2008 - PhD in Natural Sciences-Biology, Faculty of Science, University of Zagreb
2004 - MSc in Natural Sciences-Biology, Faculty of Science, University of Zagreb
1999 - BSc in Molecular Biology, Faculty of Science, University of Zagreb

Regulation of large-scale endocytosis by IQGAP-related proteins IqgC and IqgD (Croatian Science Foundation)

• Dissecting the redundancy of Rac1 isoforms in Dictyostelium discoideum - DiRac

  16.12.2024 - 15.12.2027 | 186,475.00 EUR

  CroRISIRB

• - - RegEndIqCD

  08.12.2021 - 18.02.2027 | 0.00 EUR

  CroRISIRB

• Regulacija endocitoze na velikoj skali pomoću IQGAP proteinima srodnih proteina IqgC i IqgD - RegEndIqCD

  15.02.2021 - 14.02.2025 | 130,731.97 EUR

  CroRISIRB

National award for science in 2019.

RBI award for best papers published in 2019.

Čizmar, A., D. Putar, M. Šimić, J. Scholz, M. Marinović, L. Horvat, M. Matovina, I. Weber, J. Faix, and V. Filić. 2026. IqgD is a Rac1-interacting IQGAP required for efficient growth of Dictyostelium discoideum on bacterial lawns. Cell Commun. Signal. doi:10.1186/s12964-026-03074-w.

Filić, V., and I. Weber. 2026. Queue Gaps Among the IQGAPs in Dictyostelium discoideum.  Int. J. Mol. Sci. 27. doi:10.3390/ijms27125462.

Putar, D., A. Čizmar, X. Chao, M. Šimić, M. Šoštar, T. Ćutić, L. Mijanović, A. Smolko, H. Tu, P. Cosson, I. Weber, H. Cai, and V. Filić. 2024. IqgC is a potent regulator of macropinocytosis in the presence of NF1 and its loading to macropinosomes is dependent on RasG. Open Biol. 14:230372.

Filić, V., Mijanović, L., Putar, D., Talajić, A., Ćetković, H., and Weber, I. (2021). Regulation of the Actin Cytoskeleton via Rho GTPase Signalling in Dictyostelium and Mammalian Cells: A Parallel Slalom. Cells 10, 1592.

Marinović, M., Mijanović, L., Šoštar, M., Vizovišek, M., Junemann, A., Fonović, M., Turk, B., Weber, I., Faix, J., and Filić, V. (2019). IQGAP-related protein IqgC suppresses Ras signaling during large-scale endocytosis. Proc. Natl. Acad. Sci. U.S.A 116, 1289–1298.

Filić, V., Marinović, M., Šoštar, M., and Weber, I. (2018). Modulation of small GTPase activity by NME proteins. Laboratory Investigation 98, 589–601.

Junemann, A., Filić, V., Winterhoff, M., Nordholz, B., Litschko, C., Schwellenbach, H., Stephan, T., Weber, I., and Faix, J. (2016). A Diaphanous-related formin links Ras signaling directly to actin assembly in macropinocytosis and phagocytosis. Proc. Natl. Acad. Sci. U.S.A. 113, E7464–E7473.

Sobočanec, S., Filić, V., Matovina, M., Majhen, D., Šafranko, Ž.M., Hadžija, M.P., Krsnik, Ž., Kurilj, A.G., Šarić, A., Abramić, M., et al. (2016). Prominent role of exopeptidase DPP III in estrogen-mediated protection against hyperoxia in vivo. Redox Biol 8, 149–159.

Filić, V., Marinović, M., Faix, J., and Weber, I. (2014). The IQGAP-related protein DGAP1 mediates signaling to the actin cytoskeleton as an effector and a sequestrator of Rac1 GTPases. Cell. Mol. Life Sci. 71, 2775–2785.

Filić, V., Marinović, M., Faix, J., and Weber, I. (2012). A dual role for Rac1 GTPases in the regulation of cell motility. J. Cell. Sci. 125, 387–398.

