12. 05. 1995. B. Sc. Degree: “Preparation and Characterization of Bidentate and Monodentate Nitrogen Ligands with Oxazoline”, Chemistry Department, Faculty of Science and Mathematics, University of Zagreb, Supervisor: Prof. Dr. sc. V. Šunjić

1995. – 2000 Postgraduate study of Organic Chemistry, Chemistry Department, Faculty of Science, University of Zagreb

19. 07. 2000. M. Sc. degree: “Aromatic π-π Interactions” Molecular Recognition of Nucleotides by Conjugates Phenantridinium-Nucleic Acid Base”, Supervisor: Prof. Dr. sc. M. Žinić

24. 04. 2006. Ph. D. degree: “Synthesis of Nucleotide-Selective Bisintercaland-Receptors and Their Interactions with Nucleotides and Nucleic Acids”, Supervisor: Prof. Dr. sc. M. Žinić

Lecturer assistant in:

Postgraduate studies of Chemistry, Course: "Supramolecular Chemistry" (Faculty of Science, Organic Chemistry, with Prof. dr. sc. Mladen Žinić) Postgraduate studies of Chemistry, Course: "Stereochemistry" (Faculty of Science, Organic Chemistry, with Prof. dr. sc. Mladen Žinić)

L.-M. Tumir, M. Grabar, S. Tomić, I. Piantanida, "The interactions of bis-phenanthridinium – nucleobase conjugates with nucleotides: adenine conjugate recognizes UMP in aqueous medium."; Tetrahedron 66 (2010), 2501-2513.

L.-M. Tumir, I. Piantanida, M. Žinić, I. Juranović Cindrić, Z. Meić, M. Kralj, S. Tomić; "Synthesis of phenanthridinium bis–nucleobase conjugates, interactions with poly U, nucleotides and in vitro antitumor activity of mono– and bis–nucleobase conjugates."; Eur. J. Med. Chem., 41 (2006) 1153-1166.

L.-M. Tumir, I. Piantanida, I. Juranović , Z. Meić, S. Tomić, M. Žinić, "Recognition of homo-polynucleotides containing adenine by a phenanthridinium bis-uracil conjugate in aqueous media"; Chem. Commun. (2005) 2561-2563.

V. Malinovski, L. Tumir, I. Piantanida, M. Žinić, H.-J. Schneider: "New porphyrin-nucleobase hybrid compounds and their interaction with nucleosides and nucleic acids"; Eur. J. Org. Chem. (2002) 3785-3795.

I. Juranović , Z. Meić , I. Piantanida, L.-M. Tumir, M. Žinić: "Interactions of phenanthridinium-nucleobase conjugates with polynucleotides in aqueous media. Recognition of poly U"; Chem. Commun. (2002) 1432-1433.

Journal articles

Scientific and review papers

• Matić, J., Tandarić, T., Radić Stojković, M., Šupljika, F., Karačić, Z., Tomašić Paić, A., Horvat, L., Vianello, R. & Tumir, L. (2023) Phenanthridine–pyrene conjugates as fluorescent probes for DNA/RNA and an inactive mutant of dipeptidyl peptidase enzyme. Beilstein journal of organic chemistry, 19, 550-565 doi:10.3762/bjoc.19.40.

  doiwww.beilstein-journals.orgfulir.irb.hr

• Zonjić, I., Kurutos, A., Mihovilović, P., Crnolatac, I., Tumir, L., Tomašić Paić, A., Kralj, J., Horvat, L., Brozovic, A., Stojković, R. & Radić Stojković, M. (2022) Formation of triplex rA/dA-containing nucleic acid helices induced by new thiazole orange analogues and their biological evaluation. H-aggregate formation conditioned by rA sequence. Dyes and pigments, 207, 110715, 14 doi:10.1016/j.dyepig.2022.110715.

