• Dissecting the redundancy of Rac1 isoforms in Dictyostelium discoideum - DiRac

  16.12.2024 - 15.12.2027 | 186,475.00 EUR

  CroRISIRB

Original scientific paper

• Čizmar, Anja; Putar, Darija; Šimić, Marija; Scholz, Jonas; Marinović, Maja; Horvat, Lucija; Matovina, Mihaela; Weber, Igor; Faix, Jan; Filić, Vedrana | IqgD is a Rac1-interacting IQGAP required for efficient growth of Dictyostelium discoideum on bacterial lawns // Cell Communication and Signaling, (2026), doi: 10.1186/s12964-026-03074-w

  doilink.springer.com

• Mijanović, Lucija; Putar, Darija; Mimica, Lucija; Klajn, Sabina; Filić, Vedrana; Weber, Igor | The IQGAP-related RasGAP IqgC regulates cell–substratum adhesion in Dictyostelium discoideum // Cellular & molecular biology letters, 30 (2025), 4, 27. doi: 10.1186/s11658-024-00678-3

  doicmbl.biomedcentral.comfulir.irb.hr

• Putar, Darija; Čizmar, Anja; Chao, Xiaoting; Šimić, Marija; Šoštar, Marko; Ćutić, Tamara; Mijanović, Lucija; Smolko, Ana; Tu, Hui; Cosson, Pierre et al. | IqgC is a potent regulator of macropinocytosis in the presence of NF1 and its loading to macropinosomes is dependent on RasG // Open Biology, 14 (2024), 1; 230372, 17. doi: 10.1098/rsob.230372

  doiroyalsocietypublishing.orgfulir.irb.hr

• Perenthaler, Elena ; Nikoncuk, Anita ; Yousefi, Soheil ; Berdowski, Woutje M. ; Alsagob, Maysoon ; Capo, Ivan ; van der Linde, Herma C. ; van den Berg, Paul ; Jacobs, Edwin H. ; Putar, Darija et al. | Loss of UGP2 in brain leads to a severe epileptic encephalopathy, emphasizing that bi- allelic isoform-specific start-loss mutations of essential genes can cause genetic diseases // Acta neuropathologica, 139 (2020), 3; 415-442. doi: 10.1007/s00401-019-02109-6

  doilink.springer.com

Review article (scientific)

• Filić, Vedrana; Putar, Darija; Mijanović, Lucija; Weber, Igor | Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families // FEBS Open Bio, 16 (2025), 2; 268-278. doi: 10.1002/2211-5463.70083

  doifebs.onlinelibrary.wiley.comfulir.irb.hr

• Filić, Vedrana ; Mijanović, Lucija ; Putar, Darija ; Talajić, Antea ; Ćetković, Helena ; Weber, Igor | Regulation of the Actin Cytoskeleton via Rho GTPase Signalling in Dictyostelium and Mammalian Cells: A Parallel Slalom // Cells, 10 (2021), 7; 1592, 39. doi: 10.3390/cells10071592

  doiwww.mdpi.comdoi.orgfulir.irb.hr

Conference abstract

• Čizmar, Anja; Putar, Darija; Šimić, Marija; Scholz, Jonas; Horvat, Lucija; Weber, Igor; Faix, Jan; Filić, Vedrana | Helping Cells Grab Particles: A Role of D. discoideum IqgD // 10th Faculty of Science PhD Student Symposium / Petrović Popović, Petra; Popović, Matija (ur.). | Zagreb: University of Zagreb Faculty of Science, 2026. str. 31-31

• Čizmar, Anja; Putar Brajković, Darija; Marinović, Maja; Mijanović, Lucija; Weber, Igor; Faix, Jan; Filić Mileta, Vedrana | Dictyostelium discoideum IQGAP proteins IqgC and IqgD - siblings or distant relatives // 17th Multinational Congress on Microscopy, 17 MCM Book of Abstracts / Žagar Soderžnik, Kristina; Kostanjšek, Rok; Šetina Batič, Barbara et al. (ur.). | Ljubljana: Slovene Society for Microscopy, 2025. str. 236-237

  17mcm.si

• Putar, Darija; Čizmar, Anja; Chao, Xiaoting; Šimić, Marija; Šoštar, Marko; Ćutić, Tamara; Mijanović, Lucija; Smolko, Ana; Tu, Hui; Cosson, Pierre et al. | IqgC negatively regulates macropinocytosis by deactivating RasG, but RasG is required for its recruitment to macropinocytic cups // FEBS3+ Meeting: Exploring Molecular Frontiers / Dulić, Morana; Sinčić, Nino; Stuparević, Igor (ur.). | Zagreb: Hrvatsko društvo za biokemiju i molekularnu biologiju, 2024. str. 64-65

