2008 - PhD in Natural Sciences-Biology, Faculty of Science, University of Zagreb
2004 - MSc in Natural Sciences-Biology, Faculty of Science, University of Zagreb
1999 - BSc in Molecular Biology, Faculty of Science, University of Zagreb

Regulation of large-scale endocytosis by IQGAP-related proteins IqgC and IqgD (Croatian Science Foundation)

National award for science in 2019.

RBI award for best papers published in 2019.

Putar, D., A. Čizmar, X. Chao, M. Šimić, M. Šoštar, T. Ćutić, L. Mijanović, A. Smolko, H. Tu, P. Cosson, I. Weber, H. Cai, and V. Filić. 2024. IqgC is a potent regulator of macropinocytosis in the presence of NF1 and its loading to macropinosomes is dependent on RasG. Open Biol. 14:230372.

Filić, V., Mijanović, L., Putar, D., Talajić, A., Ćetković, H., and Weber, I. (2021). Regulation of the Actin Cytoskeleton via Rho GTPase Signalling in Dictyostelium and Mammalian Cells: A Parallel Slalom. Cells 10, 1592.

Marinović, M., Mijanović, L., Šoštar, M., Vizovišek, M., Junemann, A., Fonović, M., Turk, B., Weber, I., Faix, J., and Filić, V. (2019). IQGAP-related protein IqgC suppresses Ras signaling during large-scale endocytosis. Proc. Natl. Acad. Sci. U.S.A 116, 1289–1298.

Filić, V., Marinović, M., Šoštar, M., and Weber, I. (2018). Modulation of small GTPase activity by NME proteins. Laboratory Investigation 98, 589–601.

Junemann, A., Filić, V., Winterhoff, M., Nordholz, B., Litschko, C., Schwellenbach, H., Stephan, T., Weber, I., and Faix, J. (2016). A Diaphanous-related formin links Ras signaling directly to actin assembly in macropinocytosis and phagocytosis. Proc. Natl. Acad. Sci. U.S.A. 113, E7464–E7473.

Sobočanec, S., Filić, V., Matovina, M., Majhen, D., Šafranko, Ž.M., Hadžija, M.P., Krsnik, Ž., Kurilj, A.G., Šarić, A., Abramić, M., et al. (2016). Prominent role of exopeptidase DPP III in estrogen-mediated protection against hyperoxia in vivo. Redox Biol 8, 149–159.

Filić, V., Marinović, M., Faix, J., and Weber, I. (2014). The IQGAP-related protein DGAP1 mediates signaling to the actin cytoskeleton as an effector and a sequestrator of Rac1 GTPases. Cell. Mol. Life Sci. 71, 2775–2785.

Filić, V., Marinović, M., Faix, J., and Weber, I. (2012). A dual role for Rac1 GTPases in the regulation of cell motility. J. Cell. Sci. 125, 387–398.

Zbornik sažetaka s konferencije

• Dicty 2023 Annual International Dictyostelium Conference : Book of Abstracts / Weber, Igor; Filić, Vedrana (ur.) | Zagreb: Institut Ruđer Bošković, 2023

  event.fourwaves.comapi.fourwaves.com

Izvorni znanstveni rad

• Filić, Vedrana ; Vladić, Anton ; Štefulj, Jasminka ; Čičin-Šain, Lipa ; Balija, Melita ; Sučić, Zvonimir ; Jernej, Branimir | Monoamine Oxidases A and B Gene Polymorphisms in Migraine Patients // Journal of the neurological sciences, 228 (2005), 2; 149-153. doi: 10.1016/j.jns.2004.11.045

  doiwww.sciencedirect.comdoi.org

• Jeličić, Branka ; Traven, Ana ; Filić, Vedrana ; Sopta, Mary | Mitochondrial dysfunction enhances Gal4 dependent transcription // FEMS microbiology letters, 253 (2005), 2; 207-213. doi: 10.1016/j.femsle.2005.09.033

  doiacademic.oup.comdoi.org

• Filić, Vedrana ; Marinović, Maja ; Faix, Jan ; Weber, Igor | A dual role for Rac1 GTPases in the regulation of cell motility // Journal of cell science, 125 (2012), 2; 387-398. doi: 10.1242/jcs.089680

