• 1999-2002 Ph.D., Molecular Biology, Faculty of Science, University of Zagreb, Zagreb, Croatia
• 1997-1999 M.S., Faculty of Science, University of Zagreb, Zagreb, Croatia
• 1992-1996 Biology, University of Zagreb, Faculty of Science, Zagreb, Croatia

• 2013 Stanford Advanced Project Management Certificate Program, Stanford University, Stanford, USA
• 2013 Stanford Ignite, Stanford Graduate School of Business-Academic Program for Innovation and Entrepreneurship, Stanford University, Stanford, USA

Project leader:

• 2023-2025 "Application of core-shell structured nano drug carrier in the multimodal therapy of ovarian cancer"-Large-Scale Croatian-Chinese Scientific Cooperation, Ministry of Science and Education (co-leader Prof. Dr. Wei Zhang, Dalian University of Technology, China)
• 2017-2021 "DEvOuT-Drug-induced epithelial-mesenchymal transition in ovarian cancer therapy"- Croatian Science Foundation
• 2018-2019 "Fishing „the miRNA“ in order to target drug-induced epithelial-mesenchymal transition in ovarian cancer"- Bilateral scientific-research cooperation of the Ministry of Science and Education (co-leader Prof. Dr. Zoran Culig University Innsbruck)
• 2018-2019 "When old drugs get new shape: cisplatin and statin"- Bilateral scientific-research cooperation of the Ministry of Science and Education (co-leader Prof. Dr. Janez Košmrlj University Ljubljana)
• 2018 "Ovarian cancer organoids as a model for investigation of drug-induced epithelial-mesenchymal transition" EMBO
• 2016 "Novel organometallic compounds - potential antitumor drugs"- Terry Fox Foundation-donation
• 2012-2014 "Complexes of platinum and diazecarboxamide as potential cytostatics"- Bilateral scientific-research cooperation of the Ministry of Science, Education and Sports (co-leader Prof. Dr. Janez Košmrlj University Ljubljana)

Project associate:

• 2018-2022 "Molecular recognition of DNA:RNA hybrid and multistranded structures in bioanalytical and in vitro systems"-Croatian Science Foundation (leader: PhD Marijana Radić Stojković)
• 2007-2011 "Cell response to cytotoxic agents and resistance development"-Ministry of Science, Education and Sports (leader: PhD Maja Osmak)
• 2002-2006 "Cellular response to physical, chemical and biological noxes"-Ministry of Science, Education and Sports (leader: PhD Maja Osmak)
• 1996-2002 "Cell response to genotoxic agents"-Ministry of Education (leader: PhD Maja Osmak)

• 2012-2013 "Platinum compounds: cellular response and mechanisms of resistance"-Bilateral scientific-research cooperation of the Ministry of Science and Education (leaders: PhD Maja Osmak and Prof. Dr. Gerhard Fritz, University Düsseldorf, Germany)
• 2010-2011 "Comparison of the effects of ZD0473 and cisplatin"-Bilateral scientific-research cooperation of the Ministry of Science and Education (leaders: PhD Maja Osmak and Doc. Dr. Beate Köberle, University in Mainz, Germany)
• 2009-2010 "Diaryltriazene-a new group of potential antitumor drugs"-Bilateral scientific-research cooperation of the Ministry of Science and Education (leaders: PhD Maja Osmak and Prof. Dr. Janez Košmrlj, University in Ljubljana, Slovenia)
• 2008-2009 "Molecular mechanisms determining cellular sensitivity to platinum compounds"-Bilateral scientific-research cooperation of the Ministry of Science and Education (leaders: PhD Maja Osmak and Prof. Dr. Bernd Kaina, University in Mainz, Germany)

COST Actions:

• CA22125 (2023-2027)- COST Action “Precision medicine in biliary tract cancer”-secondary proposer
• CA21154 (2022-2026)- COST Action TRANSLACORE “Translational control in cancer European Network”-member
• CA18117 (2019-2023)- COST Action GYNOCARE “European network for gynaecological rare cancer research: From Concept to Cure”-member
• CA17104 (2018-2022)- COST Action STRATAGEM  "New diagnostic and therapeutic tools against multidrug resistant tumors"-MC member