  doi

• Zonjić, I., Radić Stojković, M., Crnolatac, I., Tomašić Paić, A., Pšeničnik, S., Vasilev, A., Kandinska, M., Mondeshki, M., Baluschev, S., Landfester, K., Glavaš-Obrovac, L., Jukić, M., Kralj, J., Brozovic, A., Horvat, L. & Tumir, L. (2022) Styryl dyes with N-Methylpiperazine and N-Phenylpiperazine Functionality: AT-DNA and G-quadruplex binding ligands and theranostic agents. Bioorganic chemistry, 127, 105999, 15 doi:10.1016/j.bioorg.2022.105999.

  doi

• Zonjić, I., Tumir, L., Crnolatac, I., Šupljika, F., Racané, L., Tomić, S. & Radić Stojković, M. (2022) Recognition of ATT Triplex and DNA:RNA Hybrid Structures by Benzothiazole Ligands. Biomolecules, 12 (3), 1600173, 20 doi:10.3390/biom12030374.

  doiwww.mdpi.comdoi.orgfulir.irb.hr

• Berger, S., Rühe, J., Schwarzmann, J., Phillipps, A., Richard, A., Ferger, M., Krummenacher, I., Tumir, L., Ban, Ž., Crnolatac, I., Majhen, D., Barišić, I., Piantanida, I., Schleier, D., Griesbeck, S., Friedrich, A., Braunschweig, H. & Marder, T. (2021) Bithiophene-Cored, mono-, bis-, and tris-(Trimethylammonium)-Substituted, bis-Triarylborane Chromophores: Effect of the Number and Position of Charges on Cell Imaging and DNA/RNA Sensing. Chemistry : a European journal, 27, 14057-14072 doi:10.1002/chem.202102308.

  doichemistry-europe.onlinelibrary.wiley.comdoi.orgfulir.irb.hr

• Mikulin, I., Ljubić, I., Piantanida, I., Vasilev, A., Mondeshki, M., Kandinska, M., Uzelac, L., Martin-Kleiner, I., Kralj, M., Tumir, L. & (2021) Polycationic Monomeric and Homodimeric Asymmetric Monomethine Cyanine Dyes with Hydroxypropyl Functionality—Strong Affinity Nucleic Acids Binders. Biomolecules, 11 (8), 1075, 21 doi:10.3390/biom11081075.

  doiwww.mdpi.comdoi.orgfulir.irb.hr

• Tumir, L., Zonjić, I., Žuna, K., Radić Brkanac, S., Jukić, M., Huđek, A., Durgo, K., Crnolatac, I., Glavaš-Obrovac, L., Cardullo, N., Pulvirenti, L., Muccilli, V., Tringali, C. & Radić Stojković, M. (2020) Synthesis, DNA/RNA-interaction and biological activity of benzo[k,l]xanthene lignans. Bioorganic chemistry, 104, 104190, 12 doi:10.1016/j.bioorg.2020.104190.

  doi

• Bačinić, A., Tumir, L. & Mlakar, M. (2020) Electrochemical Characterization of Cobalt(II)-Complexes Involved in Marine Biogeochemical Processes. I. Co(II)-4-Nitrocatechol and Co(II)-Humate. Electrochimica acta, 337, 135797, 7 doi:10.1016/j.electacta.2020.135797.

  doi

• Bistrović Popov, A., Stolić, I., Krstulović, L., Taylor, M., Kelly, J., Tomić, S., Tumir, L., Bajić, M. & Raić-Malić, S. (2019) Novel symmetric bis-benzimidazoles: Synthesis, DNA/RNA binding and antitrypanosomal activity. European journal of medicinal chemistry, 173, 63-75 doi:10.1016/j.ejmech.2019.04.007.

  doi

• Pernar, M., Kokan, Z., Kralj, J., Glasovac, Z., Tumir, L., Piantanida, I., Eljuga, D., Turel, I., Brozovic, A. & Kirin, S. (2019) Organometallic ruthenium(II)-arene complexes with triphenylphosphine amino acid bioconjugates: Synthesis, characterization and biological properties. Bioorganic chemistry, 87, 432-446 doi:10.1016/j.bioorg.2019.03.048.

