Dr. Andreja Ambriović Ristov
Division of Molecular Biology
Ruđer Bošković Institute
Bijenička 54
10000 Zagreb
Croatia
Education
1989, Zagreb, Croatia, Faculty of Pharmacy and Biochemistry, University of Zagreb, B. Sc.(clinical chemistry)
1993, Zagreb, Croatia, Faculty of Science, University of Zagreb, Mr.Sc. (biology)
1997, Zagreb, Croatia, Faculty of Science, University of Zagreb, Ph. D. (biology)
Projects
(2014-2018) HRZZ Research Project
„Molecular mechanisms of chemosensitisation of human breast carcinoma and melanoma cell lines by silencing of integrins“
Role on the project: Leader
(2014-2015): bilateral project with Germany
”Sensitization of melanoma and glioma cells to alkylating drugs by integrin αvβ3, αvβ5, α3β1 and α4β1 silencing”
Role on the project: Leader
(2013-2016) FP7-REGPOT project
”Enhancement of the Innovation Potential in SEE through New Molecular Solutions in Research and Development” leader dr. sc. Oliver Vugrek
Role on the project: Co-worker
(2012-2013) bilateral project with Germany
„Platinum compounds: Drug-induced stress responses and mechanisms of drug- resistance“ Institute for toxicology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
Role on the project: Co-worker
(2008-2009) bilateral project with Germany
„Molecular mechanisms that deterimines cell sensitivity to platinum compounds” Institut for toxicology, Johannes Gutenberg University, Mainz, Germany
Role on the project: Co-worker
(2007-2013) Ministry of Science, Education and Sports, “Increase of adenovirus transduction efficacy and resistance to cytostatics”
Role on the project: Leader
(2007-2013) Ministry of Science, Education and Sports, “Cell respones to cytotoxic agents and resistance development “
Role on the project: Co-worker
(2007-2010) Technological project awarded by Ministry of Science, Education and Sports, “Regeneration of knee articular cartilage”
Role on the project: Leader
(2004-2006) Integrated action: Ministry of Science, Education and Sports and French Government: COGITO, “Adenovirus retargeting to aminopeptidase N and potential use in gene therapy of cystic fibrosis”
Role on the project: Leader
(2002-2004) NATO Science Program, Collaborative linkage grant, “Human adenovirus type 5 retargeted on aminopeptidase N”
Role on the project: Leader
(1990-1995) Ministry of Science, Education and Sports Science and Technology
“The investigation of cell resistance to genotoxic agents”
Role on the project: Co-worker
(1998-2000) Ministry of Science, Education and Sports, Young researcher grant
“Vector vaccines against pseudorabies virus”
Role on the project: Leader
(1996-2002) Ministry of Science, Education and Sports, Cell response to physical, chemical and biological noxa
Role on the project: Co-worker
Awards and Achievements
2008. Award J. J. Strossmayer (Croatian Academy of Sciences and Arts/ Zagreb fair), for the best publishing venture in science, for the book «Methods in molecular biology» by Andreja Ambriović Ristov (Editor-in-chief) and Anamaria Brozović, Branka Bruvo Mađarić, Helena Ćetković, Maja Herak Bosnar, Dubravka Hranilović, Silva Katušić, Hećimović, Nevenka Meštrović Radan, Snježana Mihaljević, Neda Slade, Dušica Vujaklija (Eds.).
2004. The award of director of Ruđer Bošković Institute for contribution in Institute development and common prosperity.
Classes
2008-, Course leader «Gene therapy», graduate Studies programme in Molecular Biotechnology, Faculty of Food Technology and Biotechnology, University of Zagreb.
2008-, Course leader «Methods in molecular biology and medicine», The Ph.D. study in biophysics, Faculty of Science, University of Split.
2007-, Course co-leader «Methods in molecular biology and medicine», PhD Studies in Molecular Biosciences, University of Osijek, University of Dubrovnik and Ruđer Bošković Institute,
2007-, Course co-leader «Methods in molecular biology and medicine-practicum», PhD Studies in Molecular Biosciences, University of Osijek, University of Dubrovnik and Ruđer Bošković Institute.
2002-, Course Leader «Molecular basis of Gene Therapy» PhD Studies in biology, Faculty of Science, University of Zagreb.