• 2020 Annual Award of Ruđer Bošković Institute for a best scientific paper 2019, Croatia
• 2018 Annual Award of Ruđer Bošković Institute for a best scientific paper 2017, Croatia
• 2012 Annual Award of Ruđer Bošković Institute for a patent US 8,217,022, Croatia
• 2004 Prize “Željko Trgovčević” for the best young scientist publication of the year, Croatia
• 2004 Poster Prize, ELSO 2004, Nice, France

• 2021- External Associate, Medical Studies, Croatian Catholic University, Croatia (principal lecturer Prof. Dr. Tomislav Domazet Lošo)
• 2017- Principal Lecturer Assistant Professor, Interdisciplinary Postgraduate Study of Molecular Biosciences, University of Osijek, Osijek, Croatia
• 2017- External Associate, Faculty of Dental Medicine, University of Zagreb, Croatia (principal lecturer Prof. Dr. Ivana Miletić)
• 2015- Principal Lecturer, Faculty of Science, University of Zagreb, Croatia

Pernar Kovač M*, Tadić V*, Kralj J, Duran GE, Stefanelli A, Stupin Polančec D, Dabelić S, Bačić N, Tomicic MT, Heffeter P, Sikic BI, Brozovic A. Carboplatin-induced upregulation of pan β-tubulin and class III β-tubulin is implicated in acquired resistance and cross-resistance of ovarian cancer. Cell Mol Life Sci. 2023 Sep 17;80(10):294. *equal contribution

Pernar Kovač M, Tadić V, Kralj J, Milković Periša M, Orešković S, Babić I, Banović V, Zhang W, Culig Z, Brozovic A. MiRNA-mRNA integrative analysis reveals epigenetically regulated and prognostic miR-103a with a role in migration and invasion of carboplatin-resistant ovarian cancer cells that acquired mesenchymal-like phenotype. Biomed Pharmacother. 2023 Aug;25;166:115349.

Kralj J, Pernar Kovač M, Dabelić S, Stupin Polančec D, Wachtmeister T, Köhrer K, Brozovic A. Transcriptome analysis of newly established carboplatin-resistant ovarian cancer cell model reveals genes shared by drug resistance and drug-induced EMT. Br J Cancer. 2023 Mar;128(7):1344-1359.

Brozovic A*. The relationship between platinum drug resistance and epithelial-mesenchymal transition. Arch Toxicol. 2017 Feb;91:605–619. *invited review

Vajs J*, Steiner I*, Brozovic A*, Pevec A, Ambriović-Ristov A, Matković M, Piantanida I, Urankar D, Osmak M, Košmrlj J. The 1,3-diaryltriazenido(p-cymene)ruthenium(II) complexes with a high in vitro anticancer activity. J Inorg Biochem. 2015 Dec;153:42-8. *equal contribution

Brozovic A, Duran GE, Wang YC, Francisco EB, Sikic BI. The miR-200 family differentially regulates sensitivity to paclitaxel and carboplatin in human ovarian carcinoma OVCAR-3 and MES-OV cells. Mol Oncol. 2015 Oct;9(8):1678-93.

Moisan F, Francisco EB, Brozovic A, Duran GE, Wang YC, Chaturvedi S, Seetharam S, Snyder LA, Doshi P, Sikic BI. Enhancement of paclitaxel and carboplatin therapies by CCL2 blockade in ovarian cancers. Mol Oncol. 2014 Oct;8(7):1231-9.

Brozovic A, Stojanović N, Ambriović-Ristov A, Brozović Krijan A, Polanc S, Osmak M. 3-Acetyl-bis(2-chloro-4-nitrophenyl)triazene is a potent antitumor agent that induces oxidative stress and independently activates the stress-activated protein kinase/c-Jun NH2-terminal kinase pathway. Anticancer Drugs. 2014 Mar;25(3):289-95.

