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Publications

2005 – current

Zaja, R., Popović, M., Lončar, J., Smital, T. (2016) Functional characterization of rainbow trout (Oncorhynchus mykiss) Abcg2a (Bcrp) transporter.Comp. Biochem. Physiol. C, 190, 15-23.

Mihaljević, I., Popović, M., Zaja, R., Smital, T. (2016) Phylogenetic, syntenic, and tissue expression analysis of slc22 genes in zebrafish (Danio rerio).BMC Genomics, 17: 626, DOI 10.1186/s12864-016-2981-y.

Lončar, J., Popović, M., Krznar, P., Zaja, R., Smital, T. (2016) The first characterization of multidrug and toxin extrusion (MATE/SLC47) proteins in zebrafish (Danio rerio).Sci. Rep.6: 28937, DOI: 10.1038/srep28937. 

Glisic, B., Mihaljevic, I., Popovic, M., Zaja, R., Loncar, J., Fent, K., Kovacevic, R., Smital, T. (2015) Characterization of glutathione-S-transferases in zebrafish (Danio rerio).Aquat. Toxicol.158: 50-62.

Popovic, M., Zaja, R., Fent, K., Smital, T. (2014) Interaction of environmental contaminants with zebrafish uptake transporter Oatp1d1 (Slco1d1).Toxicol. Appl. Pharmacol.280: 149-158.

Ferreira, M., Santos, P., Rey-Salgueiro, L., Zaja, R., Reis-Henriques, M.A., Smital, T. (2014) The first demonstration of CYP1A and the ABC protein(s) gene expression and activity in European seabass (Dicentrarchus labrax) primary hepatocytes.Chemosphere100: 152-159.

Popovic, M., Zaja, R., Fent, K., Smital, T. (2013) Molecular characterization of zebrafish Oatp1d1 (Slco1d1), a novel Organic anion transporting polypeptide.J. Biol. Chem.288: 33894–33911.

Bošnjak, I., Zaja, R., Klobučar, R.S., Sver, L., Franekić, J., Smital, T. (2013) Identification of ABC Transporter Genes in Gonad Tissue of Two Mediterranean Sea Urchin Species: Black, Arbacia lixula L., and Rocky, Paracentrotus lividus L. Bull.Environ. Contam. Toxicol.91: 415-419. 

Traven, L., Mićović, V., Vukić Lušić, D., Smital, T. (2013) The responses of the hepatosomatic index (HSI), 7-ethoxyresorufin-O-deethylase (EROD) activity and glutathione-S-transferase (GST) activity in sea bass (Dicentrarchus labrax, Linnaeus 1758) caged at a polluted site: implications for their use in environmental risk assessment.Environ Monit Assess.185: 9009-9018.

Zaja, R., Terzić, S., Senta, I., Lončar, J., Popović, M., Ahel, M., Smital, T. (2013) Identification of P-glycoprotein (P-gp, Abcb1) inhibitors in contaminated freshwater sediments.Environ. Sci. Tech.47: 4813-4821.

Smital, T., Terzić, S., Lončar, J., Senta, I., Zaja, R., Popović, M., Mikac, I., Tollefsen, K-E., Thomas, K.V., Ahel, M. (2013) Prioritisation of organic contaminants in a river basin using chemical analyses and bioassays.Environ. Sci. Poll. Res.20: 1384-1395.

Della Torre, C., Zaja, R., Loncar, J., Smital, T., Focardi, S., Corsi, I. (2012) Interaction of ABC transport proteins with toxic metals at the level of gene and transport activity in the PLHC-1 fish cell line.Chem. Biol. Interac.198: 9-17.