Book of abstracts

• Dicty 2023 Annual International Dictyostelium Conference : Book of Abstracts / Weber, Igor; Filić, Vedrana (ur.). Zagreb: Institut Ruđer Bošković, 2023

  event.fourwaves.comapi.fourwaves.com

Original scientific paper

• Čizmar, Anja; Putar, Darija; Šimić, Marija; Scholz, Jonas; Marinović, Maja; Horvat, Lucija; Matovina, Mihaela; Weber, Igor; Faix, Jan; Filić, Vedrana | IqgD is a Rac1-interacting IQGAP required for efficient growth of Dictyostelium discoideum on bacterial lawns // Cell Communication and Signaling, (2026), doi: 10.1186/s12964-026-03074-w

  doilink.springer.com

• Mijanović, Lucija; Putar, Darija; Mimica, Lucija; Klajn, Sabina; Filić, Vedrana; Weber, Igor | The IQGAP-related RasGAP IqgC regulates cell–substratum adhesion in Dictyostelium discoideum // Cellular & molecular biology letters, 30 (2025), 4, 27. doi: 10.1186/s11658-024-00678-3

  doicmbl.biomedcentral.comfulir.irb.hr

• Šoštar, Marko; Marinović, Maja; Filić, Vedrana; Pavin, Nenad; Weber, Igor | Oscillatory dynamics of Rac1 activity in Dictyostelium discoideum amoebae // Plos computational biology, 20 (2024), 12; e1012025, 42. doi: 10.1371/journal.pcbi.1012025

  doijournals.plos.orgfulir.irb.hr

• Putar, Darija; Čizmar, Anja; Chao, Xiaoting; Šimić, Marija; Šoštar, Marko; Ćutić, Tamara; Mijanović, Lucija; Smolko, Ana; Tu, Hui; Cosson, Pierre et al. | IqgC is a potent regulator of macropinocytosis in the presence of NF1 and its loading to macropinosomes is dependent on RasG // Open Biology, 14 (2024), 1; 230372, 17. doi: 10.1098/rsob.230372

  doiroyalsocietypublishing.orgfulir.irb.hr

• Skelin, Josipa; Đukić, Anamaria; Filić, Vedrana ; Hufbauer, Martin ; Akgul, Baki ; Thomas Miranda ; Lawrence, Banks ; Tomaić, Vjekoslav | MAML1-induced HPV E6 oncoprotein stability is required for cellular proliferation and migration of cervical tumor-derived cells // Journal of medical virology, 95 (2023), 3; 5, 19. doi: 10.1002/jmv.28624

  doifulir.irb.hronlinelibrary.wiley.com

• Matovina, Mihaela; Tomašić Paić, Ana; Tomić, Sanja; Brkić, Hrvoje; Horvat, Lucija; Barbarić, Lea; Filić, Vedrana; Pinterić, Marija; Jurić, Snježana; Kussayeva, Akmaral | Identification of SH2 Domain-Containing Protein 3C as a Novel, Putative Interactor of Dipeptidyl Peptidase 3 // International journal of molecular sciences, 24 (2023), 18; 14178, 19. doi: 10.3390/ijms241814178

  doiwww.mdpi.comfulir.irb.hr

• Bodinier, Romain ; Sabra, Ayman ; Leiba, Jade ; Marchetti, Anna ; Lamrabet, Otmane ; Ayadi, Imen ; Filić, Vedrana ; Kawata, Takefumi ; Weber, Igor ; Cosson, Pierre | Role of LrrkA in the Control of Phagocytosis and Cell Motility in Dictyostelium discoideum // Frontiers in cell and developmental biology, 9 (2021), 629200, 11. doi: 10.3389/fcell.2021.629200

  doiwww.frontiersin.orgfulir.irb.hr

• Podgorski, Iva I. ; Pinterić, Marija ; Marčinko, Dora ; Popović Hadžija, Marijana ; Filić, Vedrana ; Ciganek, Ivan ; Pleše, Denis ; Balog, Tihomir ; Sobočanec, Sandra | Combination of sirtuin 3 and hyperoxia diminishes tumorigenic properties of MDA-MB-231 cells // Life sciences, 254 (2020), 117812, 13. doi: 10.1016/j.lfs.2020.117812

  doiwww.sciencedirect.comdoi.org

• Pinterić, Marija ; Podgorski, Iva I. ; Popović- Hadžija, Marijana ; Filić, Vedrana ; Paradžik, Mladen ; Proust, Bastien Lucien Jean ; Dekanić, Ana ; Ciganek, Ivan ; Pleše, Denis ; Marčinko, Dora et al. | Sirt3 Exerts Its Tumor-Suppressive Role by Increasing p53 and Attenuating Response to Estrogen in MCF-7 Cells // Antioxidants, 9 (2020), 4; 294, 21. doi: 10.3390/antiox9040294