Brozovic A, Vuković L, Polančac DS, Arany I, Köberle B, Fritz G, Fiket Z, Majhen D, Ambriović-Ristov A, Osmak M. Endoplasmic reticulum stress is involved in the response of human laryngeal carcinoma cells to Carboplatin but is absent in Carboplatin-resistant cells. PLoS One. 2013 Sep 23;8(9):e76397.

Cimbora-Zovko T, Brozovic A, Piantanida I, Fritz G, Virag A, Alič B, Majce V, Kočevar M, Polanc S, Osmak M. Synthesis and biological evaluation of 4-nitro-substituted 1,3-diaryltriazenes as a novel class of potent antitumor agents. Eur J Med Chem. 2011 Jul;46(7):2971-83.

Helbig L, Damrot J, Hülsenbeck J, Köberle B, Brozovic A, Osmak M, Fiket Z, Kaina B, Fritz G. Late activation of stress-activated protein kinases/c-Jun N-terminal kinases triggered by cisplatin-induced DNA damage in repair-defective cells. J Biol Chem. 2011 Apr 15;286(15):12991-3001.

Majhen D*, Brozovic A*, Buger T, Gabrilovac J, Osmak M, Ambriović-Ristov A. Vincristine-resistant human laryngeal carcinoma cells demonstrate increased Rous sarcoma virus promoter activity. Life Sci. 2010 Oct 9;87(15-16):468-74. *equal contribution

Brozovic A, Ambriović-Ristov A, Osmak M. The relationship between cisplatin-induced reactive oxygen species, glutathione, and BCL-2 and resistance to cisplatin. Crit Rev Toxicol. 2010 Apr;40(4):347-59.

Brozovic A, Damrot J, Tsaryk R, Helbig L, Nikolova T, Hartig C, Osmak M, Roos WP, Kaina B, Fritz G. Cisplatin sensitivity is related to late DNA damage processing and checkpoint control rather than to the early DNA damage response. Mutat Res. 2009 Nov 2;670(1-2):32-41.

Brozovic A, Majhen D, Roje V, Mikac N, Jakopec S, Fritz G, Osmak M, Ambriovic-Ristov A. alpha(v)beta(3) Integrin-mediated drug resistance in human laryngeal carcinoma cells is caused by glutathione-dependent elimination of drug-induced reactive oxidative species. Mol Pharmacol. 2008 Jul;74(1):298-306.

Brozovic A, Osmak M. Activation of mitogen-activated protein kinases by cisplatin and their role in cisplatin-resistance. Cancer Lett. 2007 Jun 18;251(1):1-16.

Brozovic A, Fritz G, Christmann M, Zisowsky J, Jaehde U, Osmak M, Kaina B.Long-term activation of SAPK/JNK, p38 kinase and fas-L expression by cisplatin is attenuated in human carcinoma cells that acquired drug resistance. Int J Cancer. 2004 Dec 20;112(6):974-85.

Books and book chapters

Book chapters

• Grienke, U., Radić Brkanac, S., Vujčić, V., Urban, E., Ivanković, S., Stojković, R., Rollinger, M., Kralj, J., Brozović, A. & Radić Stojković, M. (2019) Biological Activity of Flavonoids and Rare Sesquiterpene Lactones Isolated From Centaurea ragusina L.. U: Hohmann, J., Karolina Kiss, A., Rollinger, J. & Atanasov, A. (ur.) Ethnopharmacology in Central and Eastern Europe in the Context of Global Research Developments. Lausanne, Frontiers Media, str. 20-58 doi:10.3389/fphar.2018.00972.

  doiwww.frontiersin.org

Journal articles

Scientific and review papers

• Kralj, J., Pernar Kovač, M., Dabelić, S., Stupin Polančec, D., Wachtmeister, T., Köhrer, K. & Brozovic, A. (2023) Transcriptome analysis of newly established carboplatin-resistant ovarian cancer cell model reveals genes shared by drug resistance and drug-induced EMT. British journal of cancer, 128, 1344-1359 doi:10.1038/s41416-023-02140-1.