Featured Publications
full list: Andreja Ambriovic Ristov - Google Scholar
Tadijan A., Humphries J.D., Samaržija I., Stojanović N., Zha J., Čuljak K., Tomić M., Paradžik M., Nestić D., Kang H., Humphries M.J, Ambriović-Ristov A. The tongue squamous carcinoma cell line Cal27 primarily employs integrin α6β4-containing type II hemidesmosomes for adhesion which contribute to anticancer drug sensitivity, Frontiers in Cell and Developmental Biology, 9:786758, 2021.
Tadijan A., Samaržija I., Humphries J.D., Humphries M.J., Ambriović-Ristov A. KANK family proteins in cancer, International Journal of Biochemistry & Cell Biology, 131:105903, 2021.
Stumpf H, Ambriović-Ristov A, Radenovic A, Smith AS. Recent Advances and Prospects in the Research of Nascent Adhesions, Frontiers in Physiology, 11: 574371, 2020.
Samaržija I., Dekanić A., Humphries J.D., Paradžik M., Stojanović N., Humphries M.J., Ambriović-Ristov A. Integrin Crosstalk Contributes to the Complexity of Signalling and Unpredictable Cancer Cell Fates. Cancers (Basel). Jul 15;12(7):E1910. doi: 10.3390/cancers12071910, 2020.
Paradžik M., Humphries J.D., Stojanović N., Nestić D., Majhen D., Dekanić A., Samaržija I., Sedda D., Weber I., Humphries M.J., Ambriović-Ristov A. KANK2 Links αVβ5 Focal Adhesions to Microtubules and Regulates Sensitivity to Microtubule Poisons and Cell Migration. Frontiers in Cell and Developmental Biology, Mar 3;8:125. doi: 10.3389/fcell.2020.00125, 2020.
Stojanović, N. *, Dekanić, A. *, Paradžik, M., Majhen, D., Ferenčak, K., Ruščic, J., Bardak, I., Supina, C., Tomičić, M., Christmann, M., Osmak, M., Ambriović-Ristov, A. (2018) Differential effects of integrin αv knockdown and cilengitide on sensitisation of triple- negative breast cancer and melanoma cells to microtubule poisons. Molecular Pharmacology, 118, 113027, 46 doi:10.1124/mol.118.113027. * equal contribution
Ruščić J. *, Ambriović-Ristov A.*, Majhen D., Kolundžija S., Barut M., Benihoud K., Krajačić M. Manipulating adenoviral vector ion-exchange chromatography: Hexon versus fiber. Journal of Separation Science. 39(22): 4299-4304, 2016. *equal contribution
Christmann M., Diesler K., Majhen D., Steigerwald C., Berte N., Freund H., Stojanović N., Kaina B., Osmak M., Ambriović-Ristov A.*, Tomicic M.T.* Integrin αVβ3 silencing sensitizes malignant glioma cells to temozolomide by suppression of homologous recombination repair, Oncotarget, 8(17): 27754-27771, 2017. *corresponding authors
Stojanovic N., Brozovic A., Majhen D., Herak Bosnar M., Fritz G., Osmak M., Ambriovic-Ristov A. Integrin αvβ3 expression in tongue squamous carcinoma cells Cal27 confers anticancer drug resistance through loss of pSrc(Y418), Biochimica et Biophysica Acta 1863: 1969–1978, 2016.
Majhen D., Stojanović N., Vukić D., Pichon C., Leduc C., Osmak M., Ambriović-Ristov A. Increased Adenovirus Type 5 Mediated Transgene Expression Due to RhoB Down-regulation, PLoS One, 9(1): e86698, 2014.
Majhen D., Richardson J., Vukelić B., Dodig I., Cindrić M., Benihoud K., Ambriović-Ristov A. The disulfide bond of an RGD4C motif inserted within the HI loop of the adenovirus type 5 fiber protein is critical for retargeting to αv-integrins. Journal of Gene Medicine, 14(12): 788-797, 2012.
Majhen D., Stojanović N., Špeljko T., Brozović A., De Zan T., Osmak M., Ambriović-Ristov A. Increased expression of the coxsackie and adenovirus receptor downregulates alpha v beta 3 and alpha v beta 5 integrin expression, reduces cell adehesion and migration. Life Sciences, 89(7-8): 241-249, 2011.
Brozovic A., Ambriović-Ristov A., Osmak M. The relationship between cisplatin-induced reactive oxygen species, glutathione and BCL-2, and resistance to cisplatin. Critical Reviews in Toxicology, 40(4): 347-359, 2010.
