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Uloga sirtuina 1 (SIRT1) u zloćudnim tumorima ne-malih stanica pluća

Mogući molekularni mehanizmi uključeni u poremećenu regulaciju petlje: KIAA1967/DBC1 -HIC1 - SIRT1 - p53

Kategorija projekta

Projekti Hrvatske zaklade za znanost

Ciljevi projekta su odrediti:

a) molekularne mehanizme poremećene regulacije petlje: KIAA1967/DBC1-HIC1-SIRT1-p53, in vitro;

b) funkcionalne posljedice selektivnog utišavanja SIRT1, in vitro.

Glavni istraživač / voditelj

Ivana Grbeša, dr. sc.

viši asistent

Ivana.Grbesa@irb.hr

+385 1 456 0949

Ostali suradnici

Dr. sc. Koraljka Gall Trošelj, suradnik

Dr. sc. Ruben Pio Oses, suradnik

Dr. sc. Luis Montuenga Badia, suradnik

Najnoviji radovi ZMM-a

1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro
Author(s):Teofilović, N.K. | Bihi, M. | Stojković, M.R. | Tumir, L.M. | Ester, K. | Kralj, M. | Majhen, D. | Oršolić, N. | Lepur, A. | Vrbanec, D. | Markotić, A. | Dembić, Z. | Weber, A.N.R. | Piantanida, I. | Vugrek, O. | Diken, M. | Knežević, J.
Publication year: 2017
Journal / Book title: Bioorganic and Medicinal Chemistry Letters
1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues - Model Compounds Targeting Oxidative Stress
Author(s):Velena, A. | Zarkovic, N. | Gall Troselj, K. | Bisenieks, E. | Krauze, A. | Poikans, J. | Duburs, G.
Publication year: 2016
Journal / Book title: Oxidative Medicine and Cellular Longevity
1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues - Model Compounds Targeting Oxidative Stress
Author(s):Velena, A. | Zarkovic, N. | Gall Troselj, K. | Bisenieks, E. | Krauze, A. | Poikans, J. | Duburs, G.
Publication year: 2016
Journal / Book title: Oxidative Medicine and Cellular Longevity
1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues - Model Compounds Targeting Oxidative Stress
Author(s):Velena, A. | Zarkovic, N. | Gall Troselj, K. | Bisenieks, E. | Krauze, A. | Poikans, J. | Duburs, G.
Publication year: 2016
Journal / Book title: Oxidative Medicine and Cellular Longevity
4-hydroxynonenal causes impairment of human subcutaneous adipogenesis and induction of adipocyte insulin resistance
Author(s):Elrayess, M.A. | Almuraikhy, S. | Al-Menhali, A. | Al-Khelaifi, F. | Alsayrafi, M. | Jaganjac, M.
Publication year: 2017
Journal / Book title: Free Radical Biology and Medicine
A low-grade ovarian carcinoma case with coincident LOH of PTCH1 and BRCA1, and a mutation in BRCA
Author(s): Maurac, I. , Sabol, M. , Musani, V. , Car, D. , Ozretic, P. , ...
Publication year: 2012
Journal / Book title: International Journal of Gynecological Pathology
A novel PSEN1 mutation (I238M) associated with early-onset Alzheimer's disease in an African-American woman
Author(s):Ting, S.K.S. | Benzinger, T. | Kepe, V. | Fagan, A. | Coppola, G. | Porter, V. | Hecimovic, S. | Chakraverty, S. | Alvarez-Retuerto, A.I. | Goate, A. | Ringman, J.M.
Publication year: 2014
Journal / Book title: Journal of Alzheimer's Disease
A prospective, longitudinal study of platelet serotonin and plasma brain-derived neurotrophic factor concentrations in major depression: effects of vortioxetine treatment
Author(s):Sagud, M. | Nikolac Perkovic, M. | Vuksan-Cusa, B. | Maravic, A. | Svob Strac, D. | Mihaljevic Peles, A. | Zivkovic, M. | Kusevic, Z. | Pivac, N.
Publication year: 2016
Journal / Book title: Psychopharmacology