Reifferscheid, G., Maes, H., Allner, B., Badurova, J., Belkin, S., Blum, K., Brauer, F., Bressling, J., Domeneghetti, S., Elad, T., Flückiger-Isler, S., Grummt, H.J., Guertler, R., Hecht, A., Heringa, M., Hollert, H., Huber, S., Kramer, M., Magdeburg, A., Ratte, T., Sauerborn-Klobucar, R., Sokolowski, A., Soldan, P., Smital, T., Stalter, D., Venier, P., Ziemann, C., Zipperle, J., Buchinger, S. (2012) International round-robin study on the Ames fluctuation test. Environ. Mol. Mutag. 53: 185-197.

Zaja, R., Loncar, J., Popovic.,M., Smital, T. (2011). First characterization of fish P-glycoprotein (abcb1) substrate specificity using determinations of its ATPase activity and calcein-AM assay with PLHC-1/dox cell line. Aquat. Toxicol. 103: 53-62

Fischer, S., Loncar, J., Zaja, R., Schnell, S., Schirmer, K., Smital, T., Luckenbach, T. (2011) Constitutive mRNA expression and protein activity levels of nine ABC efflux transporters in seven permanent cell lines derived from different tissues of rainbow trout (Oncorhynchus mykiss). Aquat. Toxicol. 101: 438-446

Smital, T., Terzic, S., Zaja, R., Senta, I., Pivcevic, B., Popovic, M., Mikac, I., Tollefsen, K.E., Thomas, K.V. (2011). Assessment of toxicological profiles of the municipal wastewater effluents using chemical analyses and bioassays. Ecotox. Environ. Safe. 74 (4): 844-851.

Šrut, M., Traven, L., Štambuk, A., Kralj, S., Žaja, R., Mićović, V., Klobučar, G.I.V. (2010). Genotoxicity of marine sediments in the fish hepatoma cell line plhc-1 as assessed by the comet assay. Toxicol. in Vitro. 25 (1): 308-314

Popovic, M., Zaja, R., Loncar, J., Smital, T. (2010). A novel ABC transporter: The first insight into zebrafish (Danio rerio) Abch1. Mar. Environ. Res. 69:S1-S13.

Popovic, M. Zaja, R., Smital, T. (2009). Organic anion transporting polypeptides (OATP) in zebrafish (Danio rerio): Phylogenetic analysis and tissue distribution. CBP – Part A. 155: 327-335.

Lončar, J., Popović, M., Zaja, R., Smital, T. (2010). Gene expression analysis of the ABC efflux transporters in rainbow trout (Oncorhynchus mykiss). CBP – Part C. 151:209-215.

Dragun, Z., Erk, M., Ivanković, D., Žaja, R., Filipović Marijić, V., Raspor, B. (2009). Assessment of low-level metal contamination using the Mediterranean mussel gills as the indicator tissue. Environ. Sci. Pollut. Res. 17: 977-986.

Bošnjak, Ivana; Heim, Wesley; Smital, Tvrtko; Epel, David; Coale, Kenneth; Franekić-Čolić, Jasna; Hamdoun, Amro. Multidrug resistance associated protein transport activity mediates differences in accumulation and toxicity of inorganic and organic mercury in sea urchin embryos. //Environmental science & technology. 43 (2009) ; 8374-8380.

Zaja, R., Munić, V., Klobučar, R.S., Ambriović-Ristov, A., Smital, T. (2008). Cloning and molecular characterization of apical efflux transporters (ABCB1, ABCB11 and ABCC2) in rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquat. Toxicol. 90: 322-332.

Caminada, D., Žaja, R., Smital, T., Fent, K. (2008). Human Pharmaceuticals Modulate Pgp1 (ABCB1) Transport Activity in the Fish Cell Line PLHC-1. Aquat. Toxicol. 90: 214-222.

Traven, L., Žaja, R., Lončar, J., Smital, T., Mićović, V. (2008). CYP1A induction potential and the concentration of priority pollutants in marine sediment samples – in vitro evaluation using the PLHC-1 fish hepatoma cell line. Toxicol. in vitro. 22: 1648-1656.