Majhen D., Nemet J., Richardson J., Gabrilovac J., Hajsig M., Osmak M., Eloit M., Ambriović-Ristov A. Differential role of αvβ3 and αvβ5 integrins in internalization and transduction efficacies of wild type and RGD4C fiber-modified adenoviruses. Virus Research. 139(1): 64-73, 2009.
Brozović A., Majhen D, Roje V., Mikac N., Jakopec S., Fritz G., Osmak M., Ambriović-Ristov A. αvβ3 integrin mediated drug resistance in human laryngeal carcinoma cells is caused by glutathione dependent elimination of drug induced reactive oxidative species. Molecular Pharmacology. 74: 298-306, 2008.
Majhen D., Ambriović-Ristov, A. Adenoviral vectors-how to use them in cancer gene therapy, Virus Research, 119: 121-133, 2006.
Majhen D., Gabrilovac J., Eloit M., Richardson J., Ambriović-Ristov A. Disulfide bond formation in NGR fiber-modified adenovirus is essential for retargeting to aminopeptidase N. Biochemical and Biophysical Research Communications. 348: 278-287, 2006.
Ambriović-Ristov A.*, Gabrilovac J., Čimbora-Zovko T., Osmak M. Increased adenoviral transduction efficacy in human laryngeal carcinoam cells resistant to cisplatin isassociated with increased expression of integrin αvβ3 and coxsackie adenovirus receptor, International Journal of Cancer, 110: 660-667, 2004. *corresponding
Ambriović-Ristov A., Mercier S., Eloit M. Shortening adenovirus type 5 fiber shaft decreases the efficiency of post binding steps in CAR-expressing and non-expressing cells, Virology, 312: 425-433, 2003.
Monteil M., Le Pottier M. F., Ambriović Ristov A., Cariolet R., L'Hospitalier R., Klonjkowski B., Eloit M. Single inoculation of replication-defective adenovirus-vectored vaccines at birth in piglets with maternal antibodies induces high level of antibodies and protection against pseudorabies, Vaccine, 18: 1738-1742, 2000.
Chetboul V., Adam M., Deprez I., Ambriović A., Rosenberg D., Crespeau F., Saana M., Pham I., Eloit M., Adnot S., Pouchelon JL. Expression of biologically active atrial natriuretic factor following intrahepatic injection of a replication-defective adenoviral vector in dogs, Human Gene Therapy, 10(2):281-290, 1999.
Ambriović A., Adam M., Monteil M., Paulin D., Eloit M. Efficacy of replication-defective adenovirus vectored vaccines: Protection following intramuscular injection is linked to promoter efficiency in muscle representative cells, Virology 238: 327-335, 1997.
Publications
Journal articles
Scientific and review papers
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Nestić, D., Božinović, K., Drašković, I., Kovačević, A., van den Bosch, J., Knežević, J., Custers, J., Ambriović- Ristov, A. & Majhen, D. (2022) Human adenovirus type 26 induced IL-6 gene expression in an αvβ3 integrin- and NF-κB-dependent manner. Viruses-Basel, 14 (4), 672, 16 doi:10.3390/v14040672.
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Nestić, D., Hozić, A., Brkljača, Z., Butorac, A., Pažur, K., Jullienne, B., Cindrić, M., Ambriović-Ristov, A., Benihoud, K. & Majhen, D. (2022) Integrin αvβ3 and disulfide bonds play important roles in NGR-retargeted adenovirus transduction efficiency. Life sciences, 291, 120116, 9 doi:10.1016/j.lfs.2021.120116.
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Kolarić, B., Ambriović-Ristov, A., Tabain, I. & Vilibić Čavlek, T. (2021) Waning immunity six months after BioNTech/Pfizer COVID-19 vaccination among nursing home residents in Zagreb, Croatia. Croatian medical journal, 62 (6), 630-633 doi:10.3325/cmj.2021.62.630.
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Tadijan, A., Humphries, J., Samaržija, I., Stojanović, N., Zha, J., Čuljak, K., Tomić, M., Paradžik, M., Nestić, D., Kang, H., Humphries, M. & Ambriović-Ristov, A. (2021) The Tongue Squamous Carcinoma Cell Line Cal27 Primarily Employs Integrin α6β4-Containing Type II Hemidesmosomes for Adhesion Which Contribute to Anticancer Drug Sensitivity. Frontiers in cell and developmental biology, 9, 786758, 17 doi:10.3389/fcell.2021.786758.
doiwww.frontiersin.orgdoi.orgfulir.irb.hr -
Strazic Geljic, I., Kucan Brlic, P., Musak, L., Karner, D., Ambriović- Ristov, A., Jonjic, S., Schu, P. & Rovis, T. (2021) Viral Interactions with Adaptor-Protein Complexes: A Ubiquitous Trait among Viral Species. International journal of molecular sciences, 22 (10), 5274-5300 doi:10.3390/ijms22105274.