  doiwww.mdpi.comfulir.irb.hr

• Buljubašić, Maja ; Hlevnjak, Ana ; Repar, Jelena ; Đermić, Damir ; Filić, Vedrana ; Weber, Igor ; Zahradka, Ksenija ; Zahradka, Davor | RecBCD- RecFOR-independent pathway of homologous recombination in Escherichia coli // DNA repair, 83 (2019), 102670, 16. doi: 10.1016/j.dnarep.2019.102670

  doidoi.orgwww.sciencedirect.com

• Saidu, Nathaniel Edward Bennett ; Filić, Vedrana ; Thomas, Miranda ; Sarabia-Vega, Vanessa ; Đukić, Anamaria ; Miljković, Frane ; Banks, Lawrence ; Tomaić, Vjekoslav | PDZ Domain-Containing Protein NHERF-2 Is a Novel Target of Human Papillomavirus 16 (HPV-16) and HPV-18 // Journal of virology, 94 (2019), 1; e00663-19-e00663-19. doi: 10.1128/JVI.00663-19

  doijvi.asm.orgdoi.org

• Marinović, Maja ; Mijanović, Lucija ; Šoštar, Marko ; Vizovišek, Matej ; Junemann, Alexander ; Fonović, Marko ; Turk, Boris ; Weber, Igor ; Faix, Jan ; Filić, Vedrana | IQGAP-related protein IqgC suppresses Ras signaling during large-scale endocytosis // Proceedings of the National Academy of Sciences of the United States of America, 116 (2019), 4; 1289-1298. doi: 10.1073/pnas.1810268116

  doidoi.orgwww.pnas.org

• Filić, Vedrana ; Marinović, Maja ; Šoštar, Marko ; Weber, Igor | Modulation of small GTPase activity by NME proteins // Laboratory investigation, 98 (2018), 5; 589-601. doi: 10.1038/s41374-018-0023-x

  doiwww.nature.com

• Junemann, A. ; Filić, Vedrana ; Winterhoff, M. ; Nordholz, B. ; Litschko, C. ; Schwellenbach, H. ; Stephan, T. ; Weber, Igor ; Faix, J. | A Diaphanous-related formin links Ras signaling directly to actin assembly in macropinocytosis and phagocytosis // Proceedings of the National Academy of Sciences of the United States of America, 113 (2016), 47; E7464-E7473. doi: 10.1073/pnas.1611024113

  doiwww.pnas.org

• Marinović, Maja ; Šoštar, Marko ; Filić, Vedrana ; Antolović, Vlatka ; Weber, Igor | Quantitative imaging of Rac1 activity in Dictyostelium cells with a fluorescently labelled GTPase-binding domain from DPAKa kinase // Histochemistry and cell biology, 146 (2016), 3; 267-279. doi: 10.1007/s00418-016-1440-9

  doilink.springer.com

• Sobočanec, Sandra ; Filić, Vedrana ; Matovina, Mihaela ; Majhen, Dragomira ; Šafranko, Željka Mačak ; Popović Hadžija, Marijana ; Krsnik, Željka ; Gudan Kurilj, Andrea ; Šarić, Ana ; Abramić, Marija et al. | Prominent role of exopeptidase DPP III in estrogen-mediated protection against hyperoxia in vivo // Redox Biology, 8 (2016), 149-159. doi: 10.1016/j.redox.2016.01.003

  doi

• Filić, Vedrana ; Marinović, Maja ; Faix, Jan ; Weber, Igor | The IQGAP-related protein DGAP1 mediates signaling to the actin cytoskeleton as an effector and a sequestrator of Rac1 GTPases // Cellular and molecular life sciences, 71 (2014), 15; 2775-2785. doi: 10.1007/s00018-014-1606-3

  doilink.springer.com

• Antolović, Vlatka ; Marinović, Maja ; Filić, Vedrana ; Weber, Igor | A simple optical configuration for cell tracking by dark-field microscopy // Journal of microbiological methods, 104 (2014), 9-11. doi: 10.1016/j.mimet.2014.06.006