  doi

• Fabijanić, I., Kurutos, A., Tomašić Paić, A., Tadić, V., Kamounah, F., Horvat, L., Brozovic, A., Crnolatac, I. & Radić Stojković, M. (2023) Selenium-Substituted Monomethine Cyanine Dyes as Selective G-Quadruplex Spectroscopic Probes with Theranostic Potential. Biomolecules, 13 (1), 128, 20 doi:10.3390/biom13010128.

  doiwww.mdpi.comfulir.irb.hr

• Pantalon Juraj, N., Tandarić, T., Tadić, V., Perić, B., Moreth, D., Schatzschneider, U., Brozovic, A., Vianello, R. & Kirin, S. (2022) Tuning the coordination properties of chiral pseudopeptide bis(2-picolyl)amine and iminodiacetamide ligands in Zn(II) and Cu(II) complexes. Dalton transactions, 51 (44), 17008-17021 doi:10.1039/d2dt02895f.

  doi

• Zonjić, I., Kurutos, A., Mihovilović, P., Crnolatac, I., Tumir, L., Tomašić Paić, A., Kralj, J., Horvat, L., Brozovic, A., Stojković, R. & Radić Stojković, M. (2022) Formation of triplex rA/dA-containing nucleic acid helices induced by new thiazole orange analogues and their biological evaluation. H-aggregate formation conditioned by rA sequence. Dyes and pigments, 207, 110715, 14 doi:10.1016/j.dyepig.2022.110715.

  doi

• Zonjić, I., Radić Stojković, M., Crnolatac, I., Tomašić Paić, A., Pšeničnik, S., Vasilev, A., Kandinska, M., Mondeshki, M., Baluschev, S., Landfester, K., Glavaš-Obrovac, L., Jukić, M., Kralj, J., Brozovic, A., Horvat, L. & Tumir, L. (2022) Styryl dyes with N-Methylpiperazine and N-Phenylpiperazine Functionality: AT-DNA and G-quadruplex binding ligands and theranostic agents. Bioorganic chemistry, 127, 105999, 15 doi:10.1016/j.bioorg.2022.105999.

  doi

• Wei, C., Jin, X., Wu, C., Brozović, A. & Zhang, W. (2022) Carbon spheres with high photothermal conversion efficiency for photothermal therapy of tumor. Diamond and Related Materials, 126, 109048, 9 doi:10.1016/j.diamond.2022.109048.

  doi

• Jakopec, S., Pantalon Juraj, N., Brozović, A., Jadreško, D., Perić, B., Kirin, S. & Raić-Malić, S. (2022) Ferrocene conjugates linked by 1,2,3-triazole and their Zn(II) and Cu(II) complexes: Synthesis, characterization and biological activity. Applied organometallic chemistry, 36 (4), e6575, 22 doi:10.1002/aoc.6575.

  doi

• Miletić, M., Murati, T., Šimić, B., Bilandžić, N., Brozović, A. & Kmetič, I. (2021) Ortho-substituted PCB 153: effects in CHO-K1 cells. Arhiv za higijenu rada i toksikologiju, 72 (4), 326-332 doi:10.2478/aiht-2021-72-3588.

  doihrcak.srce.hr

• Schürmann, L., Schumacher, L., Roquette, K., Brozovic, A. & Fritz, G. (2021) Inhibition of the DSB repair protein RAD51 potentiates the cytotoxic efficacy of doxorubicin via promoting apoptosis-related death pathways. Cancer letters, 520, 361-373 doi:10.1016/j.canlet.2021.08.006.

  doi

• De Las Rivas, J., Brozović, A., Izraely, S., Casas-Pais, A. & Witz IP, Figueroa, Angelica. (2021) Cancer drug resistance induced by EMT: novel therapeutic strategies. Archives of toxicology, 95, 2279-2297 doi:10.1007/s00204-021-03063-7.

  doilink.springer.comdoi.orgfulir.irb.hr

• Erin, N., Grahovac, J., Brozovic, A. & Efferth, T. (2020) Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance. Drug resistance updates, 53, 100715, 22 doi:10.1016/j.drup.2020.100715..

