• Alterations in host protein trafficking during Human papillomavirus infection and oncogenesis - HPV-TRAFF-ONCO

  25.05.2026 - 24.05.2029 | 199,530.62 EUR

  CroRISIRB

• The Role of E6 Oncoprotein in HPV-mediated Oncogenesis - HPV-E6-ONCO

  31.12.2023 - 30.12.2027 | 197,049.57 EUR

  CroRISIRB

• Elucidating the HPV E6/E7 Oncogenic Functions at Different Anatomical Sites - DOK - HPVHNC

  05.10.2018 - 31.12.2022

  CroRISIRB

• Elucidating the HPV E6/E7 Oncogenic Functions at Different Anatomical Sites - HPVHNC

  15.05.2017 - 14.05.2021 | 131,661.03 EUR

  CroRISIRB

Conference proceedings

• Power of Viruses : Book of Abstracts / Bielen, Ana ; Ježić, Marin ; Jurak, Igor et al. (ur.). Zagreb: Hrvatsko mikrobiološko društvo, 2018

Professional paper

• Butorac, Dražan ; Grdić Rajković, Marija ; Tomaić, Vjekoslav ; Stojanović, Ivana | Psihosomatika premalignih i malignih bolesti vrata maternice // Psihosomatska medicina u ginekologiji i porodništvu. | Zagreb: Naklada Slap, 2022. str. 185-193

Original scientific paper

• Repušić, Doris; Korolija, Marina; Livun, Ana; Svaguša, Tomo; Belužić, Robert; Tomaić, Vjekoslav; Karlić, Rosa; Vlahoviček, Kristian | Multi‐Layered Genomic and Clinical Analysis Identifies Novel Variants, Co‐Occurring Single Nucleotide Polymorphism Pairs, and Clinical Determinants of Host‐Pathogen Interaction in COVID‐19 Severity // Journal of medical virology, 98 (2026), 6; e70984, 18. doi: 10.1002/jmv.70984

  doionlinelibrary.wiley.com

• Lulić, Lucija; Šimić, Ivana; Božinović, Ksenija; Pešut, Ena; Manojlović, Luka; Grce, Magdalena; Dediol, Emil; Sabol, Ivan; Tomaić, Vjekoslav | Moderate SCRIB expression levels correlate with worse prognosis in OPSCC patients regardless of HPV status // Cells, 13 (2024), 12; 1002, 13. doi: 10.3390/cells13121002

  doifulir.irb.hrwww.mdpi.com

• Skelin, Josipa; Đukić, Anamaria; Filić, Vedrana ; Hufbauer, Martin ; Akgul, Baki ; Thomas Miranda ; Lawrence, Banks ; Tomaić, Vjekoslav | MAML1-induced HPV E6 oncoprotein stability is required for cellular proliferation and migration of cervical tumor-derived cells // Journal of medical virology, 95 (2023), 3; 5, 19. doi: 10.1002/jmv.28624

  doifulir.irb.hronlinelibrary.wiley.com

• Avian, Alice; Clemente, Nicolò; Mauro, Elisabetta; Isidoro, Erica; Di Napoli, Michela; Dudine, Sandra; Del Fabro, Anna; Morini, Stefano; Perin, Tiziana; Giudici, Fabiola et al. | Clinical validation of full HR-HPV genotyping HPV Selfy assay according to the international guidelines for HPV test requirements for cervical cancer screening on clinician-collected and self-collected samples // Journal of translational medicine, 20 (2022), 1; 231, 12. doi: 10.1186/s12967-022-03383-x

  doilink.springer.comfulir.irb.hr

• Lulić, Lucija ; Jakovčević, Antonia ; Manojlović, Luka ; Dediol, Emil ; Banks, Lawrence ; Tomaić, Vjekoslav | Human DLG1 and SCRIB are distinctly regulated independently of HPV-16 during the progression of oropharyngeal squamous cell carcinomas: a preliminary analysis // Cancers, 13 (2021), 17; 4461, 15. doi: 10.3390/cancers13174461