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Tadijan, A., Samaržija, I., Humphries, J., Humphries, M. & Ambriović- Ristov, A. (2021) KANK family proteins in cancer. International journal of biochemistry & cell biology, 131, 105903, 5 doi:10.1016/j.biocel.2020.105903.
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Stumpf, B., Ambriović-Ristov, A., Radenovic, A. & Smith, A. (2020) Recent Advances and Prospects in the Research of Nascent Adhesions. Frontiers in physiology, 11, 574371, 16 doi:10.3389/fphys.2020.574371.
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Božinović, K., Nestić, D., Gradišar Centa, U., Ambriović-Ristov, A., Dekanić, A., de Bisschop, L., Remškar, M. & Majhen, D. (2020) In-vitro toxicity of molybdenum trioxide nanoparticles on human keratinocytes. Toxicology, 444, 152564, 11 doi:10.1016/j.tox.2020.152564.
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Samaržija, I., Dekanić, A., Humphries, J., Paradžik, M., Stojanović, N., Humphries, M. & Ambriović- Ristov, A. (2020) Integrin Crosstalk Contributes to the Complexity of Signalling and Unpredictable Cancer Cell Fates. Cancers (Basel), 12 (7), 1910, 26. (https://www.bib.irb.hr/1073479).
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Paradžik, M., Humphries, J., Stojanović, N., Nestić, D., Majhen, D., Dekanić, A., Samaržija, I., Sedda, D., Weber, I., Humphries, M. & Ambriović-Ristov, A. (2020) KANK2 links αVβ5 focal adhesions to microtubules and regulates sensitivity to microtubule poisons and cell migration. Frontiers in cell and developmental biology, 8, 125, 17 doi:10.3389/fcell.2020.00125.
doidoi.orgwww.frontiersin.orgfulir.irb.hr -
Stojanović, N., Dekanić, A., Paradžik, M., Majhen, D., Ferenčak, K., Ruščic, J., Bardak, I., Supina, C., Tomičić, M., Christmann, M., Osmak, M. & Ambriović-Ristov, A. (2018) Differential effects of integrin αv knockdown and cilengitide on sensitisation of triple-negative breast cancer and melanoma cells to microtubule poisons. Molecular pharmacology, 94 (6), 1334-1351 doi:10.1124/mol.118.113027.
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Pinterić, M., Podgorski, I., Sobočanec, S., Popović Hadžija, M., Paradžik, M., Dekanić, A., Marinović, M., Halasz, M., Belužić, R., Davidović, G., Ambriović Ristov, A. & Balog, T. (2018) De novo expression of transfected sirtuin 3 enhances susceptibility of human MCF-7 breast cancer cells to hyperoxia treatment. Free radical research, 52 (6), 672, 684 doi:10.1080/10715762.2018.1462495.
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Christmann, M., Diesler, K., Majhen, D., Steigerwald, C., Berte, N., Freund, H., Stojanović, N., Kaina, B., Osmak, M., Ambriović-Ristov, A. & Tomicic, M. (2017) Integrin αVβ3 silencing sensitizes malignant glioma cells to temozolomide by suppression of homologous recombination repair. Oncotarget, 8, 27754-27771 doi:10.18632/oncotarget.10897.
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Stevanovic, V., Lojkic, I., Barbic, L., Kovac, Snjezana, Mojcec-Perko, Vesna, Ambriovic-Ristov, A., Hadina, S., Velic, L., Perharic, M. & Staresina, V. (2016) The genetic heterogeneity of equine infectious anaemia virus field strains in Croatia. Veterinarski arhiv, 86 (5), 623-640.
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Ruščić, J., Ambriović-Ristov, A., Majhen, D., Kolundžija, S., Barut, M., Benihoud, K. & Krajačić, M. (2016) Manipulating adenoviral vector ion-exchange chromatography: Hexon versus fiber. Journal of separation science, 39 (22), 4299-4304 doi:10.1002/jssc.201600829.
