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Bioinspired asymmetric catalysis: backdoor induction of chirality using oxazoline based amino acid bioconjugates

Start date
Nov 25th 2014
End date
Oct 30th 2016

Principal investigator

This research proposal describes the development of artificial metalloenzyme mimics with a minimal but functional outer-coordination sphere. Bioconjugates of chiral amino acids with oxazoline based nitrogen ligands and their metal complexes with Cu(I) and Pd(II) will be synthesized from simple and cheap starting materials using appropriate synthetic methods and characterized by various physico-chemical methods. The metal complexes will be used as catalysts in asymmetric cyclopropanation and in asymmetric alkylation.

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