• Privara, Anja; Putar, Darija; Weber, Igor; Filić, Vedrana | The emerging role of Dictyostelium discoideum IQGAP-related protein IqgD in large-scale endocytosis // Dicty 2023 Annual International Dictyostelium Conference : Book of Abstracts / Weber, Igor; Filić, Vedrana (ur.). | Zagreb: Institut Ruđer Bošković, 2023, P2, 1

  api.fourwaves.com

• Privara, Anja ; Putar, Darija ; Weber, Igor ; Filić, Vedrana | Dictyostelium IqgD is a Rho-regulated IQGAP involved in large-scale endocytosis // 4th Croatian Microscopy Congress with International Participation: Book of Abstracts. | Poreč: Hrvatsko mikroskopijsko društvo ; Institut Ruđer Bošković, 2022. str. 80-80

• Privara, Anja ; Putar, Darija ; Weber, Igor ; Filić, Vedrana | Dictyostelium discoideum IqgD regulates actin cytoskeleton in large-scale endocytosis // Book of Abstracts of the Congress of the Croatian Society of Biochemistry and Molecular Biology "HDBMB22: From Science to Knowledge". | Zagreb, 2022. str. 123-123

  congress2022.hdbmb.hr

• Mijanović, Lucija ; Putar, Darija ; Filić, Vedrana ; Weber, Igor | The RasGAP protein IqgC regulates cell-substratum adhesion in ameboid cells // Book of Abstracts of the Congress of the Croatian Society of Biochemistry and Molecular Biology "HDBMB22: From Science to Knowledge. | Zagreb: Hrvatsko Društvo za Biotehnologiju, 2022. str. 108-108

  congress2022.hdbmb.hr

• Putar, Darija ; Ćutić, Tamara ; Mijanović, Lucija ; Weber, Igor ; Filić, Vedrana | IqgC protein interacts with RasG and Rab5A GTPases during macropinocytosis in amoeba Dictyostelium discoideum // Book of Abstracts of the Congress of the Croatian Society of Biochemistry and Molecular Biology "HDBMB22: From Science to Knowledge". | Zagreb: Hrvatsko Društvo za Biotehnologiju, 2022. str. 125-125

  congress2022.hdbmb.hr

• Putar, Darija ; Ćutić, Tamara ; Weber, Igor ; Filić, Vedrana | Small GTPases interacting with IqgC on Dictyostelium macropinosomes // 4th Croatian Microscopy Congress with International Participation: Book of Abstracts. | Zagreb: Hrvatsko mikroskopijsko društvo ; Institut Ruđer Bošković, 2022. str. 81-82

• Mijanović, Lucija ; Putar, Darija ; Filić, Vedrana ; Weber, Igor | IqgC at the crossroads of RasGAP and IQGAP protein families // 4th Croatian Microscopy Congress with International Participation : Book of Abstracts. | Zagreb: Hrvatsko mikroskopijsko društvo ; Institut Ruđer Bošković, 2022. str. 76-77

• Putar, Darija; Mijanović, Lucija; Weber, Igor; Filić, Vedrana | Requirements for IqgC protein recruitment to macropinosomes in amoeba Dictyostelium discoideum // Microscopy conference 2021, Joint Meeting of Dreiländertagung & Multinational Congress on Microscopy. | 2021. str. 376-376

• Mijanović, Lucija; Putar, Darija; Filić, Vedrana; Weber, Igor | A novel function of the RasGAP protein IqgC in cell adhesion // Microscopy conference 2021, Joint Meeting of Dreiländertagung & Multinational Congress on Microscopy. | 2021. str. 373-374

