Dr. Ivanka Jerić
HR-10000 Zagreb
Croatia
Education
- 1994 - Faculty of Natural Sciences, University of Zagreb, Chemistry, B. Sc.
- 1997 - Faculty of Natural Sciences, University of Zagreb, Organic Chemistry, M. Sc.
- 2000 - Faculty of Natural Sciences, University of Zagreb, Organic Chemistry, PhD
Projects
Croatia Science Foundation project (2015-2019): The assembly of peptidomimetics by multicomponent reaction (MIMICRy); PI
FP7 REGPOT project (2013-2016): Enhancement of the Innovation Potential in SEE through new Molecular Solutions in Research and Development (InnoMol); WP leader
Awards and Achievements
- 2010. Annual Award for the scientific publication (Ruđer Bošković Institute)
- 2001. Krka Prize Winner (International award given by pharmaceutical company Krka, Novo Mesto, Slovenia)
Classes
- Postgraduate PhD Study in Organic Chemistry (UniversityofZagreb). Course (elective): Synthesis of peptides/proteins and their conjugates
- International PhD Study in Medicinal Chemistry (organized by RBI, University of Rijeka and GlaxoSmitKline Zagreb). Course (mandatory): Methods in peptide, carbohydrate and nucleoside synthesis. Course (elective): Synthesis of peptides/proteins and their conjugates.
- Postgraduate PhD study "Environmental Chemistry of Mediterranean" (organized by RBI and University of Split)Course (elective): Bioactive peptides from marine sources
Featured Publications
- A. Jakas, A. Višnjevac, I. Jerić, Multicomponent approach to homo- and hetero-multivalent glycomimetics bearing rare monosaccharides. J. Org. Chem. 2020, 85, 3766-3787
- K. Vlahoviček-Kahlina, J. Suć Sajko, I. Jerić, C-Linked Glycomimetic Libraries Accessed by the Passerini Reaction. Int. J. Mol. Sci. 2019, 20, 6236.
- J. Suć Sajko, V. Ljoljić Bilić, I. Kosalec, I. Jerić, Multicomponent Approach to a Library of N‑Substituted γ‑Lactams. ACS Comb. Sci. 2019, 21, 28−34.
- K. Vazdar, I. Jerić, Amino-b-lactams in Ugi reaction: An efficient method for preparation of functionalized peptidomimetics. Tetrahedron 74 (2018) 7495-7506
- K. Vlahoviček-Kahlina, M. Vazdar, A. Jakas, V. Smrečki, I. Jerić, J. Org. Chem. 2018, 83, 13146-13156
- L. Brkljačić, I. Jerić, Glutamic acid‐related hydrazine reagent for the derivatization of carbonyl compounds. J. Mass Spectrom. 2018;53:649–654
- M. Glavaš, M. Gredičak, I. Jerić, (2018) Enediyne-Comprising Amino Aldehydes in the Passerini Reaction. ACS Comb. Sci.20 (2018) 151 -155
Publications
Journal articles
Scientific and review papers
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Jakas, A., Ayyalasomayajula, R., Cudic, M. & Jerić, I. (2022) Multicomponent reaction derived small di- and tri-carbohydrate-based glycomimetics as tools for probing lectin specificity. Glycoconjugate Journal, 39, 587-597 doi:10.1007/s10719-022-10079-3.
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Suć Sajko, J. & Jerić, I. (2022) Synthesis of Nβ-Substituted 1,2-Diazetidin-3-ones by the Ugi Reaction Comprising Chiral α-Hydrazino Acids. Journal of organic chemistry, 87 (11), 7076-7084 doi:10.1021/acs.joc.2c00238.
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Glavaš, M., Gredičak, M., Štefanić, Z. & Jerić, I. (2022) Synthesis of 14-membered enediyne-embedded macrocycles. Organic & biomolecular chemistry, 20 (18), 3823-3834 doi:10.1039/d2ob00090c.
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Puškarić, A., Dunatov, M., Jerić, I., Sabljić, I. & Androš Dubraja, L. (2022) Room temperature ferroelectric copper(ii) coordination polymers based on amino acid hydrazide ligands. New journal of chemistry, 46 (7), 3504-3511 doi:10.1039/d1nj05746d.
