- PhD - Postgraduate Interdisciplinary Doctoral Study of "Molecular Biosciences", in progress, J. J. Strossmayer University of Osijek, Ruđer Bošković Institute, Zagreb and University of Dubrovnik

-  Master’s degree in biology, J. J. Strossmayer University of Osijek, Department of biology, 2011

 Bachelors’s degree in biology, J. J. Strossmayer University of Osijek, Department of biology, 2008

Ecotoxicological significance of ABC transport proteins in aquatic organisms, (2007-2011) Project supported by the Ministry of Science Education and Sports.

• Deciphering DNA-Protein Crosslink Repair in vivo using zebrafish model - DNAPRO

  01.02.2018 - 01.02.2023 | 246,997.15 EUR

  CroRISIRB

Original scientific paper

• Vujica, Lana; Dragojević, Jelena; Lončar, Jovica; Otten, Cecile; Kutnjak, Marin; Babić, Sanja; Mihaljevic, Ivan; Smital, Tvrtko | Differential toxicity of perfluorooctane sulfonate (PFOS) in wild-type and Oatp1d1 mutant zebrafish larvae // Chemico-biological interactions, 428 (2026), 111955, 12. doi: 10.1016/j.cbi.2026.111955

  doiwww.sciencedirect.com

• Lončar, Jovica; Žaja, Roko; Mihaljević, Ivan; Dragojević, Jelena; Vujica, Lana; Kutnjak, Marin; Otten, Cecile; Smital, Tvrtko | Zebrafish Abcg2a mutant line as an in vivo model for evaluation of the interaction of Abcg2a with drugs and contaminants // Aquatic toxicology, 291 (2026), 107709, 11. doi: 10.1016/j.aquatox.2026.107709

  doiwww.sciencedirect.com

• Bakija Alempijević, Saranda; Strmečki, Slađana; Mihaljević, Ivan; Frka, Sanja; Dragojević, Jelena; Jakovljević, Ivana; Smital, Tvrtko | Ecotoxicity of Nitrated Monoaromatic Hydrocarbons in Aquatic Systems: Emerging Risks from Atmospheric Deposition of Biomass Burning and Anthropogenic Aerosols // Toxics, 13 (2025), 12; 1037, 22. doi: 10.3390/toxics13121037

  doifulir.irb.hrwww.mdpi.com

• Bakija Alempijević, Saranda; Vidović, Kristijan; Vukosav, Petra; Frka, Sanja; Kroflič, Ana; Mihaljević, Ivan; Grgić, Irena; Strmečki, Slađana | Integrating voltammetry in ecotoxicology: Cu(II)-nitrocatechol complexes formation as a driver of Cu(II) and nitrocatechol toxicity in aquatic systems // Electrochimica acta, 522 (2025), 145938, 10. doi: 10.1016/j.electacta.2025.145938

  doiwww.sciencedirect.com

• Ivanković, Klaudija; Krizman-Matasić, Ivona; Dragojević, Jelena; Mihaljević, Ivan; Smital, Tvrtko; Ahel, Marijan; Terzić, Senka | Uptake/depuration kinetics, bioaccumulation potential and metabolic transformation of a complex pharmaceutical mixture in zebrafish (Danio rerio) // Journal of hazardous materials, 470 (2024), 134144, 12. doi: 10.1016/j.jhazmat.2024.134144

  doiwww.sciencedirect.comfulir.irb.hr

• Vujica, Lana; Mihaljević, Ivan; Dragojević, Jelena; Lončar, Jovica; Karaica, Dean; Dananić, Ana; Bošnjak, Arvena; Smital, Tvrtko | Functional knockout of the Oatp1d1 membrane transporter affects toxicity of diclofenac in zebrafish embryos // Aquatic toxicology, 273 (2024), 107031, 20. doi: 10.1016/j.aquatox.2024.107031

  doilinkinghub.elsevier.comfulir.irb.hr

• Vujica, Lana; Lončar, Jovica; Mišić, Lana; Lučić, Bono; Radman, Katarina; Mihaljević, Ivan; Bertoša, Branimir; Mesarić, Josip; Horvat, Marina; Smital, Tvrtko | Environmental contaminants modulate transport activity of zebrafish (Danio rerio) multidrug and toxin extrusion protein 3 (Mate3/Slc47a2.1) // Science of the total environment, 901 (2023), 165956, 9. doi: 10.1016/j.scitotenv.2023.165956

