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Testing biocompatibility of molybdenum and tungsten based nanoparticles: measuring cytotoxicity and inflammatory response in human cell lines

Principal investigator

Category
Bilateralna znanstveno-istraživačka suradnja Ministarstva znanosti, obrazovanja i športa
Start date
Jan 1st 2018
End date
Dec 31st 2019
Status
Done

Laboratory for Cell Biology and Signalling

Hospital infections represent the fourth most frequently occurring disease of the modern world and cause the most frequent complications in hospital treatment. Transfer of bacteria or bacterial biofilms is a problem also in other environments such as public transport or food packaging. For the destruction of existing bacteria, various biocidal preparations are often used which may contain various organic compounds such as trichlosan antibiotics. The use of these compounds has undesirable side effects like for example increasing antibiotic resistance of bacteria. It has been shown that ions and nanoparticles of silver and copper except anti-bacterial activity have toxic effects on human cells. Recently, it has been shown that the compounds of the molybdenum (Mo) and tungsten (W) have extremely antibacterial properties, and the efficacy of antibacterial activity of their trioxide has been demonstrated on various bacterial cultures.

Molybdenum and tungsten nanoparticles synthesized at the Jožef Stefan Institute possess a unique form and degree of anisotropy, and their antibacterial activity is confirmed in the previous study (unpublished results). In order to use nanomaterials for medical purposes it is necessary to demonstrate that once in contact with live tissue they do not cause tissue damage or allergic reaction, ie they do not induce an inflammatory response. Accordingly, it is necessary to determine the cytotoxicity of molybdenum and tungsten nanoparticles in human cells. Within this project we aim to investigate the biocompatibility of molybdenum and tungsten nanoparticles in human cells, ie examine their cytotoxicity and potentials to stimulate inflammatory response in human cells.

Other associates

dr. sc. Andreja Ambriović Ristov, senior scientist, IRB, Zagreb

mag. ing. mol. biotechn. Davor Nestić, PhD student, IRB, Zagreb

mag. biol. mol. Ana Dekanić, PhD student, IRB, Zagreb

dr. sc. Ksenija Božinović, postdoc, IRB, Zagreb

dr. sc. Maja Remškar, senior scientist, JSI, Ljubljana

mag. biol. Eva Kranjc, PhD student, JSI, Ljubljana

mag. phys. Luka Pirker, PhD student, JSI, Ljubljana

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