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Steiner, I., Stojanović, N., Bolje, A., Brozović, A., Polančec, D., Ambriović-Ristov, A., Radić Stojković, M., Piantanida, I., Eljuga, D., Košmrlj, J. & Osmak, M. (2016) Discovery of ‘click’ 1, 2, 3-triazolium salts as potential anticancer drugs. Radiology and oncology, 50 (3), 280-288 doi:10.1515/raon-2016-0027.
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Stojanović, N., Brozovic, A., Majhen, D., Herak Bosnar, M., Fritz, G., Osmak, M. & Ambriović-Ristov, A. (2016) Integrin αvβ3 Expression in Tongue Squamous Carcinoma Cells Cal27 Confers Anticancer Drug Resistance Through Loss of pSrc(Y418). Biochimica et biophysica acta-molecular cell research, 1863 (8), 1969-1978 doi:10.1016/j.bbamcr.2016.04.019.
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Vajs, J., Steiner, I., Brozović, A., Pevec, A., Ambriović-Ristov, A., Matković, M., Piantanida, I., Urankar, D., Osmak, M. & Janez Košmrlj (2015) The 1, 3-diaryltriazenido(p-cymene)ruthenium(II) complexes with a high in vitro anticancer activity. Journal of inorganic biochemistry, 153, 42-48 doi:10.1016/j.jinorgbio.2015.09.005.
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Brozović, A., Stojanović, N., Ambriović-Ristov, A., Brozović Krijan, A., Polanc, S. & Osmak, M. (2014) 3-Acetyl-bis(2-chloro-4-nitrophenyl) triazene is a potent antitumor agent that induces oxidative stress and independently activates the stress-activated protein. Anti-cancer drugs, 25 (3), 289-295 doi:10.1097/CAD.000000000000006.
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Majhen, D., Stojanović, N., Vukić, D., Pichon, C., Leduc, C., Osmak, M. & Ambriović-Ristov, A. (2014) Increased Adenovirus Type 5 Mediated Transgene Expression Due to RhoB Down-regulation. PLoS One, 9 (1) doi:10.1371/journal.pone.0086698.
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Brozović, A., Vuković, L., Stupin Polančec, D., Arany, I., Köberle, B., Fritz, G., Fiket, Ž., Majhen, D., Ambriović-Ristov, A. & Osmak, M. (2013) Endoplasmic reticulum stress is involved in response of human laryngeal carcinoma cells to carboplatin but is absent in carboplatin resistant cells. PLoS One, 8 (9), e763973-1 doi:10.1371/journal.pone.0076397.
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Arbanasić, H., Galov, A., Ambriović-Ristov, A., Grizelj, J., Arsenos, G., Marković, B., Dovenski, T., Vince, S. & Čurik, I. (2013) Extensive polymorphism of the major histocompatibility complex DRA gene in Balkan donkeys: perspectives on selection and genealogy. Animal genetics, 44 (6), 711-716 doi:10.1111/age.12054.
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Stojanović, N., Urankar, D., Brozović, A., Ambriović-Ristov, A., Osmak, M. & Košmrlj, J. (2013) Design and evaluation of biological activity of diazenecarboxamide-extended cisplatin and carboplatin analogues. Acta chimica Slovenica, 60 (2), 368-374.
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Majhen, D., Richardson, J., Vukelić, B., Dodig, I., Cindrić, M., Benihoud, K. & Ambriović-Ristov, A. (2012) The disulfide bond of an RGD4C motif inserted within the HI loop of the adenovirus type 5 fiber protein is critical for retargeting to α(v) -integrins. Journal of gene medicine, 14 (12), 788-797 doi:10.1002/jgm.2686.
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Majhen, D., Stojanović, N., Špeljko, T., Brozović, A., De Zan, T., Osmak, M. & Ambriović-Ristov, A. (2011) Increased expression of the coxsackie and adenovirus receptor downregulates alpha v beta 3 and alpha v beta 5 integrin expression, reduces cell adehesion and migration. Life sciences, 89 (7-8), 241-249 doi:10.1016/j.lfs.2011.06.009.
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Brozović, A., Ambriović-Ristov, A. & Osmak, M. (2010) The relationship between cisplatin-induced reactive oxygen species, glutathione, and BCL-2 and resistance to cisplatin. Critical reviews in toxicology, 40 (4), 347-359 doi:10.3109/10408441003601836.
