Dr. Jovica Lončar
Ruđer Bošković Institute
Bijenička 54
HR-10000 Zagreb
Education
BSc - 2005, Faculty of Food Technology and Biotechnology, Biotechnology, University of Zagreb, Zagreb, Croatia
PhD - 2007 - in progress, Faculty of Food Technology and Biotechnology, Biotechnology, University of Zagreb, Zagreb, Croatia
Featured Publications
- Traven, L., Žaja, R., Lončar, J., Smital, T., Mićović, V., 2008. CYP1A induction potential and the concentration of priority pollutants in marine sediment samples – In vitro evaluation using the PLHC-1 fish hepatoma cell line. Toxicol in Vitro. 22, 1648-1656.
- Zaja, R., Caminada, D., Lončar, J., Fent, K., Smital, T., 2008. Development and characterization of P-glycoprotein 1 (Pgp1,ABCB1)-mediated doxorubicin-resistant PLHC-1 hepatoma fish cell line. Toxicol. Appl. Pharm. 227, 207-218.
- Lončar, J.,Popović, M., Zaja, R., Smital, T., 2010. Gene expression analysis of the ABC efflux transporters in rainbow trout (Oncorhynchus mykiss). Comp. Biochem. Physiol. C-Toxicol. Pharmacol 151 (2), 209-21
- Zaja, R.,Loncar, J., Popovic.,M., Smital, T. (2011). First characterization of fish P-glycoprotein (abcb1) substrate specificity using determinations of its ATPase activity and calcein-AM assay with PLHC-1/dox cell line. Aquat. Toxicol. 103: 53-62.
Publications
Journal articles
Scientific and review papers
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Karaica, D., Mihaljević, I., Vujica, L., Bošnjak, A., Dragojević, J., Otten, C., Babić, N., Lončar, J. & Smital, T. (2022) Stage‐dependent localization of F‐actin and Na + /K + ‐ ATPase in zebrafish embryos detected using optimized cryosectioning immunostaining protocol. Microscopy Research and Technique, 2022, 1-17 doi:10.1002/jemt.24270.
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Marić, P., Ahel, M., Maraković, N., Lončar, J., Mihaljević, I. & Smital, T. (2021) Selective interaction of microcystin congeners with zebrafish (Danio rerio) Oatp1d1 transporter. Chemosphere, 283, 131155, 12 doi:10.1016/j.chemosphere.2021.131155.
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Mišić Radić, T., Čačković, A., Penezić, A., Dautović, J., Lončar, J., Omanović, D., Juraić, K. & Ljubešić, Z. (2021) Physiological and morphological response of marine diatom Cylindrotheca closterium (Bacillariophyceae) exposed to cadmium. European journal of phycology, 56 (1), 24-36 doi:10.1080/09670262.2020.1758347.
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Dragojević, J., Marić, P., Lončar, J., Popović, M., Mihaljević, I. & Smital, T. (2020) Environmental contaminants modulate transport activity of zebrafish organic anion transporters Oat1 and Oat3. Comparative biochemistry and physiology. C. Toxicology & pharmacology, 231, 108742, 8 doi:10.1016/j.cbpc.2020.108742.
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Kostanjevečki, P., Petrić, I., Lončar, J., Smital, T., Ahel, M. & Terzić, S. (2019) Aerobic biodegradation of tramadol by pre- adapted activated sludge culture: Cometabolic transformations and bacterial community changes during enrichment. Science of the total environment, 687, 858-866 doi:10.1016/j.scitotenv.2019.06.118.
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Kostanjevečki, P., Sviličić Petrić, I., Lončar, J., Smital, T., Ahel, M. & Terzić, S. (2019) Biodegradation study of methadone by adapted activated sludge: Elimination kinetics, transformation products and ecotoxicological evaluation. Chemosphere, 214, 719-728 doi:10.1016/j.chemosphere.2018.09.153.
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Karaica, D., Breljak, D., Lončar, J., Lovrić, M., Micek, V., Vrhovac Madunić, I., Brzica, H., Herak-Kramberger, C., Ivković Dupor, J., Ljubojević, M., Smital, T., Vogrinc, Ž., Burckhardt, G., Burckhardt, B. & Sabolić, I. (2018) Sex-independent expression of chloride/formate exchanger Cfex (Slc26a6) in rat pancreas, small intestine, and liver, and male-dominant expression in kidneys. Arhiv za higijenu rada i toksikologiju, 69 (4), 286-303 doi:10.2478/aiht-2018-69-3157.
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Terzić, S., Udiković-Kolić, N., Jurina, T., Krizman-Matasić, I., Senta, I., Mihaljević, I., Lončar, J., Smital, T. & Ahel, M. (2018) Biotransformation of macrolide antibiotics using enriched activated sludge culture: Kinetics, transformation routes and ecotoxicological evaluation. Journal of hazardous materials, 349, 143-152 doi:10.1016/j.jhazmat.2018.01.055.