Žaja, R., Caminada, D., Lončar, J., Fent, K., Smital, T. (2008). Development and characterization of P-glycoprotein 1 (Pgp1; ABCB1) mediated doxorubicin resistant PLHC-1 epatoma fish cell line. Toxicol. Appl. Pharmacol. 227: 207-218.

Žaja, R., Munić, V., Smital, T. (2008). Cloning and mRNA expression analysis of an ABCG2 (BCRP) efflux transporter in rainbow trout (Oncorhynchus mykiss) liver and primary hepatocytes. Mar. Environ. Res. 66 (1): 77-79.

Epel, David; Stevenson, Charlotte N.; MacManus-Spencer, Laura A.; Luckenbach, Till; Hamdoun, Amro; Smital, Tvrtko.
 Efflux transporters: newly appreciated roles in protection against pollutants. //Environmental Science and Technology. 42 (2008) , 11; 3914-3920.

Tomić, Silvia; Dolanski Babić, Sanja; Ivek, Tomislav; Vuletić, Tomislav; Krča, Sanja; Livolant, Francoise; Podgornik, Rudi. Short-fragment Na-DNA dilute aqueous solutions: Fundamental length scales and screening. // Europhysics Letters. 81 (2008) , 6; 68003-p1-68003-p5 (članak, znanstveni).

3. Tomić, Silvia; Dolanski Babić, Sanja; Vuletić, Tomislav; Krča, Sanja; Ivanković, Dušica; Griparić, Lorena; Podgornik, Rudi. Dielectric relaxation of DNA aqueous solutions. //Physical Review E - Statistical Physics, Plasmas, Fluids, & Related Interdisciplinary Topics. 75 (2007) , 2 Part 1; 021905-1-021905-13 (članak, znanstveni).

Krča, S., Žaja, R., Čalić, V., Terzić, S., Grubešić, M., Ahel, M., Smital, T. (2007). Hepatic biomarker responses to organic contaminants in feral chub (Leuciscus cephalus) – laboratory characterisation and field study in the Sava river, Croatia. Environ. Tox. Chem. 26 (12): 2620-2633.

Žaja, R., Klobučar, R.S., Smital, T. (2007). Detection and functional characterization of Pgp1 (ABCB1) and MRP3 (ABCC3) efflux transporters in the PLHC-1 fish hepatoma cell line. Aquat. Toxicol. 81, 365-376.

Källqvist, Torsten; Milačič, Radmila; Smital, Tvrtko; Thomas, Kevin V; Vranes, Sanja; Tollefsen, Knut-Erik. Chronic toxicity of the Sava River (SE Europe) sediments and river water to the algae Pseudokirchneriella subcapitata. //Water Research. 42 (2007) , 8-9; 2146-2156.

Žaja, R., Klobučar, G.I.V., Klobučar R.S., Hackenberger B.K., Smital T. (2006). Haemolymph as compartment for efficient and non-destructive determination of P-glycoprotein (Pgp) mediated MXR activity in bivalves. Comp. Biochem. Phys. C. 143, 103-112.

Pivcevic, B., Žaja, R. (2006). Pesticides and their binary combinations as P-glycoprotein inhibitors in NIH 3T3/MDR1 cells. ETAP. 22, 268–276. 

Tomić, Silvia; Vuletić, Tomislav; Dolanski Babić, Sanja; Krča, Sanja; Ivanković, Dušica; Griparić, Lorena; Podgornik, Rudi. Screening and Fundamental Length Scales in Semidilute Na-DNA Aqueous Solutions. //Physical Review Letters. 97 (2006) ; 098303-1-098303-4.

2004 - 2000

Sauerborn, R., Polancec, D.S., Zaja, R., Smital, T. (2004). Identification of the multidrug resistance-associated protein (mrp) related gene in red mullet (Mullus barbatus). Mar. Environ. Res. 58, 199-204.

