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Assessment of efficacy and toxicity of biologically active substances

Project type
Znanstveno-istraživački projekti
European Commission
Start date
Jan 1st 2024
End date
Dec 31st 2027
Total cost
763985 EUR

The BioMolTox project is focused on researching the mechanism of action of biologically active molecules that currently represent a general health problem such as organic pollutants, synthetic drugs, and nanoparticles, but also their complex mixtures that are present in the environment and organisms. Knowledge of the mechanism of action of these substances of natural and/or synthetic origin, to which we are exposed in the short or long term in our daily lives, is extremely important for assessing possible negative effects on human health and the environment. Research will take place in four directions: 1) determination of the effects of selected xenobiotics on the living organism, 2) development and evaluation of potential new drugs, 3) development and implementation of new research methods, 4) population biomonitoring. The multidisciplinarity of the project will enable a better characterization of the effects of selected biologically active substances using the methods of chemical analysis, enzyme kinetics, genetics and molecular toxicology, and toxicology in vivo. The main goal of the project is a comprehensive in silico/in vitro/ex vivo and in vivo analysis of the effects of selected biologically active substances and the risk assessment of their harmful effects on the organism. The proposed research follows the guidelines of the European Union, which include the protection of human health and the environment as one of the main objectives of the strategy for a sustainable climate-neutral, and circular economy.

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