Dragomira Majhen

Dragomira Majhen

dr.sc.

senior research associate
+385 1 456 1145

1545
1876

Krilo 5/6

Ruder Boskovic Institute
Department of Molecular Biology
Laboratory for Cell Biology and Signalling
Bijenicka 54
10000 Zagreb
Croatia

Majhen_CV_2017_eng.pdf 187.63 kB

Education

  • 2008 Zagreb, Croatia, Faculty of Science, Unversity of Zagreb. PhD; Field of biochemistry and molecular biology
  • 2005 Zagreb, Croatia, Faculty of Science, Unversity of Zagreb, Mr. Sc. ; Field of biology
  • 2001 Zagreb, Croatia, Faculty of Science, Unversity of Zagreb, B. Sc. ; Field of molecular biology

Projects

2018-2019 HR SLO bilateral project: Testing biocompatibility of molybdenum and tungsten based nanoparticles: measuring cytotoxicity and inflammatory response in human cell lines

2016-2017 HAMAG BICRO Proof of concept: VirusHunter-identifying new potentially pathogen viruses

2015-2018 Croatian Science Foundation Installation research project: Understanding cell entry pathway of Adenovirus type 26: way of improving vaccine vectors

2010-2011 UKF: Deciphering entry pathway of NGR-retargeted adenovirus vectors by confocal microscopy

Classes

Assistant on postgraduate study:

  • Faculty of Science, Zagreb; “Molecular basis of gene therapy”, assistant to principal lecturer dr Andreja Ambriovic Ristov;
  • Faculty of food technology and biotechnology, Zagreb; “Gene therapy”, assistant to principal  lecturer dr Andreja Ambriovic Ristov

Featured Publications

http://www.ncbi.nlm.nih.gov/pubmed/?term=majhen

  1. Nestić D, Uil TG, Ma J, Roy S, Vellinga J, Baker AH, Custers J, Majhen D. αvβ3 Integrin is Required for Efficient Infection of Epithelial Cells with Human Adenovirus Type 26. J Virol. 2018 Oct 17. pii: JVI.01474-18. 
  2. Bressy C, Majhen D, Raddi N, Jdey W, Cornilleau G, Zig L, Guirouilh-Barbat J, Lopez BS, Bawa O, Opolon P, Grellier E, Benihoud K. Combined therapy of colon carcinomas with an oncolytic adenovirus and valproic acid. Oncotarget. 2017 Oct 26;8(57):97344-97360.
  3. MajhenD, Calderon H, Chandra N, Fajardo CA, Rajan A, Alemany R, Custers J. Adenovirus-based vaccines for fighting infectious diseases and cancer: progress in the field. Hum Gene Ther. 2014 Apr;25(4):301-17.
  4. MajhenD, Stojanović N, Vukić D, Pichon C, Leduc C, Osmak M, Ambriović-Ristov A. Increased adenovirus Type 5 mediated transgene expression due to RhoB down-regulation. PLoS One. 2014 Jan 22;9(1):e86698.
  5. MajhenD, Richardson J, Vukelić B, Dodig I, Cindrić M, Benihoud K, Ambriović-Ristov A. The disulfide bond of an RGD4C motif inserted within the Hi loop of the adenovirus type 5 fiber protein is critical for retargeting to αv -integrins. J Gene Med. 2012 Dec;14(12):788-97.
  6. Majhen D, Stojanović N, Špeljko T, Brozovic A, De Zan T, Osmak M, Ambriović-Ristov A. Increased expression of the coxsackie and adenovirus receptor downregulates αvβ3 and αvβ5 integrin expression, reduces cell adhesion and migration. Life Sci. 2011.  Life Sci. 2011 Aug 15;89(7-8):241-9.
  7. Majhen D, Brozovic A, Buger T, Gabrilovac J, Osmak M, Ambriović-Ristov A. Vincristine-resistant human laryngeal carcinoma cells demonstrate increased Rous sarcoma virus promoter activity. Life Sci. 2010 Oct 9;87(15-16):468-74.
  8. Majhen D, Nemet J, Richardson J, Gabrilovac J, Hajsig M, Osmak M, Eloit M, Ambriović-Ristov A. Differential role of alpha(v)beta(3) and alpha(v)beta(5) integrins in internalization and transduction efficacies of wild type and RGD4C fiber-modified adenoviruses. Virus Res. 2009 Jan;139(1):64-73.
  9. Majhen D, Gabrilovac J, Eloit M, Richardson J, Ambriović-Ristov A. Disulfide bond formation in    NGR fiber-modified adenovirus is essential for retargeting to aminopeptidase N. Biochem Biophys Res Commun. 2006 Sep 15;348(1):278-87.
  10. Majhen D, Ambriović-Ristov A. Adenoviral vectors--how to use them in cancer gene therapy? Virus Res. 2006 Aug;119(2):121-33.

Membership in professional associations / societies

  • Member of “French Society for Cell and Gene Therapy”
  • Member of “Croatian Association for Cancer Research”
  • Member of “Croatian Society of Biochemistry and Molecular Biology”
  • Member of “Croatian Microbiology Society”

Miscellaneous

Awarded grants and fellowships:

  • 2013-2014. Crucell Holland BV, The Netherlands, Experienced Researcher in the FP7 Marie Curie ITN ADVance program
  • 2010-2012. CNRS UMR8203 IGR Villejuif, France; postdoctoral fellowship: Gaining Experience Grant, Unity Through Knowledge Fund
  • 2010-2012. CNRS UMR8203 IGR Villejuif, France; Croatian Science Foundation Postdoctoral grant
  • 2009. UMR 1161 Virologie INRA-AFSSA- ENVA, Ecole Nationale Veterinaire, Maisons Alfort, France; Boehringer Ingelheim travel grant
  • 2007. INSERM U 524, Institute de Recherche sur le Cancer, Lille, France; Croatian Ministry of science fellowship
  • 2006. . INSERM U 524, Institute de Recherche sur le Cancer, Lille, France; FEMS short term fellowship
  • 2004. UMR 1161 Virologie INRA-AFSSA- ENVA, Ecole Nationale Veterinaire, Maisons Alfort,, France; French Embassy fellowship
  • 2003. UMR 1161 Virologie INRA-AFSSA- ENVA, Ecole Nationale Veterinaire, Maisons Alfort, France; EMBO short term fellowship

Organisation skills, committees and boards:

  • 2005-2010: representative of assistants of Department of Molecular biology at Assistant Council at Ruđer Bošković Institute, vice president of Assistant Council
  • 2005-2006, 2007-2010: member of Board  of postgraduate students association "Mreža mladih znanstvenika", MLAZ www.mlaz.net
  • 2002-2003.  coordinator of "Mladi istraživači", section of Croatian Biological Society
  • 2007-2008. member of organizing committee of workshop: "Adenoviruses basic biology to gene therapy" www.hmd-cms.hr/adenoviruses/index.html
  • 2007- 2014, Board member of  "Festival of Conversation for Culture and Science" http://www.flow-festival.com/
  • 2013-2014. member of organizing committee of summer school: "Power of Viral Vectors in Gene Therapy and Basic Science”, http://hmd-cms.hr/viral-vectors/

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