  doiwww.mdpi.comfulir.irb.hr

• Kirschberg, Matthias ; Heuser, Sandra ; Marcuzzi, Gian Paolo ; Hufbauer, Martin ; Seeger, Jens Michael ; Đukić, Anamaria ; Tomaić, Vjekoslav ; Majewski, Slawomir ; Wagner, Steffen ; Wittekindt, Claus et al. | ATP synthase modulation leads to an increase of spare respiratory capacity in HPV associated cancers // Scientific reports, 10 (2020), 1; 17339, 12. doi: 10.1038/s41598-020-74311-6

  doiwww.nature.comwww.ncbi.nlm.nih.govdoi.orgfulir.irb.hr

• Saidu, Nathaniel Edward Bennett ; Filić, Vedrana ; Thomas, Miranda ; Sarabia-Vega, Vanessa ; Đukić, Anamaria ; Miljković, Frane ; Banks, Lawrence ; Tomaić, Vjekoslav | PDZ Domain-Containing Protein NHERF-2 Is a Novel Target of Human Papillomavirus 16 (HPV-16) and HPV-18 // Journal of virology, 94 (2019), 1; e00663-19-e00663-19. doi: 10.1128/JVI.00663-19

  doijvi.asm.orgdoi.org

• Szalmás, Anita ; Tomaić, Vjekoslav ; Basukala, Om ; Massimi, Paola ; Mittal, Suruchi ; Kónya , József ; Banks, Lawrence | The PTPN14 tumour suppressor is a degradation target of Human Papillomavirus E7 // Journal of virology, 91 (2017), 7; e00057-17. doi: 10.1128/JVI.00057-17

  doijvi.asm.orgdoi.org

• Zine El Abidine, Amira ; Tomaić, Vjekoslav ; Bel Haj Rhoumaa, Rahima ; Massimi, Paola ; Guizani, Ikram ; Boubaker, Samir ; Ennaifera, Emna ; Banks, Lawrence | A naturally occurring variant of HPV-16 E7 exerts increased transforming activity through acquisition of an additional phospho-acceptor site // Virology (New York, N.Y.), 500 (2017), 218-225. doi: 10.1016/j.virol.2016.10.023

  doiwww.sciencedirect.comdoi.org

• Subbaiah, Vanitha Krishna ; Zhang, Zhou Yan ; Rajagopalan, Deepa ; Abdullah, Nurrul Lissa ; Yeo-Teh, Nicole Shu ; Tomaić, Vjekoslav ; Banks, Lawrence ; Myers, Michael P. ; Chow, Edward Kai-Hua ; Jha, Sudhakar | E3 ligase EDD1/UBR5 is utilized by the HPV E6 oncogene to destabilize tumor suppressor TIP60 // Oncogene, 35 (2016), 2062-2074. doi: 10.1038/onc.2015.268

  doiwww.nature.com

• Ganti, Ketaki ; Massimi, Paola ; Manzo-Merino, Joaquin ; Tomaić, Vjekoslav ; Pim, David ; Playford, Martin P. ; Marcela, Lizano ; Roberts, Sally ; Kranjec, Christian ; Doorbar, John et al. | Interaction of the Human Papillomavirus E6 Oncoprotein with Sorting Nexin 27 Modulates Endocytic Cargo Transport Pathways // Plos pathogens, 12 (2016), 1-22. doi: 10.1371/journal.ppat.1005854

  doidoi.orgjournals.plos.org

• Kranjec, Christian ; Tomaić, Vjekoslav ; Massimi, Paola ; Nicolaides, Lietta ; Doorbar, John ; Banks, Lawrence | The high-risk HPV E6 target scribble (hScrib) is required for HPV E6 expression in cervical tumour-derived cell lines // Papillomavirus research, 2 (2016), 70-77. doi: 10.1016/j.pvr.2016.04.001

