CASCADE will develop a set of concerted and coordinated actions including monitoring (observing and modelling) and management (Maritime Spatial Planning - MSP,Integrated Coastal Zone Management - ICZM, Land-Sea Interaction - LSI) to enhance the knowledge and to evaluate the quality and assess the vulnerability of inland, coastal and marine ecosystems in Italy and Croatia with the final objective to restore endangered species and to support integrated management. The integrated modelling and observing systems will be developed to design and implement MSP/LSI/ICZM, management and restoration actions in 11 pilot areas. Pilot actions will assess and protect coastal and marine biodiversity in degraded areas, set up restoration actions, assess the impacts of extreme events on ecosystems and understand how to avoid conflicts and boost synergies in the areas. The project will consolidate long-lasting esearch capabilities in the field through a concrete dialogue with stakeholders and the participation of Agencies, research centres and universities in order to enhance inland, coastal and marine knowledge. Such shared information and monitoring protocols are essential for supporting concrete actions dealing with environmental vulnerability, fragmentation and safeguarding of ecosystem services at cross-border level.