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Unlocking the antibiotic production potential in soil bacteria Streptomyces coelicolor

Principal investigator

Project type
Znanstveno-istraživački projekti
Horizon 2020
European Commission
Start date
Oct 18th 2019
End date
Oct 17th 2021
Total cost
147463 EUR
More information

The majority of antibiotics for medical, veterinary and agricultural applications are derived from secondary metabolites produced by the Streptomyces bacteria. However, the huge number of antimicrobial compounds these bacteria currently supply is likely to be only the tip of the iceberg. Much remains unknown about their metabolic pathways. ADP-ribosylation (addition of ADP linked to the sugar ribose) is widely conserved in viruses, bacteria and eukaryotes. It is important in numerous cellular processes and has been linked to antibiotic resistance in bacteria. Following the trail of ADP-ribosylation pathways in Streptomyces, STREPUNLOCKED plans to unlock the potential of these bacteria to deliver novel and effective therapeutics that combat the perfidious and increasing emergence of multi-drug resistant microorganisms.

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