  doifulir.irb.hrwww.sciencedirect.comdoi.org

• Tomaić, Vjekoslav ; Banks, Lawrence | Angelman syndrome-associated ubiquitin ligase UBE3A/E6AP mutants interfere with the proteolytic activity of the proteasome // Cell Death & Disease, 6 (2015), e1625-1-e1625-8. doi: 10.1038/cddis.2014.572

  doiwww.nature.com

• Boon, Siaw Shi ; Tomaić, Vjekoslav ; Thomas, Miranda ; Roberts, Sally ; Banks, Lawrence | Cancer-Causing Human Papillomavirus E6 Proteins Display Major Differences in the Phospho-Regulation of Their PDZ Interactions // Journal of virology, 89 (2015), 3; 1579-1586. doi: 10.1128/JVI.01961-14

  doijvi.asm.orgjvi.asm.org

• Ganti Ketaki ; Broniarczyk Justyna ; Manoubi Wiem ; Massimi Paola ; Mittal Suruchi ; Pim David ; Szalmas Anita ; Thatte Jayashree ; Thomas Miranda ; Tomaić Vjekoslav et al. | The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy // Viruses, 7 (2015), 3530-3551

• Nagasaka, Kazunori ; Pim, David ; Massimi, Paola ; Thomas, Miranda ; Tomaić, Vjekoslav ; Subbaiah, Vanitha, Krishna ; Kranjec, Christian ; Nakagawa, Shunsuke ; Yano, Tetsu ; Taketani, Yuji et al. | The cell polarity regulator hScrib controls ERK activation through a KIM site-dependent interaction // Oncogene, 29 (2010), 38; 5311-5321. doi: 10.1038/onc.2010.265

  doi

• Tomaić, Vjekoslav ; Pim, David ; Banks, Lawrence | The stability of the human papillomavirus E6 oncoprotein is E6AP dependent // Virology (New York, N.Y.), 393 (2009), 1; 7-10. doi: 10.1016/j.virol.2009.07.029

  doi

• Pim, David ; Tomaić, Vjekoslav ; Banks, Lawrence | The human papillomavirus (HPV) E6* proteins from high-risk, mucosal HPVs can direct degradation of cellular proteins in the absence of full-length E6 protein. // Journal of virology, 83 (2009), 19; 9863-9874. doi: 10.1128/JVI.00539-09

  doi

• Gammoh, Noor ; Isaacson, Erin ; Tomaić, Vjekoslav ; Jackson, Deborah J ; Doorbar, John ; Banks, Lawrence | Inhibition of HPV-16 E7 oncogenic activity by HPV- 16 E2 // Oncogene, 28 (2009), 23; 2299-2304. doi: 10.1038/onc.2009.78

  doi

• Tomaić, Vjekoslav ; Gardiol, Daniela ; Massimi, Paola ; Ozbun, Michelle ; Myers, Michael ; Banks, Lawrence | Human and primate tumour viruses use PDZ binding as an evolutionarily conserved mechanism of targeting cell polarity regulators // Oncogene, 28 (2009), 1; 1-8. doi: 10.1038/onc.2008.365

  doi

• Thomas, Miranda ; Narayan, Nisha ; Pim, David ; Tomaić, Vjekoslav ; Massimi, Paola ; Nagasaka, Kazunori ; Kranjec, Christian ; Gammoh, Noor ; Banks, Lawrence | Human papillomaviruses, cervical cancer and cell polarity // Oncogene, 27 (2008), 55; 7018-7030. doi: 10.1038/onc.2008.351

  doi

• Liu, Xuefeng ; Disbrow, Gary L. ; Yuan, Hang ; Tomaić, Vjekoslav ; Schlegel, Richard | Myc and human papillomavirus type 16 E7 genes cooperate to immortalize human keratinocytes. // Journal of virology, 81 (2007), 22; 12689-12695. doi: 10.1128/JVI.00669-07

  doi

• Liu, Xuefeng ; Yuan, Hang ; Fu, Baojin ; Disbrow, Gary L. ; Apolinario, Tania ; Tomaić, Vjekoslav ; Kelley, Melissa L. ; Baker, Carl C. ; Huibregtse, Jon ; Schlegel, Richard | The E6AP Ubiquitin Ligase Is Required for Transactivation of the hTERT Promoter by the Human Papillomavirus E6 Oncoprotein // The Journal of biological chemistry, 280 (2005), 11; 10807-10816. doi: 10.1074/jbc.M410343200

  doi

Review article (scientific)