  doi

• Saftić, D., Ban, Ž., Matić, J., Tumir, L. & Piantanida, I. (2019) Conjugates of classical DNA/RNA binder with nucleobase: chemical, biochemical and biomedical applications. Current medicinal chemistry, 26 (30), 5609-5624 doi:10.2174/0929867325666180508090640.

  doi

• Saftić, D., Radić Stojković, M., Žinić, B., Glavaš-Obrovac, L., Jukić, M., Piantanida, I. & Tumir, L. (2017) Impact of linker between triazolyl-uracil and phenanthridine on recognition of DNA and RNA. Recognition of uracil – containing RNA.. New journal of chemistry, 41 (22), 13240-13252 doi:10.1039/C7NJ02699D.

  doi

• Knežević Teofilović, N., Bihi, M., Radić Stojković, M., Tumir, L., Ester, K., Kralj, M., Majhen, D., Oršolić, N., Lepur, A., Vrbanec, D., Markotić, A., Dembić, Z., Weber, A., Piantanida, I., Vugrek, O., Diken, M. & Knežević, J. (2017) 1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro. Bioorganic & medicinal chemistry letters, 27 (7), 1530-1537 doi:10.1016/j.bmcl.2017.02.048.

  doi

• Mlakar, M., Pavković, S., Tumir, L., Vukosav, P. & Gašparović, B. (2017) Electrochemical characterization of biochemically active Cu(II) mixed ligand complex with histidine and cysteine. Electroanalysis, 29 (2), 392-397 doi:10.1002/elan.201600253.

  doi

• Suć, J., Tumir, L., Glavaš-Obrovac, L., Jukić, M., Piantanida, I. & Jerić, I. (2016) The impact of alpha-hydrazino acids embedded in short fluorescent peptides on peptide interactions with DNA and RNA. Organic & biomolecular chemistry, 14 (21), 4865-4874 doi:10.1039/c6ob00425c.

  doi

• Tumir, L., Šupljika, F. & Piantanida, I. (2016) Bisphenanthridinium – adenine conjugates as fluorescent and CD reporters for fine structural differences in ds-DNA/RNA and ss-RNA structures. Supramolecular chemistry, 28 (3-4), 267-274 doi:10.1080/10610278.2015.1099655.

  doi

• Matić, J., Tumir, L., Radić Stojković, M. & Piantanida, I. (2016) Advances in peptide-based DNA/RNA-intercalators. Current protein & peptide science, 17 (2), 127-134 doi:10.2174/138920371702160209124439.

  doi

• Tumir, L., Radić Stojković, M. & Piantanida, I. (2014) Come-back of phenanthridine and phenanthridinium derivatives in 21st century. Beilstein journal of organic chemistry, 10, 2930-2954 doi:10.3762/bjoc.10.312.

  doifulir.irb.hr

• Crnolatac, I., Tumir, L., Lesev, N., Vasilev, A., Deligeorgiev, T., Mišković, K., Glavaš-Obrovac, L., Vugrek, O. & Piantanida, I. (2013) Probing the structural properties of DNA/RNA grooves by sterically restricted phosphonium dyes ; screening of dye cell toxicity and uptake. ChemMedChem, 8 (7), 1093-1103 doi:10.1002/cmdc.201300085.

  doi

• Grabar Branilović, M., Tomić, S., Tumir, L. & Piantanida, I. (2013) The bis-phenanthridinium system flexibility and position of covalently bound uracil finely tunes the interaction with polynucleotides. Molecular biosystems, 9 (8), 2051-2062 doi:10.1039/C3MB25578F.

  doi

• Tumir, L., Crnolatac, I., Deligeorgiev, T., Vasilev, A., Kaloyanova, S., Grabar Branilović, M., Tomić, S. & Piantanida, I. (2012) Kinetic differentiation between homo- and alternating AT-DNA by sterically restricted phosphonium dyes. Chemistry : a European journal, 18 (13), 3859-3864 doi:10.1002/chem.201102968.