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Lončar, J. & Smital, T. (2018) Interaction of environmental contaminants with zebrafish multidrug and toxin extrusion protein 7 (Mate7/Slc47a7). Aquatic toxicology, 205, 193-203 doi:10.1016/j.aquatox.2018.10.016.
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Žaja, R., Popović, M., Lončar, J. & Smital, T. (2016) Functional characterization of rainbow trout (Oncorhynchus mykiss) Abcg2a (Bcrp) transporter. Comparative biochemistry and physiology. C. Toxicology & pharmacology, 190, 15-23 doi:10.1016/j.cbpc.2016.07.005.
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Lončar, J., Popović, M., Krznar, P., Žaja, R. & Smital, T. (2016) The first characterization of multidrug and toxin extrusion (MATE/SLC47) proteins in zebrafish (Danio rerio). Scientific Reports, 6, 28937, 15 doi:10.1038/srep28937.
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Glišić, B., Mihaljević, I., Popović, M., Žaja, R., Lončar, J., Fent, K., Kovačević, R. & Smital, T. (2015) Characterization of Glutathione-S-transferases in zebrafish (Danio rerio). Aquatic toxicology, 158, 50-62 doi:10.1016/j.aquatox.2014.10.013.
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Zaja, R., Terzić, S., Senta, I., Lončar, J., Popović, M., Ahel, M. & Smital, T. (2013) Identification of P-Glycoprotein Inhibitors in Contaminated Freshwater Sediments. Environmental science & technology, 47 (9), 4813-4821 doi:10.1021/es400334t.
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Smital, T., Terzić, S., Lončar, J., Senta, I., Žaja, R., Popović, M., Mikac, I., Tollefsen, K., Thomas, K. & Ahel, M. (2013) Prioritisation of organic contaminants in a river basin using chemical analyses and bioassays. Environmental science and pollution research international, 20 (3), 1384-1395 doi:10.1007/s11356-012-1059-x.
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Della Torre, C., Žaja, R., Lončar, J., Smital, T., Focardi, S. & Corsi, I. (2012) Interaction of ABC transport proteins with toxic metals at the level of gene and transport activity in the PLHC-1 fish cell line. Chemico-biological interactions, 198 (1/3), 9-17 doi:10.1016/j.cbi.2012.04.008.
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Fischer, S., Lončar, J., Žaja, R., Schnell, S., Schirmer, K., Smital, T. & Luckenbach, T. (2011) Constitutive mRNAexpression and protein activity levels of nine ABC efflux transporters in seven permanent cell lines derived from different tissues of rainbow trout (Oncorhynchus mykiss). Aquatic toxicology, 101 (2), 438-446 doi:10.1016/j.aquatox.2010.11.010.
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Žaja, R., Lončar, J., Popović, M. & Smital, T. (2011) First characterisation of fish P-glycoprotein (abcb1) substrate specificity using determinations of its ATPase activity and calcein-AM assay with PLHC-1/dox cell line. Aquatic toxicology, 103 (1/2), 53-62 doi:10.1016/j.aquatox.2011.02.005.
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Lončar, J., Popović, M., Žaja, R. & Smital, T. (2010) Gene expression analysis of the ABC efflux transporters in rainbow trout (Oncorhynchus mykiss). Comparative biochemistry and physiology. C. Toxicology & pharmacology, 151 (2), 209-215 doi:10.1016/j.cbpc.2009.10.009.
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Popović, M., Žaja, R., Lončar, J. & Smital, T. (2010) A novel ABC transporter: the first insight into zebrafish (Danio rerio) Abch1. Marine environmental research, 69 (S1), S11-S13 doi:10.1016/j.marenvres.2009.10.016.
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Traven, L., Žaja, R., Lončar, J., Smital, T. & Mićović, V. (2008) CYP1A induction potential and the concentration of priority pollutants in marine sediment samples – In vitro evaluation using the PLHC-1 fish hepatoma cell line. Toxicology in vitro, 22 (6), 1648-1656 doi:10.1016/j.tiv.2008.06.012.
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Žaja, R., Caminada, D., Lončar, J., Fent, K. & Smital, T. (2008) Development and characterization of P-glycoprotein 1 (Pgp1 ; ABCB1) mediated doxorubicin-resistant PLHC-1 hepatoma fish cell line. Toxicology and Applied Pharmacology, 227 (2), 207-218 doi:10.1016/j.taap.2007.11.001.
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Theses
Doctoral dissertation
Lončar, J. (2015) 'Function and regulation of ABC transport proteins in rainbow trout (Onchorynchus mykiss) tissues and cell lines', doktorska disertacija, Prehrambeno-biološki fakultet, Zagreb.
Membership in professional associations / societies
Croatian society of biochemistry and molecular biology - member