Our new paper on the role of Tyrosyl-DNA phosphodiesterase 2 (Tdp2) in DPC repair is out!

Oct 1st 2023

August, 2024

We have shown that silencing of TDP2 in zebrafish embryos causes accumulation of DNA-protein crosslinks and leads to the accumulation of double strand breaks. We found that Ku80-DPCs are removed by TDP2, whereas histone H3-DPCs are not. In addition, we have found that in vivo, TDP1 and TDP2 cannot compensate for each other, as overexpression of Tdp2 does not result in the cleavage of a Tdp1 substrate in embryos. Our results contribute to a more comprehensive understanding of DPC repair at the organismal level and underscore the significance of TDP2 in maintaining genome stability.

https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2024.1394531/full

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Our new paper on the role of Tyrosyl-DNA phosphodiesterase 2 (Tdp2) in DPC repair is out!

Institut Ruđer Bošković

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