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Publications

2005 – current 

Zaja, R., Loncar, J., Popovic.,M., Smital, T. (2011). First characterization of fish P-glycoprotein (abcb1) substrate specificity using determinations of its ATPase activity and calcein-AM assay with PLHC-1/dox cell line. Aquat. Toxicol. 103: 53-62

Fischer, S., Loncar, J., Zaja, R., Schnell, S., Schirmer, K., Smital, T., Luckenbach, T. (2011) Constitutive mRNA expression and protein activity levels of nine ABC efflux transporters in seven permanent cell lines derived from different tissues of rainbow trout (Oncorhynchus mykiss). Aquat. Toxicol. 101: 438-446

Smital, T., Terzic, S., Zaja, R., Senta, I., Pivcevic, B., Popovic, M., Mikac, I., Tollefsen, K.E., Thomas, K.V. (2011). Assessment of toxicological profiles of the municipal wastewater effluents using chemical analyses and bioassays. Ecotox. Environ., Safe. 74 (4): 844-851.

Šrut, M., Traven, L., Štambuk, A., Kralj, S., Žaja, R., Mićović, V., Klobučar, G.I.V. (2010). Genotoxicity of marine sediments in the fish hepatoma cell line plhc-1 as assessed by the comet assay. Toxicol. in Vitro. 25 (1): 308-314

Popovic, M., Zaja, R., Loncar, J., Smital, T. (2010). A novel ABC transporter: The first insight into zebrafish (Danio rerio) Abch1. Mar. Environ. Res. 69:S1-S13.

Popovic, M. Zaja, R., Smital, T. (2009). Organic anion transporting polypeptides (OATP) in zebrafish (Danio rerio): Phylogenetic analysis and tissue distribution. CBP – Part A. 155: 327-335.

Lončar, J., Popović, M., Zaja, R., Smital, T. (2010). Gene expression analysis of the ABC efflux transporters in rainbow trout (Oncorhynchus mykiss). CBP – Part C. 151:209-215.

Dragun, Z., Erk, M., Ivanković, D., Žaja, R., Filipović Marijić, V., Raspor, B. (2009). Assessment of low-level metal contamination using the Mediterranean mussel gills as the indicator tissue. Environ. Sci. Pollut. Res. 17: 977-986.

Bošnjak, Ivana; Heim, Wesley; Smital, Tvrtko; Epel, David; Coale, Kenneth; Franekić-Čolić, Jasna; Hamdoun, Amro. Multidrug resistance associated protein transport activity mediates differences in accumulation and toxicity of inorganic and organic mercury in sea urchin embryos. //Environmental science & technology. 43 (2009) ; 8374-8380.

Zaja, R., Munić, V., Klobučar, R.S., Ambriović-Ristov, A., Smital, T. (2008). Cloning and molecular characterization of apical efflux transporters (ABCB1, ABCB11 and ABCC2) in rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquat. Toxicol. 90: 322-332.

Caminada, D., Žaja, R., Smital, T., Fent, K. (2008). Human Pharmaceuticals Modulate Pgp1 (ABCB1) Transport Activity in the Fish Cell Line PLHC-1. Aquat. Toxicol. 90: 214-222.

Traven, L., Žaja, R., Lončar, J., Smital, T., Mićović, V. (2008). CYP1A induction potential and the concentration of priority pollutants in marine sediment samples – in vitro evaluation using the PLHC-1 fish hepatoma cell line. Toxicol. in vitro. 22: 1648-1656.

Žaja, R., Caminada, D., Lončar, J., Fent, K., Smital, T. (2008). Development and characterization of P-glycoprotein 1 (Pgp1; ABCB1) mediated doxorubicin resistant PLHC-1 epatoma fish cell line. Toxicol. Appl. Pharmacol. 227: 207-218.

Žaja, R., Munić, V., Smital, T. (2008). Cloning and mRNA expression analysis of an ABCG2 (BCRP) efflux transporter in rainbow trout (Oncorhynchus mykiss) liver and primary hepatocytes. Mar. Environ. Res. 66 (1): 77-79.

Epel, David; Stevenson, Charlotte N.; MacManus-Spencer, Laura A.; Luckenbach, Till; Hamdoun, Amro; Smital, Tvrtko.
Efflux transporters: newly appreciated roles in protection against pollutants. //Environmental Science and Technology. 42 (2008) , 11; 3914-3920.