  doi

• Torić, J., Brozović, A., Baus Lončar, M., Jakobušić Brala, C., Karković Marković, A., Benčić, Đ. & Barbarić, M. (2020) Biological Activity of Phenolic Compounds in Extra Virgin Olive Oils through Their Phenolic Profile and Their Combination with Anticancer Drugs Observed in Human Cervical Carcinoma and Colon Adenocarcinoma Cells. Antioxidants, 9 (5), 453, 15 doi:10.3390/antiox9050453.

  doiwww.mdpi.comfulir.irb.hr

• Kralj, J., Bolje, A., Stupin Polančec, D., Gržan, T., Tupek, A., Steiner, I., Stojanović, N., Hohloch, S., Urankar, D., Osmak, M., Sarkar, B., Brozovic, A. & Košmrlj, J. (2019) Half-Sandwich Ir(III) and Os(II) Complexes of Pyridyl-Mesoionic Carbenes as Potential Anticancer Agents. Organometallics, 38 (21), 4082-4092 doi:10.1021/acs.organomet.9b00327.

  doi

• Assaraf, Y., Brozović, A., Gonçalves, A., Jurkovicova , D., Linē, A., Machuqueiro, M., Saponara, S., Sarmento-Ribeiro, A., Xavier, C. & Vasconcelos, M. (2019) The multi-factorial nature of clinical multidrug resistance in cancer. Drug resistance updates, 46, 100645, 78 doi:10.1016/j.drup.2019.100645.

  doiwww.sciencedirect.comdoi.org

• Tomičić, M., Steigerwald, C., Rasenberger, B., Brozović, A. & Christmann, M. (2019) Functional mismatch repair and inactive p53 drive sensitization of colorectal cancer cells to irinotecan via the IAP antagonist BV6. Archives of toxicology, 93 (8), 2265-2277 doi:10.1007/s00204-019-02513-7.

  doi

• Matić, J., Šupljika, F., Tandarić, T., Dukši, M., Piotrowski, P., Vianello, R., Brozović, A., Piantanida, I., Schmuck, C. & Radić Stojković, M. (2019) DNA/RNA recognition controlled by the glycine linker and the guanidine moiety of phenanthridine peptides. International journal of biological macromolecules, 134, 422-434 doi:10.1016/j.ijbiomac.2019.05.063.

  doifulir.irb.hr

• Pernar, M., Kokan, Z., Kralj, J., Glasovac, Z., Tumir, L., Piantanida, I., Eljuga, D., Turel, I., Brozovic, A. & Kirin, S. (2019) Organometallic ruthenium(II)-arene complexes with triphenylphosphine amino acid bioconjugates: Synthesis, characterization and biological properties. Bioorganic chemistry, 87, 432-446 doi:10.1016/j.bioorg.2019.03.048.

  doi

• Grienke, U., Radić Brkanac, S., Vujčić, V., Urban, E., Ivanković, S., Stojković, R., Rollinger, J., Kralj, J., Brozović, A. & Radić Stojković, M. (2018) Biological Activity of Flavonoids and Rare Sesquiterpene Lactones Isolated From Centaurea ragusina L.. Frontiers in Pharmacology, 9, 972, 15 doi:10.3389/fphar.2018.00972.

  doifulir.irb.hrwww.frontiersin.orgdoi.org

• Kokan, Z., Perić, B., Kovačević, G., Brozovic, A., Metzler-Nolte, N. & Kirin, S. (2017) Cis- vs. trans- square-planar palladium(II) and platinum(II) complexes with triphenylphosphine amino acid bioconjugates. European journal of inorganic chemistry, 2017 (33), 3928-3937 doi:10.1002/ejic.201700679.

  doi

• Brozović, A. (2017) The relationship between platinum drug resistance and epithelial–mesenchymal transition. Archives of toxicology, 91 (2), 605-619 doi:10.1007/s00204-016-1912-7.