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Majhen, D., Brozović, A., Buger, T., Gabrilovac, J., Osmak, M. & Ambriović-Ristov, A. (2010) Vincristine-resistant human laryngeal carcinoma cells demonstrate increased Rous sarcoma virus promoter activity. Life sciences, 87 (15/16), 468-474 doi:10.1016/j.lfs.2010.08.012.
doi Čubrić Čurik, V., Feligini, M., Ferenčaković, M., Džidić, A., Salajpal, K., Ambriović-Ristov, A., Ćetković, H., Majhen, D. & Čurik, I. (2009) Sequence polymorphism of PrP exon 3 gene in Istrian and crossbred sheep. Italian journal of animal science, 8 (S3), 86-88. (https://www.bib.irb.hr/416266).
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Majhen, D., Nemet, J., Richardson, J., Gabrilovac, J., Hajsig, M., Osmak, M., Eloit, M. & Ambriović-Ristov, A. (2009) Differential Role OF α vβ 3 and α vβ 5 Integrins in Iinternalization and Transduction Efficacies of Wild Type and RGD4C Fiber-modified Adenoviruses. Virus research, 139 (1), 64-73 doi:10.1016/j.virusres.2008.10.004.
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Brozović, A., Majhen, D., Roje, V., Mikac, N., Jakopec, S., Fritz, G., Osmak, M. & Ambriović-Ristov, A. (2008) Alpha v beta 3 integrin mediated drug resistance in human laryngeal carcinoma cells is caused by glutathione dependent elimination of drug induced reactive oxidative species. Molecular pharmacology, 74 (1), 298-306 doi:10.1124/mol.107.043836.
doi Žaja, R., Munić, V., Sauerborn Klobučar, R., Ambriović-Ristov, A. & Smital, T. (2008) Cloning and molecular characterization of apical efflux transporters (ABCB1, ABCB11 and ABCC2) in rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquatic Toxicology, 90 (4), 322-332.
Čimbora-Zovko, T., Ambriović-Ristov, A., Lončarek, J. & Osmak, M. (2007) Altered cell-cell adhesion in cisplatin-resistant human carcinoma cells: A link between β -catenin/plakoglobin ratio and cisplatin resistance. European Journal of Pharmacology, 558 (1-3), 27-36.
Majhen, D., Gabrilovac, J., Eloit, M., Richardson, J. & Ambriović-Ristov, A. (2006) Disulfide bond formation in NGR fiber-modified adenovirus is essential for retargeting to aminopeptidase N. Biochemical and Biophysical Research Communications, 348, 278-287.
Majhen, D. & Ambriović-Ristov, A. (2006) Adenoviral vectors-How to use them in cancer gene therapy?. Virus Research, 119, 121-133.
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Ambriović-Ristov, A. & Osmak, M. (2006) Integrin-mediated drug resistance. Current Signal Transduction Therapy, 1 (2), 227-237 doi:10.2174/157436206777012048.
doi Breljak, D., Ambriović-Ristov, A., Kapitanović, S., Čačev, T. & Gabrilovac, J. (2005) Comparison of three RT-PCR-based methods for relative quantification of mRNA.. Food technology and biotechnology, 43 (4), 379-388.
Gabrilovac, J., Breljak, D., Čupić, B. & Ambriović-Ristov, A. (2005) Regulation of aminopeptidase N (EC 3.4.11.2 ; APN ; CD13) by interferon-gamma on the HL-60 cell line. Life sciences, 76 (23), 2681-2697.
Vuković, L., Ambriović-Ristov, A., Čimbora Zovko, T., Ćetković, H., Brozović, A., Majhen, D. & Osmak, M. (2004) Expression of apoptotic genes in low, clinically relevant levels of drug resistance. Periodicum Biologorum, 106 (2), 173-177.
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Ambriović-Ristov, A., Gabrilovac, J., Čimbora Zovko, T. & Osmak, M. (2004) Increased adenoviral transduction efficacy in human laryngeal carcinoma cells resistant to cisplatin is associated with increased expression of integrin avb3 and coxsackie adenovirus receptor. International journal of cancer, 110 (5), 660-667 doi:10.1002/ijc.20176.
doi Ambriović-Ristov, A., Mercier, S. & Eloit, M. (2003) Shortening adenovirus type 5 fiber shaft decreases the efficiency of post binding steps in CAR-expressing and non-expressing cells. Virology, 312, 425-433.
