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Synthesis of Supramolecular Self-assembled Nanostructures for Construction of Advanced Functional Materials

Principal Investigator

Category
Projekti Hrvatske zaklade za znanost
Project code
IP-2018-01-6910
Finance value
1.000.000,00
HRK
Start date
Nov 6th 2018
End date
Nov 5th 2022
Status
Active
Synthesis of Supramolecular Self-assembled Nanostructures for Construction of Advanced Functional Materials

Research in the framework of the proposed project is interdisciplinary with the aim of design, supramolecular synthesis and characterization of new functional supramolecular self-assembled nanostructures for construction of advanced functional materials. Molecular self-assembly usually takes advantage of supramolecular interactions (ionic, hydrophobic, van der Waals, hydrogen and coordination bonds) which allow construction of new nanostructures with attractive properties. Based on the rules of supramolecular chemistry, the bottom-up approach to design functional structures at the nanoscale is currently producing highly sophisticated materials for wide application. These structural features are nowadays well understood and can be finely controlled in order to introduce and tune specific functional properties of self-assembled nanomaterials. Further, such systems exhibit a complex array of morphologies and dynamics and have a huge potential for new applications in biomedical sciences, information technologies and environmental sciences. In continuation of our previous research of self-assembly systems the attention in this project will be focused on two main areas of research: 1) nanofabrication, preparation and characterization of new soft nanomaterials based on organo- and hydro-gels with incorporated oxalylamide or fumaramide central units and synthesis of bioinspirated supramolecular systems based on self-assembled natural peptides, the preparation of new materials by gel polymerization and the development of new supramolecular materials that incorporate photoactive functional groups 2) design, preparation and characterization of new functional supramolecular systems based on liposomes and ß-cyclodextrines for targeted drug delivery and surface recognition studies. Further, biological potential of synthesized functional supramolecular systems in drug and gene delivery will be tested.

Other associates

Researchers on the project IP-2018-01-6910:

  • Nika Gazdek, mag. appl. chem., Ph.D. Student Research / Assistant, ZOKB, LBIS, IRB
  • Ivona Čipor, mag. appl. chem., Ph.D. Student Research / Assistant, ZOKB, LBIS, IRB
  • Tomislav Gregorić, mag. appl. chem., Ph.D. Student Research / Assistant, ZOKB, LSK, IRB
  • Tomislav Portada, Dr., research associate, ZOKB, IRB
  • Berislav Perić, dr. sc., research associate, ZKM, LSSCCS, IRB
  • Petra Radošević, technician, ZOKB, IRB
  • Ruža Frkanec, Dr., Scientific advisor, Center for Research and Knowledge Transfer in Biotechnology, University of Zagreb
  • Adela Štimac, Dr., Center for Research and Knowledge Transfer in Biotechnology, University of Zagreb
  • Vladislav Tomišić, Prof. Dr., Division of Physical Chemistry, Faculty of Science of the University of Zagreb
  • Žiga Jakopin, prof. dr. sc., Faculty of Pharmacy, Faculty of Pharmacy, University of Ljubljana, Slovenia
  • Mladen Žinić, Prof. Dr., full member of Croatian Academy of Sciences and Arts (HAZU)

Consultant:

  • Peter Johann Walde, Prof. Dr., Department of Materials (D-​MATL), ETH Zurich, Zurich, Schweiz

Bibliography of the project HRZZ-IP-2018-01-6910  (Croatian Scientific Bibliography CROSBI)

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