• Skelin, Josipa; Luk, Ho Yin; Butorac, Dražan; Boon, Siaw Shi; Tomaić, Vjekoslav | The effects of HPV oncoproteins on host communication networks: Therapeutic connotations // Journal of medical virology, 95 (2023), 12; e29315, 18. doi: 10.1002/jmv.29315

  doifulir.irb.hronlinelibrary.wiley.com

• Milutin Gašperov, Nina ; Sabol, Ivan ; Tomaić, Vjekoslav ; Grce, Magdalena | Epigenetički biljezi u tumorima glave i vrata: posebni osvrt na tumore orofarinksa povezane s HPV-om // Liječnički vjesnik : glasilo Hrvatskoga liječničkog zbora, 144 (2022), 3-4; 96-105. doi: 10.26800/lv-144-3-4-6

  doilijecnicki-vjesnik.hlz.hrfulir.irb.hr

• Tomaić, Vjekoslav ; Milutin Gašperov, Nina ; Sabol, Ivan ; Grce, Magdalena | Onkogeneza povezana s HPV-om u tumorima glave i vrata // Liječnički vjesnik : glasilo Hrvatskoga liječničkog zbora, 144 (2022), 3-4; 106-111. doi: 10.26800/lv-144-3-4-7

  doilijecnicki-vjesnik.hlz.hrfulir.irb.hr

• Skelin, Josipa ; Sabol, Ivan ; Tomaić, Vjekoslav | Do or Die: HPV E5, E6 and E7 in Cell Death Evasion // Pathogens, 11 (2022), 9; 1027, 16. doi: 10.3390/pathogens11091027

  doiwww.mdpi.comfulir.irb.hr

• Pešut, Ena ; Đukić, Anamaria ; Lulić, Lucija ; Skelin, Josipa ; Šimić, Ivana ; Gašperov, Nina Milutin ; Tomaić, Vjekoslav ; Sabol, Ivan ; Grce, Magdalena | Human Papillomaviruses-Associated Cancers: An Update of Current Knowledge // Viruses, 13 (2021), 11; 2234, 32. doi: 10.3390/v13112234

  doiwww.mdpi.comfulir.irb.hrdoi.org

• Đukić, Anamaria ; Lulić, Lucija ; Thomas, Miranda ; Skelin, Josipa ; Saidu, Nathaniel Edward Bennett ; Grce, Magdalena ; Banks, Lawrence ; Tomaić, Vjekoslav | HPV Oncoproteins and the Ubiquitin Proteasome System: A Signature of Malignancy? // Pathogens, 9 (2020), 2; 1-27. doi: 10.3390/pathogens9020133

  doiwww.mdpi.comdoi.orgfulir.irb.hr

• Tomaić, Vjekoslav | Functional Roles of E6 and E7 Oncoproteins in HPV-Induced Malignancies at Diverse Anatomical Sites // Cancers, 8 (2016), 10; 95, 22. doi: 10.3390/cancers8100095

  doifulir.irb.hrwww.mdpi.com

Other

• Tomaić, Vjekoslav ; Ganti, Ketaki ; Pim, David ; Bauer, Christina ; Blattner, Christine ; Banks, Lawrence | Interaction of HPV E6 oncoproteins with specific proteasomal subunits // Virology (New York, N.Y.), 446 (2013), 1-2; 389-396. doi: 10.1016/j.virol.2013.08.016