Smital, Tvrtko; Sauerborn, Roberta; Hackenberger, Branimir. Inducibility of the multixenobiotic resistance mechanism (MXR) transport activity in the marine mussel Mytilus galloprovincialis and the freshwater mussel Dreissena polymorpha. //Aquatic Toxicology. 65 (2003) ; 443-465.

Smital, Tvrtko; Sauerborn, Roberta. Measurement of the activity of multixenobiotic resistance mechanism in the common carp Cyprinus carpio. //Marine Environmental Research. 54 (2002) ; 449-453.

Krasko, Anatolij; Kurelec, Branko; Batel, Renato; Muller I.M.; Muller W.E.G. Potential multidrug resistance gene POHL : an ecologically relevant indicator in marine sponges. //Environmental toxicology and chemistry. 20 (2001) , 1; 198-204.

Kurelec, Branko; Smital, Tvrtko; Pivčević, Branka; Eufemia, Nancy; Epel, David. Multixenobiotic resistance, P-glycoprotein, and chemosensitizers. //Ecotoxicology. 9 (2000) , 5; 307-327.

Ramljak, Sanja; Hackenberger, Branimir; Smital, Tvrtko; Britvić, Smiljana.  Evaluation of the genotoxic and cytochrome P450 monooxigenase-inhibitory potential of Dicuran on procaryotic and eucaryotic test systems. //Journal of Environmental Science and Health - Part B: Pesticides, Food Contaminants, and Agricultural Wastes. 35 (2000) , 6; 751-770

Smital, Tvrtko; Sauerborn, Roberta; Pivčević, Branka; Krča, Sanja; Kurelec, Branko. Interspecies differences in P-glycoprotein mediated activity of multixenobiotic resistance mechanism in several marine and freshwater invertebrates. //Comparative Biochemistry and Physiology C. 126 (2000) ; 175-186.

1999 - 1995

Britvić, Smiljana; Kurelec, Branko. The effect of inhibitors of multixenobiotic resistance mechanism on the production of mutagens by Dreissena polymorpha in waters spiked with premutagens. //Aquatic toxicology. 47 (1999) , 2; 107-116.

Kurelec, Branko; Britvić, Smiljana; Pivčević, Branka; Smital, Tvrtko. Fragility of multixenobiotic resistance in aquatic organisms enhances the complexity of risk assessment. //Marine environmental research. 46 (1998) , 1-5; 415-419

Osmak, Maja; Brozović, Anamaria; Ambriović-Ristov, Andreja; Hadžija, Mirko; Pivčević, Branka; Smital, Tvrtko. Inhibition of apoptosis is the cause of resistance to doxorubicin in human breast adenocarcinoma cells. //Neoplasma. 45 (1998) , 4; 223-230.

Smital, Tvrtko; Kurelec, Branko. The activity of multixenobiotic resistance mechanism determined by rhodamine B-efflux method as a biomarker of exposure. //Marine environmental research. 46 (1998) , 1-5; 443-447.

Smital, Tvrtko; Kurelec, Branko. The chemosenzitizers of multixenobiotic resistance mechanism in aquatic invertebrates : a new class of pollutants. //Mutation research. 399 (1998) , 1; 43-53. 

Muleller, E.G. Werner; Riemer, Siegurd; Kurelec, Branko; Smodlaka, Nenad; Puškarić, Staša; Jagić, Bela; Mueller-Niklas, Gerald; Queric, V. Nadia. Chemosenzitizers of the multixenobiotic resistance in amorphous aggregates (marine snow) : etiology of mass killing on the benthos in the Northern Adriatic?. //Environmental toxicology and pharmacology. 6 (1998) , 4; 229-238.

Schroeder, C. Heinz; Badria, A. Farid; Ayyad, N. Seif; Batel, Renato; Wiens, Matthias; Hassanein, M.A. Hamdy; Kurelec, Branko; Mueller, E.G. Werner. Inhibitory effects of extracts from the marine alga Caulerpa taxifolia and of toxin from Caulerpa racemosa on multixenobiotic resistance in the marine sponge Geodia cydonium. //Environmental toxicology and pharmacology. 5 (1998) , 2; 119-126.