  doi

• Vajs, J., Proud, C., Brozović, A., Gazvoda, M., Lloyd, A., Roper, D., Osmak, M., Košmrlj, J. & Dowson, C. (2017) Diaryltriazenes as Antibacterial Agents Against Methicillin Resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis. European journal of medicinal chemistry, 127, 223-234 doi:10.1016/j.ejmech.2016.12.060.

  doi

• Steiner, I., Stojanović, N., Bolje, A., Brozović, A., Polančec, D., Ambriović-Ristov, A., Radić Stojković, M., Piantanida, I., Eljuga, D., Košmrlj, J. & Osmak, M. (2016) Discovery of ‘click’ 1, 2, 3-triazolium salts as potential anticancer drugs. Radiology and oncology, 50 (3), 280-288 doi:10.1515/raon-2016-0027.

  doiwww.ncbi.nlm.nih.gov

• Stojanović, N., Brozovic, A., Majhen, D., Herak Bosnar, M., Fritz, G., Osmak, M. & Ambriović-Ristov, A. (2016) Integrin αvβ3 Expression in Tongue Squamous Carcinoma Cells Cal27 Confers Anticancer Drug Resistance Through Loss of pSrc(Y418). Biochimica et biophysica acta-molecular cell research, 1863 (8), 1969-1978 doi:10.1016/j.bbamcr.2016.04.019.

  doi

• Vajs, J., Steiner, I., Brozović, A., Pevec, A., Ambriović-Ristov, A., Matković, M., Piantanida, I., Urankar, D., Osmak, M. & Janez Košmrlj (2015) The 1, 3-diaryltriazenido(p-cymene)ruthenium(II) complexes with a high in vitro anticancer activity. Journal of inorganic biochemistry, 153, 42-48 doi:10.1016/j.jinorgbio.2015.09.005.

  doi

• Brozovic, A., Duran, G., Wang, Y., Francisco, B. & Sikic, B. (2015) The miR-200 family differentially regulates sensitivity to paclitaxel and carboplatin in human ovarian carcinoma OVCAR-3 and MES-OV cells. Molecular Oncology, 9 (8), 1678-1693 doi:10.1016/j.molonc.2015.04.015.

  doi

• Murati, T., Šimić, B., Brozović, A., Kniewald, J., Miletić Gospić, A., Bilandžić, N. & Kmetič, I. (2015) PCB 77 action in ovary cells – cytotoxicity, apoptosis induction and cell cycle analysis. Toxicology mechanisms and methods, 25 (4), 302-311 doi:10.3109/15376516.2015.1028605.

  doi

• Moisan, F., Francisco, E., Brozović, A., Duran, G., Wang, Y., Chaturvedi, S., Seetharamb, S., Snyder, L., Doshi, P. & Sikić, B. (2014) Enhancement of Paclitaxel and Carboplatin Therapies by CCL2 Blockade in Ovarian Cancers. Molecular Oncology, 8 (7), 1231-1239 doi:10.1016/j.molonc.2014.03.016.

  doi

• Brozović, A., Stojanović, N., Ambriović-Ristov, A., Brozović Krijan, A., Polanc, S. & Osmak, M. (2014) 3-Acetyl-bis(2-chloro-4-nitrophenyl) triazene is a potent antitumor agent that induces oxidative stress and independently activates the stress-activated protein. Anti-cancer drugs, 25 (3), 289-295 doi:10.1097/CAD.000000000000006.

  doi

• Brozović, A., Vuković, L., Stupin Polančec, D., Arany, I., Köberle, B., Fritz, G., Fiket, Ž., Majhen, D., Ambriović-Ristov, A. & Osmak, M. (2013) Endoplasmic reticulum stress is involved in response of human laryngeal carcinoma cells to carboplatin but is absent in carboplatin resistant cells. PLoS One, 8 (9), e763973-1 doi:10.1371/journal.pone.0076397.

  doifulir.irb.hr

• Stojanović, N., Urankar, D., Brozović, A., Ambriović-Ristov, A., Osmak, M. & Košmrlj, J. (2013) Design and evaluation of biological activity of diazenecarboxamide-extended cisplatin and carboplatin analogues. Acta chimica Slovenica, 60 (2), 368-374.

  fulir.irb.hr

• Sauerborn Klobučar, R., Brozović, A. & Štambuk, A. (2013) Ecotoxicological assessment of nitrofurantoin in fish cell lines, unicellular algae Desmodesmus subspicatus, and bacterial strains of Salmonella typhimurium. Fresenius environmental bulletin, 22 (9a), 2669-2675.