  doiwww.sciencedirect.com

• Bursać, Slađana ; Cokarić Brdovčak, Maja ; Pfannkuchen, Martin ; Oršolić, Ines ; Golomb, Lior ; Zhu, Yan ; Katz, Chen ; Daftuar, Lylin ; Grabušić, Kristina ; Vukelić, Iva et al. | Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress // Proceedings of the National Academy of Sciences of the United States of America, 109 (2012), 50; 20467-20472. doi: 10.1073/pnas.1218535109

  doiwww.pnas.org

• Filić, Vedrana ; Marinović, Maja ; Faix, Jan ; Weber, Igor | A dual role for Rac1 GTPases in the regulation of cell motility // Journal of cell science, 125 (2012), 2; 387-398. doi: 10.1242/jcs.089680

  doijcs.biologists.org

• Annesley, Sarah J. ; Bago, Ružica ; Herak Bosnar, Maja ; Filić, Vedrana ; Marinović, Maja ; Weber, Igor ; Mehta, Anil ; Fisher, Paul R. | Dictyostelim discoideum nucleoside diphosphate kinase C plays a negative regulatory role in phagocytosis, macropinocytosis and exocytosis // PLoS One, 6 (2011), 10; e26024, 11. doi: 10.1371/journal.pone.0026024

  doifulir.irb.hrjournals.plos.org

• Jeličić, Branka ; Traven, Ana ; Filić, Vedrana ; Sopta, Mary | Mitochondrial dysfunction enhances Gal4 dependent transcription // FEMS microbiology letters, 253 (2005), 2; 207-213. doi: 10.1016/j.femsle.2005.09.033

  doiacademic.oup.comdoi.org

• Filić, Vedrana ; Vladić, Anton ; Štefulj, Jasminka ; Čičin-Šain, Lipa ; Balija, Melita ; Sučić, Zvonimir ; Jernej, Branimir | Monoamine Oxidases A and B Gene Polymorphisms in Migraine Patients // Journal of the neurological sciences, 228 (2005), 2; 149-153. doi: 10.1016/j.jns.2004.11.045

  doiwww.sciencedirect.comdoi.org

Review article (scientific)

• Filić, Vedrana; Weber, Igor | Queue Gaps Among the IQGAPs in Dictyostelium discoideum // International journal of molecular sciences, 27 (2026), 12; 5462-5462. doi: 10.3390/ijms27125462

  doiwww.mdpi.com

• Svob Strac, Dubravka; Filic, Vedrana; Filosevic Vujnovic, Ana; Vrhovac Madunic, Ivana; Madunic, Josip; Cipak Gasparovic, Ana; Havelka Mestrovic, Ana; Andretic Waldowski, Rozi | Non-mammalian models for mitochondria research in CNS disorders // Biomolecules, 16 (2026), 7; 1072, 33. doi: 10.3390/biom16071072

  doiwww.mdpi.com

• Filić, Vedrana; Putar, Darija; Mijanović, Lucija; Weber, Igor | Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families // FEBS Open Bio, 16 (2025), 2; 268-278. doi: 10.1002/2211-5463.70083

  doifebs.onlinelibrary.wiley.comfulir.irb.hr

• Filić, Vedrana; Weber, Igor | A young researcher’s guide to three-dimensional fluorescence microscopy of living cells // Periodicum biologorum, 125 (2023), 1-2; 133-137. doi: 10.18054/pb.v125i1-2.25140

  doihrcak.srce.hrfulir.irb.hr

• Filić, Vedrana ; Mijanović, Lucija ; Putar, Darija ; Talajić, Antea ; Ćetković, Helena ; Weber, Igor | Regulation of the Actin Cytoskeleton via Rho GTPase Signalling in Dictyostelium and Mammalian Cells: A Parallel Slalom // Cells, 10 (2021), 7; 1592, 39. doi: 10.3390/cells10071592

  doiwww.mdpi.comdoi.orgfulir.irb.hr

Editorial

• Filić, Vedrana; Weber, Igor | Rho GTPases in Model Systems // Cells, 12 (2023), 5; 779, 4. doi: 10.3390/cells12050779

  doidoi.orgfulir.irb.hr

Croatian Society of Biochemistry and Molecular Biology, member of Executive Committee

Croatian Microscopy Society