Šprem, M., Babić, D., Abramić, M., Vrhovec, I., Škrk, J., Miličić, D., Ambriović Ristov, A., Kalafatić, D. & Osmak, M. (2001) Glutathione and glutathione S-transferases as early markers for ovarian carcinomas: case series. Croatian Medical Journal, 42 (6), 393-398.
Osmak, M., Bordukalo, T., Ambriović-Ristov, A., Jernej, B., Košmrlj, J. & Polanc, S. (2000) Diazenes as modificators of drug-resistance in tumor cells. Neoplasma, 47 (6), 390-395.
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Monteil, M., Le Pottier, M., Ambriović-Ristov, A., Cariolet, R., L'Hospitalier, R., Klonjkowski, B. & Eloit, M. (2000) Single inoculation of replication-defective adenovirus-vectored vaccine at birth in piglets with maternal antibodies induces high level of antibodies and protection against pseudorabies. Vaccine, 18 (17), 1738-1742 doi:10.1016/S0264-410X(99)00545-9.
doi Osmak, M., Nikšić, D., Brozović, A., Ambriović-Ristov, A., Vrhovec, I. & Škrk, J. (1999) Drug resistant tumour cells have increased levels of tumor markers for invasion and metastasis. Anticancer research, 19 (4B), 3193-3197.
Chetboul, V., Adam, M., Deprez, I., Ambriović-Ristov, A., Rosenberg, D., Crespeau, F., Saana, M., Pham, I., Eloit, M., Adnot, S. & Pouchelon, J. (1999) Expression of biologically active atrial natriuretic factor following intrahepatic injection of a replication-defective adenoviral vector in dogs. Human gene therapy, 10 (2), 281-290.
Osmak, M., Brozović, A., Ambriović-Ristov, A., Hadžija, M., Pivčević, B. & Smital, T. (1998) Inhibition of apoptosis is the cause of resistance to doxorubicin in human breast adenocarcinoma cells. Neoplasma, 45 (4), 223-230.
Ambriović, A., Adam, M., Monteil, M., Paulin, D. & Eloit, M. (1997) Efficacy of replication-defective adenovirus-vectored vaccines: protection following intramuscular injection is linked to promoter efficiency in muscle representative cells. Virology, 238 (2), 327-335.
Osmak, M., Babić, D., Abramić, M., Ambriović, A., Miličić, D., Eljuga, D. & Vuković, L. (1997) Glutathione S-transferase activity as an early marker for malignant tumors of corpus uteri. Neoplasma, 44 (5), 324-328.
Ambriović, A. & Novak Despot, Đ. (1995) Identification of glycoproteins gE and gC of the pseudorabies virus strain B-Kal 68 by SDS-PAGE and monoclonal antibodies. Periodicum biologorum, 97 (4), 317-322.
Osmak, M., Miljanić, S., Ambriović, A. & Kapitanović, S. (1995) Characterization of human primary lung fibroblasts exposed to repeated low doses of gamma-rays. Periodicum biologorum, 97 (3), 229-234.
Membership in professional associations / societies
Croatian Society for Biochemistry and Molecular Biology (thus member of FEBS)
Croatian Microbiological Society (thus member of FEMS)
Croatian society of genetic engineers
Croatian Association for Cancer Research
Croatian Genetic Society
2003-2013 The founder and director of educational project “Methodological Courses in Biology and Medicine”
Editor in chief of a book “Methods in molecular biology” with contributions from 119 authors from Ruđer Bošković Institute and University which has been accepted as a regular textbook by the University in Zagreb. Institut Ruđer Bošković (Editor), 2007, Zagreb. http://www.mmb.irb.hr/
MENTORSHIP
Doctoral Thesis
1. Ana Dekanić, „The effect of silencing of integrin subunits α in human melanoma cells on sensitivity to antitumour drugs and motility“, Josip Juraj Strossmayer University of Osijek, University of Dubrovnik, Ruđer Bošković Institute, University postgraduate interdisciplinary Doctoral Study of Molecular biosciences, 2019.
2. Nikolina Stojanović, „Integrin αvβ3 mediated drug resistance in human tongue squamous carcinoma cells“, Josip Juraj Strossmayer University of Osijek, University of Dubrovnik, Ruđer Bošković Institute, University postgraduate interdisciplinary Doctoral Study of Molecular biosciences, 2014.
3. Dragomira Majhen, „Augmentation of adenovirus transduction: Changing expression of natural receptors and retargeting to new ones“, Faculty of Science University of Zagreb, 2008.
