Cardiovascular and cerebrovascular diseases remain among the leading causes of death and disability worldwide, and although stents are routinely used as an established solution for restoring the patency of narrowed or occluded blood vessels, their further development still depends on advanced surface modification strategies and precisely designed functional coatings capable of controlling interfacial and biological properties while reducing adverse biological responses and post-interventional complications.This project is focused on the development of functional surface coatings for stents, based on self-assembled fatty acid (FA) layers and their modification by ionizing radiation. It builds on our group’s recent discovery that self-assembled FA molecular layers can be crosslinked under irradiation, contrary to the earlier assumption that such sensitive systems would primarily undergo degradation. In parallel, irradiation generates reactive surface sites suitable for the controlled attachment of therapeutic molecules. The project therefore establishes a platform for nano-thin coatings on metallic stents, in which FA layers form a polymeric substrate and a bioactive layer. In contrast to conventional polymer coatings, these systems offer well-defined thickness, chemical architecture, and biocompatibility. An additional advantage is that ionizing radiation enables crosslinking, attachment of bioactive molecules, and sterilization within a single processing step.The concept will be extended to permanent and biodegradable stent metals by adjusting FA composition and crosslinking density in order to control interfacial stability and degradation. Radiation-induced radical formation, lifetime, and reactivity will be quantified and exploited for precise molecular attachment. Surface-sensitive, electrochemical, and biological analyses will establish structure–property relationships under physiological conditions.