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Kopriva, I., Jerić, I., Popović Hadžija, M., Hadžija, M. & Vučić Lovrenčić, M. (2021) Nonnegative Least Squares Approach to Quantification of 1H Nuclear Magnetic Resonance Spectra of Human Urine. Analytical chemistry, 93 (2), 745-751 doi:10.1021/acs.analchem.0c02837.
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Vlahoviček-Kahlina, K., Štefanić, Z., Vazdar, K. & Jerić, I. (2020) N‐Alkylated C‐Glycosyl Amino Acid Derivatives: Synthesis by a One‐Pot Four‐Component Ugi Reaction. ChemPlusChem, 85 (5), 838-844 doi:10.1002/cplu.202000177.
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Jakas, A., Višnjevac, A. & Jerić, I. (2020) Multicomponent Approach to Homo- and Hetero- Multivalent Glycomimetics Bearing Rare Monosaccharides. Journal of organic chemistry, 85 (5), 3766-3787 doi:10.1021/acs.joc.9b03401.
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Ćehić, M., Suć Sajko, J., Karačić, Z., Piotrowski, P., Šmidlehner, T., Jerić, I., Schmuck, C., Piantanida, I. & Tomić, S. (2020) The guanidiniocarbonylpyrrole - fluorophore conjugates as theragnostic tools for DPP III monitoring and inhibition. Journal of biomolecular structure & dynamics, 38 (13), 3790-3800 doi:10.1080/07391102.2019.1664936.
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Glavač, D., Jerić, I. & Gredičak, M. (2019) Organocatalytic Synthesis of α,α–Diaryl Substituted α–Amino Acid Derivatives by an Interrupted Three-Component Ugi Reaction. Croatica chemica acta, 92 (2), 203-209 doi:10.5562/cca3536.
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Vlahoviček-Kahlina, K., Suć Sajko, J. & Jerić, I. (2019) C-Linked Glycomimetic Libraries Accessed by the Passerini Reaction. International journal of molecular sciences, 20 (24), 6236, 19 doi:10.3390/ijms20246236.
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Kopriva, I., Jerić, I., Popović Hadžija, M., Hadžija, M., Vučić Lovrenčić, M. & Brkljačić, L. (2019) Library-Assisted Nonlinear Blind Separation and Annotation of Pure Components from a Single 1H Nuclear Magnetic Resonance Mixture Spectra. Analytica chimica acta, 1080, 55-65 doi:10.1016/j.aca.2019.07.004.
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Suć Sajko, J., Ljoljić Bilić, V., Kosalec, I. & Jerić, I. (2019) Multicomponent Approach to a Library of N- Substituted γ-Lactams. ACS Combinatorial Science, 21 (1), 28-34 doi:10.1021/acscombsci.8b00147.
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Vazdar, K. & Jerić Ivanka (2018) Amino-β-lactams in Ugi reaction: An efficient method for preparation of functionalized peptidomimetics. Tetrahedron, 74 (52), 7495-7506 doi:10.1016/j.tet.2018.11.028.
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Belužić, L., Grbeša, I., Belužić, R., Park, J., Kong, H., Kopjar, N., Espadas, G., Sabidó, E., Lepur, A., Rokić, F., Jerić, I., Brkljačić, L. & Vugrek, O. (2018) Knock-down of AHCY and depletion of adenosine induces DNA damage and cell cycle arrest. Scientific Reports, 8, 14012, 16 doi:10.1038/s41598-018-32356-8.
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Vlahoviček-Kahlina, K., Vazdar, M., Jakas, A., Smrečki, V. & Jerić, I. (2018) Synthesis of Glycomimetics by Diastereoselective Passerini Reaction. Journal of organic chemistry, 83 (21), 13146-13156 doi:10.1021/acs.joc.8b01874.
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Brkljačić, L. & Jerić, I. (2018) Glutamic acid‐related hydrazine reagent for the derivatization of carbonyl compounds. Journal of mass spectrometry, 53 (8), 649-654 doi:10.1002/jms.4201.
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Androš Dubraja, L., Jerić, I., Puškarić, A., Bronić, J. & Moreno-Pineda, E. (2018) Coordination ability of amino acid hydrazide ligands and their influence on magnetic properties in copper(II) coordination polymers. Crystengcomm, 20 (17), 2396-2403 doi:10.1039/C8CE00210J.
