA.. New journal of chemistry, 41 (22), 13240-13252 doi:10.1039/C7NJ02699D.
doi
Ključarić, V., Kobetić, R., Rinkovec, J., Kazazić, S., Gembarovski, D., Saftić, D., Matić, J., Ban, Ž. & Žinić, B. (2016) ESI-MS studies of the non-covalent interactions between biologically important metal ions and N- sulfonylcytosine derivatives. Journal of mass spectrometry, 51 (11), 998-1005 doi:10.1002/jms.3810.
doi
Saftić, D., Vianello, R. & Žinić, B. (2015) 5-Triazolyluracils and Their N1-Sulfonyl Derivatives: Intriguing Reactivity Differences in the Sulfonation of Triazole N1'-Substituted and N1'-Unsubstituted Uracil Molecules. European journal of organic chemistry, 35, 7695-7704 doi:10.1002/ejoc.201501088.
doi
Krstulović, L., Saftić, D., Matić, J., Bajić, M. & Žinić, B. (2015) 1, 3-Dipolar Cycloaddition (Part II): Three- Component Cu(I) Catalysed Click Reactions. Kemija u industriji : časopis kemičara i tehnologa Hrvatske, 64 (9-10), 499-512 doi:10.15255/KUI.2014.019.
doihttpfulir.irb.hr
Saftić, D., Krstulović, L., Bajić, M. & Žinić, B. (2015) 1, 3-Dipolar Cycloaddition (Part I): Synthesis of 1, 2, 3-Triazole Derivatives in Nucleoside Chemistry. Kemija u industriji : časopis kemičara i tehnologa Hrvatske, 64 (9-10), 481-498 doi:10.15255/KUI.2014.020.
doihrcak.srce.hrfulir.irb.hr
Župančić, N., Ban, Ž., Matić, J., Saftić, D., Glavaš-Obrovac, L. & Žinić, B. (2015) Synthesis and Biological Activity of Reversed Pyrimidine Nucleosides. Croatica chemica acta, 88 (1), 43-52 doi:10.5562/cca2531.
doihrcak.srce.hrfulir.irb.hr
Cetina, M., Nagl, A., Gašo-Sokač, D., Kovač, S., Bušić, V. & Saftić, D. (2012) Extensive Intramolecular and Intermolecular Interactions in Two Quaternary Salts of the Pyridoxal Oxime. Journal of chemical crystallography, 42 (7), 752-758 doi:10.1007/s10870-012-0312-y.
doi
Saftić, D., Žinić, B. & Višnjevac, A. (2012) DBU induced formation of 8-bromoguanosine dimer with three hydrogen bonds between the GG- pairs. Tetrahedron, 68 (4), 1062-1070 doi:10.1016/j.tet.2011.11.086.
doi

Theses

Doctoral dissertation

Saftić, D. (2013) 'Novel 1, 4-Disubstituted 1, 2, 3-Triazole Derivatives of the Purine and Pyrimidine Series: Synthesis and Biological Evaluation', doktorska disertacija, Prirodoslovno-matematički fakultet, Zagreb.

Membership in professional associations / societies

Croatian Chemical Society (HKD)
Member of COST Action TD1304: The Network for the Biology of Zinc (Zinc-Net)
The alumni society of the chemical engineers and their friends at the University of Zagreb (AMACIZ) and Academic Choir Vladimir Prelog

CONFERENCE AND WORKSHOP PARTICIPATION

The Anton Paar Synthesis Seminar, Anton Paar Croatia d.o.o., Zagreb, Croatia (January, 28, 2020)
Workshop on Molecular modeling organised by Croatian Association for Cancer Research (HDIR), Ruđer Bošković Institute, Zagreb, Croatia (October 24 – 25, 2019)
1^st ITALIAN-UK Platelet Meeting 2017, Bath, United Kingdom (September 7–8, 2017) (poster)
EFMC-ASMC'17, EFMC International Symposium of Advances in Synthetic and Medicinal Chemistry, Vienna, Austria (August 27–31, 2017) (poster)
XXII. International Roundtable on Nucleosides, Nucleotides and Nucleic Acids, Pasteur Institute, Paris, France (July 18–22, 2016) (poster)
InnoMol New Platforms for Molecular Solutions in Research and Development Workshop, Ruđer Bošković Institute, Zagreb, Croatia (May 11–12, 2016)
Symposium & Workshop on Microscale Thermophoresis, Faculty of Science, University of Zagreb, Zagreb, Croatia (June 30 - July 01, 2015)
XXIV. Croatian Meeting of Chemists and Chemical Engineers, Zagreb, Croatia (April 21–24, 2015) (posters)
Zn-Net COST Action TD1304, Zn-Net Conference & Workshop˝Measuring Zinc˝, London, United Kingdom (November 03–05, 2014)
InnoMol Bioimaging Workshop, Institute of Physics, Zagreb, Croatia (October 20–22, 2014)
5^th Euchems Chemistry Congress-2014, Istanbul, Turkey (August 31 - September 04, 2014) (poster)
The Royal Society of Chemistry, Biological and Medicinal Chemistry Sector and the Croatian Chemical Society Meeting: ˝Macrocycles: Synthesis, Medicinal Chemistry and Biological Activity˝, Zagreb, Croatia (April 28–29, 2014) (poster)
Zn-Net COST Action TD1304 (member ofWorking Group 1: Chemical Biology), Budapest, Hungary (March 25–26, 2014)
E-WiSPOC 2014 European-Winter School on Physical Organic Chemistry, Bressanone, Italy (February 02–07, 2014) (COST Action CM1005)
XX. International Roundtable on Nucleosides, Nucleotides and Nucleic Acids, Montréal, Québec, Canada (August 05–09, 2012) (poster)
XXII. Croatian Meeting of Chemists and Chemical Engineers, Zagreb, Croatia (February 13–16, 2011) (poster)
Cambridge Structural Database Workshop, Ruđer Bošković Institute, Zagreb, Croatia (March 03–04, 2010)
18^th Croatian – Slovenian Crystallographic Meeting, Varaždin, Croatia (June 17–21, 2009)
XXI. Croatian Meeting of Chemists and Chemical Engineers, Split, Croatia (April 19–22, 2009) (posters)
Workshop on the topic of˝Stationary phase of the HPLC and UPLC columns (News in liquid chromatography)˝, Zagreb, Croatia (March 03, 2009)
Mass spectroscopy - Quadrupole UPLC/MS Innovations and Applications, Slovenian-Croatian Waters LC & MS Users' Meeting, Moravske Toplice, Slovenia (November 04–07, 2008)
Congress of the Croatian Society of Biochemistry and Molecular Biology HDBMB 2008, Osijek, Croatia (September 17–20, 2008) (poster)

INVITED TALKS

XXIII. Croatian Meeting of Chemists and Chemical Engineers, Osijek, Croatia (April 21–24, 2013)

SERVICE TO SCIENTIFIC COMMUNITY

Committee member and participant of the project - Festival of Science by Young Researchers at RBI, Zagreb, Croatia (2011)
Active participation in the projects related to the promotion of science - Coordination and participation at the Open days RBI, Zagreb, Croatia (2008, 2010, 2013, 2015, 2016, 2019)
Coordination and participation at the Festival of Science organized by the University of Zagreb, British Council and the Technical Museum in Zagreb, Zagreb, Croatia (2012, 2013)