  doijcs.biologists.org

• Annesley, Sarah J. ; Bago, Ružica ; Herak Bosnar, Maja ; Filić, Vedrana ; Marinović, Maja ; Weber, Igor ; Mehta, Anil ; Fisher, Paul R. | Dictyostelim discoideum nucleoside diphosphate kinase C plays a negative regulatory role in phagocytosis, macropinocytosis and exocytosis // PLoS One, 6 (2011), 10; e26024, 11. doi: 10.1371/journal.pone.0026024

  doiwww.plosone.orgwww.plosone.orgfulir.irb.hr

• Bursać, Slađana ; Cokarić Brdovčak, Maja ; Pfannkuchen, Martin ; Oršolić, Ines ; Golomb, Lior ; Zhu, Yan ; Katz, Chen ; Daftuar, Lylin ; Grabušić, Kristina ; Vukelić, Iva et al. | Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress // Proceedings of the National Academy of Sciences of the United States of America, 109 (2012), 50; 20467-20472. doi: 10.1073/pnas.1218535109

  doiwww.pnas.org

• Antolović, Vlatka ; Marinović, Maja ; Filić, Vedrana ; Weber, Igor | A simple optical configuration for cell tracking by dark-field microscopy // Journal of microbiological methods, 104 (2014), 9-11. doi: 10.1016/j.mimet.2014.06.006

  doiwww.sciencedirect.com

• Filić, Vedrana ; Marinović, Maja ; Faix, Jan ; Weber, Igor | The IQGAP-related protein DGAP1 mediates signaling to the actin cytoskeleton as an effector and a sequestrator of Rac1 GTPases // Cellular and molecular life sciences, 71 (2014), 15; 2775-2785. doi: 10.1007/s00018-014-1606-3

  doilink.springer.com

• Sobočanec, Sandra ; Filić, Vedrana ; Matovina, Mihaela ; Majhen, Dragomira ; Šafranko, Željka Mačak ; Popović Hadžija, Marijana ; Krsnik, Željka ; Gudan Kurilj, Andrea ; Šarić, Ana ; Abramić, Marija et al. | Prominent role of exopeptidase DPP III in estrogen-mediated protection against hyperoxia in vivo // Redox Biology, 8 (2016), 149-159. doi: 10.1016/j.redox.2016.01.003

  doi

• Marinović, Maja ; Šoštar, Marko ; Filić, Vedrana ; Antolović, Vlatka ; Weber, Igor | Quantitative imaging of Rac1 activity in Dictyostelium cells with a fluorescently labelled GTPase-binding domain from DPAKa kinase // Histochemistry and cell biology, 146 (2016), 3; 267-279. doi: 10.1007/s00418-016-1440-9

  doilink.springer.com

• Junemann, A. ; Filić, Vedrana ; Winterhoff, M. ; Nordholz, B. ; Litschko, C. ; Schwellenbach, H. ; Stephan, T. ; Weber, Igor ; Faix, J. | A Diaphanous-related formin links Ras signaling directly to actin assembly in macropinocytosis and phagocytosis // Proceedings of the National Academy of Sciences of the United States of America, 113 (2016), 47; E7464-E7473. doi: 10.1073/pnas.1611024113

  doiwww.pnas.org

• Filić, Vedrana ; Marinović, Maja ; Šoštar, Marko ; Weber, Igor | Modulation of small GTPase activity by NME proteins // Laboratory investigation, 98 (2018), 5; 589-601. doi: 10.1038/s41374-018-0023-x

  doiwww.nature.com

• Marinović, Maja ; Mijanović, Lucija ; Šoštar, Marko ; Vizovišek, Matej ; Junemann, Alexander ; Fonović, Marko ; Turk, Boris ; Weber, Igor ; Faix, Jan ; Filić, Vedrana | IQGAP-related protein IqgC suppresses Ras signaling during large-scale endocytosis // Proceedings of the National Academy of Sciences of the United States of America, 116 (2019), 4; 1289-1298. doi: 10.1073/pnas.1810268116

  doidoi.orgwww.pnas.org

• Buljubašić, Maja ; Hlevnjak, Ana ; Repar, Jelena ; Đermić, Damir ; Filić, Vedrana ; Weber, Igor ; Zahradka, Ksenija ; Zahradka, Davor | RecBCD- RecFOR-independent pathway of homologous recombination in Escherichia coli // DNA repair, 83 (2019), 102670, 16. doi: 10.1016/j.dnarep.2019.102670