  doiwww.sciencedirect.com

• Karaica, Dean; Mihaljević, Ivan; Vujica, Lana; Bošnjak, Arvena; Dragojević, Jelena; Otten, Cecile; Babić, Nency; Lončar, Jovica; Smital, Tvrtko | Stage-dependent localization of F-actin and Na+/K+-ATPase in zebrafish embryos detected using optimized cryosectioning immunostaining protocol // Microscopy research and technique, 86 (2022), 3; 294-310. doi: 10.1002/jemt.24270

  doianalyticalsciencejournals.onlinelibrary.wiley.com

• Marić, Petra; Ahel, Marijan; Maraković, Nikola; Lončar, Jovica; Mihaljević, Ivan; Smital, Tvrtko | Selective interaction of microcystin congeners with zebrafish (Danio rerio) Oatp1d1 transporter // Chemosphere, 283 (2021), 131155, 12. doi: 10.1016/j.chemosphere.2021.131155

  doiwww.sciencedirect.comfulir.irb.hr

• Dragojević, Jelena ; Marić, Petra ; Lončar, Jovica ; Popović, Marta ; Mihaljević, Ivan ; Smital, Tvrtko | Environmental contaminants modulate transport activity of zebrafish organic anion transporters Oat1 and Oat3 // Comparative biochemistry and physiology. C. Toxicology & pharmacology, 231 (2020), 108742, 8. doi: 10.1016/j.cbpc.2020.108742

  doiwww.sciencedirect.comdoi.org

• Mihaljević, Ivan ; Bašica, Branka ; Maraković, Nikola ; Kovačević, Radmila ; Smital, Tvrtko | Interaction of organotin compounds with three major glutathione S-transferases in zebrafish // Toxicology in vitro, 62 (2020), 104713, 9. doi: 10.1016/j.tiv.2019.104713

  doiwww.sciencedirect.comdoi.org

• Dragojević, Jelena ; Mihaljević, Ivan ; Popović, Marta ; Smital, Tvrtko | Zebrafish (Danio rerio) Oat1 and Oat3 transporters and their interaction with physiological compounds // Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 236 (2019), 110309, 11. doi: 10.1016/j.cbpb.2019.110309

  doiwww.sciencedirect.comdoi.org

• Bašica, Branka ; Mihaljević, Ivan ; Maraković, Nikola ; Kovačević, Radmila ; Smital, Tvrtko | Molecular characterization of zebrafish Gstr1, the only member of teleost-specific glutathione S- transferase class // Aquatic toxicology, 208 (2019), 196-207. doi: 10.1016/j.aquatox.2019.01.005

  doiwww.sciencedirect.com

• Terzić, Senka ; Udiković-Kolić, Nikolina ; Jurina, Tamara ; Krizman-Matasić, Ivona ; Senta, Ivan ; Mihaljević, Ivan ; Lončar, Jovica ; Smital, Tvrtko ; Ahel, Marijan | Biotransformation of macrolide antibiotics using enriched activated sludge culture: Kinetics, transformation routes and ecotoxicological evaluation // Journal of hazardous materials, 349 (2018), 143-152. doi: 10.1016/j.jhazmat.2018.01.055

  doiwww.sciencedirect.com

• Mihaljević, Ivan ; Popović, Marta ; Žaja, Roko ; Maraković, Nikola ; Šinko, Goran ; Smital, Tvrtko | Interaction between zebrafish Oct1 and endo- and xenobiotics // Aquatic toxicology, 187 (2017), 18-28. doi: 10.1016/j.aquatox.2017.03.012

  doiwww.sciencedirect.comdx.doi.org

• Dragojević, Jelena ; Mihaljević, Ivan ; Popović, Marta ; Žaja, Roko ; Smital, Tvrtko | In vitro characterization of zebrafish (Danio rerio) organic anion transporters Oat2a-e // Toxicology in vitro, 46 (2017), 246-256. doi: 10.1016/j.tiv.2017.09.026

  doiwww.sciencedirect.com

• Mihaljević, Ivan ; Popović, Marta ; Žaja, Roko ; Smital, Tvrtko | Phylogenetic, syntenic, and tissue expression analysis of slc22 genes in zebrafish (Danio rerio) // Bmc genomics, 17 (2016), 626-1-626-13. doi: 10.1186/s12864-016-2981-y