Smital, Tvrtko; Kurelec, Branko. The concentrations of inhibitors of multixenobiotic resistance mechanism in natural waters: The direct in vivo demonstration of their effect. //Environmental toxicology and chemistry. 16 (1997) , 10; 2164-2170.

Kurelec, Branko; Krča, Sanja; Lucić, Davor. Expression of multixenobiotic resistance mechanism in a marine mussel Mytilus galloprovincialisas as a biomarker of exposure to polluted environment. //Comparative biochemistry and physiology C : pharmacology, toxicology and endocrinology. 113 (1996) , 2; 283-289.

Kurelec, Branko; Waldmann, Petra; Zahn, Rudolf K. The modulation of protective effects of the multixenobiotic resistance mechanism in a clam Corbicula fluvinea. //Marine environmental research. 42 (1996) , 1-4; 383-387 .

 Mueller, Werner E.G.; Stefen, Renate; Rinkevich, Baruch; Matranga, Valeria; Kurelec, Branko. The multixenobiotic resistance mechanism in the marine sponge suberites domuncula - its potential applicability for the evaluation of environmental pollution by toxic compounds. //Marine biology. 125 (1996) , 1; 165-170.

Kurelec, Branko; Lucić, Dalibor; Pivčević, Branka; Krča, Sanja. Induction and reversion of multixenobiotic resistance in the marine snail Monodonta turbinata. //Marine Biology. 123 (1995) ; 305-312.

Kurelec, Branko; Pivčević, Branka; Müller, Werner E. G. Determination of pollutants with multixenobiotic -resistance inhibiting properties. //Marine Environmental Research. 39 (1995) ; 261-265.

Waldman, Petra; Pivčević, Branka; Müller, Werner E. G.; Zahn, Rudolf K.; Kurelec, Branko. Increased genotoxicity of acetylaminofluorene by modulators of multixenobiotic resistance mechanism: studies with the fresh water clam Corbicula fluminea. //Mutation Research - Genetic Toxicology. 342 (1995) ; 113-123.

Kurelec, Branko. Reversion of multixenobiotic resistance mechanism in gills of a marine mussel Mytilus galloprovincialis by model- and environmental-inhibitors of P170-glycoprotein. //Aquatic toxicology. 33 (1995) , 2; 93-103.

Müller, Werner E.G.; Koziol, Claudia; Kurelec, Branko; Dapper, Jutta; Batel, Renato; Rinkevich, Baruch. Combinatory effects of temperature stress and nonionic organic pollutants on stress protein (HSP70) gene expression in the freshwater sponge Ephydatia fluviatilis. //Environmental toxicology and chemistry. 14 (1995) , 7; 1203-1208.

1994 - ...

Kurelec, Branko; Krča, Sanja; Pivčević, Branka; Ugarković, Đurđica; Bachmann, Michael; Imsiecke, Georg; Müller, Werner E.G. Expression of P-glycoprotein gene in marine sponges. Identification and characterization of the 125 kDa drug-binding glycoprotein. //Carcinogenesis. 13 (1992) ; 69-76.

Kurelec, Branko; Pivčević, Branka. The multidrug resistance-like mechanism in the marine sponge Tethya aurantium. // Marine Environmental Research. 34 (1992) ; 249-253.

Kurelec, Branko; Pivčević, Branka. Evidence for a multixenobiotic resistance mechanism in the mussel Mytilus galloprovincialis. //Aquatic Toxicology. 19 (1991) ; 291-302.

Kurelec, Branko; Pivčević, Branka. Distinct glutathione-dependent enzyme activities and a verapamil-sensitive binding of xenobiotics in a fresh-water mussel Anodonta cygnea. //Biochemical and Biophysical Research Communications. 164 (1989) ; 934-940.

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Division for Marine and Environmental Research

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