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Glavaš, M., Gredičak, M. & Jerić, I. (2018) Enediyne-comprising amino aldehydes in the Passerini reaction. ACS Combinatorial Science, 20 (3), 151-155 doi:10.1021/acscombsci.7b00167.
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Suć, J., Barić, D. & Jerić, I. (2016) Multicomponent synthesis of hydrazino depsipeptides. RSC Advances, 6 (102), 99664-99675 doi:10.1039/c6ra23317a.
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Suć, J., Tumir, L., Glavaš-Obrovac, L., Jukić, M., Piantanida, I. & Jerić, I. (2016) The impact of alpha-hydrazino acids embedded in short fluorescent peptides on peptide interactions with DNA and RNA. Organic & biomolecular chemistry, 14 (21), 4865-4874 doi:10.1039/c6ob00425c.
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Kopriva, I., Jerić, I. & Brkljačić, L. (2015) Explicit-Implicit Mapping Approach to Nonlinear Blind Separation of Sparse Nonnegative Dependent Sources from a Single-Mixture: Pure Component Extraction from Nonlinear Mixture Mass Spectra. Journal of chemometrics, 29 (11), 615-626 doi:10.1002/cem.2745.
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Suć, J. & Jerić, I. (2015) Synthesis of hybrid hydrazino peptides: protected vs unprotected chiral α-hydrazino acids. SpringerPlus, 4, 507-1 doi:10.1186/s40064-015-1288-9.
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Kopriva, I., Jerić, I., Filipović, M. & Brkljačić, L. (2014) Empirical Kernel Map Approach to Nonlinear Underdetermined Blind Separation of Sparse Nonnegative Dependent Sources: Pure Components Extraction from Nonlinear Mixtures Mass Spectra. Journal of chemometrics, 28 (9), 704-715 doi:10.1002/cem.2635.
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Ukrainczyk, M., Gredičak, M., Jerić, I. & Kralj, D. (2014) Interactions of Scalenohedral Calcite Crystals with Acidic Amino Acid Derivatives of Salicylic Acid. Crystal growth & design, 14 (9), 4334-4346 doi:10.1021/cg500396x.
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Kokan, Z., Glasovac, Z., Majerić Elenkov, M., Gredičak, M., Jerić, I. & Kirin, S. (2014) "Backdoor induction" of chirality: asymmetric hydrogenation with rhodium(I) complexes of triphenylphosphane-substituted beta-turn mimetics. Organometallics, 33 (15), 4005-4015 doi:10.1021/om5005385.
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Kopriva, I. & Jerić, I. (2014) Blind separation of analytes in nuclear magnetic resonance spectroscopy: improved model for nonnegative matrix factorization. Chemometrics and intelligent laboratory systems, 137, 47-56 doi:10.1016/j.chemolab.2014.06.004.
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Kopriva, I., Jerić, I. & Brkljačić, L. (2013) Nonlinear Mixture-wise Expansion Approach to Underdetermined Blind Separation of Nonnegative Dependent Sources. Journal of chemometrics, 27 (7/8), 189-197 doi:10.1002/cem.2512.
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Gredičak, M., Bregović, N., Carić, D. & Jerić, I. (2012) Amino acid-based tweezers: the role of turn-like conformation in the binding of copper(II). Journal of inorganic biochemistry, 116, 45-52 doi:10.1016/j.jinorgbio.2012.07.014.
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Gredičak, M., Abramić, M. & Jerić, I. (2012) Cyclic Enediyne-Amino Acid Chimeras as New Aminopeptidase N Inhibitors. Amino acids (Wien), 43 (5), 2087-2100 doi:10.1007/s00726-012-1292-0.
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Ukrainczyk, M., Gredičak, M., Jerić, I. & Kralj, D. (2012) Interactions of salicylic acid derivatives with calcite crystals. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 365 (1), 296-307 doi:10.1016/j.jcis.2011.09.009.
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Radman, A., Gredičak, M., Kopriva, I. & Jerić, I. (2011) Predicting antitumor activity of peptides by consensus of regression models trained on a small data sample. International journal of molecular sciences, 12 (12), 8415-8430 doi:10.3390/ijms12128415.
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Brkljačić, L., Sabalić, M., Salarić, I., Jerić, I., Alajbeg, I. & Nemet, I. (2011) Development and validation of a liquid chromatography – tandem mass spectrometry method for the quantification of opiorphin in human saliva. Journal of chromatography. B, 879 (32), 3920-3926 doi:10.1016/j.jchromb.2011.11.003.