• Gabrilovac, J., Čupić, B., Zapletal, E. & Brozović, A. (2012) IFN-γ up-regulates kappa opioid receptors (KOR) on murine macrophage cell line J774. Journal of neuroimmunology, 245 (1-2), 56-65 doi:10.1016/j.jneuroim.2012.02.006.

  doi

• Majhen, D., Stojanović, N., Špeljko, T., Brozović, A., De Zan, T., Osmak, M. & Ambriović-Ristov, A. (2011) Increased expression of the coxsackie and adenovirus receptor downregulates alpha v beta 3 and alpha v beta 5 integrin expression, reduces cell adehesion and migration. Life sciences, 89 (7-8), 241-249 doi:10.1016/j.lfs.2011.06.009.

  doi

• Čimbora-Zovko, T., Brozović, A., Piantanida, I., Fritz, G., Virag, A., Alič, B., Majce, V., Kočevar, M., Polanc, S. & Osmak, M. (2011) Synthesis and biological evaluation of 4-nitro-substituted 1, 3-diaryltriazenes as a novel class of potent antitumor agents. European journal of medicinal chemistry, 46 (7), 2971-2983 doi:10.1016/j.ejmech.2011.04.024.

  doi

• Helbig, L., Damrot, J., Johannes Hülsenbeck, Köberle, B., Brozović, A., Osmak, M., Fiket, Ž., Kaina, B. & Fritz, G. (2011) Late activation of stress-activated protein kinases/C-JUN-N- terminal kinases triggered by cisplatin-induced DNA damage repair defective cells. The Journal of biological chemistry, 286 (15), 12991-13001 doi:10.1074/jbc.M110.190645.

  doi

• Brozović, A., Ambriović-Ristov, A. & Osmak, M. (2010) The relationship between cisplatin-induced reactive oxygen species, glutathione, and BCL-2 and resistance to cisplatin. Critical reviews in toxicology, 40 (4), 347-359 doi:10.3109/10408441003601836.

  doi

• Majhen, D., Brozović, A., Buger, T., Gabrilovac, J., Osmak, M. & Ambriović-Ristov, A. (2010) Vincristine-resistant human laryngeal carcinoma cells demonstrate increased Rous sarcoma virus promoter activity. Life sciences, 87 (15/16), 468-474 doi:10.1016/j.lfs.2010.08.012.

  doi

• Sauerborn Klobučar, R., Žaja, R., Franjević, D., Brozović, A. & Smital, T. (2010) Presence of Ecotoxicologically Relevant Pgp- and MRP- Transcripts and Proteins in Cyprinid Fish. Arhiv za higijenu rada i toksikologiju, 61 (2), 175-181. (https://www.bib.irb.hr/446731).

  hrcak.srce.hr

• Brozović, A., Damrot, J., Tsaryk, R., Helbig, L., Nikolova, T., Hartig, C., Osmak, M., Roos, W., Kaina, B. & Fritz, G. (2009) Cisplatin sensitivity is related to late DNA damage processing and checkpoint control rather than to the early DNA damage response. Mutation research, 670 (1-2), 32-41 doi:10.1016/j.mrfmmm.2009.07.002.

  doi

• Brozović, A., Majhen, D., Roje, V., Mikac, N., Jakopec, S., Fritz, G., Osmak, M. & Ambriović-Ristov, A. (2008) Alpha v beta 3 integrin mediated drug resistance in human laryngeal carcinoma cells is caused by glutathione dependent elimination of drug induced reactive oxidative species. Molecular pharmacology, 74 (1), 298-306 doi:10.1124/mol.107.043836.