  doi

• Thomas, Miranda ; Tomaić, Vjekoslav ; Pim, David ; Myers, Michael P. ; Tommasino, Massimo ; Banks, Lawrence | Interactions between E6AP and E6 proteins from alpha and beta HPV types // Virology (New York, N.Y.), 435 (2013), 2; 357-362. doi: 10.1016/j.virol.2012.11.004

  doi

• Pim, David ; Bergant, Martina ; Boon, Siaw S. ; Ganti, Ketaki ; Kranjec, Christian ; Massimi, Paola ; Subbaiah, Vanitha K. ; Thomas, Miranda ; Tomaić, Vjekoslav ; Banks, Lawrence | Human papillomaviruses and the specificity of PDZ domain targeting // The FEBS journal, 279 (2012), 19; 3530-3537. doi: 10.1111/j.1742-4658.2012.08709.x

  doi

• Tomaic, V. ; Pim, D. ; Thomas, M. ; Massimi, P. ; Myers, M. P. ; Banks, L. | Regulation of the Human Papillomavirus Type 18 E6/E6AP Ubiquitin Ligase Complex by the HECT Domain-Containing Protein EDD // Journal of virology, 85 (2011), 7; 3120-3127. doi: 10.1128/jvi.02004-10

  doi

Short communication

• Lulić, Lucija; Jakovčević, Antonia; Kovačić, Iva; Manojlović, Luka; Dediol, Emil; Skelin, Josipa; Tomaić, Vjekoslav | HPV16 impacts NHERF2 expression in oropharyngeal cancers // Pathogens, 12 (2023), 8; 1013, 11. doi: 10.3390/pathogens12081013

  doiwww.mdpi.comfulir.irb.hr

Review, commentary, critique

• Skelin, Josipa; Tomaić, Vjekoslav | Comparative Analysis of Alpha and Beta HPV E6 Oncoproteins: Insights into Functional Distinctions and Divergent Mechanisms of Pathogenesis // Viruses, 15 (2023), 11; 2253, 25. doi: 10.3390/v15112253

  doifulir.irb.hrwww.mdpi.com

Conference abstract

• Đukić, Anamaria ; Skelin, Josipa; Filić, Vedrana ; Hufbauer, Martin ; Akgul, Baki ; Thomas Miranda ; Lawrence, Banks ; Tomaić, Vjekoslav | MAML1-induced HPV E6 oncoprotein stability is required for cellular proliferation and migration of cervical tumor-derived cells // 1st Biomedicine and Health PhD Students Congress “Science and Us” with international participation - Book of Abstracts. | Rijeka: Medicinski fakultet u Rijeci, 2022. str. 21-22

• Lulić, Lucija ; Đukić, Anamaria ; Skelin, Josipa ; Dediol, Emil ; Manojlović, Luka ; Tomaić, Vjekoslav | Novi potencijalni biomarkeri za određivanje razvoja HPV-uzrokovanih malignosti na području glave i vrata // Simpozij studenata doktorskih studija PMF-a : knjiga sažetaka. | Zagreb: Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu, 2020. str. 100-100

  urn.nsk.hr

• Đukić, Anamaria ; Thatte, Jayashree Vijay ; Thomas, Miranda ; Massimi, Paola ; Skelin Josipa ; Lulić, Lucija ; Banks, Lawrence ; Tomaić, Vjekoslav | Onkogeni potencijal varijanti E6 onkoproteina HPV- 16 // Simpozij "Prvih 10 godina HDIR-a" – knjiga sažetaka. | Zagreb: Hrvatsko društvo za istraživanje raka (HDIR), 2019. str. 21-21

  hdir.hr

• Đukić, Anamaria ; Thatte, Jayashree Vijay ; Thomas, Miranda ; Massimi, Paola ; Skelin, Josipa ; Lulić, Lucija ; Banks, Lawrence ; Tomaić, Vjekoslav | Oncogenic Potential of Naturally Occurring HPV- 16 E6 Variants // ICGEB DNA Tumour Virus Meeting. | Trst: Lithostampa SrL, Udine, Italija, 2019. str. 141-141