  doi

• Tumir, L. & Piantanida, I. (2010) Recognition of single stranded and double stranded DNA / RNA sequences in aqueous medium by small bis-aromatic derivatives. Mini-reviews in medicinal chemistry, 10 (4), 299-308 doi:10.2174/138955710791330990.

  doi

• Tumir, L., Grabar, M., Tomić, S. & Piantanida, I. (2010) The interactions of bis-phenanthridinium – nucleobase conjugates with nucleotides: adenine conjugate recognizes UMP in aqueous medium. Tetrahedron, 66 (13), 2501-2513 doi:10.1016/j.tet.2010.01.063.

  doifulir.irb.hr

• Tumir, L., Piantanida, I., Žinić, M., Juranović Cindrić, I., Meić, Z., Kralj, M. & Tomić, S. (2006) Synthesis of phenanthridinium bis-nucleobase conjugates, interactions with poly U, nucleotides and in vitro antitumor activity of mono- and bis-nucleobase conjugates. European Journal of Medicinal Chemistry, 41 (10), 1153-1166.

• Tumir, L., Piantanida, I., Juranović, I., Meić, Z., Tomić, S. & Žinić, M. (2005) Recognition of homo-polynucleotides containing adenine by phenanthridinium bis-uracil conjugate in aqueous media.. Chemical communications, - (20), 2561-2563.

• Tumir, L., Piantanida, I., Juranović Cindrić, I., Hrenar, T., Meić, Z. & Žinić, M. (2003) New Permanently Charged Phenantridinium-Nucleobase Conjugates. Interactions with Nucleotides and Polynucleotides and Recognition of ds-PolyAH, J.. Journal of Physical Organic Chemistry, 16 (12), 891-899.

• Malinovski, V., Tumir, L., Piantanida, I., Žinić, M. & Schneider, H. (2002) New porphyrin-nucleobase hybrid compounds and their interaction with nucleosides and nucleic acids. European Journal of Organic Chemistry, 2002 (22), 3785-3795.

• Juranović, I., Meić, Z., Piantanida, I., Tumir, L. & Žinić, M. (2002) Interactions of phenanthridinium-nucleobase conjugates with polynucleotides in aqueous media. Recognition of poly U. Chemical communications, 13, 1432-1433.

• Tumir, L., Piantanida, I., Novak, P. & Žinić, M. (2002) Interactions of novel phenanthridinium-nucleobase conjugates with complementary and non-complementary nucleotides in aqueous media. Journal of Physical Organic Chemistry, 15 (8), 599-607.

• Đaković, S., Liščić-Tumir, L., Kirin, S., Vinković, V., Raza, Z., Šuste, A. & Šunjić, V. (1997) Enantioselectivity in Cyclopropanation Catalyzed by Cu(I) Catalytic Complexes Increased by pi Stacking of Two Monodentate Ligands. Journal of Molecular Catalysis. A, Chemical, 118 (1), 27-31 doi:10.1016/S1381-1169(96)00113-6.

  doi

• Čaplar, V., Tumir, L. & Žinić, M. (1996) A novel type of rigid macrocycle with bis(3-uracilyl)methane and hexadiyne units - the uracilophane. Croatica chemica acta, 69 (4), 1617-1631.

  hrcak.srce.hr

Theses

Doctoral dissertation

• Tumir, L. (2006) 'Synthesis of Nucleotide-Selective Bisintercaland-Receptors and their Interactions with Nucleotides and Nucleic Acids', doktorska disertacija, Prirodoslovno-matematički fakultet, Zagreb.

Master thesis

• Tumir, L. (2000) 'Aromatic pi-pi interactions. Molecular recognition of nucleotides by phenanthridinium-nucleic base conjugates.', magistarski rad, Prirodoslovno-matematički, Zagreb.

Croatian Chemical Society