Master of Science Thesis:
1. Dragomira Majhen: «Adenovirus type 5 retargeting on amniopeptidase N», Faculty of Science University of Zagreb, 2005.
Diploma Thesis
1. Zrinka Vitković, „Karakterizacija adhesoma u stanicama trostruko negativnog karcinoma dojke MDA-MB-231 nakon stabilnog utišavanja gena za integrin αv“, Faculty of Science, University of Zagreb, 2018.
2. Kristina Čuljak, Karakterizacija adhesoma u stanicama karcinoma pločastog epitela jezika Cal27 nakon de novo ekspresije integrina αvβ3, Faculty of Science, University of Zagreb, 2018.
3. Christine Supina, Kombinirani utjecaj cilengitida i paklitaksela na stanične linije trostruko negativnog tumora dojke i melanoma, Faculty of Science, University of Zagreb, 2018.
4. Nebojša Vujnović, „Kombinirani učinak inhibitora tirozin kinaza i protutumorskih lijekova u stanicama melanoma čovjeka“, Faculty of Science, University of Zagreb, 2017.
5. Delphine Sedda, „Knockdown of the integrin subunit αV in MDA-MB-435 cells decreases sensitivity to cisplatin, Masters „Science of Life“, Masther thesis of biochemistry, molecular biology and biotechnology, University of Orleans, France, 2016.
6. Alen Kovačević, „Proteomic analysis of human breast cancer cells MDA-MB-435S after silencing integrin alpha v“, Faculty of Science, University of Zagreb, 2015. Co-menthors Andreja Ambriović-Ristov and Mario Cindrić
7. Ivan Faraho, „Differential proteome analysis of Cal27 and Cal27-2B1 human tongue squamous cell carcinoma cell lines“, Faculty of Science, University of Zagreb, 2015. Co-menthors Andreja Ambriović-Ristov and Mario Cindrić
8. Kristijan Pažur, „Disulfide bonds in retargeting motifs RGD or NGR inserted into the adenovirus type 5“, Faculty of Science, University of Zagreb, 2013.
9. Krešimir Ferenčak, „Effect of integrin αv or α4 silencing on sensitivity of human breast cancer cells to vincristine and paclitaxel“, Faculty of Science, University of Zagreb, 2013.
10. Buger Tvrtko, „Vincristine cell resistance is accompanied by changes in integrin expression and adenovirus transduction efficiency“, Faculty of Science, University of Zagreb, 2012.
11. Dekanić Ana, „Influence of integrin αvβ3 and αvβ5 silencing on sensitivity of tumor cells to cisplatin“, Faculty of Science, University of Zagreb, 2012.
12. Irena Bardak, „Influence of αvβ3 and αvβ5 integrin silencing on attachment, internalization and transduction with adenoviral vectors“, Faculty of Science, University of Zagreb, 2011.
13. Dunja Vukić, „Increased Ad5-mediated transgene expression in cisplatin-resistant human laryngeal carcinoma cells“, Faculty of Pharmacy and Biochemistry, University of Zagreb, 2010.
14. Tea Špeljko, „The influence of the coxsackie adenovirus receptor expression on integrin expression in human rhabdomyosarcoma cell line“, Faculty of Science, University of Zagreb, 2010.
15. Nikolina Stojanović, „αvβ3 integrin mediated drug resistance in human tongue squamous cell carcinoma“, Faculty of Science, University of Zagreb, 2009.
16. Tihana Jelušić, „Retargeting adenovirus type 5 to integrin α4β1“, Faculty of Science, University of Zagreb, 2009.
VISITS TO FOREIGN RESEARCH INSTITUTIONS
Visiting professor (duration 1 month) year 2018/2019: Molecular Biotechnology Center, University of Torino, Torino, Italy
Visiting professor (duration 1 month) year 2016/2017: Molecular Biotechnology Center, University of Torino, Torino, Italy
Visiting professor (duration 1 month) year 2013/2014: University of Orleans, France.
Visiting professor (duration 1 month) year 2010/2011: University of Orleans, France.
INRA postdoc fellowship; March-August, 2001; Ecole Nationale Veterinaire D’Alfort, 7 avenue du General de Gaulle, 94704 Maisons Alfort, France.
French Government Fellowship: November, 1994 - August, 1995, Ecole Nationale Veterinaire D’Alfort, 7 avenue du General de Gaulle, 94704 Maisons Alfort, France.