  doibmcgenomics.biomedcentral.com

• Glišić, Branka ; Mihaljević, Ivan ; Popović, Marta ; Žaja, Roko ; Lončar, Jovica ; Fent, Karl ; Kovačević, Radmila ; Smital, Tvrtko | Characterization of Glutathione-S-transferases in zebrafish (Danio rerio) // Aquatic toxicology, 158 (2015), 50-62. doi: 10.1016/j.aquatox.2014.10.013

  doiwww.sciencedirect.com

Conference abstract

• Karaica, Dean ; Breljak, Davorka ; Brzica, Hrvoje ; Lončar, Jovica ; Ljubojević, Marija ; Herak-Kramberger, Carol M. ; Micek, Vedran ; Vrhovac, Ivana ; Ivković Dupor, Jana ; Mihaljević, Ivan et al. | CFEX (Slc26a6) in rat kidneys, liver, and small intestine in an experimental model of oxalate nephrolitiasis // Arhiv za higijenu rada i toksikologiju, 2015. str. 228-228

  hrcak.srce.hrhrcak.srce.hr

Unpublished conference paper

• Bakija Alempijević, Saranda; Mihaljević, Ivan; Frka, Sanja; Strmečki Kos, Slađana | Voltammetry of Copper-Nitrocatechol Interactions Explains Their Binary Toxic Effects to Microalgae // 36th Topical Meeting of the International Society of Electrochemistry | Šibenik, Hrvatska, 26.05.2024-29.05.2024

  topical36.ise-online.org

• Vujica, Lana; Mihaljević, Ivan; Dragojević, Jelena; Lončar, Jovica; Smital, Tvrtko | Phenotype changes in zebrafish Oatp1d1 mutants // Pollutant Responses in Marine Organisms | Nantes, Francuska, 26.05.2024-29.05.2024

  primo22.org

• Ivanković Koprivić, Klaudija; Dragojević, Jelena; Mihaljević, Ivan; Smital, Tvrtko; Ahel, Marijan; Terzić, Senka | Kinetika akumulacije i eliminacije smjese farmaceutski aktivnih spojeva u modelnom organizmu Danio rerio // Znanstvena škola o okolišu 2023 : Nekonvencionalni pristupi konvencionalnim izazovima | Zagreb, Hrvatska, 27.11.2023-29.11.2023

• Vujica, Lana; Lončar, Jovica; Lučić, Bono; Radman, Katarina; Mihaljević, Ivan; Bertoša, Branimir; Mesarić, Josip; Horvat, Marina; Smital, Tvrtko | First in vitro and in silico characterization of zebrafish (Danio rerio) multidrug and toxin extrusion protein 3 (Mate3/Slc47a2.1) // 12th European Zebrafish Meeting | Krakov, Poljska, 09.07.2023-13.07.2023

• Vujica, Lana; Mišić, Lana; Horvat, Marina; Lončar, Jovica; Mihaljević, Ivan; Smital, Tvrtko | Interaction of environmental contaminants with zebrafish (danio rerio) multidrug and toxin extrusion protein 3 (Mate3/Slc47a3) // International Congress of the Croatian Society of Biochemistry and Molecular Biology HDBMB22: From Science to Knowledge | Brela, Hrvatska, 28.09.2022-01.10.2022

• Vujica, Lana; Mišić, Lana; Horvat, Marina; Lončar, Jovica; Mihaljević, Ivan; Smital, Tvrtko | Interaction of environmental contaminants with zebrafish (Danio rerio) multidrug and toxin extrusion protein 3 (Mate3/Slc47a3) // 21st International Symposium on Pollutant Responses In Marine Organisms (PRIMO21) | Göteborg, Švedska, 22.05.2022-25.05.2022

Doctoral thesis

• Mihaljević, Ivan | Characterization of organic cation transporters in zebrafish (Danio rerio Hamilton, 1882) / Smital, Tvrtko (mentor). | Osijek, Sveučilište Josipa Jurja Strossmayera u Osijeku / Sveučilište u Dubrovniku, 2015

Croatian society for biochemistry and molecular biology

Croatian biophysical society