• Tomaić, Vjekoslav | Human papillomaviruses: From Infectious Entry to Malignancy // 5. Hrvatski simpozij o prevenciji i liječenju početnog raka vrata maternice s međunarodnim sudjelovanjem. | 2019. str. 2-2

• Saidu, Nathaniel Edward Bennett ; Filić Mileta, Vedrana ; Thomas, Miranda ; Miljković, Frane ; Banks, Lawrence ; Tomaić, Vjekoslav | PDZ-domain Containing Protein NHERF-2 is a Novel Target of Human Papillomavirus type 16 (HPV-16) and HPV- 18 // ICGEB DNA Tumour Virus Meeting. | Udine: Lithostampa SrL, 2019. str. 119-119

• Đukić, Anamaria ; Thatte Jayashree Vijay ; Božinović, Ksenija ; Dediol, Emil ; Grce, Magdalena ; Banks, Lawrence ; Tomaić, Vjekoslav | Biochemical Characterization of Naturally Occurring HPV-16 E6 and E7 Variants // Power of Viruses. | Zagreb: Hrvatsko mikrobiološko društvo, 2018. str. 69-69

• Tomaić, Vjekoslav | HPV-16 E7 Roles in Malignancy // FEBS3+ Conference: From Molecules to Living Systems : Final Programme & Book of Abstracts. | Veszprém, 2018. str. 45-45

Extended conference abstract

• Korolija, Marina ; Karlić, Rosa ; Livun, Ana ; Belužić, Robert ; Tomaić, Vjekoslav ; Glavaš, Dunja ; Mamić, Antonija ; Ledić, Andrea ; Vlahoviček, Kristian | COVID-19 pandemic from the forensic standpoint: A platform against future biological threats // Proceedings of the American Academy of Forensic Sciences 74th Annual Scientific Conference. | 2022. str. 540-540

  www.aafs.org

Conference abstract

• Repušić, Doris ; Korolija, Marina ; Livun, Ana ; Svaguša, Tomo ; Belužić, Robert ; Tomaić, Vjekoslav ; Karlić, Rosa ; Vlahoviček, Kristian | Predicting COVID-19 symptom severity based on host genetic predisposition // Arhiv za higijenu rada i toksikologiju, 75, 2024. str. 169-169

• Đukić, Anamaria ; Thatte, Jayashree Vijay ; Božinović Ksenija ; Dediol, Emil ; Grce, Magdalena ; Banks, Lawrence ; Tomaić, Vjekoslav | Biochemical Differences Among Naturally Occurring HPV-16 E6 Variants // Libri oncologici : Croatian journal of oncology, 2018. str. 45-45

  hrcak.srce.hr

• Szalmás, Anita ; Tomaić, Vjekoslav ; Massimi, Paola ; Gyöngyösi, Eszter ; Kónya, József ; Banks, Lawrence | Reprogramming of tyrosine phosphorylation regulated signalling pathways by HPV oncoproteins // Acta microbiologica et immunologica Hungarica, 2017. str. 171-172

  akjournals.com

• Tomaić, Vjekoslav | HPV-16 E7 phoshorylation as a signature of malignancy // Acta microbiologica et immunologica Hungarica, 2017. str. 179-180

  akjournals.com

• Tomaić, Vjekoslav | Interaction of the Human Papillomavirus E6 Oncoprotein with Sorting Nexin 27 Modulates Endocytic Cargo Transport Pathways // Libri oncologici : Croatian journal of oncology, 44, 2016. str. 19-19

Rukopis

• Skelin, Josipa; Luk, Ho Yin; Butorac, Dražan; Boon, Siaw Shi; Tomaić, Vjekoslav | The effects of HPV oncoproteins on host communication networks: Therapeutic connotations, 2023