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Gredičak, M., Matanović, I., Zimmermann, B. & Jerić, I. (2010) Bergman cyclization of acyclic amino acid-derived enediynes leads to the formation of 2, 3-dihydro-benzo[f]isoindoles. Journal of organic chemistry, 75, 6219-6228 doi:101021/jo101302n.
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Kopriva, I. & Jerić, I. (2010) Blind separation of analytes in nuclear magnetic resonance spectroscopy and mass spectrometry: sparseness-based robust multicomponent analysis. Analytical chemistry, 82 (5), 1911-1920 doi:10.1021/ac902640y.
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Jerić, I. & Horvat, Š. (2009) Screening for glucose-triggered modifications of glutathione. Journal of peptide science, 15 (8), 540-547 doi:10.1002/psc.1159.
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Kopriva, I. & Jerić, I. (2009) Multi-component Analysis: Blind Extraction of Pure Components Mass Spectra using Sparse Component Analysis. Journal of mass spectrometry, 44 (9), 1378-1388 doi:10.10002/jms.1627.
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Kopriva, I., Jerić, I. & Cichocki, A. (2009) Blind Decomposition of Infrared Spectra Using Flexible Component Analysis. Chemometrics and intelligent laboratory systems, 97 (2), 170-178 doi:10.1016/j.chemolab.2009.04.002.
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Gredičak, M. & Jerić, I. (2009) The Sonogashira Cross-Coupling Reaction of Alkenyl Chlorides with Aliphatic Acetylenes. Synlett, 2009 (7), 1063-1066 doi:10.1055/s-0028-1088208.
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Kopriva, I., Jerić, I. & Smrečki, V. (2009) Extraction of multiple pure component 1H and 13C NMR spectra from two mixtures: novel solution obtained by sparse component analysis-based blind decomposition. Analytica chimica acta, 653 (2), 143-153 doi:10.1016/j.aca.2009.09.019.
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Horvat, Š., Kralj, M., Perc, M., Jerić, I., Varga-Defterdarović, L., Jakas, A., Roščić, M., Šuman, L. & Gredičak, M. (2009) Novel side-chain glucosylated and adamantylated [Asp2/Glu2]enkephalin analogues: synthesis and in vitro growth inhibition of human tumor cells. Chemical biology & drug design, 73 (2), 253-257 doi:10.1111/j.1747-0285.2008.00763.x.
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Gredičak, M., Kolonić, A. & Jerić, I. (2008) Novel chloroenyne-modified amino acid derivatives. Amino Acids, 35 (1), 185-194 doi:10.1007/s00726-007-0572-6.
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Gredičak, M. & Jerić, I. (2007) Enediyne compounds - new promises in anticancer therapy. Acta Pharmaceutica, 57 (2), 133-150 doi:10.2478/v10007-007-0011-y.
doi Jerić, I. & Chen, H. (2007) Synthetic route to enediyne-bridged amino acids. Tetrahedron Letters, 48 (27), 4687-4690.
Jerić, I., Momčilović, M., Bratoš, I. & Horvat, Š. (2006) Synthesis of Trehalose-Centered Dipeptide Esters. Croatica chemica acta, 79 (2), 261-272.
Jerić, I. (2004) Peptide Mimetics: Why and How?. Kemija u industriji : časopis kemičara i tehnologa Hrvatske, 53 (11), 495-504.
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Jerić, I., Versluis, C., Horvat, Š. & Heck, A. (2002) Tracing glycoprotein structures: electron ionization tandem mass spectrometric analysis of sugar-peptide adducts. Journal of mass spectrometry, 37 (8), 803-811 doi:10.1002/jms.337.
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Jerić, I., Novak, P., Vinković, M. & Horvat, Š. (2001) Conformational analysis of sugar-peptide adducts in the solution state by NMR spectroscopy and molecular modelling. Journal of the Chemical Society. Perkin Transactions 2 (2001), (10), 1944-1950 doi:10.1039/b104239b.
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Horvat, Š., Jerić, I., Varga-Defterdarović, L., Roščić, M. & Horvat, J. (2001) Ester-linked Glycopeptides as Tools for Studies of Biological Phenomena. Croatica chemica acta, 74 (4), 787-799.