  doidoi.orgwww.sciencedirect.com

• Saidu, Nathaniel Edward Bennett ; Filić, Vedrana ; Thomas, Miranda ; Sarabia-Vega, Vanessa ; Đukić, Anamaria ; Miljković, Frane ; Banks, Lawrence ; Tomaić, Vjekoslav | PDZ Domain-Containing Protein NHERF-2 Is a Novel Target of Human Papillomavirus 16 (HPV-16) and HPV-18 // Journal of virology, 94 (2019), 1; e00663-19-e00663-19. doi: 10.1128/JVI.00663-19

  doijvi.asm.orgdoi.org

• Pinterić, Marija ; Podgorski, Iva I. ; Popović- Hadžija, Marijana ; Filić, Vedrana ; Paradžik, Mladen ; Proust, Bastien Lucien Jean ; Dekanić, Ana ; Ciganek, Ivan ; Pleše, Denis ; Marčinko, Dora et al. | Sirt3 Exerts Its Tumor-Suppressive Role by Increasing p53 and Attenuating Response to Estrogen in MCF-7 Cells // Antioxidants, 9 (2020), 4; 294, 21. doi: 10.3390/antiox9040294

  doiwww.mdpi.comfulir.irb.hr

• Podgorski, Iva I. ; Pinterić, Marija ; Marčinko, Dora ; Popović Hadžija, Marijana ; Filić, Vedrana ; Ciganek, Ivan ; Pleše, Denis ; Balog, Tihomir ; Sobočanec, Sandra | Combination of sirtuin 3 and hyperoxia diminishes tumorigenic properties of MDA-MB-231 cells // Life sciences, 254 (2020), 117812, 13. doi: 10.1016/j.lfs.2020.117812

  doiwww.sciencedirect.comdoi.org

• Bodinier, Romain ; Sabra, Ayman ; Leiba, Jade ; Marchetti, Anna ; Lamrabet, Otmane ; Ayadi, Imen ; Filić, Vedrana ; Kawata, Takefumi ; Weber, Igor ; Cosson, Pierre | Role of LrrkA in the Control of Phagocytosis and Cell Motility in Dictyostelium discoideum // Frontiers in cell and developmental biology, 9 (2021), 629200, 11. doi: 10.3389/fcell.2021.629200

  doiwww.frontiersin.orgfulir.irb.hr

• Matovina, Mihaela; Tomašić Paić, Ana; Tomić, Sanja; Brkić, Hrvoje; Horvat, Lucija; Barbarić, Lea; Filić, Vedrana; Pinterić, Marija; Jurić, Snježana; Kussayeva, Akmaral | Identification of SH2 Domain-Containing Protein 3C as a Novel, Putative Interactor of Dipeptidyl Peptidase 3 // International journal of molecular sciences, 24 (2023), 18; 14178, 19. doi: 10.3390/ijms241814178

  doiwww.mdpi.com

• Skelin, Josipa; Đukić, Anamaria; Filić, Vedrana ; Hufbauer, Martin ; Akgul, Baki ; Thomas Miranda ; Lawrence, Banks ; Tomaić, Vjekoslav | MAML1-induced HPV E6 oncoprotein stability is required for cellular proliferation and migration of cervical tumor-derived cells // Journal of medical virology, 95 (2023), 3; 5, 19. doi: https://doi.org/10.1002/jmv.28624

  doi

• Putar, Darija; Čizmar, Anja; Chao, Xiaoting; Šimić, Marija; Šoštar, Marko; Ćutić, Tamara; Mijanović, Lucija; Smolko, Ana; Tu, Hui; Cosson, Pierre et al. | IqgC is a potent regulator of macropinocytosis in the presence of NF1 and its loading to macropinosomes is dependent on RasG // Open Biology, 14 (2024), 1; 230372, 17. doi: 10.1098/rsob.230372

  doiroyalsocietypublishing.org

Pregledni rad (znanstveni)