Krča, S., Žaja, R., Čalić, V., Terzić, S., Grubešić, M., Ahel, M., Smital, T. (2007). Hepatic biomarker responses to organic contaminants in feral chub (Leuciscus cephalus) – laboratory characterisation and field study in the Sava river, Croatia. Environ. Tox. Chem. 26 (12): 2620-2633.

Žaja, R., Klobučar, R.S., Smital, T. (2007). Detection and functional characterization of Pgp1 (ABCB1) and MRP3 (ABCC3) efflux transporters in the PLHC-1 fish hepatoma cell line. Aquat. Toxicol. 81, 365-376.

Källqvist, Torsten; Milačič, Radmila; Smital, Tvrtko; Thomas, Kevin V; Vranes, Sanja; Tollefsen, Knut-Erik. Chronic toxicity of the Sava River (SE Europe) sediments and river water to the algae Pseudokirchneriella subcapitata. //Water Research. 42 (2007) , 8-9; 2146-2156.

Žaja, R., Klobučar, G.I.V., Klobučar R.S., Hackenberger B.K., Smital T. (2006). Haemolymph as compartment for efficient and non-destructive determination of P-glycoprotein (Pgp) mediated MXR activity in bivalves. Comp. Biochem. Phys. C. 143, 103-112.

Pivcevic, B., Žaja, R. (2006). Pesticides and their binary combinations as P-glycoprotein inhibitors in NIH 3T3/MDR1 cells. ETAP. 22, 268–276. 

2005 - 2006

Sauerborn, R., Polancec, D.S., Zaja, R., Smital, T. (2004). Identification of the multidrug resistance-associated protein (mrp) related gene in red mullet (Mullus barbatus). Mar. Environ. Res. 58, 199-204.

Smital, Tvrtko; Sauerborn, Roberta; Hackenberger, Branimir. Inducibility of the multixenobiotic resistance mechanism (MXR) transport activity in the marine mussel Mytilus galloprovincialis and the freshwater mussel Dreissena polymorpha. //Aquatic Toxicology. 65 (2003) ; 443-465.

Smital, Tvrtko; Sauerborn, Roberta. Measurement of the activity of multixenobiotic resistance mechanism in the common carp Cyprinus carpio. //Marine Environmental Research. 54 (2002) ; 449-453.

Kurelec, Branko; Smital, Tvrtko; Pivčević, Branka; Eufemia, Nancy; Epel, David. Multixenobiotic resistance, P-glycoprotein, and chemosensitizers. //Ecotoxicology. 9 (2000) , 5; 307-327.

Ramljak, Sanja; Hackenberger, Branimir; Smital, Tvrtko; Britvić, Smiljana.  Evaluation of the genotoxic and cytochrome P450 monooxigenase-inhibitory potential of Dicuran on procaryotic and eucaryotic test systems. //Journal of Environmental Science and Health - Part B: Pesticides, Food Contaminants, and Agricultural Wastes. 35 (2000) , 6; 751-770

Smital, Tvrtko; Sauerborn, Roberta; Pivčević, Branka; Krča, Sanja; Kurelec, Branko. Interspecies differences in P-glycoprotein mediated activity of multixenobiotic resistance mechanism in several marine and freshwater invertebrates. //Comparative Biochemistry and Physiology C. 126 (2000) ; 175-186.

... - 2000

Kurelec, Branko; Britvić, Smiljana; Pivčević, Branka; Smital, Tvrtko. Fragility of multixenobiotic resistance in aquatic organisms enhances the complexity of risk assessment. //Marine environmental research. 46 (1998) , 1-5; 415-419

Osmak, Maja; Brozović, Anamaria; Ambriović-Ristov, Andreja; Hadžija, Mirko; Pivčević, Branka; Smital, Tvrtko. Inhibition of apoptosis is the cause of resistance to doxorubicin in human breast adenocarcinoma cells. //Neoplasma. 45 (1998) , 4; 223-230.

27. Smital, Tvrtko; Kurelec, Branko. The activity of multixenobiotic resistance mechanism determined by rhodamine B-efflux method as a biomarker of exposure. //Marine environmental research. 46 (1998) , 1-5; 443-447.

28. Smital, Tvrtko; Kurelec, Branko. The concentrations of inhibitors of multixenobiotic resistance mechanism in natural waters: The direct in vivo demonstration of their effect. //Environmental toxicology and chemistry. 16 (1997) , 10; 2164-2170.

Smital, Tvrtko; Kurelec, Branko. The chemosenzitizers of multixenobiotic resistance mechanism in aquatic invertebrates : a new class of pollutants. //Mutation research. 399 (1998) , 1; 43-53. 

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Division for Marine and Environmental Research

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