  doi

• Jakopec, S., Karlović, D., Dubravčić, K., Batinić, D., Sorić, J., Brozović, A., Buljan, D. & Osmak, M. (2008) Lithium effect on glutamate induced damage in glioblastoma cells. Collegium antropologicum, 32 (S1), 87-91.

  hrcak.srce.hr

• Brozović, A. & Osmak, M. (2007) Activation of mitogen-activated protein kinases by cisplatin and their role in cisplatin-resistance. Cancer letters, 251 (1), 1-16 doi:10.1016/j.canlet.2006.10.007.

  doi

• Jakopec, S., Dubravčić, K., Brozović, A., Polanc, S. & Osmak, M. (2006) Structurally similar diazenes exhibit significantly different biological activity. Cell biology and toxicology, 22 (1), 61-71 doi:10.1007/s10565-006-0023-2.

  doi

• Brozović, A., Fritz, G., Christmann, M., Zisowsky, J., Jaehde, U., Osmak, M. & Kaina, B. (2004) Long-term activation of SAPK/JNK, p38 kinase and fas-L expression by cisplatin is attenuated in human carcinoma cells that aquired drug resistance. International journal of cancer, 112 (6), 974-985 doi:10.1002/lijc.20522.

  doi

• Vuković, L., Ambriović-Ristov, A., Čimbora Zovko, T., Ćetković, H., Brozović, A., Majhen, D. & Osmak, M. (2004) Expression of apoptotic genes in low, clinically relevant levels of drug resistance. Periodicum Biologorum, 106 (2), 173-177.
• Brozović, A., Šimaga, Š. & Osmak, M. (2001) Induction of heat shock protein 70 in drug-resistant cells by anticancer drugs and hyperthermia. Neoplasma, 48 (2), 99-103.
• Osmak, M., Nikšić, D., Brozović, A., Ambriović-Ristov, A., Vrhovec, I. & Škrk, J. (1999) Drug resistant tumour cells have increased levels of tumor markers for invasion and metastasis. Anticancer research, 19 (4B), 3193-3197.
• Osmak, M., Brozović, A., Ambriović-Ristov, A., Hadžija, M., Pivčević, B. & Smital, T. (1998) Inhibition of apoptosis is the cause of resistance to doxorubicin in human breast adenocarcinoma cells. Neoplasma, 45 (4), 223-230.
• Osmak, M., Abramić, M., Brozović, A. & Hadžija, M. (1997) Cell respose to repeated doses of ionising radiation: inhibition of apoptosis in cisplatin treated human cells. Periodicum biologorum, 99 (3), 329-333.

Conference proceedings papers

Scientific conference proceedings papers

• Osmak, M. & Brozović, A. (2003) Low doses of gamma rays reduce the sensitivity of cervical carcinoma cells to cisplatin. U: Krajcar-Bronić, I., Miljanić, S. & Obelić, M. (ur.)Zbornik radova V. Simpozija Hrvatskog društva za zaštitu od zračenja.

Patents

• Osmak, M., Slovenko, Polanc, Čimbora-Zovko, Tamara, Brozović, A., Kočevar, M., Majce, V. & Alić, B. (2012) Analogues of 1, 3-bis(4-nitrophenyl)triazenes, their pharmaceutically acceptable salts and N-acyl derivatives for tumour treatment, US 8, 217, 022 B2.

Theses

Doctoral dissertation

• Brozović, A. (2002) 'Molecular mechanisms of apoptosis and DNA damage repair involved in cell-sensitivity to cisplatin', doktorska disertacija, Prirodoslovno-matematički fakultet, Zagreb.

Master thesis

• Brozović, A. (1999) 'Induction of Heat shock proteins in cells after treatment with cytostatics or hyperthermia', magistarski rad, Prirodoslovno-matematički, Zagreb.

• Croatian Association for Cancer Research
• American Association for Cancer Research
• Croatian Society of Biochemistry and Molecular Biology
• Croatian Genetic Society