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Jerić, I. & Horvat, Š. (2001) Novel Ester-Linked Carbohydrate-Peptide Adducts: Effect of the Peptide Substituent on the Pathways of Intramolecular Reactions. European journal of organic chemistry, 2001 (8), 1533-1539 doi:10.1002/1099-0690(200104)2001:83.0.CO ; 2-Y.
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Jerić, I., Šimičić, L., Stipetić, M. & Horvat, Š. (2000) Synthesis and reactivity of the monosaccharide esters of amino acids as models of teichoic acid fragment. Glycoconjugate journal, 17 (5), 273-282 doi:10.1023/A:1007157018792.
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Kojić-Prodić, B., Antolić, S., Kveder, M., Žigrović, I., Kidrič, J. & Horvat, Š. (1999) Conformational studies in solid state and solution of protected C-terminal dipeptide fragment (Boc-Phe-Pro-HN2) of morphiceptin. Croatica chemica acta, 72 (2-3), 259-277.
hrcak.srce.hr Žigrović, I., Kidrič, J. & Horvat, Š. (1998) Influence of glycation on cis/trans isomerization and tautomerization in novel morphiceptin-related Amadori compounds. Glycoconjugate journal, 15 (-), 563-570.
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Žigrović, I., Versluis, C., Horvat, Š. & Heerma, W. (1998) Mass spectrometric characterization of Amadori compounds related to the opioid peptide morphiceptin. RCM. Rapid communications in mass spectrometry, 12 (4), 181-187 doi:10.1002/(SICI)1097-0231(19980227)12:43.0.CO ; 2-V.
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Heerma, W., Versluis, C., de Koster, C., Kruijtzer, J., Žigrović, I. & Liskamp, R. (1996) Comparing Mass Spectrometric Characteristics of Peptides and Peptoids. RCM. Rapid communications in mass spectrometry, 10 (4), 459-464 doi:10.1002/(SICI)1097-0231(19960315)10:43.0.CO ; 2-J.
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Kamenar, B., Stefanović, A. & Žigrović, I. (1995) Crystal structure of bis(N-methyl-3-ethoxysalicylideneaminato)-copper(II). Zeitschrift fur Kristallographie-Crystalline Materials, 210 (9), 662-664 doi:10.1524/zkri.1995.210.9.662.
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Patents
Institut Ruđer Bošković (2022) COMPOSITION COMPRISING OXALAMIDE GELATORS AND VEGETABLE OIL, EP3897560 (B1).
Institut Ruđer Bošković (2021) Composition comprising oxalamide gelators and vegetable oil, WO 2020/125926.
St.Onge Steward Johnston & Reens, LLS, Stamford, CT 06905-5619 (Conecticut), US (2012) Method of and system for blind extraction of more pure components than mixtures in 1D and 2D NMR spectroscopy and mass spectrometry combining sparse component analysis and single component points, US 8, 165, 373. (https://www.bib.irb.hr/580121).
Kopriva, I., Jerić, I. & Hadžija, M. System and method for blind extraction of features from measurement data.
Institut Ruđer Bošković Method of and system for blind extraction of more pure components than mixtures in 1D and 2D NMR spectroscopy and mass spectrometry by means of combined sparse component analysis and detection of single component points.
Institut Ruđer Bošković, Zagreb, Hrvatska Method of and system for blind extraction of more than two pure components out of spectroscopic and spectrometric measurements of only two mixtures by means of sparse component analysis.
Theses
Doctoral dissertation
Jerić, I. (2000) 'Synthesis and Amadori rearrangement of neoglycopeptides with an ester type of linkage', doktorska disertacija, Prirodoslovno-matematički fakultet, Zagreb.
Master thesis
Žigrović, I. (1997) 'Synthesis and characterization of Amadori compounds related to morphiceptin, opioid peptide derived from milk', magistarski rad, Prirodoslovno-matematički fakultet, Zagreb.
Membership in professional associations / societies
- Member of the American Chemical Society
- Member of the European Peptide Society
- Member of the Croatian Chemical Society
- Treasurer of the Croatian Chemical Society (2008-)
Assistant Director (2018-)
Assistant Director for Structural Funds (2016-2018)
Coordinator of the RBI committee for structural funds (2012-)
Coordinator of the Organizing Committee of RBI "Open days (2010)"