• Mijanović, Lucija ; Putar, Darija ; Filić, Vedrana ; Weber, Igor | Uloga proteina IqgC porodice RasGAP u staničnoj adheziji // Simpozij studenata doktorskih studija PMF-a : knjiga sažetaka = PhD student symposium 2021 : book of abstracts. | Zagreb: Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu, 2021. str. 219-220

  www.pmf.unizg.hr

• Putar, Darija ; Mijanović, Lucija ; Weber, Igor ; Filić, Vedrana | Recruitment mechanisms of RasGAP protein IqgC to macropinosomes in amoeba Dictyostelium discoideum // Simpozij studenata doktorskih studija PMF-a : knjiga sažetaka = PhD student symposium 2021 : book of abstracts. | Zagreb: Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu, 2021. str. 235-236

  www.pmf.unizg.hr

• Putar, Darija ; Zima, David ; Trnski, Sara ; Bobić Rasonja, Mihaela ; Jovanov Milošević, Nataša | The semaphorin5a developmental expression and functional role in mice telencephalon // 7th Croatian neuroscience congress : book of abstracts. | Zagreb, 2019. str. 88-88

  hdn.hr

• Marinović, Maja ; Mijanović, Lucija ; Šoštar, Marko ; Putar, Darija ; Filić, Vedrana ; Weber, Igor | Dictyostelium IQGAP-related proteins negatively regulate roles of small GTPases in promoting actin protrusions // Book of Abstracts of the Congress of the Croatian Society of Biochemistry and Molecular Biology “Crossroads in Life Sciences”, HDBMB2019. | Zagreb: Hrvatsko Društvo za Biotehnologiju, 2019. str. 102-102

• Putar, Darija ; Zima, David ; Trnski, Sara ; Bobić Rasonja, Mihaela ; Jovanov Milošević, Nataša | In vitro and in situ study of the role of Sema5A in the developing mouse telencephalon // Pokusne životinje u znanstvenim istraživanjima: knjiga sažetaka. | Zagreb: Hrvatsko društvo za znanost o laboratorijskim životinjama, 2018. str. 51-52

Conference abstract

• Mijanović, Lucija ; Putar, Darija ; Filić, Vedrana ; Weber, Igor | Dissection of the role of IqgC domains in the cell substratum adhesion // FEBS Open Bio, 12, S1, 2022. str. 205-206

  febs.onlinelibrary.wiley.com

• Putar, Darija ; Ćutić, Tamara ; Mijanović, Lucija ; Weber, Igor ; Filić, Vedrana | IQGAP-related protein IqgC interacts with RasG and Rab5A on Dictyostelium macropinosomes // FEBS Open Bio, 2022. str. 206-206

  doi.org

• Mijanović, Lucija ; Putar, Darija ; Filić, Vedrana ; Weber, Igor | IQGAP-related protein IqgC involved in large- scale endocytosis regulates cell-substratum adhesion and migration in Dictyostelium // FEBS Open Bio, 2021. str. 182-182

  2021.febscongress.orgfebs.onlinelibrary.wiley.com

• Zima, David ; Putar, Darija ; Trnski, Sara ; Bobić Rasonja, Mihaela ; Jovanov Milošević, Nataša | The role of Semaphorin5A protein during brain development in rodents // Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti, 2019. str. 76-76

  hrcak.srce.hr

Unpublished conference paper

• Filić, Vedrana; Marinović, Maja; Mijanović, Lucija; Putar, Darija; Čizmar, Anja; Weber, Igor; Faix, Jan; Cai, Huaqing | The IQGAP-related protein IqgC regulates macropinocytosis by inactivating its cognate GTPase RasG // Regulation and Function of Small GTPases | Sjedinjene Američke Države, 23.06.2024-27.06.2024

• Čizmar, Anja; Putar, Darija; Weber, Igor; Filić, Vedrana | Dictyostelium discoideum IqgD regulates the dynamics of the actin cytoskeleton via interaction with Rac1 GTPases // Regulation and Function of Small GTPases | Sjedinjene Američke Države, 23.06.2024-27.06.2024

• Putar, Darija; Privara, Anja; Chao, Xiaoting; Šoštar, Marko; Ćutić, Tamara; Mijanović, Lucija; Smolko, Ana; Tu, Hui; Cosson, Pierre; Weber, Igor et al. | Small GTPases RasG and Rab5A regulate IqgC localization during macropinocytosis // The International Dictyostelium conference | Opatija, Hrvatska, 27.08.2023-31.08.2023

  api.fourwaves.com

• Mijanović, Lucija; Putar, Darija; Filić, Vedrana; Weber, Igor | Touch and Go: Adhesion of Dictyostelium Amoebae to Surfaces // Adhere1 | Zadar, Hrvatska, 06.09.2023-09.09.2023

Doctoral thesis

• Putar Brajković, Darija | Uloga proteina IqgC u regulaciji makropinocitoze u amebi Dictyostelium discoideum / Filić, Vedrana (mentor). | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2024