A prospective, longitudinal study of platelet serotonin and plasma brain-derived neurotrophic factor concentrations in major depression: effects of vortioxetine treatment
Author(s):Sagud, M. | Nikolac Perkovic, M. | Vuksan-Cusa, B. | Maravic, A. | Svob Strac, D. | Mihaljevic Peles, A. | Zivkovic, M. | Kusevic, Z. | Pivac, N.
Publication year: 2016
Journal / Book title: Psychopharmacology
Abnormal hypermethylation at imprinting control regions in patients with S-adenosylhomocysteine hydrolase (AHCY) deficiency
Author(s):Motzek, A. | Knežević, J. | Switzeny, O.J. | Cooper, A. | Baric, I. | Beluzić, R. | Strauss, K.A. | Puffenberger, E.G. | Mudd, S.H. | Vugrek, O. | Zechner, U.
Publication year: 2016
Journal / Book title: PLoS ONE
Absence of Helicobacter pylori in healthy laryngeal mucosa
Author(s): Pajić-Penavić, I. , Danić, D. , Maslovara, S. , Gall-Trošelj, K.
Publication year: 2012
Journal / Book title: Journal of Laryngology and Otology
Accumulation of β-agonists clenbuterol and salbutamol in black and white mouse hair
Author(s): Vulić, A. , Pleadin, J. , Perši, N. , Stojković, R. , Ivanković, S.
Publication year: 2011
Journal / Book title: Journal of Analytical Toxicology
Accurate models for P-gp drug recognition induced from a cancer cell line cytotoxicity screen
Author(s):Levatić, J. | Ćurak, J. | Kralj, M. | Šmuc, T. | Osmak, M. | Supek, F.
Publication year: 2013
Journal / Book title: Journal of Medicinal Chemistry
Accurate models for P-gp drug recognition induced from a cancer cell line cytotoxicity screen
Author(s):Levatić, J. | Ćurak, J. | Kralj, M. | Šmuc, T. | Osmak, M. | Supek, F.
Publication year: 2013
Journal / Book title: Journal of Medicinal Chemistry
Activation of aerobic metabolism by Amaranth oil improves heart rate variability both in athletes and patients with type 2 diabetes mellitus
Author(s): Yelisyeyeva, O. , Semen, K. , Zarkovic, N. , Kaminskyy, D. , Lutsyk, O. , ...
Publication year: 2012
Journal / Book title: Archives of Physiology and Biochemistry
Acute treatment with fluvoxamine elevates rat brain serotonin synthesis in some terminal regions: An autoradiographic study
Author(s): Muck-Seler, D. , Pivac, N. , Diksic, M.
Publication year: 2012
Journal / Book title: Nuclear Medicine and Biology
Acute treatment with fluvoxamine elevates rat brain serotonin synthesis in some terminal regions: An autoradiographic study
Author(s):Muck-Seler, D. | Pivac, N. | Diksic, M.
Publication year: 2012
Journal / Book title: Nuclear Medicine and Biology
Adsorption of proteins and cell adhesion to plasma treated polymer substrates
Author(s):Recek, N. | Mozetic, M. | Jaganjac, M. | Milkovic, L. | Zarkovic, N. | Vesel, A.
Publication year: 2014
Journal / Book title: International Journal of Polymeric Materials and Polymeric Biomaterials
Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): An overview of their mechanisms of formation
Author(s):Vistoli, G. | De Maddis, D. | Cipak, A. | Zarkovic, N. | Carini, M. | Aldini, G.
Publication year: 2013
Journal / Book title: Free Radical Research
Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): An overview of their mechanisms of formation
Author(s):Vistoli, G. | De Maddis, D. | Cipak, A. | Zarkovic, N. | Carini, M. | Aldini, G.
Publication year: 2013
Journal / Book title: Free Radical Research

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Uloga sirtuina 1 (SIRT1) u zloćudnim tumorima ne-malih stanica pluća

Ivana Grbeša, dr. sc.

Zavod za molekularnu medicinu