• Filić, Vedrana ; Mijanović, Lucija ; Putar, Darija ; Talajić, Antea ; Ćetković, Helena ; Weber, Igor | Regulation of the Actin Cytoskeleton via Rho GTPase Signalling in Dictyostelium and Mammalian Cells: A Parallel Slalom // Cells, 10 (2021), 7; 1592, 39. doi: 10.3390/cells10071592

  doiwww.mdpi.comdoi.orgfulir.irb.hr

• Filić, Vedrana; Weber, Igor | A young researcher’s guide to three-dimensional fluorescence microscopy of living cells // Periodicum biologorum, 125 (2023), 1-2; 133-137. doi: 10.18054/pb.v125i1-2.25140

  doihrcak.srce.hrfulir.irb.hr

Sažetak izlaganja sa skupa

• Filić, Vedrana ; Vladić, Anton ; Balija, Melita ; Jernej, Branimir | MAO-A and MAO-B genes polymorphisms in migrainous patients // Neurologia Croatica. Supplement / Zurak, N. (ur.). 2003. str. 51-51

• Marinović, Maja ; Mijanović, Lucija ; Šoštar, Marko ; Vizovišek, Matej ; Junemann, Alexander ; Fonović, Marko ; Turk, Boris ; Weber, Igor ; Faix, Jan ; Filić, Vedrana | IQGAP-related protein IqgC suppresses Ras signaling during macropinocytosis // Libri oncologici : Croatian journal of oncology / Ozretić, Petar ; Levanat, Sonja (ur.). 2018. str. 62-62

  hrcak.srce.hr

• Pinterić, Marija ; Podgorski, Iva I. ; Sobočanec, Sandra ; Popović Hadžija, Marijana ; Filić, Vedrana ; Ciganek, Ivan ; Pleše, Denis ; Marčinko, Dora ; Balog, Tihomir | The role of de novo expressed sirtuin 3 in triple negative human breast cancer cells upon oxidative stress // Free radical biology & medicine. 2019

  www.sciencedirect.com

• Mijanović, Lucija ; Putar, Darija ; Filić, Vedrana ; Weber, Igor | IQGAP­-related protein IqgC involved in large­- scale endocytosis regulates cell­-substratum adhesion and migration in Dictyostelium // FEBS Open Bio. 2021. str. 182-182

  2021.febscongress.orgfebs.onlinelibrary.wiley.com

• Mijanović, Lucija ; Putar, Darija ; Filić, Vedrana ; Weber, Igor | Dissection of the role of IqgC domains in the cell­ substratum adhesion // FEBS Open Bio. 2022. str. 205-206 doi: 10.1002/2211-5463.13440

  doi

• Putar, Darija ; Ćutić, Tamara ; Mijanović, Lucija ; Weber, Igor ; Filić, Vedrana | IQGAP-related protein IqgC interacts with RasG and Rab5A on Dictyostelium macropinosomes // FEBS Open Bio. 2022. str. 206-206

  doi.org

Neobjavljeni prilog sa skupa

• Pinterić, Marija ; Podgorski, Iva I. ; Sobočanec, Sandra ; Popović Hadžija, Marijana ; Dekanić, Ana ; Filić, Vedrana ; Ciganek, Ivan ; Pleše, Denis ; Marčinko, Dora ; Ambriović Ristov, Andreja et al. | Uloga Sirtuina 3 u estrogen-posredovanoj proliferaciji MCF-7 stanica raka dojke // Simpozij „Prvih 10 godina HDIR-a“ | Zagreb, Hrvatska, 04.06.2019-04.06.2019

  161.53.22.65

• Putar, Darija; Privara, Anja; Chao, Xiaoting; Šoštar, Marko; Ćutić, Tamara; Mijanović, Lucija; Smolko, Ana; Tu, Hui; Cosson, Pierre; Weber, Igor et al. | Small GTPases RasG and Rab5A regulate IqgC localization during macropinocytosis // The International Dictyostelium conference | Opatija, Hrvatska, 27.08.2023-31.08.2023

Magistarski rad (mr. sc. i mr. art.)

• Filić, Vedrana | Molekularno-genetička i biokemijska istraživanja monoamin-oksidaze A i B u zdravih ispitanika i osoba koje boluju od migrene / Jernej, Branimir (mentor); | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, . 2004

Doktorska disertacija

• Filić Mileta, Vedrana | Uloga proteina Rac1A u regulaciji dinamike citoskeleta protista Dictyostelium discoideum / Weber, Igor (mentor); | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, . 2008

• Putar Brajković, Darija | Uloga proteina IqgC u regulaciji makropinocitoze u amebi Dictyostelium discoideum / Filić, Vedrana (mentor); | Zagreb, Prirodoslovno-matematički fakultet, Zagreb, 2024

Croatian Society of Biochemistry and Molecular Biology, member of Executive Committee

Croatian Microscopy Society